{"id":"https://openalex.org/W7225450889","doi":"https://doi.org/10.64898/2026.10.29.762935","title":"RoDPAA: A Robust Dissimilarity-Based Principal Angle Analysis Framework for Multi-View Microbiome Data Integration","display_name":"RoDPAA: A Robust Dissimilarity-Based Principal Angle Analysis Framework for Multi-View Microbiome Data Integration","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225450889","doi":"https://doi.org/10.64898/2026.10.29.762935"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.29.762935","doi":"https://doi.org/10.64898/2026.10.29.762935","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.10.29.762935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.10.29.762935.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133277912","display_name":"Yanyan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyan Xu","raw_affiliation_strings":["university of colorado cu anschutz;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"university of colorado cu anschutz;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100372041","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-4847-8826","observed_orcids":["https://orcid.org/0000-0002-4847-8826"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yue Wang","raw_affiliation_strings":["University of Colorado Anschutz Medical Campus"],"raw_orcid":"https://orcid.org/0000-0002-4847-8826","affiliations":[{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100372041"],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13141","display_name":"Statistical Methods and Applications","score":0.08429999649524689,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.06689999997615814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multi-view-data-integration","display_name":"multi-view data integration","score":0.7879999876022339},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bray-curtis-dissimilarity","display_name":"Bray-Curtis dissimilarity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/compositional-data","display_name":"compositional data","score":0.7799999713897705},{"id":"https://openalex.org/keywords/zero-inflated-data","display_name":"zero-inflated data","score":0.9240000247955322},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8510000109672546},{"id":"https://openalex.org/keywords/permutation-tests","display_name":"permutation tests","score":0.3310000002384186},{"id":"https://openalex.org/keywords/eigenvalue-decomposition","display_name":"eigenvalue decomposition","score":0.6309999823570251},{"id":"https://openalex.org/keywords/jive","display_name":"JIVE","score":0.5199999809265137},{"id":"https://openalex.org/keywords/mofa","display_name":"MOFA","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5799000263214111},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5396000146865845},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.506600022315979},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.4893999993801117},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46889999508857727},{"id":"https://openalex.org/C12362212","wikidata":"https://www.wikidata.org/wiki/Q728435","display_name":"Linear subspace","level":2,"score":0.45809999108314514},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4494999945163727},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.4410000145435333},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4368000030517578},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4316999912261963},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.41670000553131104},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C144559511","wikidata":"https://www.wikidata.org/wiki/Q2986279","display_name":"Principal (computer security)","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C33676613","wikidata":"https://www.wikidata.org/wiki/Q13415176","display_name":"Dimension (graph theory)","level":2,"score":0.382099986076355},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3328999876976013},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31279999017715454},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.28949999809265137},{"id":"https://openalex.org/C151437367","wikidata":"https://www.wikidata.org/wiki/Q7884646","display_name":"UniFrac","level":4,"score":0.2879999876022339},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2867000102996826},{"id":"https://openalex.org/C203519979","wikidata":"https://www.wikidata.org/wiki/Q865360","display_name":"Jaccard index","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C91682802","wikidata":"https://www.wikidata.org/wiki/Q620538","display_name":"Multidimensional scaling","level":2,"score":0.25940001010894775}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.29.762935","doi":"https://doi.org/10.64898/2026.10.29.762935","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.10.29.762935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.29.762935","doi":"https://doi.org/10.64898/2026.10.29.762935","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.29.762935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.10.29.762935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225450889.pdf","grobid_xml":"https://content.openalex.org/works/W7225450889.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7203600515","https://openalex.org/W6920608648","https://openalex.org/W4280539066","https://openalex.org/W7223122748","https://openalex.org/W3126439515","https://openalex.org/W2525068948","https://openalex.org/W4398763684","https://openalex.org/W4417117614","https://openalex.org/W7045510264","https://openalex.org/W4376132442"],"abstract_inverted_index":{"Multiview":[0],"microbiome":[1],"studies":[2],"profile":[3],"the":[4,102,144],"same":[5],"participants":[6],"across":[7],"body":[8],"sites":[9],"or":[10,55],"molecular":[11],"layers,":[12],"but":[13],"integration":[14],"is":[15],"hampered":[16],"by":[17,73],"sparse,":[18,116],"compositional":[19],"data,":[20,118],"modest":[21],"sample":[22],"sizes":[23],"and":[24,68,71,83,92,99],"methods":[25],"that":[26,41,124],"recognize":[27],"only":[28,81,145],"exact":[29],"sharing.":[30],"We":[31],"present":[32],"RoDPAA":[33,58,89,120],"(Robust":[34],"Dissimilarity-based":[35],"Principal":[36],"Angle":[37],"Analysis),":[38],"a":[39],"framework":[40],"represents":[42],"each":[43],"view":[44],"through":[45,63],"any":[46],"data-appropriate":[47],"dissimilarity,":[48],"such":[49],"as":[50],"Bray--Curtis,":[51],"without":[52,140],"log-ratio":[53],"transformation":[54],"likelihood":[56],"assumptions.":[57],"aligns":[59],"view-specific":[60],"signal":[61],"subspaces":[62],"principal":[64],"angles,":[65],"captures":[66],"complete":[67],"partial":[69],"sharing,":[70],"tests":[72],"permutation":[74],"how":[75],"many":[76],"components":[77],"are":[78],"shared,":[79],"using":[80],"eigendecomposition":[82],"little":[84],"tuning.":[85],"In":[86,108],"Gaussian":[87],"simulations,":[88],"matched":[90],"JIVE":[91],"MOFA":[93],"given":[94],"true":[95],"ranks,":[96],"ran":[97],"faster":[98],"alone":[100],"recovered":[101,121],"shared":[103,122],"dimension":[104],"in":[105],"every":[106],"replicate.":[107],"two":[109],"inflammatory":[110],"bowel":[111],"disease":[112,141],"(IBD)":[113],"cohorts":[114],"with":[115,148],"zero-inflated":[117],"Bray--Curtis-based":[119],"structure":[123],"was":[125],"stable":[126],"to":[127],"prevalence":[128],"filtering,":[129],"whereas":[130],"log-ratio-based":[131],"alternatives":[132],"were":[133,143],"not.":[134],"Its":[135],"leading":[136],"microbiome--metabolome":[137],"factors,":[138],"learned":[139],"labels,":[142],"ones":[146],"associated":[147],"IBD.":[149]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-08T00:00:00"}