{"id":"https://openalex.org/W7225452891","doi":"https://doi.org/10.1038/s42004-026-02270-6","title":"Integrating noncanonical amino acids and synthetic cofactors for the development of artificial metalloenzymes","display_name":"Integrating noncanonical amino acids and synthetic cofactors for the development of artificial metalloenzymes","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225452891","doi":"https://doi.org/10.1038/s42004-026-02270-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42998977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13744570"},"language":"en","primary_location":{"id":"doi:10.1038/s42004-026-02270-6","doi":"https://doi.org/10.1038/s42004-026-02270-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-026-02270-6","pdf_url":"https://www.nature.com/articles/s42004-026-02270-6.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42004-026-02270-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161228445","display_name":"Si-Meng Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Meng Ding","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782100","display_name":"Yuxin Shi","orcid":"https://orcid.org/0000-0001-8051-448X","observed_orcids":["https://orcid.org/0000-0001-8051-448X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Xin Shi","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053324140","display_name":"Gao Ren-jun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ren-Jun Gao","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. gaorj@jlu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. gaorj@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085976943","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0002-8436-7082","observed_orcids":["https://orcid.org/0000-0002-8436-7082"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Department of Biological and Chemical Engineering, Faculty of Technical Sciences, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark. guo@bce.au.dk"],"raw_orcid":"https://orcid.org/0000-0002-8436-7082","affiliations":[{"raw_affiliation_string":"Department of Biological and Chemical Engineering, Faculty of Technical Sciences, Aarhus University, Gustav Wieds Vej 10, Aarhus, Denmark. guo@bce.au.dk","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053324140","https://openalex.org/A5085976943"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I204337017"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.25780001282691956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.25780001282691956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.1193000003695488,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.10429999977350235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-metalloenzymes","display_name":"artificial metalloenzymes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-code-expansion","display_name":"genetic code expansion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/codon-optimization","display_name":"codon optimization","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bioorthogonal-chemistry","display_name":"bioorthogonal chemistry","score":0.7440000176429749},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.6600000262260437},{"id":"https://openalex.org/keywords/biomimetic-catalysis","display_name":"biomimetic catalysis","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.7264000177383423},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6729999780654907},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6240000128746033},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.5580999851226807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5347999930381775},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5277000069618225},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5210000276565552},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5080999732017517},{"id":"https://openalex.org/C10853874","wikidata":"https://www.wikidata.org/wiki/Q180618","display_name":"Genetic code","level":3,"score":0.4392000138759613},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.41679999232292175},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.38530001044273376},{"id":"https://openalex.org/C2777757664","wikidata":"https://www.wikidata.org/wiki/Q704923","display_name":"Molybdenum cofactor","level":4,"score":0.36820000410079956},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.336899995803833},{"id":"https://openalex.org/C2779379725","wikidata":"https://www.wikidata.org/wiki/Q2914572","display_name":"Artificial enzyme","level":3,"score":0.33070001006126404},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33009999990463257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32850000262260437},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.3206999897956848},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3199999928474426},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.31139999628067017},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C145770059","wikidata":"https://www.wikidata.org/wiki/Q751908","display_name":"Catalytic triad","level":4,"score":0.26269999146461487},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.25209999084472656},{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s42004-026-02270-6","doi":"https://doi.org/10.1038/s42004-026-02270-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-026-02270-6","pdf_url":"https://www.nature.com/articles/s42004-026-02270-6.