{"id":"https://openalex.org/W7225449270","doi":"https://doi.org/10.1056/nejmoa2606634","title":"Discontinuing Statins in Older Adults without Cardiovascular Disease","display_name":"Discontinuing Statins in Older Adults without Cardiovascular Disease","publication_year":2026,"publication_date":"2026-11-07","ids":{"openalex":"https://openalex.org/W7225449270","doi":"https://doi.org/10.1056/nejmoa2606634","pmid":"https://pubmed.ncbi.nlm.nih.gov/43001742"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa2606634","doi":"https://doi.org/10.1056/nejmoa2606634","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa2606634","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48620/102383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028632973","display_name":"Nicolas Rodondi","orcid":"https://orcid.org/0000-0001-9083-6896","observed_orcids":["https://orcid.org/0000-0001-9083-6896"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicolas Rodondi","raw_affiliation_strings":["Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082484468","display_name":"Moa Lina Haller","orcid":"https://orcid.org/0009-0006-2380-349X","observed_orcids":["https://orcid.org/0009-0006-2380-349X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Moa Lina Haller","raw_affiliation_strings":["University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093823941","display_name":"Julia B. Bardoczi","orcid":"https://orcid.org/0009-0001-5914-512X","observed_orcids":["https://orcid.org/0009-0001-5914-512X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julia Bianca Bardoczi","raw_affiliation_strings":["Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003004245","display_name":"Luise Adam","orcid":"https://orcid.org/0000-0001-7741-2677","observed_orcids":["https://orcid.org/0000-0001-7741-2677"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4210118453","display_name":"Spit\u00e4ler Schaffhausen","ror":"https://ror.org/02fmm1979","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210118453"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luise Adam","raw_affiliation_strings":["Department of Angiology, Cantonal Hospital of Schaffhausen, Schaffhausen, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Angiology, Cantonal Hospital of Schaffhausen, Schaffhausen, Switzerland","institution_ids":["https://openalex.org/I4210118453"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053382062","display_name":"Manuel R. Blum","orcid":"https://orcid.org/0000-0003-4638-775X","observed_orcids":["https://orcid.org/0000-0003-4638-775X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]},{"id":"https://openalex.org/I4210103212","display_name":"Privatklinik Meiringen","ror":"https://ror.org/00tbqf005","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210103212"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manuel Raphael Blum","raw_affiliation_strings":["Department of General Internal Medicine, Frutigen Meiringen Interlaken Hospitals, Hospital Interlaken, Interlaken, Switzerland","Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Frutigen Meiringen Interlaken Hospitals, Hospital Interlaken, Interlaken, Switzerland","institution_ids":["https://openalex.org/I4210103212"]},{"raw_affiliation_string":"Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086449617","display_name":"Bari\u015f Gencer","orcid":"https://orcid.org/0000-0002-8954-9694","observed_orcids":["https://orcid.org/0000-0002-8954-9694"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Baris Gencer","raw_affiliation_strings":["Cardiology Division, Lausanne University Hospital, Lausanne, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Lausanne University Hospital, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083146299","display_name":"Tamar Itach","orcid":"https://orcid.org/0000-0002-7419-0631","observed_orcids":["https://orcid.org/0000-0002-7419-0631"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tamar Itach","raw_affiliation_strings":["University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161206628","display_name":"Julian Simon Flury","orcid":"https://orcid.org/0009-0003-6576-0238","observed_orcids":["https://orcid.org/0009-0003-6576-0238"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julian Simon Flury","raw_affiliation_strings":["Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":"https://orcid.org/0009-0003-6576-0238","affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018997832","display_name":"Lara Aurora Brockhus","orcid":"https://orcid.org/0009-0007-0045-4933","observed_orcids":["https://orcid.org/0009-0007-0045-4933"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lara Aurora