{"id":"https://openalex.org/W7225457150","doi":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","title":"INDIVIDUALIZATION OF VANCOMYCIN DOSING USING THERAPEUTIC DRUG MONITORING IN THE TREATMENT OF MRSA INFECTIONS","display_name":"INDIVIDUALIZATION OF VANCOMYCIN DOSING USING THERAPEUTIC DRUG MONITORING IN THE TREATMENT OF MRSA INFECTIONS","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225457150","doi":"https://doi.org/10.22159/ajpcr.2026v19i11.60625"},"language":"en","primary_location":{"id":"doi:10.22159/ajpcr.2026v19i11.60625","doi":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","pdf_url":"https://journals.innovareacademics.in/index.php/ajpcr/article/download/60625/34705","source":{"id":"https://openalex.org/S2764968390","display_name":"Asian Journal of Pharmaceutical and Clinical Research","issn_l":"0974-2441","issn":["0974-2441","2455-3891"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutical and Clinical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.innovareacademics.in/index.php/ajpcr/article/download/60625/34705","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161222091","display_name":"SHAFEENA T","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94948490","display_name":"B.S. Abdur Rahman Crescent Institute of Science & Technology","ror":"https://ror.org/01fqhas03","country_code":"IN","type":"education","lineage":["https://openalex.org/I94948490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"SHAFEENA T","raw_affiliation_strings":["Department of Pharmacy Practice, Crescent School of Pharmacy, B.S Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Crescent School of Pharmacy, B.S Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I94948490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161224790","display_name":"LULU SHERIN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LULU SHERIN","raw_affiliation_strings":["Department of Pharmacy Practice , Iqraa International Hospital and Research Centre , Kozhikode , Kerala , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice , Iqraa International Hospital and Research Centre , Kozhikode , Kerala , India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160900689","display_name":"Venkatalakshmi Ranganathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94948490","display_name":"B.S. Abdur Rahman Crescent Institute of Science & Technology","ror":"https://ror.org/01fqhas03","country_code":"IN","type":"education","lineage":["https://openalex.org/I94948490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"VENKATALAKSHMI RANGANATHAN","raw_affiliation_strings":["Department of Pharmaceutics, Crescent School of Pharmacy, B.S Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Crescent School of Pharmacy, B.S Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I94948490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"163","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9359999895095825},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mrsa-infection","display_name":"MRSA infection","score":0.9330000281333923},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.9210000038146973},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.8339999914169312},{"id":"https://openalex.org/keywords/microbiological-clearance","display_name":"microbiological clearance","score":0.6830000281333923},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/antibiotic-dosing-optimization","display_name":"antibiotic dosing optimization","score":0.5809999704360962},{"id":"https://openalex.org/keywords/antibiotic-duration","display_name":"antibiotic duration","score":0.47099998593330383},{"id":"https://openalex.org/keywords/subtherapeutic-drug-levels","display_name":"subtherapeutic drug levels","score":0.6259999871253967},{"id":"https://openalex.org/keywords/supratherapeutic-drug-levels","display_name":"supratherapeutic drug levels","score":0.7900000214576721},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.36000001430511475},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8708000183105469},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.8549000024795532},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7608000040054321},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.6279000043869019},{"id":"https://openalex.org/C31785415","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough level","level":4,"score":0.5630000233650208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5554999709129333},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5543000102043152},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.47940000891685486},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C2910800852","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough Concentration","level":3,"score":0.44620001316070557},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.38440001010894775},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.36649999022483826},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3619999885559082},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.36070001125335693},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.30169999599456787},{"id":"https://openalex.org/C7453019","wikidata":"https://www.wikidata.org/wiki/Q16254302","display_name":"Negativity effect","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C35294091","wikidata":"https://www.wikidata.org/wiki/Q6663385","display_name":"Loading dose","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22159/ajpcr.2026v19i11.60625","doi":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","pdf_url":"https://journals.innovareacademics.in/index.php/ajpcr/article/download/60625/34705","source":{"id":"https://openalex.org/S2764968390","display_name":"Asian