{"id":"https://openalex.org/W7225456565","doi":"https://doi.org/10.12669/pjms.42.11.21109","title":"Hepatic response score and its association with radiological features and neurological recovery in traumatic brain injury: A retrospective cohort study","display_name":"Hepatic response score and its association with radiological features and neurological recovery in traumatic brain injury: A retrospective cohort study","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225456565","doi":"https://doi.org/10.12669/pjms.42.11.21109"},"language":"en","primary_location":{"id":"doi:10.12669/pjms.42.11.21109","doi":"https://doi.org/10.12669/pjms.42.11.21109","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.11.21109","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/21109/11760","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pjms.org.pk/index.php/pjms/article/download/21109/11760","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078602250","display_name":"Sundas Irshad","orcid":"https://orcid.org/0000-0001-7503-4676","observed_orcids":["https://orcid.org/0000-0001-7503-4676"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sundas Irshad","raw_affiliation_strings":["Resident Trainee, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-7503-4676","affiliations":[{"raw_affiliation_string":"Resident Trainee, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090235612","display_name":"Naeem-ul-Hassan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Naeem-Ul-Hassan","raw_affiliation_strings":["Senior Registrar, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Registrar, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149490817","display_name":"Jazalah Atif","orcid":"https://orcid.org/0009-0002-0803-5876","observed_orcids":["https://orcid.org/0009-0002-0803-5876"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Jazalah Atif","raw_affiliation_strings":["Resident Trainee, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0009-0002-0803-5876","affiliations":[{"raw_affiliation_string":"Resident Trainee, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050732302","display_name":"Haseeb Mehmood Qadri","orcid":"https://orcid.org/0000-0003-0675-9934","observed_orcids":["https://orcid.org/0000-0003-0675-9934"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Haseeb Mehmood Qadri","raw_affiliation_strings":["Resident Trainee and Clinical Research Fellow, Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-0675-9934","affiliations":[{"raw_affiliation_string":"Resident Trainee and Clinical Research Fellow, Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079211506","display_name":"Zubair Mustafa Khan","orcid":"https://orcid.org/0009-0000-3745-8339","observed_orcids":["https://orcid.org/0009-0000-3745-8339"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zubair Mustafa Khan","raw_affiliation_strings":["Associate Professor, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0009-0000-3745-8339","affiliations":[{"raw_affiliation_string":"Associate Professor, Dept. of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405254933"],"apc_list":{"value":400,"currency":"USD","value_usd":400},"apc_paid":{"value":400,"currency":"USD","value_usd":400},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"11","first_page":"3192","last_page":"3197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11467","display_name":"Trauma and Emergency Care Studies","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.6150000095367432},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8510000109672546},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":1.0},{"id":"https://openalex.org/keywords/total-bilirubin","display_name":"total bilirubin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/enteral-nutrition","display_name":"enteral nutrition","score":0.640999972820282},{"id":"https://openalex.org/keywords/midline-shift","display_name":"midline shift","score":0.8640000224113464},{"id":"https://openalex.org/keywords/marshall-classification","display_name":"Marshall classification","score":0.7059999704360962},{"id":"https://openalex.org/keywords/radiographic-severity","display_name":"radiographic severity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/neurological-outcome","display_name":"neurological outcome","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9573000073432922},{"id":"https://openalex.org/C190892606","wikidata":"https://www.wikidata.org/wiki/Q3512464","display_name":"Radiological weapon","level":2,"score":0.840499997138977},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7369999885559082},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.5699999928474426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5551999807357788},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5146999955177307},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.44929999113082886},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.414000004529953},{"id":"https://openalex.org/C2908939727","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Hepatic