Brockhus","raw_affiliation_strings":["University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111744414","display_name":"Philipp Aebi","orcid":"https://orcid.org/0009-0000-2034-9793","observed_orcids":["https://orcid.org/0009-0000-2034-9793"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philipp Stefan Aebi","raw_affiliation_strings":["Department of General Internal Medicine, Thun Hospital, Thun, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Thun Hospital, Thun, Switzerland","institution_ids":[]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076894759","display_name":"Martin Feller","orcid":"https://orcid.org/0000-0003-2519-836X","observed_orcids":["https://orcid.org/0000-0003-2519-836X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin Feller","raw_affiliation_strings":["University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047065502","display_name":"Claudia Gregoriano","orcid":"https://orcid.org/0000-0002-3621-441X","observed_orcids":["https://orcid.org/0000-0002-3621-441X"]},"institutions":[{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Claudia Gregoriano","raw_affiliation_strings":["Department of Internal Medicine, Cantonal Hospital Aarau, Medical University Clinic, Aarau, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Cantonal Hospital Aarau, Medical University Clinic, Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024259580","display_name":"Roxane de La Harpe","orcid":"https://orcid.org/0000-0002-2885-3799","observed_orcids":["https://orcid.org/0000-0002-2885-3799"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roxane de la Harpe","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013373829","display_name":"Jacobijn Gussekloo","orcid":"https://orcid.org/0000-0001-7186-8278","observed_orcids":["https://orcid.org/0000-0001-7186-8278"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jacobijn Gussekloo","raw_affiliation_strings":["Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands","Leiden University Medical Center, Center for Health and Ageing, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden University Medical Center, Center for Health and Ageing, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040348689","display_name":"Nathalie Schwab","orcid":"https://orcid.org/0000-0003-4379-3509","observed_orcids":["https://orcid.org/0000-0003-4379-3509"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nathalie Schwab","raw_affiliation_strings":["Department of Infectious Diseases, Inselspital, University Hospital Bern, Bern, Switzerland","University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000159140","display_name":"Pierre Poulizac","orcid":"https://orcid.org/0009-0002-5431-3822","observed_orcids":["https://orcid.org/0009-0002-5431-3822"]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Poulizac","raw_affiliation_strings":["Centre Hospitalier Universitaire (CHU) de Bordeaux, Direction de la Recherche Clinique et de l\u2019Innovation, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire (CHU) de Bordeaux, Direction de la Recherche Clinique et de l\u2019Innovation, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091160797","display_name":"Simon Pieter Mooijaart","orcid":"https://orcid.org/0000-0003-3106-3568","observed_orcids":["https://orcid.org/0000-0003-3106-3568"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Simon Pieter Mooijaart","raw_affiliation_strings":["Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands","Leiden University Medical Center, Center for Health and Ageing, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden University Medical Center, Center for Health and Ageing, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019077055","display_name":"J\u00fcrg Hans Beer","orcid":"https://orcid.org/0000-0002-7199-0406","observed_orcids":["https://orcid.org/0000-0002-7199-0406"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00fcrg-Hans Beer","raw_affiliation_strings":["Baden Cantonal Hospital Internal Medicine, Baden, Switzerland","University of Zurich, Center for Molecular Cardiology, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baden Cantonal Hospital Internal Medicine, Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]},{"raw_affiliation_string":"University of Zurich, Center for Molecular Cardiology, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054449752","display_name":"St\u00e9phanie Baggio","orcid":"https://orcid.org/0000-0002-5347-5937","observed_orcids":["https://orcid.org/0000-0002-5347-5937"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Baggio","raw_affiliation_strings":["University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","University of Lausanne Institute of Psychology, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"University