{"id":"https://openalex.org/W7225453589","doi":"https://doi.org/10.1016/j.lssr.2026.11.001","title":"Simulated Microgravity Reprograms Human Megakaryocyte Biology: Phenotypic, Transcriptomic, and Autophagic Evidence from a Ground-Based Analogue Study","display_name":"Simulated Microgravity Reprograms Human Megakaryocyte Biology: Phenotypic, Transcriptomic, and Autophagic Evidence from a Ground-Based Analogue Study","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225453589","doi":"https://doi.org/10.1016/j.lssr.2026.11.001"},"language":"en","primary_location":{"id":"doi:10.1016/j.lssr.2026.11.001","doi":"https://doi.org/10.1016/j.lssr.2026.11.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lssr.2026.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S2764866528","display_name":"Life Sciences in Space Research","issn_l":"2214-5524","issn":["2214-5524","2214-5532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences in Space Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.lssr.2026.11.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010435311","display_name":"Marina Leardini-Trist\u00e3o","orcid":"https://orcid.org/0000-0001-5252-6272","observed_orcids":["https://orcid.org/0000-0001-5252-6272"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Leardini-Tristao","raw_affiliation_strings":["Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057356565","display_name":"Neal D. Tolley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal D. Tolley","raw_affiliation_strings":["Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044753697","display_name":"Jesse W. Rowley","orcid":"https://orcid.org/0000-0003-4444-1724","observed_orcids":["https://orcid.org/0000-0003-4444-1724"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse W. Rowley","raw_affiliation_strings":["Division of Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA","Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161152178","display_name":"Mia E.G. Schwertz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mia E.G. Schwertz","raw_affiliation_strings":["Aerospace Medicine Program, University of Central Florida, Orlando, FL, USA","Division of Occupational Medicine, University of Utah, Salt Lake City, UT, USA","Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerospace Medicine Program, University of Central Florida, Orlando, FL, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Division of Occupational Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161171638","display_name":"Lilian J.M. Schwertz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lilian J.M. Schwertz","raw_affiliation_strings":["Aerospace Medicine Program, University of Central Florida, Orlando, FL, USA","Division of Occupational Medicine, University of Utah, Salt Lake City, UT, USA","Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerospace Medicine Program, University of Central Florida, Orlando, FL, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Division of Occupational Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007461026","display_name":"Matthew Thomas Rondina","orcid":"https://orcid.org/0000-0003-3455-3730","observed_orcids":["https://orcid.org/0000-0003-3455-3730"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210164726","display_name":"George E. Wahlen Department of VA Medical Center","ror":"https://ror.org/05n5drh21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540","https://openalex.org/I4210164726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew T. Rondina","raw_affiliation_strings":["Department of Internal Medicine, George E. Wahlen Salt Lake City VAMC, Salt Lake City, UT, USA","Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA","Department of Pathology, University of Utah, Salt Lake City, UT, USA","Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, George E. Wahlen Salt Lake City VAMC, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I4210164726"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Pathology, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078010467","display_name":"Hansj\u00f6rg Schwertz","orcid":"https://orcid.org/0000-0002-0597-8206","observed_orcids":["https://orcid.org/0000-0002-0597-8206"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hansjorg Schwertz","raw_affiliation_strings":["Aerospace Medicine Program, University of Central Florida, Orlando, FL, USA","Division of Occupational Medicine, University of Utah, Salt Lake City, UT, USA","Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aerospace