{"id":"https://openalex.org/W7225457381","doi":"https://doi.org/10.1056/nejmoa2612922","title":"Intensive Blood-Pressure Lowering in Patients with Type 2 Diabetes","display_name":"Intensive Blood-Pressure Lowering in Patients with Type 2 Diabetes","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225457381","doi":"https://doi.org/10.1056/nejmoa2612922","pmid":"https://pubmed.ncbi.nlm.nih.gov/43001746"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa2612922","doi":"https://doi.org/10.1056/nejmoa2612922","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa2612922","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018285612","display_name":"Karla Santo","orcid":"https://orcid.org/0000-0001-9047-8865","observed_orcids":["https://orcid.org/0000-0001-9047-8865"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karla Santo","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038677581","display_name":"Eduardo Bello Martins","orcid":"https://orcid.org/0000-0001-8752-2175","observed_orcids":["https://orcid.org/0000-0001-8752-2175"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo Martins","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135474192","display_name":"Gisele Sampaio Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gisele S. Silva","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo","Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008329263","display_name":"Patr\u00edcia O. Guimar\u00e3es","orcid":"https://orcid.org/0000-0002-0626-2250","observed_orcids":["https://orcid.org/0000-0002-0626-2250"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patricia O. Guimar\u00e3es","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108595478","display_name":"Caio A.M. Tavares","orcid":"https://orcid.org/0000-0002-2366-3371","observed_orcids":["https://orcid.org/0000-0002-2366-3371"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Caio A.M. Tavares","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052928542","display_name":"Jo\u00e3o Brainer Clares de Andrade","orcid":"https://orcid.org/0000-0001-8768-7164","observed_orcids":["https://orcid.org/0000-0001-8768-7164"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o B. Andrade","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo","Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069396501","display_name":"Frederico Monfardini","orcid":"https://orcid.org/0000-0002-9590-5448","observed_orcids":["https://orcid.org/0000-0002-9590-5448"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Frederico Monfardini","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104246020","display_name":"Josu\u00e9 Nieri","orcid":"https://orcid.org/0000-0002-8409-8601","observed_orcids":["https://orcid.org/0000-0002-8409-8601"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Josu\u00e9 Nieri","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002943087","display_name":"Silvia Regina Lamas Assis","orcid":"https://orcid.org/0009-0007-8440-1299","observed_orcids":["https://orcid.org/0009-0007-8440-1299"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvia R.L. Assis","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050177931","display_name":"Jo\u00e3o Soares Fel\u00edcio","orcid":"https://orcid.org/0000-0003-4002-988X","observed_orcids":["https://orcid.org/0000-0003-4002-988X"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o S. Fel\u00edcio","raw_affiliation_strings":["Jo\u00e3o de Barros Barreto University Hospital, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jo\u00e3o de Barros Barreto University Hospital, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048401998","display_name":"F\u00e1bio Serra Silveira","orcid":"https://orcid.org/0000-0002-2924-7328","observed_orcids":["https://orcid.org/0000-0002-2924-7328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F\u00e1bio S. Silveira","raw_affiliation_strings":["Centro de Pesquisa Cl\u00ednica do Cora\u00e7\u00e3o, Aracaju, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Pesquisa Cl\u00ednica do Cora\u00e7\u00e3o, Aracaju, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038809185","display_name":"Marcos S. Silveira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcos S. Silveira","raw_affiliation_strings":["Centro de Pesquisa Cl\u00ednica do Cora\u00e7\u00e3o, Aracaju, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Pesquisa Cl\u00ednica do Cora\u00e7\u00e3o, Aracaju, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010734379","display_name":"Audes D. M. Feitosa","orcid":"https://orcid.org/0000-0002-9983-4720","observed_orcids":["https://orcid.org/0000-0002-9983-4720"]},"institutions":[{"id":"https://openalex.org/I71437568","display_name":"Universidade de Pernambuco","ror":"https://ror.org/00gtcbp88","country_code":"BR","type":"education","lineage":["https://openalex.org/I71437568"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Audes D.M. Feitosa","raw_affiliation_strings":["Pronto Socorro Cardiol\u00f3gico de Pernambuco, University of Pernambuco, Recife, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pronto Socorro Cardiol\u00f3gico de Pernambuco, University of Pernambuco, Recife, Brazil","institution_ids":["https://openalex.org/I71437568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015377698","display_name":"Miguel Nasser