{"id":"https://openalex.org/W7225456350","doi":"https://doi.org/10.1007/s00210-026-06022-0","title":"Bisdemethoxycurcumin disrupts Chk1-associated DNA damage checkpoint signaling and induces apoptosis in nasopharyngeal carcinoma cells","display_name":"Bisdemethoxycurcumin disrupts Chk1-associated DNA damage checkpoint signaling and induces apoptosis in nasopharyngeal carcinoma cells","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225456350","doi":"https://doi.org/10.1007/s00210-026-06022-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42998157"},"language":"en","primary_location":{"id":"doi:10.1007/s00210-026-06022-0","doi":"https://doi.org/10.1007/s00210-026-06022-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00210-026-06022-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00210-026-06022-0.pdf","source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00210-026-06022-0.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076685122","display_name":"Hsin\u2010Yu Ho","orcid":"https://orcid.org/0000-0002-8496-1313","observed_orcids":["https://orcid.org/0000-0002-8496-1313"]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]},{"id":"https://openalex.org/I882009436","display_name":"Central Taiwan University of Science and Technology","ror":"https://ror.org/03d4d3711","country_code":"TW","type":"education","lineage":["https://openalex.org/I882009436"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Yu Ho","raw_affiliation_strings":["Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung, 406, Taiwan","Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung, 406, Taiwan","institution_ids":["https://openalex.org/I882009436"]},{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071253670","display_name":"Ming\u2010Ju Hsieh","orcid":"https://orcid.org/0000-0001-9726-3234","observed_orcids":["https://orcid.org/0000-0001-9726-3234"]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Ju Hsieh","raw_affiliation_strings":["Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404328, Taiwan","Graduate Institute of Clinical Medicine, College of Medicine, National Chung Hsing University, Taichung, 402202, Taiwan","Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404328, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Graduate Institute of Clinical Medicine, College of Medicine, National Chung Hsing University, Taichung, 402202, Taiwan","institution_ids":["https://openalex.org/I162838928"]},{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066930128","display_name":"Yu\u2010Sheng Lo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Sheng Lo","raw_affiliation_strings":["Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125333234","display_name":"Min-Yun Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Min-Yun Kao","raw_affiliation_strings":["Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161163402","display_name":"Chia-Chieh Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Chieh Lin","raw_affiliation_strings":["Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089619899","display_name":"Yi\u2010Ching Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ching Chuang","raw_affiliation_strings":["Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161253046","display_name":"Mu-Kuan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]},{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Mu-Kuan Chen","raw_affiliation_strings":["Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, No.135, Nanxiao St., Changhua City, Changhua, 50006, Taiwan. 53780@cch.org.tw","Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, 402, Taiwan. 53780@cch.org.tw","Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan. 53780@cch.org.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, No.135, Nanxiao St., Changhua City, Changhua, 50006, Taiwan. 53780@cch.org.tw","institution_ids":["https://openalex.org/I4210159511"]},{"raw_affiliation_string":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, 402, Taiwan. 53780@cch.org.tw","institution_ids":["https://openalex.org/I162838928"]},{"raw_affiliation_string":"Oral Cancer Research Center, Changhua Christian Hospital, Changhua, 50006, Taiwan. 53780@cch.org.tw","institution_ids":["https://openalex.org/I4210159511"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5161253046"],"corresponding_institution_ids":["https://openalex.org/I162838928","https://openalex.org/I4210159511"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisdemethoxycurcumin","display_name":"bisdemethoxycurcumin","score":1.0},{"id":"https://openalex.org/keywords/curcuminoids","display_name":"curcuminoids","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.8790000081062317},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7360000014305115},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.7609999775886536},{"id":"https://openalex.org/keywords/caspase-independent-apoptosis","display_name":"caspase-independent apoptosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.696399986743927},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6923999786376953},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6633999943733215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5615000128746033},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5134999752044678},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5060999989509583},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4537999927997589},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.44279998540878296},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4413999915122986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4352000057697296},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.3449999988079071},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3319000005722046},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3301999866962433},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.321399986743927},{"id":"https://openalex.org/C2910325170","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"Checkpoint Kinase 