Medicine Program, University of Central Florida, Orlando, FL, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Division of Occupational Medicine, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078010467","https://openalex.org/A5161152178","https://openalex.org/A5161171638"],"corresponding_institution_ids":["https://openalex.org/I106165777","https://openalex.org/I223532165"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd34-hematopoietic-progenitor-cells","display_name":"CD34+ hematopoietic progenitor cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/proplatelet-formation","display_name":"proplatelet formation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6370000243186951},{"id":"https://openalex.org/keywords/thromboinflammation","display_name":"thromboinflammation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/astronaut-health","display_name":"astronaut health","score":0.5950000286102295},{"id":"https://openalex.org/keywords/deep-space-missions","display_name":"deep space missions","score":0.5989999771118164},{"id":"https://openalex.org/keywords/countermeasures","display_name":"countermeasures","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.7967000007629395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6029999852180481},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4528999924659729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4399999976158142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.387800008058548},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.23469999432563782},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.22519999742507935},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.22050000727176666},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21809999644756317},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.21809999644756317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.lssr.2026.11.001","doi":"https://doi.org/10.1016/j.lssr.2026.11.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lssr.2026.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S2764866528","display_name":"Life Sciences in Space Research","issn_l":"2214-5524","issn":["2214-5524","2214-5532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences in Space Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.lssr.2026.11.001","doi":"https://doi.org/10.1016/j.lssr.2026.11.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lssr.2026.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S2764866528","display_name":"Life Sciences in Space Research","issn_l":"2214-5524","issn":["2214-5524","2214-5532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences in Space Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332374","display_name":"Ames Research Center","ror":"https://ror.org/02acart68"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W255281808","https://openalex.org/W1582565049","https://openalex.org/W1738348680","https://openalex.org/W1929308123","https://openalex.org/W1943527316","https://openalex.org/W1963521777","https://openalex.org/W1979438759","https://openalex.org/W1992643412","https://openalex.org/W1996151753","https://openalex.org/W2001524479","https://openalex.org/W2015897559","https://openalex.org/W2045338741","https://openalex.org/W2047033624","https://openalex.org/W2059473497","https://openalex.org/W2065592028","https://openalex.org/W2072088679","https://openalex.org/W2073963703","https://openalex.org/W2084224210","https://openalex.org/W2087153492","https://openalex.org/W2093681208","https://openalex.org/W2095423071","https://openalex.org/W2103398208","https://openalex.org/W2107789427","https://openalex.org/W2119488140","https://openalex.org/W2122398847","https://openalex.org/W2125487451","https://openalex.org/W2134536161","https://openalex.org/W2161007761","https://openalex.org/W2164778558","https://openalex.org/W2168295368","https://openalex.org/W2205539307","https://openalex.org/W2209211422","https://openalex.org/W2234668029","https://openalex.org/W2265613367","https://openalex.org/W2300220838","https://openalex.org/W2321489508","https://openalex.org/W2331658704","https://openalex.org/W2339346602","https://openalex.org/W2507141719","https://openalex.org/W2610196480","https://openalex.org/W2751588367","https://openalex.org/W2767020540","https://openalex.org/W2769776686","https://openalex.org/W2804496804","https://openalex.org/W2807742671","https://openalex.org/W2809193267","https://openalex.org/