dysfunction","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2824000120162964},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.257099986076355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12669/pjms.42.11.21109","doi":"https://doi.org/10.12669/pjms.42.11.21109","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.11.21109","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/21109/11760","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12669/pjms.42.11.21109","doi":"https://doi.org/10.12669/pjms.42.11.21109","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.11.21109","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/21109/11760","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225456565.pdf","grobid_xml":"https://content.openalex.org/works/W7225456565.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1618670194","https://openalex.org/W2015918023","https://openalex.org/W2131940641","https://openalex.org/W2299547040","https://openalex.org/W2465411673","https://openalex.org/W2979380312","https://openalex.org/W3038882858","https://openalex.org/W3120170330","https://openalex.org/W3164490702","https://openalex.org/W3194980465","https://openalex.org/W4367595458","https://openalex.org/W4408408405","https://openalex.org/W4412370486","https://openalex.org/W4413054679","https://openalex.org/W7091357287","https://openalex.org/W7163543784","https://openalex.org/W7168245068","https://openalex.org/W7214470898"],"related_works":["https://openalex.org/W2166031143","https://openalex.org/W2198541568","https://openalex.org/W7161238444","https://openalex.org/W7119505457","https://openalex.org/W2604362418","https://openalex.org/W4416647764","https://openalex.org/W2010642911","https://openalex.org/W2150923135","https://openalex.org/W4405963136","https://openalex.org/W2014612935"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"develop":[2],"a":[3,106,161],"principal":[4,93],"component":[5,94],"analysis":[6,95,159],"(PCA)-derived":[7],"hepatic":[8,101,108,167,186,243,276],"response":[9,102,109,168,187,244,277],"factor":[10,169,188,245,278],"and":[11,18,58,68,153,177,203,213,227,250],"assess":[12],"its":[13],"association":[14],"with":[15,48,134,170,191,261,283],"radiological":[16,66,193,271],"features":[17],"neurological":[19,69,284],"recovery":[20],"after":[21,208],"traumatic":[22],"brain":[23],"injury":[24,258,264],"(TBI).":[25],"Methodology:":[26],"This":[27],"retrospective":[28],"observational":[29],"cohort":[30],"study":[31,129],"was":[32,96,131,145,151,155,189],"conducted":[33],"at":[34,215],"the":[35,80,84,123,147,274],"Department":[36],"of":[37,42,114,128,165,257,270],"Neurosurgery,":[38],"Unit-I,":[39],"Punjab":[40],"Institute":[41],"Neurosciences,":[43],"Lahore,":[44],"Pakistan,":[45],"involving":[46],"patients":[47,116],"TBI":[49,119,196,267],"who":[50],"were":[51,71,77,120],"on":[52,173],"enteral":[53],"nutrition":[54],"between":[55],"January":[56],"2026":[57],"May":[59],"2026.":[60],"Data":[61,76],"regarding":[62],"patient":[63,74],"clinical":[64],"characteristics,":[65],"features,":[67,272],"outcomes":[70],"collected":[72],"from":[73,118],"records.":[75],"analyzed":[78],"using":[79],"Statistical":[81],"Package":[82],"for":[83,210],"Social":[85],"Sciences":[86],"(SPSS),":[87],"version":[88],"29.":[89],"After":[90],"descriptive":[91],"analysis,":[92],"performed":[97],"to":[98,104,200],"identify":[99],"latent":[100],"dimensions":[103],"construct":[105],"PCA-derived":[107,166,185,242,275],"factor.":[110],"Results:":[111],"A":[112],"total":[113,142],"56":[115],"suffering":[117],"included":[121],"in":[122,195,266,268],"study.":[124],"The":[125,140],"mean":[126,141,148],"age":[127],"participants":[130],"34.9\u00b116.6":[132],"years,":[133],"male":[135],"predominance":[136],"(78.6%;":[137],"44)":[138],"males.":[139],"bilirubin":[143,251],"level":[144],"0.91\u00b10.43,":[146],"AST":[149],"value":[150],"39.1\u00b116.9,":[152],"ALT":[154],"38.6\u00b115.5.":[156],"Spearman\u2019s":[157],"correlation":[158,164],"revealed":[160],"significant":[162,262],"positive":[163],"midline":[171],"shift":[172],"CT":[174,179,205],"(r=0.294,":[175],"p=0.028)":[176],"Rotterdam":[178,204],"severity":[180,194,265],"score":[181],"(r=0.406,":[182],"p=0.002).":[183],"Higher":[184],"associated":[190,260,282],"greater":[192],"when":[197],"graded":[198],"according":[199],"Marshal":[201],"classification":[202],"grading":[206],"system":[207],"adjustment":[209],"age,":[211],"gender":[212],"GCS":[214],"admission":[216],"(\u03b2=":[217],"0.848,":[218],"adjusted":[219,230],"OR:2.33,":[220],"95%":[221,233],"CI:":[222,234],"1.01-5.38,":[223],"p":[224,236],"=":[225,237],"0.046)":[226],"\u03b2=":[228],"0.850,":[229],"OR:":[231],"2.340,":[232],"1.25-4.39,":[235],"0.008).":[238],"Conclusion:":[239],"An":[240],"early":[241],"developed":[246],"through":[247],"ALT,":[248],"AST,":[249],"levels":[252],"obtained":[253],"within":[254],"24":[255],"hours":[256],"is":[259,279],"structural":[263],"terms":[269],"though":[273],"not":[280],"directly":[281],"outcomes.":[285]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}
