{"id":"https://openalex.org/W7225455259","doi":"https://doi.org/10.61784/jpmr3101","title":"ASSOCIATION OF METABOLIC SYNDROME AND ITS COMPONENT BURDEN WITH UPPER URINARY TRACT STONE COMPOSITION: A RETROSPECTIVE OBSERVATIONAL STUDY","display_name":"ASSOCIATION OF METABOLIC SYNDROME AND ITS COMPONENT BURDEN WITH UPPER URINARY TRACT STONE COMPOSITION: A RETROSPECTIVE OBSERVATIONAL STUDY","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225455259","doi":"https://doi.org/10.61784/jpmr3101"},"language":"en","primary_location":{"id":"doi:10.61784/jpmr3101","doi":"https://doi.org/10.61784/jpmr3101","is_oa":true,"landing_page_url":"https://doi.org/10.61784/jpmr3101","pdf_url":"https://upubjournals.com/jpmr/article/download/2903/254","source":{"id":"https://openalex.org/S4390297112","display_name":"Journal of Pharmaceutical and Medical Research","issn_l":"2663-1954","issn":["2663-1954","2663-1962"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://upubjournals.com/jpmr/article/download/2903/254","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161046414","display_name":"FangMing Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FangMing Xu","raw_affiliation_strings":["The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161096814","display_name":"ZiLe Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZiLe Pan","raw_affiliation_strings":["School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, Hebei, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161062465","display_name":"KaiLu Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"KaiLu Wei","raw_affiliation_strings":["The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147037090","display_name":"Min Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Xiong","raw_affiliation_strings":["The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161028557","display_name":"JiaQiang Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"JiaQiang Pan","raw_affiliation_strings":["The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, China","institution_ids":["https://openalex.org/I176134282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5161028557"],"corresponding_institution_ids":["https://openalex.org/I176134282"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"40","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9919999837875366},{"id":"https://openalex.org/keywords/upper-urinary-tract-stones","display_name":"upper urinary tract stones","score":0.9649999737739563},{"id":"https://openalex.org/keywords/kidney-stone-composition","display_name":"kidney stone composition","score":0.6890000104904175},{"id":"https://openalex.org/keywords/uric-acid-stones","display_name":"uric acid stones","score":0.9959999918937683},{"id":"https://openalex.org/keywords/calcium-oxalate","display_name":"calcium oxalate","score":0.843999981880188},{"id":"https://openalex.org/keywords/calcium-phosphate","display_name":"calcium phosphate","score":0.8539999723434448},{"id":"https://openalex.org/keywords/struvite","display_name":"struvite","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6520000100135803},{"id":"https://openalex.org/keywords/firth-penalized-logistic-regression","display_name":"Firth penalized logistic regression","score":0.7490000128746033},{"id":"https://openalex.org/keywords/monte-carlo-resampling","display_name":"Monte Carlo resampling","score":0.7649999856948853},{"id":"https://openalex.org/keywords/overfitting","display_name":"overfitting","score":0.39800000190734863},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7876999974250793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7684999704360962},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.7487999796867371},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5633000135421753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5382000207901001},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5361999869346619},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.48649999499320984},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.47929999232292175},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.47440001368522644},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4350000023841858},{"id":"https://openalex.org/C2777993539","wikidata":"https://www.wikidata.org/wiki/Q3443022","display_name":"Hyperuricosuria","level":4,"score":0.3889000117778778},{"id":"https://openalex.org/C2993461684","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Upper urinary tract","level":3,"score":0.3646000027656555},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.33390000462532043},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29429998993873596},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C2991848491","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disease","level":2,"score":0.2736999988555908}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.61784/jpmr3101","doi":"https://doi.org/10.61784/jpmr3101","is_oa":true,"landing_page_url":"https://doi.org/10.61784/jpmr3101","pdf_url":"https://upubjournals.com/jpmr/article/download/2903/254","source":{"id":"https://openalex.org/S4390297112","display_name":"Journal of Pharmaceutical and Medical Research","issn_l":"2663-1954","issn":["2663-1954","2663-1962"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Medical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.61784/jpmr3101","doi":"https://doi.org/10.61784/jpmr3101","is_oa":true,"landing_page_url":"https://doi.org/10.61784/jpmr3101","pdf_url":"https://upubjournals.com/jpmr/article/download/2903/254","source":{"id":"https://openalex.org/S4390297112","display_name":"Journal of Pharmaceutical and Medical Research","issn_l":"2663-1954","issn":["2663-1954","2663-1962"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225455259.pdf","grobid_xml":"https://content.openalex.org/works/W7225455259.