Hissa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel N. Hissa","raw_affiliation_strings":["Centro de Pesquisas em Diabetes e Doen\u00e7as End\u00f3crino-Metab\u00f3licas/Cl\u00ednica Popular Endocrinologia, Fortaleza, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Pesquisas em Diabetes e Doen\u00e7as End\u00f3crino-Metab\u00f3licas/Cl\u00ednica Popular Endocrinologia, Fortaleza, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084181315","display_name":"D\u00e1rio Celestino Sobral Filho","orcid":"https://orcid.org/0000-0002-5301-7741","observed_orcids":["https://orcid.org/0000-0002-5301-7741","https://orcid.org/0000-0003-2662-1246"]},"institutions":[{"id":"https://openalex.org/I71437568","display_name":"Universidade de Pernambuco","ror":"https://ror.org/00gtcbp88","country_code":"BR","type":"education","lineage":["https://openalex.org/I71437568"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Dario C. Sobral-Filho","raw_affiliation_strings":["Pronto Socorro Cardiol\u00f3gico de Pernambuco, University of Pernambuco, Recife, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pronto Socorro Cardiol\u00f3gico de Pernambuco, University of Pernambuco, Recife, Brazil","institution_ids":["https://openalex.org/I71437568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082745029","display_name":"Jos\u00e9 Fernando Vilela-Martin","orcid":"https://orcid.org/0000-0001-6960-2825","observed_orcids":["https://orcid.org/0000-0001-6960-2825"]},"institutions":[{"id":"https://openalex.org/I1340031499","display_name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto","ror":"https://ror.org/052e6h087","country_code":"BR","type":"education","lineage":["https://openalex.org/I1340031499"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 F. Vilela-Martin","raw_affiliation_strings":["State Medicine School of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Medicine School of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil","institution_ids":["https://openalex.org/I1340031499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053324113","display_name":"Elizabeth do Esp\u00edrito Santo Cest\u00e1rio","orcid":"https://orcid.org/0000-0001-8621-0305","observed_orcids":["https://orcid.org/0000-0001-8621-0305"]},"institutions":[{"id":"https://openalex.org/I1340031499","display_name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto","ror":"https://ror.org/052e6h087","country_code":"BR","type":"education","lineage":["https://openalex.org/I1340031499"]},{"id":"https://openalex.org/I4210126477","display_name":"Centro Universit\u00e1rio de Votuporanga","ror":"https://ror.org/03c1bg807","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126477"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elizabeth E.S. Cestario","raw_affiliation_strings":["State Medicine School of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil","University Center of Votuporanga, Votuporanga, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Medicine School of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil","institution_ids":["https://openalex.org/I1340031499"]},{"raw_affiliation_string":"University Center of Votuporanga, Votuporanga, Brazil","institution_ids":["https://openalex.org/I4210126477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054658743","display_name":"Juan Carlos Yugar\u2010Toledo","orcid":"https://orcid.org/0000-0001-6583-6536","observed_orcids":["https://orcid.org/0000-0001-6583-6536"]},"institutions":[{"id":"https://openalex.org/I1340031499","display_name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto","ror":"https://ror.org/052e6h087","country_code":"BR","type":"education","lineage":["https://openalex.org/I1340031499"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juan C. Yugar-Toledo","raw_affiliation_strings":["State Medicine School of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Medicine School of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil","institution_ids":["https://openalex.org/I1340031499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102898664","display_name":"Marcelo Cidade Batista","orcid":"https://orcid.org/0000-0003-0012-4639","observed_orcids":["https://orcid.org/0000-0003-0012-4639"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo C. Batista","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo","Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066628509","display_name":"Nelson Rassi","orcid":"https://orcid.org/0009-0006-2145-3377","observed_orcids":["https://orcid.org/0009-0006-2145-3377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelson Rassi","raw_affiliation_strings":["NS Cl\u00ednica de Diabetes e Endocrinologia, Goi\u00e2nia, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NS Cl\u00ednica de Diabetes e Endocrinologia, Goi\u00e2nia, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161187265","display_name":"Marco A.M. Gomes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137548","display_name":"Centro Universit\u00e1rio Cesmac","ror":"https://ror.org/03rzfjh59","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210137548"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marco A.M. Gomes","raw_affiliation_strings":["Centro de Pesquisas Cl\u00ednicas Dr. Marco Mota, Centro Universit\u00e1rio Cesmac/Hospital do Cora\u00e7\u00e3o de