2","level":5,"score":0.3165000081062317},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31630000472068787},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.30570000410079956},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.3003000020980835},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.2635999917984009},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00210-026-06022-0","doi":"https://doi.org/10.1007/s00210-026-06022-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00210-026-06022-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00210-026-06022-0.pdf","source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:42998157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42998157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00210-026-06022-0","doi":"https://doi.org/10.1007/s00210-026-06022-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00210-026-06022-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00210-026-06022-0.pdf","source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225456350.pdf","grobid_xml":"https://content.openalex.org/works/W7225456350.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1966534221","https://openalex.org/W1967630574","https://openalex.org/W1975514591","https://openalex.org/W1979803759","https://openalex.org/W1994909028","https://openalex.org/W1999608828","https://openalex.org/W2008710925","https://openalex.org/W2013744555","https://openalex.org/W2041680250","https://openalex.org/W2043870205","https://openalex.org/W2045305010","https://openalex.org/W2063702713","https://openalex.org/W2063953032","https://openalex.org/W2076314401","https://openalex.org/W2090464175","https://openalex.org/W2096352820","https://openalex.org/W2108791713","https://openalex.org/W2117314668","https://openalex.org/W2134405883","https://openalex.org/W2134842896","https://openalex.org/W2140990686","https://openalex.org/W2175630612","https://openalex.org/W2232144191","https://openalex.org/W2263768870","https://openalex.org/W2551167473","https://openalex.org/W2746514480","https://openalex.org/W2766718087","https://openalex.org/W2810867486","https://openalex.org/W2892113269","https://openalex.org/W3010143180","https://openalex.org/W3010249167","https://openalex.org/W3012729187","https://openalex.org/W3013726226","https://openalex.org/W3023865431","https://openalex.org/W3032920186","https://openalex.org/W3044365150","https://openalex.org/W4296326257","https://openalex.org/W4379768647","https://openalex.org/W4386887823","https://openalex.org/W4392348336"],"related_works":["https://openalex.org/W2175630612","https://openalex.org/W2021774265","https://openalex.org/W1959569723","https://openalex.org/W2573912933","https://openalex.org/W2022043280","https://openalex.org/W2573730053","https://openalex.org/W4283030336","https://openalex.org/W2295755787","https://openalex.org/W1975514591","https://openalex.org/W2371068626"],"abstract_inverted_index":{"Curcuminoids":[0],"have":[1],"been":[2,20],"widely":[3],"explored":[4],"for":[5,251],"their":[6],"diverse":[7],"bioactivities,":[8],"including":[9],"antioxidant,":[10],"anti-inflammatory,":[11],"and":[12,26,57,67,75,98,129,144,147,199,231,243],"antitumor":[13,220],"effects.":[14],"Among":[15],"them,":[16],"bisdemethoxycurcumin":[17],"(BDMC)":[18],"has":[19],"reported":[21],"to":[22,138],"suppress":[23],"tumor":[24],"proliferation":[25],"metastasis":[27],"in":[28,41,102,112,255],"several":[29],"cancer":[30],"types.":[31],"However,":[32],"the":[33,37,196,200,212,219],"molecular":[34,76],"mechanisms":[35],"underlying":[36],"effects":[38,48,93,221],"of":[39,49,117,140,149,157,162,181,222,227],"BDMC":[40,50,90,122,136,207,223],"nasopharyngeal":[42],"carcinoma":[43],"(NPC)":[44],"remain":[45],"unclear.":[46],"The":[47],"on":[51],"apoptosis,":[52,178],"cell-cycle":[53],"progression,":[54],"DNA":[55,150,202],"damage,":[56,151],"Chk1":[58,133,158,164],"activity":[59],"were":[60,79],"examined":[61],"using":[62,81],"immunoblotting,":[63],"flow":[64],"cytometry,":[65],"immunocytochemistry,":[66],"cellular":[68],"thermal":[69],"shift":[70],"assay":[71],"(CETSA).":[72],"Molecular":[73],"docking":[74],"dynamics":[77],"simulations":[78],"performed":[80],"BIOVIA":[82],"Discovery":[83],"Studio":[84],"2024.":[85],"Our":[86],"results":[87],"demonstrated":[88],"that":[89,195,218],"exerted":[91],"cytotoxic":[92],"by":[94,135,153,206],"inducing":[95],"both":[96],"intrinsic":[97],"extrinsic":[99],"apoptotic":[100,113,197,229],"pathways":[101],"NPC":[103],"cells.":[104],"c-Jun":[105],"N-terminal":[106],"kinase":[107,126],"(JNK)":[108],"signaling":[109,230],"was":[110],"involved":[111],"induction":[114],"through":[115],"suppression":[116],"JNK":[118],"phosphorylation.":[119,132],"In":[120],"parallel,":[121],"directly":[123],"engaged":[124],"checkpoint":[125,141,233],"1":[127],"(Chk1)":[128],"inhibited":[130],"its":[131,245],"inhibition":[134,180],"led":[137],"disruption":[139],"control,":[142],"S-":[143],"G2/M-phase":[145],"arrest,":[146],"accumulation":[148],"accompanied":[152],"a":[154,248],"distinct":[155,225],"inactivation":[156],"phosphorylation":[159],"without":[160],"alteration":[161],"total":[163],"protein":[165],"expression.":[166],"Notably,":[167],"CHEK1":[168],"silencing":[169],"did":[170,186],"not":[171,187],"significantly":[172],"alter":[173],"BDMC-induced":[174,189,241],"caspase":[175],"activation":[176],"or":[177],"whereas":[179],"caspase-dependent":[182],"apoptosis":[183],"with":[184],"Z-VAD":[185],"affect":[188],"\u03b3H2AX":[190],"accumulation.":[191],"These":[192,235],"findings":[193,236],"suggest":[194],"response":[198,204],"Chk1-associated":[201],"damage":[203],"induced":[205],"are":[208],"functionally":[209],"separable":[210],"under":[211],"conditions":[213],"examined.":[214],"This":[215],"study":[216],"reveals":[217],"involve":[224],"modulation":[226],"JNK-associated":[228],"Chk1-mediated":[232],"dysfunction.":[234],"provide":[237],"mechanistic":[238],"insight":[239],"into":[240],"cytotoxicity":[242],"support":[244],"potential":[246],"as":[247],"lead":[249],"compound":[250],"further":[252],"pharmacological":[253],"investigation":[254],"NPC.":[256]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}