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1500424871","https://openalex.org/W2002842493","https://openalex.org/W2012257212","https://openalex.org/W2013416277","https://openalex.org/W2074860742","https://openalex.org/W2077502347","https://openalex.org/W2078129874","https://openalex.org/W2117062848","https://openalex.org/W2149309802","https://openalex.org/W2164812957","https://openalex.org/W2588771666","https://openalex.org/W2590254599","https://openalex.org/W2593185514","https://openalex.org/W2599076725","https://openalex.org/W2905482938","https://openalex.org/W2974005781","https://openalex.org/W3003792915","https://openalex.org/W4402418672","https://openalex.org/W4415995575","https://openalex.org/W4416608274"],"related_works":["https://openalex.org/W2164812957","https://openalex.org/W1500424871","https://openalex.org/W3031998728","https://openalex.org/W2391524383","https://openalex.org/W4400745087","https://openalex.org/W2036213917","https://openalex.org/W4396855275","https://openalex.org/W3003792915","https://openalex.org/W2233151367","https://openalex.org/W2605333998"],"abstract_inverted_index":{"Upper":[0],"urinary":[1,62,83,301],"tract":[2,63,84,302],"stones":[3,85,201,206],"are":[4],"chemically":[5],"heterogeneous,":[6],"with":[7,60,66,81,133,141,225,243,248,298,307,344],"compositions":[8],"that":[9,319],"reflect":[10],"distinct":[11],"underlying":[12],"metabolic":[13,23,104,324,347],"perturbations.":[14],"Metabolic":[15,157],"syndrome":[16,105],"(MetS)":[17,106],"comprises":[18],"a":[19,67,130],"cluster":[20],"of":[21,32,52,57,96,205,228,257,310],"interconnected":[22],"abnormalities,":[24],"but":[25],"the":[26,29,50,55,92,151,208,214,218,244,268,277,283,320],"relationship":[27],"between":[28],"cumulative":[30],"burden":[31,159],"these":[33],"components":[34,59,253],"and":[35,54,86,108,154,165,198,251],"specific":[36],"stone":[37,64,110,144,231,313],"phenotypes":[38],"remains":[39],"incompletely":[40],"characterized":[41],"in":[42,174,207,213,267,330,340],"Chinese":[43],"populations.":[44],"This":[45,74],"study":[46,77],"aimed":[47],"to":[48],"investigate":[49],"associations":[51,140],"MetS":[53,191,209,222,304],"number":[56],"its":[58],"upper":[61,82,300],"composition,":[65],"particular":[68],"focus":[69],"on":[70],"uric":[71,120,142,199,229,258,311],"acid":[72,143,200,230,259,312],"stones.":[73],"retrospective":[75],"observational":[76],"included":[78],"800":[79,178],"patients":[80,247,297],"infrared":[87],"spectroscopic":[88],"stone-composition":[89],"analysis":[90,317],"at":[91],"Second":[93],"Affiliated":[94],"Hospital":[95],"Guilin":[97],"Medical":[98],"University.":[99],"Patients":[100],"were":[101,127,182,293],"stratified":[102],"by":[103,129,190],"status,":[107],"predominant":[109],"composition":[111,125,145,232],"was":[112,160,172,223,265,305],"categorized":[113],"as":[114,184],"calcium":[115,117],"oxalate,":[116],"phosphate,":[118],"struvite,":[119],"acid,":[121],"or":[122],"other.":[123],"Overall":[124],"differences":[126],"assessed":[128,161],"chi-square":[131],"test":[132],"Monte":[134],"Carlo":[135,194],"resampling.":[136],"Logistic":[137],"regression":[138,171],"examined":[139],"after":[146],"sequential":[147],"adjustment":[148],"for":[149,203],"age,":[150],"female/male":[152],"classification,":[153],"serum":[155],"creatinine.":[156],"component":[158,325],"using":[162],"both":[163],"categorical":[164,278,316],"linear":[166,284],"terms;":[167],"Firth":[168,291],"penalized":[169],"logistic":[170],"used":[173],"sensitivity":[175],"analyses.":[176],"Among":[177,296],"patients,":[179],"280":[180],"(35.0%)":[181],"classified":[183],"having":[185],"MetS.":[186],"Stone-composition":[187],"distributions":[188],"differed":[189],"status":[192],"(Monte":[193],"P":[195,239,288],"=":[196,234,240,272,289],"0.0058),":[197],"accounted":[202],"13.2%":[204],"group":[210,270],"versus":[211],"5.6%":[212],"non-MetS":[215],"group.":[216],"In":[217],"fully":[219],"adjusted":[220],"model,":[221],"associated":[224,306],"greater":[226],"odds":[227,256,309],"(OR":[233,271],"2.65,":[235],"95%":[236,274],"CI":[237,275],"1.57\u20134.50;":[238],"0.00028).":[241],"Compared":[242],"zero-component":[245],"group,":[246],"two,":[249],"three,":[250],"four":[252],"showed":[254],"elevated":[255],"composition.":[260,314],"The":[261],"category-specific":[262],"point":[263],"estimate":[264],"highest":[266],"three-component":[269],"6.06,":[273],"2.46\u201318.31);":[276],"specification":[279],"fitted":[280],"better":[281],"than":[282],"term":[285],"(likelihood":[286],"ratio":[287],"0.040).":[290],"estimates":[292],"directionally":[294],"similar.":[295],"confirmed":[299],"stones,":[303],"increased":[308],"A":[315],"suggested":[318],"association":[321],"varied":[322],"across":[323],"counts,":[326],"although":[327],"sparse":[328],"events":[329],"some":[331],"groups":[332],"warrant":[333],"cautious":[334],"interpretation.":[335],"These":[336],"findings":[337],"merit":[338],"confirmation":[339],"independent":[341],"patient":[342],"cohorts":[343],"more":[345],"complete":[346],"profiling.":[348]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}