Alagoas, Macei\u00f3, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Pesquisas Cl\u00ednicas Dr. Marco Mota, Centro Universit\u00e1rio Cesmac/Hospital do Cora\u00e7\u00e3o de Alagoas, Macei\u00f3, Brazil","institution_ids":["https://openalex.org/I4210137548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054137805","display_name":"Ricardo Reinaldo Bergo","orcid":"https://orcid.org/0009-0000-6328-9487","observed_orcids":["https://orcid.org/0009-0000-6328-9487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricardo R. Bergo","raw_affiliation_strings":["Centro de Pesquisa do Hospital Santa Lucia, Po\u00e7os de Caldas, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Pesquisa do Hospital Santa Lucia, Po\u00e7os de Caldas, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010720429","display_name":"Bruno Geloneze","orcid":"https://orcid.org/0000-0002-0557-4578","observed_orcids":["https://orcid.org/0000-0002-0557-4578"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Geloneze","raw_affiliation_strings":["Centro de Endocrinologia Geloneze, Campinas, Brazil","Obesity and Comorbidities Research Center, State University of Campinas, Campinas, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Endocrinologia Geloneze, Campinas, Brazil","institution_ids":[]},{"raw_affiliation_string":"Obesity and Comorbidities Research Center, State University of Campinas, Campinas, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161195184","display_name":"Jos\u00e9 G. Mill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 G. Mill","raw_affiliation_strings":["Hospital Universit\u00e1rio Cassiano Antonio de Moraes, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universit\u00e1rio Cassiano Antonio de Moraes, Vit\u00f3ria, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161186253","display_name":"Lilia Nigro-Maia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155407","display_name":"Hospital de Base","ror":"https://ror.org/04qbxyj42","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210155407"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lilia Nigro-Maia","raw_affiliation_strings":["Centro Integrado de Pesquisas to Hospital de Base de Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Integrado de Pesquisas to Hospital de Base de Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil","institution_ids":["https://openalex.org/I4210155407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161245598","display_name":"Marcio Gon\u00e7alves Sousa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152499","display_name":"Instituto Dante Pazzanese de Cardiologia","ror":"https://ror.org/04spxqa35","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210152499"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcio G. Sousa","raw_affiliation_strings":["Instituto Dante Pazzanese, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Dante Pazzanese, S\u00e3o Paulo","institution_ids":["https://openalex.org/I4210152499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007820479","display_name":"Mauro Esteves Hernandes","orcid":"https://orcid.org/0000-0002-5998-5364","observed_orcids":["https://orcid.org/0000-0002-5998-5364"]},"institutions":[{"id":"https://openalex.org/I4210129004","display_name":"Santa Casa de Votuporanga","ror":"https://ror.org/02w3v2343","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210129004"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mauro E. Hernandes","raw_affiliation_strings":["Santa Casa de Votuporanga, Votuporanga, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Casa de Votuporanga, Votuporanga, Brazil","institution_ids":["https://openalex.org/I4210129004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044760122","display_name":"Luiz Alberto Andreotti Turatti","orcid":"https://orcid.org/0000-0002-0089-5794","observed_orcids":["https://orcid.org/0000-0002-0089-5794"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz Turatti","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018931040","display_name":"Andr\u00e9a Ara\u00fajo Brand\u00e3o","orcid":"https://orcid.org/0000-0002-7040-396X","observed_orcids":["https://orcid.org/0000-0002-7040-396X"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andrea A. Brand\u00e3o","raw_affiliation_strings":["Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084743868","display_name":"Weimar Kunz Sebba Barroso","orcid":"https://orcid.org/0000-0002-1265-1930","observed_orcids":["https://orcid.org/0000-0002-1265-1930"]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Weimar S. Barroso","raw_affiliation_strings":["Hypertension Unit, Medicine School, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Unit, Medicine School, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086183706","display_name":"Andrei Carvalho Sposito","orcid":"https://orcid.org/0000-0001-7127-2052","observed_orcids":["https://orcid.org/0000-0001-7127-2052"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andrei C. Sposito","raw_affiliation_strings":["Clinical Research Center, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7127-2052","affiliations":[{"raw_affiliation_string":"Clinical Research Center, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032013233","display_name":"Luciano