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},{"id":"pmid:42998977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42998977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13744570","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13744570/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Chem","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a787184fe9cf468aa24b60d2503ebca4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a787184fe9cf468aa24b60d2503ebca4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Chemistry, Vol 9, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s42004-026-02270-6","doi":"https://doi.org/10.1038/s42004-026-02270-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-026-02270-6","pdf_url":"https://www.nature.com/articles/s42004-026-02270-6.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225452891.pdf","grobid_xml":"https://content.openalex.org/works/W7225452891.grobid-xml"},"referenced_works_count":215,"referenced_works":["https://openalex.org/W168348071","https://openalex.org/W1031680929","https://openalex.org/W1530488687","https://openalex.org/W1595347157","https://openalex.org/W1604752385","https://openalex.org/W1937431683","https://openalex.org/W1966013120","https://openalex.org/W1967635741","https://openalex.org/W1969726382","https://openalex.org/W1978818959","https://openalex.org/W1978964903","https://openalex.org/W1989744091","https://openalex.org/W1993922491","https://openalex.org/W1995254028","https://openalex.org/W1999491456","https://openalex.org/W2005043252","https://openalex.org/W2005094522","https://openalex.org/W2013616490","https://openalex.org/W2017602203","https://openalex.org/W2022471606","https://openalex.org/W2023490488","https://openalex.org/W2025583929","https://openalex.org/W2025608159","https://openalex.org/W2034971743","https://openalex.org/W2037908382","https://openalex.org/W2039723215","https://openalex.org/W2050963438","https://openalex.org/W2052060414","https://openalex.org/W2053235167","https://openalex.org/W2053631465","https://openalex.org/W2055881275","https://openalex.org/W2058079617","https://openalex.org/W2063035812","https://openalex.org/W2067263502","https://openalex.org/W2069269641","https://openalex.org/W2074606375","https://openalex.org/W2081242643","https://openalex.org/W2085330586","https://openalex.org/W2088109071","https://openalex.org/W2093357065","https://openalex.org/W2094784806","https://openalex.org/W2098709503","https://openalex.org/W2101683782","https://openalex.org/W2105199418","https://openalex.org/W2105668062","https://openalex.org/W2110260818","https://openalex.org/W2111118274","https://openalex.org/W2115980730","https://openalex.org/W2118233996","https://openalex.org/W2118568444","https://openalex.org/W2123768693","https://openalex.org/W2125520334","https://openalex.org/W2132262459","https://openalex.org/W2151043202","https://openalex.org/W2151341878","https://openalex.org/W2156684055","https://openalex.org/W2160528924","https://openalex.org/W2160574842","https://openalex.org/W2169880270","https://openalex.org/W2172081763","https://openalex.org/W2201202899","https://openalex.org/W2296423762","https://openalex.org/W2317873538","https://openalex.org/W2331937820","https://openalex.org/W2344658806","https://openalex.org/W2511472401","https://openalex.org/W2517891003","https://openalex.org/W2518508903","https://openalex.org/W2554142923","https://openalex.org/W2609044629","https://openalex.org/W2617704854","https://openalex.org/W2620894439","https://openalex.org/W2735709426","https://openalex.org/W2735839143","https://openalex.org/W2745296900","https://openalex.org/W2748658427","https://openalex.org/W2753393433","https://openalex.org/W2763278454","https://openalex.org/W2766423195","https://openalex.org/W2775784830","https://openalex.org/W2783286140","https://openalex.org/W2784164549","https://openalex.org/W2785178119","https://openalex.org/W2790952789","https://openalex.org/W2797583159","https://openalex.org/W2799372563","https://openalex.org/W2803536627","https://openalex.org/W2888141749","https://openalex.org/W2891766517","https://openalex.org/W2901526026","https://openalex.org/W2902321532","https://openalex.org/W2904011061","https://openalex.org/W2906170671","https://openalex.org/W2911989070","https://openalex.org/W2923384196","https://openalex.org/W2930575615","https://openalex.org/W2930951846","https://openalex.org/W2936649658","https://openalex.org/W2944014204","https://openalex.org/W2944245644","https://openalex.org/W2944948391","https://openalex.org/W2946086616","https://openalex.org/W2946417732","https://openalex.org/W2953759951","https://openalex.org/W2958582554","https://openalex.org/W2965826331","https://openalex.org/W2966010975","https://openalex.org/W2966057938","https://openalex.org/W2969793649","https://openalex.org/W2971880457","https://openalex.org/W2972546585","https://openalex.org/W2979820155","https://openalex.org/W2987964167","https://openalex.org/W2989539936","https://openalex.org/W2993021988","https://openalex.org/W2999044305","https://openalex.org/W3002774878","https://openalex.org/W3004536106","https://openalex.org/W3010020074","https://openalex.org/W3011259889","https://openalex.org/W3013283329","https://openalex.org/W3022417565","https://openalex.org/W3038115123","https://openalex.org/W3038570617","https://openalex.org/W3038719188","https://openalex.org/W3044466810","https://openalex.org/W3048735122","https://openalex.org/W3085860853","https://openalex.org/W3086090953","https://openalex.org/W3086845129","https://openalex.org/W3088774199","https://openalex.org/W3089838238","https://openalex.org/W3093646295","https://openalex.org/W3094176296","https://openalex.org/W3109463159","https://openalex.org/W3111568439","https://openalex.org/W3111698