W2897146269","https://openalex.org/W2901639637","https://openalex.org/W2912044184","https://openalex.org/W2914441092","https://openalex.org/W2927545200","https://openalex.org/W2943400272","https://openalex.org/W2948810228","https://openalex.org/W2950208982","https://openalex.org/W2972174881","https://openalex.org/W2981571441","https://openalex.org/W2981849539","https://openalex.org/W2983119182","https://openalex.org/W2996799502","https://openalex.org/W3016741145","https://openalex.org/W3108936441","https://openalex.org/W3128185269","https://openalex.org/W3144745948","https://openalex.org/W3155931976","https://openalex.org/W3158295431","https://openalex.org/W3196573451","https://openalex.org/W3208793661","https://openalex.org/W4206012410","https://openalex.org/W4211046327","https://openalex.org/W4220901780","https://openalex.org/W4229977181","https://openalex.org/W4241801356","https://openalex.org/W4293879830","https://openalex.org/W4376619460","https://openalex.org/W4377011281","https://openalex.org/W4381885437","https://openalex.org/W4386332841","https://openalex.org/W4386501699","https://openalex.org/W4386504057","https://openalex.org/W4387357213","https://openalex.org/W4391469862","https://openalex.org/W4392812801","https://openalex.org/W4400048509","https://openalex.org/W4401211256","https://openalex.org/W4404823277","https://openalex.org/W4405332505","https://openalex.org/W4408945767","https://openalex.org/W4414745991","https://openalex.org/W4415916667","https://openalex.org/W4416386340","https://openalex.org/W4416571821","https://openalex.org/W4416997917","https://openalex.org/W7123758064","https://openalex.org/W7124141156","https://openalex.org/W7124877929","https://openalex.org/W7211999992"],"related_works":["https://openalex.org/W3047145605","https://openalex.org/W2318527660","https://openalex.org/W2990593649","https://openalex.org/W4407017850","https://openalex.org/W2368163750","https://openalex.org/W3035786852","https://openalex.org/W3004232365","https://openalex.org/W1603667906","https://openalex.org/W2970333610","https://openalex.org/W3022664291"],"abstract_inverted_index":{"Megakaryocytes":[0],"(MKs)":[1],"integrate":[2],"inflammatory,":[3],"immune,":[4],"and":[5,8,14,60,76,83,113,121,135,145,151],"hemostatic":[6],"functions,":[7],"their":[9],"dysregulation":[10],"may":[11],"promote":[12],"inflammation":[13],"thrombosis,":[15],"key":[16],"risks":[17],"for":[18,149],"spaceflight":[19],"crew":[20],"health.":[21],"Despite":[22],"this":[23],"relevance,":[24],"MK":[25,73,133],"responses":[26],"to":[27,66],"spaceflight-related":[28],"gravitational":[29,130],"changes":[30,110],"remain":[31],"poorly":[32],"defined.":[33],"Using":[34],"a":[35,78],"NASA-approved":[36],"randomizing":[37],"gravitational-vector":[38],"system":[39],"(RCCS),":[40],"CD34\u207a":[41],"hematopoietic":[42],"progenitor":[43],"cells":[44],"were":[45,64],"differentiated":[46],"into":[47],"MKs":[48],"under":[49],"simulated":[50],"microgravity":[51,71],"conditions.":[52],"Viability,":[53],"proliferation,":[54],"proplatelet":[55],"formation,":[56],"morphology,":[57],"flow":[58,84],"cytometry,":[59],"transcriptomic":[61],"profiling":[62],"(RNA-seq)":[63],"used":[65],"identify":[67],"gravity-sensitive":[68],"processes.":[69],"Simulated":[70],"altered":[72],"growth":[74],"dynamics":[75],"showed":[77],"trend":[79],"toward":[80],"reduced":[81],"viability,":[82],"cytometry":[85],"demonstrated":[86],"significantly":[87],"enhanced":[88],"expression":[89],"of":[90,102,132],"megakaryocytic":[91],"maturation":[92],"markers.":[93],"Microgravity":[94],"conditions":[95],"further":[96],"revealed":[97],"disrupted":[98],"autophagic":[99],"flux":[100],"indicative":[101],"an":[103],"early-stage":[104],"inhibition.":[105],"RNA-seq":[106],"identified":[107],"significant":[108],"transcriptional":[109],"involving":[111],"immune":[112],"inflammatory":[114],"signaling,":[115],"transcription,":[116],"protein":[117],"biogenesis,":[118],"lipid":[119],"regulation,":[120],"mitochondrial":[122],"management.":[123],"Together,":[124],"these":[125],"findings":[126],"uncover":[127],"previously":[128],"unrecognized":[129],"control":[131],"development":[134,148],"function,":[136],"addressing":[137],"critical":[138],"knowledge":[139],"gaps":[140],"in":[141],"spaceflight-associated":[142],"thromboinflammatory":[143],"risk":[144],"informing":[146],"countermeasure":[147],"long-duration":[150],"deep-space":[152],"missions.":[153]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-08T00:00:00"}