F. Drager","orcid":"https://orcid.org/0000-0002-2081-6846","observed_orcids":["https://orcid.org/0000-0002-2081-6846"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciano F. Drager","raw_affiliation_strings":["Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo","Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268","https://openalex.org/I4405258467"]},{"raw_affiliation_string":"Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007614613","display_name":"Luiz Aparecido Bortolotto","orcid":"https://orcid.org/0000-0002-4865-6442","observed_orcids":["https://orcid.org/0000-0002-4865-6442"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz A. Bortolotto","raw_affiliation_strings":["Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000196689","display_name":"Marcelo Franken","orcid":"https://orcid.org/0000-0002-4286-8559","observed_orcids":["https://orcid.org/0000-0002-4286-8559"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Franken","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058932304","display_name":"Pedro A. Lemos","orcid":"https://orcid.org/0000-0002-6782-750X","observed_orcids":["https://orcid.org/0000-0002-6782-750X"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]},{"id":"https://openalex.org/I3121512035","display_name":"Universidad Aut\u00f3noma de Chile","ror":"https://ror.org/010r9dy59","country_code":"CL","type":"education","lineage":["https://openalex.org/I3121512035"]}],"countries":["BR","CL"],"is_corresponding":false,"raw_author_name":"Pedro A. Lemos","raw_affiliation_strings":["Faculty of Health Sciences, Universidad Aut\u00f3noma de Chile, Providencia, Chile","Hospital Israelita Albert Einstein, S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Universidad Aut\u00f3noma de Chile, Providencia, Chile","institution_ids":["https://openalex.org/I3121512035"]},{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053901502","display_name":"Raul Dias Santos","orcid":"https://orcid.org/0000-0002-9860-6582","observed_orcids":["https://orcid.org/0000-0002-9860-6582"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raul D. Santos","raw_affiliation_strings":["Hospital Israelita Albert Einstein, S\u00e3o Paulo","Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo"],"raw_orcid":"https://orcid.org/0000-0002-9860-6582","affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, S\u00e3o Paulo","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Instituto do Cora\u00e7\u00e3o, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077448560","display_name":"Sandra Cristina Pereira Costa Fuchs","orcid":"https://orcid.org/0000-0001-6351-9588","observed_orcids":["https://orcid.org/0000-0001-6351-9588"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sandra C. Fuchs","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I4210097146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015704931","display_name":"Anthony Rodgers","orcid":"https://orcid.org/0000-0003-1282-1896","observed_orcids":["https://orcid.org/0000-0003-1282-1896"]},"institutions":[{"id":"https://openalex.org/I183874623","display_name":"The George Institute for Global Health","ror":"https://ror.org/04h0zjx60","country_code":"GB","type":"facility","lineage":["https://openalex.org/I183874623","https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Anthony Rodgers","raw_affiliation_strings":["George Institute for Global Health UK, London","George Institute for Global Health, Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Institute for Global Health UK, London","institution_ids":["https://openalex.org/I183874623"]},{"raw_affiliation_string":"George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049535333","display_name":"Paul Kieran Whelton","orcid":"https://orcid.org/0000-0002-2225-383X","observed_orcids":["https://orcid.org/0000-0002-2225-383X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul K. Whelton","raw_affiliation_strings":["Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans"],"raw_orcid":"https://orcid.org/0000-0002-2225-383X","affiliations":[{"raw_affiliation_string":"Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023045743","display_name":"Fl\u00e1vio Danni Fuchs","orcid":"https://orcid.org/0000-0002-1191-0523","observed_orcids":["https://orcid.org/0000-0002-1191-0523"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Flavio D. Fuchs","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723","https://openalex.org/I4210097146"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026937673","display_name":"Otavio B Berwanger","orcid":"https://orcid.org/0000-0002-4972-2958","observed_orcids":["https://orcid.org/0000-0002-4972-2958"]},"institutions":[{"id":"https://openalex.org/I183874623","display_name":"The George Institute for Global Health","ror":"https://ror.org/04h0zjx60","country_code":"GB","type":"facility","lineage":["https://openalex.org/I183874623","https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Otavio Berwanger","raw_affiliation_strings":["George Institute for Global Health UK, London","Imperial College London, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Institute for Global Health UK, London","institution_ids":["https://openalex.org/I183874623"]},{"raw_affiliation_string":"Imperial College London, London","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":23,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intensive-blood-pressure-lowering","display_name":"intensive