of Lausanne Institute of Psychology, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085690340","display_name":"Sebastian Carballo","orcid":"https://orcid.org/0000-0002-8344-4293","observed_orcids":["https://orcid.org/0000-0002-8344-4293"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sebastian Carballo","raw_affiliation_strings":["Division of General Internal Medicine, Geneva University Hospitals, Geneva","University of Geneva Faculty of Medicine, Geneva"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine, Geneva University Hospitals, Geneva","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"University of Geneva Faculty of Medicine, Geneva","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086902696","display_name":"Fabrice Bonnet","orcid":"https://orcid.org/0000-0001-9255-8228","observed_orcids":["https://orcid.org/0000-0001-9255-8228"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Bonnet","raw_affiliation_strings":["CHU de Bordeaux, Service de M\u00e9decine Interne et Maladies Infectieuses, H\u00f4pital Saint-Andr\u00e9, Bordeaux, France","University of Bordeaux, Institut de Sant\u00e9 Publique, d\u2019\u00c9pid\u00e9miologie, et de D\u00e9veloppement (ISPED), INSERM U1219, Bordeaux Population Health Research Center (BPH), Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Bordeaux, Service de M\u00e9decine Interne et Maladies Infectieuses, H\u00f4pital Saint-Andr\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"raw_affiliation_string":"University of Bordeaux, Institut de Sant\u00e9 Publique, d\u2019\u00c9pid\u00e9miologie, et de D\u00e9veloppement (ISPED), INSERM U1219, Bordeaux Population Health Research Center (BPH), Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041865783","display_name":"Dina Zekry","orcid":"https://orcid.org/0000-0002-6263-7803","observed_orcids":["https://orcid.org/0000-0002-6263-7803"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dina Zekry","raw_affiliation_strings":["Division of Internal Medicine for the Aged, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva","University of Geneva Faculty of Medicine, Geneva"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine for the Aged, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"University of Geneva Faculty of Medicine, Geneva","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018582355","display_name":"Luca Gabutti","orcid":"https://orcid.org/0000-0002-1929-6759","observed_orcids":["https://orcid.org/0000-0002-1929-6759"]},"institutions":[{"id":"https://openalex.org/I4210090532","display_name":"Ospedale regionale di Lugano","ror":"https://ror.org/00gkheh82","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210090532","https://openalex.org/I4210095212"]},{"id":"https://openalex.org/I4210095212","display_name":"Ente Ospedaliero Cantonale","ror":"https://ror.org/00sh19a92","country_code":"CH","type":"other","lineage":["https://openalex.org/I4210095212"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luca Gabutti","raw_affiliation_strings":["Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Institute of Family Medicine, Lugano, Switzerland","Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Family Medicine Service, Regional Hospital of Lugano, Lugano, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Institute of Family Medicine, Lugano, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Family Medicine Service, Regional Hospital of Lugano, Lugano, Switzerland","institution_ids":["https://openalex.org/I4210090532","https://openalex.org/I4210095212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015427235","display_name":"Maria Monika Wertli","orcid":"https://orcid.org/0000-0001-6347-0198","observed_orcids":["https://orcid.org/0000-0001-6347-0198"]},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]},{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maria Monika Wertli","raw_affiliation_strings":["Baden Cantonal Hospital Internal Medicine, Baden, Switzerland","Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baden Cantonal Hospital Internal Medicine, Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]},{"raw_affiliation_string":"Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027819939","display_name":"Drahomir Aujesky","orcid":"https://orcid.org/0000-0002-3970-2670","observed_orcids":["https://orcid.org/0000-0002-3970-2670"]},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Drahomir Aujesky","raw_affiliation_strings":["Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161213247","display_name":"Douglas Charles Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Charles Bauer","raw_affiliation_strings":["Division of General Internal