Journal of Pharmaceutical and Clinical Research","issn_l":"0974-2441","issn":["0974-2441","2455-3891"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutical and Clinical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22159/ajpcr.2026v19i11.60625","doi":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ajpcr.2026v19i11.60625","pdf_url":"https://journals.innovareacademics.in/index.php/ajpcr/article/download/60625/34705","source":{"id":"https://openalex.org/S2764968390","display_name":"Asian Journal of Pharmaceutical and Clinical Research","issn_l":"0974-2441","issn":["0974-2441","2455-3891"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutical and Clinical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225457150.pdf","grobid_xml":"https://content.openalex.org/works/W7225457150.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2095891729","https://openalex.org/W2169228559","https://openalex.org/W2620769769","https://openalex.org/W2809184459","https://openalex.org/W4214917850","https://openalex.org/W4388724396","https://openalex.org/W4399330944"],"related_works":["https://openalex.org/W3195778608","https://openalex.org/W2464926597","https://openalex.org/W6964698288","https://openalex.org/W2531562607","https://openalex.org/W7159880348","https://openalex.org/W2801352875","https://openalex.org/W1619915988","https://openalex.org/W3096071868","https://openalex.org/W2980988432","https://openalex.org/W4213142415"],"abstract_inverted_index":{"Objectives:":[0],"This":[1],"study":[2,50],"aimed":[3],"to":[4,25,33,101,247,268,332,338],"evaluate":[5],"the":[6,27,82,177,309,319,329,333],"optimization":[7],"of":[8,29,89,129,219,241,312],"vancomycin":[9,30,68,77,284],"dosing":[10,342],"through":[11],"therapeutic":[12,92,147,283],"drug":[13],"monitoring":[14,337],"(TDM)":[15],"in":[16,37,56,266,281,291,314],"patients":[17,60,90,131,159,180,186,196,202,220],"with":[18,123,302],"methicillin-resistant":[19],"Staphylococcus":[20],"aureus":[21],"(MRSA)":[22],"infections":[23,71],"and":[24,74,99,107,119,151,170,212,259,286],"assess":[26],"duration":[28],"treatment":[31],"required":[32,161,167,173,187,197],"achieve":[34],"culture":[35,104,223,248],"negativity":[36,224,249,269],"a":[38,46,52,189],"tertiary":[39,53],"care":[40,54],"hospital":[41,55],"setting.":[42],"Methods:":[43],"We":[44],"conducted":[45],"6-month":[47],"prospective":[48],"observational":[49],"at":[51],"South":[57],"India.":[58],"Hospitalized":[59],"aged":[61],">18":[62],"years":[63],"who":[64,166,172,203,209,214],"were":[65,72,79,132,298],"receiving":[66],"intravenous":[67],"for":[69,321],"MRSA":[70],"enrolled,":[73],"trough":[75,93,141],"serum":[76],"concentrations":[78],"measured":[80],"before":[81],"fourth":[83],"or":[84],"fifth":[85],"dose.":[86],"The":[87,217],"proportion":[88],"achieving":[91,282],"levels":[94,142,148,155,285],"(10\u201320":[95],"mg/L)":[96],"was":[97,105],"determined,":[98],"time":[100,246,267],"first":[102],"negative":[103],"recorded":[106],"analyzed":[108],"using":[109,326],"Fisher\u2019s":[110],"exact":[111],"test,":[112],"Spearman\u2019s":[113],"rank":[114],"correlation,":[115],"ordinal":[116,232],"logistic":[117,233],"regression,":[118],"Kaplan-Meier":[120],"survival":[121],"analysis":[122,261],"log-rank":[124],"tests.":[125],"Results:":[126],"A":[127],"total":[128],"49":[130],"included.":[133],"Following":[134],"initial":[135],"weight-based":[136],"dosing,":[137],"53.1%":[138],"had":[139,146,153],"subtherapeutic":[140],"(<15":[143],"\u03bcg/mL),":[144,150],"22.4%":[145],"(15\u201320":[149],"24.5%":[152],"supratherapeutic":[154],"(>20":[156],"\u03bcg/mL).":[157],"Twenty-one":[158],"(42.8%)":[160],"dose":[162,168,174,183,191,230,243,271],"adjustment,":[163],"comprising":[164],"15":[165],"escalation":[169,244],"6":[171],"reduction,":[175],"while":[176,317],"remaining":[178],"28":[179],"needed":[181,204,210,215],"no":[182,236,263],"modification.":[184],"Most":[185],"only":[188],"single":[190],"adjustment":[192],"(n=17),":[193],"whereas":[194],"four":[195],"multiple":[198],"adjustments,":[199,231],"including":[200],"two":[201,205],"adjustments":[206],"each,":[207],"one":[208,213],"three,":[211],"four.":[216],"majority":[218],"(65.4%)":[221],"achieved":[222],"within":[225],"10":[226],"days.":[227],"After":[228],"TDM-guided":[229],"regression":[234],"showed":[235],"statistically":[237],"significant":[238,264],"independent":[239],"effect":[240],"post-trough":[242,296],"on":[245],"(adjusted":[250],"odds":[251],"ratio":[252],"1.42,":[253],"95%":[254],"confidence":[255],"interval":[256],"0.78\u20132.58;":[257],"p=0.25),":[258],"Kaplan\u2013Meier":[260],"revealed":[262],"difference":[265],"across":[270],"categories":[272],"(log-rank":[273],"p=0.48).":[274],"Conclusion:":[275],"TDM":[276,313],"plays":[277],"an":[278],"important":[279],"role":[280],"safeguarding":[287],"patient":[288],"safety.":[289],"However,":[290],"this":[292],"pilot":[293],"cohort,":[294],"higher":[295],"doses":[297],"not":[299],"significantly":[300],"associated":[301],"earlier":[303],"microbiological":[304],"clearance.":[305],"These":[306],"findings":[307],"support":[308],"routine":[310],"use":[311],"clinical":[315],"practice":[316],"underscoring":[318],"need":[320],"larger,":[322],"adequately":[323],"powered":[324],"studies":[325],"area":[327],"under":[328],"concentration\u2013time":[330],"curve":[331],"minimum":[334],"inhibitory":[335],"concentration-guided":[336],"establish":[339],"definitive":[340],"optimal":[341],"strategies.":[343]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}