831","https://openalex.org/W3133314164","https://openalex.org/W3149259670","https://openalex.org/W3153423392","https://openalex.org/W3160202700","https://openalex.org/W3161194636","https://openalex.org/W3161240351","https://openalex.org/W3163260644","https://openalex.org/W3165276985","https://openalex.org/W3188717228","https://openalex.org/W3196406727","https://openalex.org/W4200377887","https://openalex.org/W4207028768","https://openalex.org/W4220651970","https://openalex.org/W4220762570","https://openalex.org/W4234714728","https://openalex.org/W4281390243","https://openalex.org/W4283217362","https://openalex.org/W4285007601","https://openalex.org/W4285167570","https://openalex.org/W4287092409","https://openalex.org/W4291109269","https://openalex.org/W4308834822","https://openalex.org/W4310957608","https://openalex.org/W4323652890","https://openalex.org/W4324122348","https://openalex.org/W4360946940","https://openalex.org/W4361989976","https://openalex.org/W4365443842","https://openalex.org/W4377008977","https://openalex.org/W4379140912","https://openalex.org/W4381469587","https://openalex.org/W4386453144","https://openalex.org/W4387098259","https://openalex.org/W4388492286","https://openalex.org/W4391332029","https://openalex.org/W4392233352","https://openalex.org/W4392963201","https://openalex.org/W4398235392","https://openalex.org/W4399768188","https://openalex.org/W4400272780","https://openalex.org/W4400421150","https://openalex.org/W4400851308","https://openalex.org/W4401628928","https://openalex.org/W4401701781","https://openalex.org/W4402126487","https://openalex.org/W4402512090","https://openalex.org/W4402900883","https://openalex.org/W4403660587","https://openalex.org/W4404146103","https://openalex.org/W4404370463","https://openalex.org/W4404998322","https://openalex.org/W4405429400","https://openalex.org/W4406085432","https://openalex.org/W4407056257","https://openalex.org/W4407165242","https://openalex.org/W4407313438","https://openalex.org/W4407528844","https://openalex.org/W4407853893","https://openalex.org/W4410329865","https://openalex.org/W4410507288","https://openalex.org/W4411079797","https://openalex.org/W4411396131","https://openalex.org/W4412038644","https://openalex.org/W4412601263","https://openalex.org/W4413330953","https://openalex.org/W4413814842","https://openalex.org/W4414191948","https://openalex.org/W4414594453","https://openalex.org/W4415225792","https://openalex.org/W4415380687","https://openalex.org/W4416092231","https://openalex.org/W4417193249","https://openalex.org/W4417325896","https://openalex.org/W4417530088","https://openalex.org/W7118594124","https://openalex.org/W7130316259","https://openalex.org/W7131780991","https://openalex.org/W7140384267"],"related_works":["https://openalex.org/W2784164549","https://openalex.org/W4414191948","https://openalex.org/W4403985437","https://openalex.org/W2735839143","https://openalex.org/W4401287879","https://openalex.org/W7164052601","https://openalex.org/W3037656691","https://openalex.org/W4406085432","https://openalex.org/W2961566029","https://openalex.org/W4307299648"],"abstract_inverted_index":{"Natural":[0],"metalloenzymes":[1,37],"harness":[2],"the":[3,18,23,59,81,107,116,134,148],"sophisticated":[4],"synergy":[5],"between":[6,61],"canonical":[7],"amino":[8,26,55],"acids":[9,27,56],"and":[10,65,73,96,106,125,153,182,187],"metal":[11,123],"cofactors":[12,41,128,155],"to":[13,45],"catalyze":[14],"life-sustaining":[15],"reactions.":[16],"However,":[17],"limited":[19],"chemical":[20,89],"diversity":[21],"of":[22,84,103,110,119,136,151],"twenty":[24],"standard":[25],"often":[28],"restricts":[29],"non-natural":[30],"transformations.":[31],"To":[32],"overcome":[33],"these":[34,164],"constraints,":[35],"artificial":[36],"(ArMs)":[38],"integrate":[39],"synthetic":[40,66,127,154],"into":[42],"protein":[43,161],"scaffolds":[44],"enable":[46,99],"unnatural":[47],"catalytic":[48,177],"functions.":[49],"This":[50],"review":[51],"highlights":[52],"how":[53],"noncanonical":[54],"(ncAAs)":[57],"bridge":[58],"gap":[60],"natural":[62,168],"enzyme":[63],"architecture":[64],"chemistry.":[67],"We":[68],"examine":[69],"genetic":[70],"code":[71],"expansion":[72],"codon":[74],"optimization":[75],"technologies":[76],"as":[77,91],"robust":[78],"strategies":[79],"for":[80,133,160,173,185],"site-specific":[82],"incorporation":[83],"ncAAs.":[85],"By":[86],"introducing":[87],"unique":[88],"moieties-such":[90],"chelating":[92],"groups,":[93],"photo-responsive":[94],"elements,":[95],"bio-orthogonal":[97,130],"handles-ncAAs":[98],"precise":[100],"mechanistic":[101],"probing":[102],"active":[104],"sites":[105],"rational":[108],"design":[109,150],"biomimetic":[111],"centers.":[112],"Furthermore,":[113],"we":[114],"discuss":[115],"strategic":[117],"use":[118],"ncAAs":[120,152],"in":[121],"anchoring":[122],"ions":[124],"large-sized":[126],"via":[129],"reactions,":[131],"allowing":[132],"creation":[135],"hybrid":[137],"catalysts":[138],"that":[139],"maintain":[140],"structural":[141,165],"integrity":[142],"while":[143],"exhibiting":[144],"novel":[145],"reactivity.":[146],"Ultimately,":[147],"combinatorial":[149],"provides":[156],"a":[157,171],"transformative":[158],"toolkit":[159],"engineering.":[162],"Integrating":[163],"elements":[166],"transcends":[167],"limitations,":[169],"laying":[170],"foundation":[172],"ArMs":[174],"with":[175],"enhanced":[176],"efficiency,":[178],"expanded":[179],"substrate":[180],"scope":[181],"programmable":[183],"activity":[184],"industrial":[186],"therapeutic":[188],"applications.":[189]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-08T00:00:00"}
