{"id":"https://openalex.org/W7225449289","doi":"https://doi.org/10.64898/2026.11.05.26367396","title":"GLP-1 Receptor Agonists Added to Statin Therapy and Cardiovascular Outcomes in ASCVD A Propensity Score-Matched Cohort Study","display_name":"GLP-1 Receptor Agonists Added to Statin Therapy and Cardiovascular Outcomes in ASCVD A Propensity Score-Matched Cohort Study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225449289","doi":"https://doi.org/10.64898/2026.11.05.26367396"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.26367396","doi":"https://doi.org/10.64898/2026.11.05.26367396","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.26367396","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.05.26367396.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.05.26367396.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082889529","display_name":"Sunanda Tah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sunanda Tah","raw_affiliation_strings":["West Virginia University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University School of Medicine","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5099115614","display_name":"Michael D Cheshire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Cheshire","raw_affiliation_strings":["West Virginia University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University School of Medicine","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082889529"],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9449999928474426},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":1.0},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":1.0},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7680000066757202},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9203000068664551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7324000000953674},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.6259999871253967},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5841000080108643},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.526199996471405},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.510699987411499},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5056999921798706},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43299999833106995},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.42340001463890076},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.3944999873638153},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.3391999900341034},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.3334999978542328},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C2776210653","wikidata":"https://www.wikidata.org/wiki/Q20707753","display_name":"Atherosclerosis Risk in Communities","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C2781223611","wikidata":"https://www.wikidata.org/wiki/Q357496","display_name":"Obesity paradox","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C2779543058","wikidata":"https://www.wikidata.org/wiki/Q4200712","display_name":"Mass index","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25859999656677246},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.26367396","doi":"https://doi.org/10.64898/2026.11.05.26367396","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.26367396","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.05.26367396.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.26367396","doi":"https://doi.org/10.64898/2026.11.05.26367396","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.26367396","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.05.26367396.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225449289.pdf","grobid_xml":"https://content.openalex.org/works/W7225449289.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1906135245","https://openalex.org/W2117317003","https://openalex.org/W2137983259","https://openalex.org/W2425644022","https://openalex.org/W2475233216","https://openalex.org/W2519510391","https://openalex.org/W2948612418","https://openalex.org/W3152705473","https://openalex.org/W3172134520","https://openalex.org/W3195404919","https://openalex.org/W4388592674","https://openalex.org/W4389193757","https://openalex.org/W4393581969","https://openalex.org/W4401244402","https://openalex.org/W7126021714","https://openalex.org/W7135214394"],"related_works":["https://openalex.org/W7220898716","https://openalex.org/W7225426974","https://openalex.org/W7225431522","https://openalex.org/W7160382656","https://openalex.org/W4399116539","https://openalex.org/W4409530292","https://openalex.org/W4412356100","https://openalex.org/W4402890485","https://openalex.org/W7225425403","https://openalex.org/W4407381117"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"whether":[3],"GLP-1":[4,58,103,150,194,207],"RA":[5,59,104,151,195],"use":[6,105,196],"added":[7],"to":[8,156,214],"statins":[9,55],"is":[10],"associated":[11,107,198],"with":[12,28,50,108,190,199],"lower":[13,110,201],"all-cause":[14,111],"mortality,":[15,202],"myocardial":[16],"infarction":[17],"(MI),":[18],"and":[19,36,93,129,146,204],"ischemic":[20,130],"stroke":[21,131],"versus":[22,61],"statin":[23,215],"monotherapy":[24],"in":[25,182,217],"ASCVD":[26,48,188],"patients":[27,49,189],"body":[29],"mass":[30],"index":[31],"(BMI)":[32],"30":[33,52],"kg/m2.":[34],"Approach":[35],"Results:Using":[37],"the":[38,142,170,183],"TriNetX":[39],"Research":[40],"Network":[41],"(108":[42],"U.S.":[43],"healthcare":[44],"organizations),":[45],"we":[46],"identified":[47],"BMI":[51,82,143],"kg/m2":[53],"on":[54,68,192],"initiating":[56],"a":[57,81,94],"(n=166,278)":[60],"statin-only":[62],"controls":[63],"(n=920,176).":[64],"Propensity":[65],"score":[66],"matching":[67],"34":[69],"covariates":[70],"yielded":[71],"119,911":[72],"matched":[73,100],"pairs":[74],"followed":[75],"3":[76],"years.":[77],"Prespecified":[78],"analyses":[79,90],"included":[80],"35":[83,144],"subgroup":[84,145],"(62,385":[85],"pairs),":[86],"four":[87],"washout":[88,148],"sensitivity":[89],"(30-120":[91],"days),":[92],"familial":[95],"hypercholesterolemia":[96],"exclusion":[97,185],"analysis":[98,163,172],"(161,312":[99],"pairs).":[101],"Results.":[102],"was":[106,173,180,197],"significantly":[109],"mortality":[112],"(4.0%":[113],"vs.":[114,165],"7.5%;":[115],"HR":[116],"0.479;":[117],"95%":[118,125,134],"CI:":[119,126,135],"0.463-0.496;":[120],"p<0.001),":[121,128],"MI":[122],"(HR":[123,132,175],"0.762;":[124],"0.737-0.788;":[127],"0.671;":[133],"0.588-0.766;":[136],"p<0.001).":[137],"Benefits":[138],"were":[139,153],"consistent":[140],"across":[141],"all":[147],"analyses.":[149],"users":[152],"more":[154],"likely":[155],"achieve":[157],"LDL":[158],"<55":[159],"mg/dL":[160],"by":[161],"risk":[162],"(17.1%":[164],"15.3%;":[166],"RR":[167],"1.118;":[168],"p<0.001);":[169],"Kaplan-Meier":[171],"non-significant":[174],"1.007;":[176],"p=0.538).":[177],"Mortality":[178],"benefit":[179],"preserved":[181],"FH":[184],"analysis.":[186],"Conclusion:":[187],"obesity":[191],"statins,":[193],"substantially":[200],"MI,":[203],"stroke,":[205],"suggesting":[206],"RAs":[208],"may":[209],"serve":[210],"as":[211],"cardioprotective":[212],"adjuncts":[213],"therapy":[216],"this":[218],"population.":[219]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-08T00:00:00"}