Medicine, University of California, San Francisco, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine, University of California, San Francisco, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089784097","display_name":"Rita F. Redberg","orcid":"https://orcid.org/0000-0001-6281-0250","observed_orcids":["https://orcid.org/0000-0001-6281-0250"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Fran Redberg","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111611266","display_name":"Philip Greenland","orcid":"https://orcid.org/0000-0002-6327-2439","observed_orcids":["https://orcid.org/0000-0002-6327-2439"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Greenland","raw_affiliation_strings":["Departments of Preventive Medicine and Medicine, Northwestern University Feinberg School of Medicine, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Medicine and Medicine, Northwestern University Feinberg School of Medicine, Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210147348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000002986","display_name":"Rosalinde K. E. Poortvliet","orcid":"https://orcid.org/0000-0001-6521-8770","observed_orcids":["https://orcid.org/0000-0001-6521-8770"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rosalinde Klazina Elisabeth Poortvliet","raw_affiliation_strings":["Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands","Leiden University Medical Center, Center for Health and Ageing, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden University Medical Center, Center for Health and Ageing, Leiden, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037540908","display_name":"Philipp Sch\u00fcetz","orcid":"https://orcid.org/0000-0001-6400-4949","observed_orcids":["https://orcid.org/0000-0001-6400-4949","https://orcid.org/0000-0002-4191-7603","https://orcid.org/0000-0001-7564-1468"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philipp Schuetz","raw_affiliation_strings":["Department of Internal Medicine, Cantonal Hospital Aarau, Medical University Clinic, Aarau, Switzerland","Medical Faculty, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Cantonal Hospital Aarau, Medical University Clinic, Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]},{"raw_affiliation_string":"Medical Faculty, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016855835","display_name":"Marie M\u00e9an","orcid":"https://orcid.org/0000-0003-0477-7899","observed_orcids":["https://orcid.org/0000-0003-0477-7899"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marie M\u00e9an","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161215941","display_name":"Alan Gary Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alan Gary Haynes","raw_affiliation_strings":["Department of Clinical Research, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057426061","display_name":"Sven Trelle","orcid":"https://orcid.org/0000-0002-8162-8910","observed_orcids":["https://orcid.org/0000-0002-8162-8910"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sven Trelle","raw_affiliation_strings":["Department of Clinical Research, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8162-8910","affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":24,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statin-discontinuation","display_name":"statin discontinuation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9679999947547913},{"id":"https://openalex.org/keywords/primary-prevention","display_name":"primary prevention","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.7630000114440918},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5759999752044678},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349000215530396},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6263999938964844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4129999876022339},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3028999865055084},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.26460000872612},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.25049999356269836},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.25029999017715454}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1056/nejmoa2606634","doi":"https://doi.org/10.1056/nejmoa2606634","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa2606634","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:43001742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43001742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"doi:10.48620/102383","doi":"https://doi.org/10.48620/102383","is_oa":true,"landing_page_url":"https://doi.org/10.48620/102383","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.48620/102383","doi":"https://doi.org/10.48620/102383","is_oa":true,"landing_page_url":"https://doi.org/10.48620/102383","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323367","display_name":"Gottfried