{"id":"https://openalex.org/W7225449355","doi":"https://doi.org/10.6084/m9.figshare.34944686","title":"Chaetomorpha linum (O.F.M\u00fcller) K\u00fctzing 1845 attenuates glucotoxicity via modulation of polyol pathway, oxidative stress and glucose metabolism in adipose tissue","display_name":"Chaetomorpha linum (O.F.M\u00fcller) K\u00fctzing 1845 attenuates glucotoxicity via modulation of polyol pathway, oxidative stress and glucose metabolism in adipose tissue","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225449355","doi":"https://doi.org/10.6084/m9.figshare.34944686"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.34944686","doi":"https://doi.org/10.6084/m9.figshare.34944686","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34944686","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34944686","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061413176","display_name":"S\u2019thandiwe Nozibusiso Magwaza","orcid":"https://orcid.org/0000-0003-4885-6126","observed_orcids":["https://orcid.org/0000-0003-4885-6126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u2019thandiwe N. Magwaza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007783744","display_name":"Kolawole Ayodapo Olofinsan","orcid":"https://orcid.org/0000-0002-2987-0996","observed_orcids":["https://orcid.org/0000-0002-2987-0996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kolawole Olofinsan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161194455","display_name":"Md. Shahidul Islam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md. Shahidul Islam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chaetomorpha-linum","display_name":"Chaetomorpha linum","score":1.0},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/polyol-pathway","display_name":"polyol pathway","score":0.8510000109672546},{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"aldose reductase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9309999942779541},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7509999871253967},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8709999918937683},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.7889999747276306},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.5019999742507935},{"id":"https://openalex.org/keywords/digestive-enzyme-inhibition","display_name":"digestive enzyme inhibition","score":0.6970000267028809},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6439999938011169},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2776795634","wikidata":"https://www.wikidata.org/wiki/Q161100","display_name":"Linum","level":2,"score":0.8436999917030334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6891999840736389},{"id":"https://openalex.org/C136502266","wikidata":"https://www.wikidata.org/wiki/Q7226667","display_name":"Polyol pathway","level":4,"score":0.6165000200271606},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5740000009536743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5673999786376953},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5496000051498413},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43549999594688416},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4311000108718872},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.42160001397132874},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.3950999975204468},{"id":"https://openalex.org/C2781171952","wikidata":"https://www.wikidata.org/wiki/Q415812","display_name":"Polyol","level":3,"score":0.38760000467300415},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.37599998712539673},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.30219998955726624},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26269999146461487},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.34944686","doi":"https://doi.org/10.6084/m9.figshare.34944686","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34944686","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34944686.v1","doi":"https://doi.org/10.6084/m9.figshare.34944686.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34944686.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34944686","doi":"https://doi.org/10.6084/m9.figshare.34944686","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34944686","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4214714920","https://openalex.org/W4416789057","https://openalex.org/W2542173968","https://openalex.org/W3116770239","https://openalex.org/W4210346126","https://openalex.org/W2325584033","https://openalex.org/W4280644942","https://openalex.org/W4406362524","https://openalex.org/W2039933245","https://openalex.org/W3209318096"],"abstract_inverted_index":{"Chronic":[0],"hyperglycaemia":[1],"in":[2,32],"type":[3],"2":[4],"diabetes":[5,152],"drives":[6],"a":[7,145],"self-perpetuating":[8],"cycle":[9],"of":[10,18,148],"glucotoxicity.":[11],"This":[12],"study":[13],"investigated":[14],"the":[15,21,45,55,101,120],"therapeutic":[16],"potential":[17],"extracts":[19,71,102],"from":[20],"green":[22],"seaweed":[23],"Chaetomorpha":[24],"linum":[25,70,143],"(O.F.M\u00fcller)":[26],"K\u00fctzing,":[27],"1845":[28],"to":[29],"mitigate":[30],"glucotoxicity":[31],"rats":[33],"adipocytes.":[34],"Liquid":[35],"chromatography-mass":[36],"spectrometry":[37],"(LC-MS)":[38],"analysis":[39],"revealed":[40],"distinct":[41],"phytochemical":[42],"profiles,":[43],"with":[44,117],"aqueous":[46],"extract":[47,57],"containing":[48,58],"isolobinine,":[49],"kurarinol,":[50],"rutaevin,":[51],"and":[52,54,62,95,128,134],"proanthocyanidin-A2,":[53],"ethanol":[56],"caryoptin,":[59],"mesembrinol,":[60],"12-deoxyphorbol-13-octadecanoate,":[61],"aspulvinone":[63],"H.":[64],"Bioactivity":[65],"assays":[66],"showed":[67],"that":[68],"C.":[69,142],"reversed":[72],"glucotoxicity-induced":[73],"pathologies,":[74],"restoring":[75],"glucose":[76],"uptake":[77],"(3.9\u20136.1":[78],"mg/g":[79],"adipose":[80],"tissue":[81],"at":[82,92,109],"240":[83,93,110],"\u00b5g/mL),":[84,94],"suppressing":[85],"polyol":[86],"pathway":[87],"enzyme":[88],"activities":[89],"(2.7\u20139.5":[90],"\u00b5mol/min/mg,":[91],"enhancing":[96],"antioxidant":[97],"defense":[98],"markers.":[99],"Concurrently,":[100],"inhibited":[103],"key":[104],"digestive":[105],"enzymes":[106],"(26.7\u201341.0":[107],"\u00b5mol/min/\u00b5L,":[108],"\u00b5g/mL).":[111],"Molecular":[112],"docking":[113],"supported":[114],"these":[115],"findings,":[116],"rutaevin":[118],"showing":[119],"high":[121],"affinity":[122],"for":[123,130,151],"aldose":[124],"reductase":[125],"(\u221211.7":[126],"kcal/mol)":[127,133],"proanthocyanidin-A2":[129],"lipase":[131],"(\u22129.9":[132],"glutathione":[135],"peroxidase":[136],"(\u22127":[137],"kcal/mol).":[138],"These":[139],"findings":[140],"highlight":[141],"as":[144],"promising":[146],"source":[147],"bioactive":[149],"compounds":[150],"management.":[153]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}