{"id":"https://openalex.org/W7225457935","doi":"https://doi.org/10.1080/01913123.2026.2752218","title":"The neuroprotective effect of N-acetylcysteine and therapeutic effect of bone marrow-derived mesenchymal stromal cells on locus coeruleus in a rat model of cuprizone-induced central nervous system demyelination: behavioral and histological study","display_name":"The neuroprotective effect of N-acetylcysteine and therapeutic effect of bone marrow-derived mesenchymal stromal cells on locus coeruleus in a rat model of cuprizone-induced central nervous system demyelination: behavioral and histological study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225457935","doi":"https://doi.org/10.1080/01913123.2026.2752218","pmid":"https://pubmed.ncbi.nlm.nih.gov/42995466"},"language":"en","primary_location":{"id":"doi:10.1080/01913123.2026.2752218","doi":"https://doi.org/10.1080/01913123.2026.2752218","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01913123.2026.2752218","pdf_url":null,"source":{"id":"https://openalex.org/S196754188","display_name":"Ultrastructural Pathology","issn_l":"0191-3123","issn":["0191-3123","1521-0758"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrastructural Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161210403","display_name":"Laila F. Ammar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Laila F. Ammar","raw_affiliation_strings":["Tanta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tanta University","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161208849","display_name":"Kawther A. Elmehi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Kawther A. Elmehi","raw_affiliation_strings":["Tanta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tanta University","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009661053","display_name":"Samah Kandeel","orcid":"https://orcid.org/0000-0003-4559-9005","observed_orcids":["https://orcid.org/0000-0003-4559-9005"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Samah K. Kandeel","raw_affiliation_strings":["Tanta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tanta University","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113739229","display_name":"Amany Mousa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amany M. Mousa","raw_affiliation_strings":["Tanta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tanta University","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5097351162","display_name":"Abd-El Moniem Fareed Zamzam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abd-EL Mon\u2019em F. Zamzam","raw_affiliation_strings":["Tanta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tanta University","institution_ids":["https://openalex.org/I21376657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161210403"],"corresponding_institution_ids":["https://openalex.org/I21376657"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.11060000211000443,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cuprizone","display_name":"cuprizone","score":0.8700000047683716},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.878000020980835},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stromal-cells","display_name":"bone marrow-derived mesenchymal stromal cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/noradrenergic-neurons","display_name":"noradrenergic neurons","score":0.8830000162124634},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.753000020980835},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9290000200271606},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-ultrastructure","display_name":"cell ultrastructure","score":0.5450000166893005},{"id":"https://openalex.org/keywords/pkh26-labeling","display_name":"PKH26 labeling","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.9010999798774719},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8022000193595886},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7960000038146973},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5853000283241272},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5418999791145325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5317999720573425},{"id":"https://openalex.org/C2779740913","wikidata":"https://www.wikidata.org/wiki/Q5184693","display_name":"Cresyl violet","level":3,"score":0.4611000120639801},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.42559999227523804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3898000121116638},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3273000121116638},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.3231000006198883},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29190000891685486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2856999933719635},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26499998569488525},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.25839999318122864}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/01913123.2026.2752218","doi":"https://doi.org/10.1080/01913123.2026.2752218","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01913123.2026.2752218","pdf_url":null,"source":{"id":"https://openalex.org/S196754188","display_name":"Ultrastructural Pathology","issn_l":"0191-3123","issn":["0191-3123","1521-0758"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrastructural Pathology","raw_type":"journal-article"},{"id":"pmid:42995466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42995466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrastructural pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1667322406","https://openalex.org/W1871573964","https://openalex.org/W2034555062","https://openalex.org/W2042537187","https://openalex.org/W2107920234","https://openalex.org/W2117530544","https://openalex.org/W2137177783","https://openalex.org/W2176136593","https://openalex.org/W2183025739","https://openalex.org/W2274789024","https://openalex.org/W2293281822","https://openalex.org/W2338913024","https://openalex.org/W2439394256","https://openalex.org/W2516428217","https://openalex.org/W2518726441","https://openalex.org/W2528806637","https://openalex.org/W2531265877","https://openalex.org/W2601334523","https://openalex.org/W2609030733","https://openalex.org/W2621834629","https://openalex.org/W2761098718","https://openalex.org/W2766285099","https://openalex.org/W2790708337","https://openalex.org/W2890224686","https://openalex.org/W2896014118","https://openalex.org/W2896124359","https://openalex.org/W2897588160","https://openalex.org/W2901781996","https://openalex.org/W2904968162","https://openalex.org/W2907975539","https://openalex.org/W2920516624","https://openalex.org/W2921019730","https://openalex.org/W2943105308","https://openalex.org/W2946516308","https://openalex.org/W2963481271","https://openalex.org/W2967632531","https://openalex.org/W2974296850","https://openalex.org/W2978849696","https://openalex.org/W2986708361","https://openalex.org/W2996671611","https://openalex.org/W3034168552","https://openalex.org/W3039518797","https://openalex.org/W3081099132","https://openalex.org/W3102531121","https://openalex.org/W3108923360","https://openalex.org/W3132055201","https://openalex.org/W3158335718","https://openalex.org/W3164822468","https://openalex.org/W3182932762","https://openalex.org/W3193418223","https://openalex.org/W4200337346","https://openalex.org/W4205506400","https://openalex.org/W4220932880","https://openalex.org/W4229064788","https://openalex.org/W4251401024","https://openalex.org/W4289833894","https://openalex.org/W4360969606","https://openalex.org/W4364356346","https://openalex.org/W4366595104","https://openalex.org/W4379375519","https://openalex.org/W4381094114","https://openalex.org/W4382632558","https://openalex.org/W4385727630","https://openalex.org/W4385811174","https://openalex.org/W4386370043","https://openalex.org/W4388654807","https://openalex.org/W4388733957","https://openalex.org/W4393044872","https://openalex.org/W4408956655","https://openalex.org/W4409377293","https://openalex.org/W4414298203"],"related_works":["https://openalex.org/W3158335718","https://openalex.org/W2767215765","https://openalex.org/W3037534488","https://openalex.org/W4321243221","https://openalex.org/W2803292801","https://openalex.org/W4409603389","https://openalex.org/W2555073061","https://openalex.org/W3121847686","https://openalex.org/W4388522146","https://openalex.org/W2615523400"],"abstract_inverted_index":{"Cuprizone":[0],"(CPZ)":[1],"is":[2],"widely":[3],"used":[4],"experimentally":[5],"to":[6,34,66],"induce":[7],"CNS":[8],"toxic":[9],"injury":[10,84],"accompanied":[11],"by":[12,184,247],"oxidative":[13,38],"stress,":[14],"mitochondrial":[15],"dysfunction":[16],"and":[17,37,44,57,73,98,119,146,157,179,188,203,215,221,231,238],"demyelination.":[18],"The":[19,60],"locus":[20,87,164,249],"coeruleus":[21,88,165],"(LC),":[22],"a":[23,131,235],"predominantly":[24],"unmyelinated":[25],"or":[26],"sparsely":[27],"myelinated":[28],"noradrenergic":[29,181],"nucleus,":[30],"may":[31],"be":[32],"vulnerable":[33],"such":[35],"metabolic":[36],"insults.":[39],"N-acetylcysteine":[40,230],"(NAC)":[41],"has":[42],"antioxidant":[43],"neuroprotective":[45,58,69,237],"properties,":[46],"whereas":[47],"bone":[48,77,137],"marrow-derived":[49,78,138],"mesenchymal":[50,79,139,251],"stromal":[51,80,140,232,252],"cells":[52,81,141,233],"(BM-MSCs)":[53],"have":[54],"potential":[55],"regenerative":[56],"effects.":[59],"purpose":[61],"of":[62,71,76,85,135,169,217,224,244],"this":[63],"work":[64],"was":[65],"study":[67],"the":[68,86,225],"effect":[70,75,240],"NAC":[72],"therapeutic":[74],"on":[82,241],"cuprizone-induced":[83],"in":[89,175],"adult":[90,103],"male":[91,102],"albino":[92,104],"rats":[93,105,129],"using":[94],"behavioral,":[95,154],"histological,":[96],"immunohistochemical":[97,194],"ultrastructural":[99],"assessments.":[100],"Forty-five":[101],"were":[106,147,161],"divided":[107],"into;":[108],"Group":[109,112,116,121,167,213],"I:":[110],"control;":[111],"II:":[113],"cuprizone":[114,118,123],"treated;":[115],"III:":[117],"N-acetylcysteine;":[120],"IV:":[122],"treated":[124],"then":[125],"24":[126],"hours":[127],"later,":[128],"received":[130],"single":[132],"intravenous":[133],"injection":[134],"1\u00d7106":[136],"into":[142],"rat":[143],"tail":[144],"vein":[145],"left":[148],"for":[149,163],"another":[150],"10":[151],"days.":[152],"Finally,":[153],"statistical,":[155],"light":[156],"electron":[158,207],"microscopic":[159,208],"tissues":[160],"evaluated":[162],"(LC).":[166],"II":[168],"LC":[170,218,245],"showed":[171,219],"highly":[172],"significant":[173,193,236],"changes":[174,243],"different":[176],"behavioral":[177],"tests":[178],"affected":[180],"neurons":[182],"seen":[183],"H&E,":[185],"toluidine":[186],"blue":[187],"cresyl":[189],"violet":[190],"stains.":[191],"Also,":[192],"findings":[195,209],"regarding":[196,210],"anti-tyrosine":[197],"hydroxylase,":[198],"anti-glial":[199],"fibrillary":[200],"acidic":[201],"protein":[202],"anti-caspase-3.":[204],"Besides,":[205],"marked":[206,222],"cell":[211],"organelles.":[212],"III":[214],"IV":[216],"mild":[220],"improvement":[223],"previously":[226],"mentioned":[227],"findings,":[228],"respectively.":[229],"had":[234],"ameliorative":[239],"histopathological":[242],"induced":[246],"cuprizone.Cuprizone,":[248],"coeruleus,":[250],"cells,":[253],"N-acetylcysteine,":[254],"PKH26.":[255]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}