und Julia Bangerter-Rhyner-Stiftung","ror":"https://ror.org/04r25nk19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1560696636","https://openalex.org/W1997810742","https://openalex.org/W2003065114","https://openalex.org/W2024321525","https://openalex.org/W2076372308","https://openalex.org/W2079393363","https://openalex.org/W2163744159","https://openalex.org/W2166326771","https://openalex.org/W2171541729","https://openalex.org/W2764336450","https://openalex.org/W2783127478","https://openalex.org/W2895001427","https://openalex.org/W2895778623","https://openalex.org/W2909851367","https://openalex.org/W2914546434","https://openalex.org/W2964473028","https://openalex.org/W2980378453","https://openalex.org/W3030513959","https://openalex.org/W3131360124","https://openalex.org/W3165900016","https://openalex.org/W3181572830","https://openalex.org/W3190593840","https://openalex.org/W3216165672","https://openalex.org/W4282941192","https://openalex.org/W4292841356","https://openalex.org/W4313524107","https://openalex.org/W4321458319","https://openalex.org/W4401079318","https://openalex.org/W4407301444","https://openalex.org/W4410630300","https://openalex.org/W7202196109","https://openalex.org/W7204647505"],"related_works":["https://openalex.org/W7214909717","https://openalex.org/W7071410243","https://openalex.org/W2004614766","https://openalex.org/W4233267373","https://openalex.org/W2412898768","https://openalex.org/W2597643540","https://openalex.org/W2028393209","https://openalex.org/W2621004698","https://openalex.org/W7214352504","https://openalex.org/W2618921671"],"abstract_inverted_index":{"BACKGROUND:":[0],"Whether":[1],"discontinuing":[2],"statin":[3,69,248],"therapy":[4,70,249],"in":[5,60,108,161,193,200,215,220,225,227],"older":[6,233],"adults":[7,42,234],"with":[8,117,235,254],"at":[9,43,114,168,236,265],"least":[10,44,209,237],"two":[11,238],"chronic":[12,239],"conditions":[13,240],"but":[14,241],"no":[15,242],"known":[16,243],"cardiovascular":[17,25,244,258],"disease":[18],"affects":[19],"the":[20,102,105,136,142,149,162,194,201,218,221,228,270],"time":[21,113,167],"to":[22,64,135,141,178,252,256],"a":[23,61,79,118,184,205],"first":[24],"event":[26,213],"is":[27],"not":[28],"well":[29],"characterized.":[30],"METHODS:":[31],"We":[32],"conducted":[33],"an":[34],"international,":[35],"open-label,":[36],"randomized,":[37],"controlled":[38],"trial":[39],"that":[40],"enrolled":[41],"70":[45],"years":[46,170],"of":[47,81,104,121,127,148,187,217,247],"age":[48,147],"who":[49],"were":[50,57,133,156],"taking":[51],"statins":[52],"for":[53,181],"primary":[54,76,97],"prevention.":[55],"Participants":[56],"randomly":[58],"assigned":[59,134],"1:1":[62],"ratio":[63],"either":[65],"discontinue":[66],"or":[67,88,260],"continue":[68],"and":[71,139,154,197,224],"other":[72],"lipid-lowering":[73],"therapies.":[74],"The":[75,96,145,158],"outcome":[77],"was":[78,151,171,250],"composite":[80],"nonfatal":[82,85],"myocardial":[83],"infarction,":[84],"ischemic":[86],"stroke,":[87],"death":[89,261],"from":[90,262],"any":[91,263],"cause,":[92],"whichever":[93],"occurred":[94,214],"first.":[95],"analysis":[98],"assessed":[99],"noninferiority":[100,119],"on":[101],"basis":[103],"between-group":[106,159],"difference":[107,160],"restricted":[109,163],"mean":[110,146,164],"event-free":[111,165],"survival":[112,166],"2":[115,169,266],"years,":[116,153],"margin":[120],"-5.2":[122],"weeks.":[123],"RESULTS:":[124],"A":[125],"total":[126],"1880":[128],"participants":[129,150,191,219],"underwent":[130],"randomization:":[131],"938":[132],"discontinuation":[137,195,222,246],"group":[138,196,203,223],"942":[140],"continuation":[143,202,229,253],"group.":[144,230],"77.5":[152],"46.9%":[155],"women.":[157],"-2.0":[172],"weeks":[173],"(95%":[174],"confidence":[175],"interval,":[176],"-3.7":[177],"-0.3;":[179],"P<0.001":[180],"noninferiority).":[182],"Over":[183],"median":[185],"follow-up":[186],"103":[188],"weeks,":[189],"119":[190],"(12.7%)":[192],"87":[198],"(9.2%)":[199],"had":[204],"primary-outcome":[206],"event.":[207],"At":[208],"one":[210],"serious":[211],"adverse":[212],"43.0%":[216],"39.8%":[226],"CONCLUSIONS:":[231],"Among":[232],"disease,":[245],"noninferior":[251],"respect":[255],"major":[257],"events":[259],"cause":[264],"years.":[267],"(Funded":[268],"by":[269],"Swiss":[271],"National":[272],"Science":[273],"Foundation;":[274],"STREAM":[275],"ClinicalTrials.gov":[276],"number,":[277],"NCT05178420.).":[278]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-08T00:00:00"}