blood pressure lowering","score":0.921999990940094},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/systolic-blood-pressure-target","display_name":"systolic blood pressure target","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.6230000257492065},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8180000185966492},{"id":"https://openalex.org/keywords/high-cardiovascular-risk","display_name":"high cardiovascular risk","score":0.7080000042915344},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7936999797821045},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6434000134468079},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5396999716758728},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24240000545978546},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.23849999904632568}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa2612922","doi":"https://doi.org/10.1056/nejmoa2612922","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa2612922","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:43001746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43001746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323916","display_name":"Minist\u00e9rio da Sa\u00fade","ror":"https://ror.org/02y7p0749"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2136145230","https://openalex.org/W2144403818","https://openalex.org/W2147663252","https://openalex.org/W2920258695","https://openalex.org/W3084574705","https://openalex.org/W3098066709","https://openalex.org/W3150595609","https://openalex.org/W3198533772","https://openalex.org/W3204320219","https://openalex.org/W3211912548","https://openalex.org/W4286615932","https://openalex.org/W4377246657","https://openalex.org/W4400066882","https://openalex.org/W4404436453","https://openalex.org/W4409704602","https://openalex.org/W4413031254","https://openalex.org/W7170801271"],"related_works":["https://openalex.org/W4404436464","https://openalex.org/W2410091771","https://openalex.org/W2326121988","https://openalex.org/W2566575776","https://openalex.org/W6910906602","https://openalex.org/W2355415971","https://openalex.org/W2412388701","https://openalex.org/W2510369338","https://openalex.org/W2095491543","https://openalex.org/W2517462611"],"abstract_inverted_index":{"BACKGROUND:":[0],"Uncertainty":[1],"persists":[2],"regarding":[3],"the":[4,93,124,139,148,156,185,199,262,275],"effects":[5],"of":[6,46,60,73,123,138,163,245,264,278],"intensive":[7,39,106,223],"blood-pressure":[8],"lowering":[9],"in":[10,24,147,155,175,184,189,198,218,226],"patients":[11,26,97,125,177,191,220,228,235],"with":[12,27,222,230,236,253],"type":[13,31,237],"2":[14,32,238],"diabetes.":[15],"METHODS:":[16],"In":[17],"this":[18],"multicenter,":[19],"open-label,":[20],"randomized":[21],"trial":[22],"conducted":[23],"Brazil,":[25],"elevated":[28],"blood":[29,44,58,132,243],"pressure,":[30],"diabetes,":[33,239],"and":[34,108,121,151,188,225,274],"high":[35],"cardiovascular":[36,76,266],"risk":[37],"received":[38],"therapy":[40,54,107,224],"targeting":[41,55,240],"a":[42,56,71,160,171,241],"systolic":[43,57,131,242],"pressure":[45,59,133,244],"less":[47,61,246,254],"than":[48,62,247,255],"120":[49,248],"mm":[50,64,145,153,249,257],"Hg":[51,146,154],"or":[52,83,88],"standard":[53,112,231],"140":[63,256],"Hg.":[65],"The":[66,114,129],"primary":[67],"end":[68],"point":[69],"was":[70,118,143],"composite":[72],"death":[74],"from":[75],"causes,":[77],"nonfatal":[78,81],"myocardial":[79],"infarction,":[80],"stroke,":[82],"hospitalization":[84],"for":[85],"unstable":[86],"angina":[87],"heart":[89],"failure.":[90],"RESULTS:":[91],"Of":[92],"9476":[94],"ethnically":[95],"diverse":[96],"who":[98],"were":[99,102,127],"enrolled,":[100],"4745":[101],"assigned":[103],"to":[104,110,169,209],"receive":[105,111],"4731":[109],"therapy.":[113,232],"mean":[115,130],"(\u00b1SD)":[116],"age":[117],"64.7\u00b18.2":[119],"years,":[120],"5871":[122],"(62.0%)":[126],"women.":[128],"during":[134],"follow-up":[135,162],"(with":[136],"exclusion":[137],"first":[140],"3":[141],"months)":[142],"121.8\u00b110.8":[144],"intensive-therapy":[149,186],"group":[150,187,201],"135.4\u00b18.2":[152],"standard-therapy":[157,200],"group.":[158],"During":[159],"median":[161],"4.0":[164],"years":[165],"(interquartile":[166],"range,":[167],"3.9":[168],"4.0),":[170],"primary-outcome":[172],"event":[173],"occurred":[174,217],"286":[176],"(6.0%;":[178],"1.65":[179],"events":[180,194,216],"per":[181,195],"100":[182,196],"person-years)":[183,197],"315":[190],"(6.7%;":[192],"1.83":[193],"(hazard":[202],"ratio,":[203],"0.90;":[204],"95%":[205],"confidence":[206],"interval,":[207],"0.77":[208],"1.06;":[210],"P":[211],"=":[212],"0.20).":[213],"Serious":[214],"adverse":[215],"706":[219],"(14.9%)":[221],"693":[227],"(14.6%)":[229],"CONCLUSIONS:":[233],"Among":[234],"Hg,":[250,258],"as":[251],"compared":[252],"did":[259],"not":[260],"reduce":[261],"occurrence":[263],"major":[265],"events.":[267],"(Funded":[268],"by":[269],"Hospital":[270],"Israelita":[271],"Albert":[272],"Einstein":[273],"Brazilian":[276],"Ministry":[277],"Health;":[279],"OPTIMAL-DIABETES":[280],"ClinicalTrials.gov":[281],"number,":[282],"NCT04040634.).":[283]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-08T00:00:00"}