{"id":"https://openalex.org/W7225449049","doi":"https://doi.org/10.1002/jbt.71171","title":"Neuroprotective Effect of Magnoflorine Through Inhibition of Caspase\u20103\u2010Mediated Neuronal Apoptosis: In Silico to In Vitro Validation","display_name":"Neuroprotective Effect of Magnoflorine Through Inhibition of Caspase\u20103\u2010Mediated Neuronal Apoptosis: In Silico to In Vitro Validation","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225449049","doi":"https://doi.org/10.1002/jbt.71171","pmid":"https://pubmed.ncbi.nlm.nih.gov/42998250"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.71171","doi":"https://doi.org/10.1002/jbt.71171","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.71171","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71171","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71171","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085119469","display_name":"Randeep Singh","orcid":"https://orcid.org/0000-0001-7310-0617","observed_orcids":["https://orcid.org/0000-0001-7310-0617"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Randeep Singh","raw_affiliation_strings":["Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0000-0001-7310-0617","affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076107433","display_name":"Sahil Arora","orcid":"https://orcid.org/0000-0001-7911-5609","observed_orcids":["https://orcid.org/0000-0001-7911-5609"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sahil Arora","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0000-0001-7911-5609","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161255999","display_name":"Rimple Kaur","orcid":"https://orcid.org/0009-0003-6170-5370","observed_orcids":["https://orcid.org/0009-0003-6170-5370"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rimple Kaur","raw_affiliation_strings":["Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0009-0003-6170-5370","affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103081676","display_name":"A. Gharib","orcid":"https://orcid.org/0009-0008-7485-2712","observed_orcids":["https://orcid.org/0009-0008-7485-2712"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ali Gharib Gharib","raw_affiliation_strings":["Department of Computational Sciences, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0009-0008-7485-2712","affiliations":[{"raw_affiliation_string":"Department of Computational Sciences, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024620095","display_name":"Vikash Prashar","orcid":"https://orcid.org/0000-0002-3722-0774","observed_orcids":["https://orcid.org/0000-0002-3722-0774"]},"institutions":[{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikash Prashar","raw_affiliation_strings":["Department of Allied Health Sciences, School of Allied and Healthcare Sciences Lovely Professional University Phagwara Punjab India"],"raw_orcid":"https://orcid.org/0000-0002-3722-0774","affiliations":[{"raw_affiliation_string":"Department of Allied Health Sciences, School of Allied and Healthcare Sciences Lovely Professional University Phagwara Punjab India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114778212","display_name":"Tania Arora","orcid":"https://orcid.org/0000-0002-0122-2081","observed_orcids":["https://orcid.org/0000-0002-0122-2081"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tania Arora","raw_affiliation_strings":["Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459478","display_name":"Arti Sharma","orcid":"https://orcid.org/0000-0003-4128-8058","observed_orcids":["https://orcid.org/0000-0003-4128-8058","https://orcid.org/0009-0004-9373-4886"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arti Sharma","raw_affiliation_strings":["Department of Computational Sciences, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0009-0004-9373-4886","affiliations":[{"raw_affiliation_string":"Department of Computational Sciences, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057197137","display_name":"Balachandar Vellingiri","orcid":"https://orcid.org/0000-0002-3043-6839","observed_orcids":["https://orcid.org/0000-0002-3043-6839","https://orcid.org/0009-0000-6863-0170"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balachandar Vellingiri","raw_affiliation_strings":["Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0000-0002-3043-6839","affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071208511","display_name":"Jyoti Parkash","orcid":"https://orcid.org/0000-0002-6399-700X","observed_orcids":["https://orcid.org/0000-0002-6399-700X"]},"institutions":[{"id":"https://openalex.org/I114724429","display_name":"Central University of Punjab","ror":"https://ror.org/02kknsa06","country_code":"IN","type":"education","lineage":["https://openalex.org/I114724429"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jyoti Parkash","raw_affiliation_strings":["Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India"],"raw_orcid":"https://orcid.org/0000-0002-6399-700X","affiliations":[{"raw_affiliation_string":"Department of Zoology, School of Basic Sciences Central University of Punjab Bathinda Punjab India","institution_ids":["https://openalex.org/I114724429"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071208511"],"corresponding_institution_ids":["https://openalex.org/I114724429"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":{"value":4020,"currency":"USD","value_usd":4020},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84102564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.3391000032424927,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.3391000032424927,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.18150000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.09730000048875809,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnoflorine","display_name":"magnoflorine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caspase-3-inhibition","display_name":"caspase-3 inhibition","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9520000219345093},{"id":"https://openalex.org/keywords/kainic-acid-neurotoxicity","display_name":"kainic acid neurotoxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.6489999890327454},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/binding-affinity-prediction","display_name":"binding affinity prediction","score":0.6259999871253967},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6349999904632568},{"id":"https://openalex.org/keywords/mm-gbsa","display_name":"MM-GBSA","score":0.7020000219345093},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.9035000205039978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7501000165939331},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7174999713897705},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5763999819755554},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.49559998512268066},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.49050000309944153},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4875999987125397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4625999927520752},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.43470001220703125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4250999987125397},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.37880000472068787},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3529999852180481},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.2973000109195709},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.26429998874664307}],"mesh":[{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001060","descriptor_name":"Aporphines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.71171","doi":"https://doi.org/10.1002/jbt.71171","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.71171","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71171","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:42998250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42998250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jbt.71171","doi":"https://doi.org/10.1002/jbt.71171","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.71171","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71171","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306227","display_name":"Arthritis National Research Foundation","ror":"https://ror.org/03abbex33"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225449049.pdf","grobid_xml":"https://content.openalex.org/works/W7225449049.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1563498244","https://openalex.org/W1580445881","https://openalex.org/W1977426392","https://openalex.org/W1977709892","https://openalex.org/W1998778991","https://openalex.org/W2002113106","https://openalex.org/W2006801926","https://openalex.org/W2033602484","https://openalex.org/W2033822461","https://openalex.org/W2088895984","https://openalex.org/W2096747776","https://openalex.org/W2122162592","https://openalex.org/W2132629607","https://openalex.org/W2168939326","https://openalex.org/W2269367396","https://openalex.org/W2321912578","https://openalex.org/W2731397344","https://openalex.org/W2767711842","https://openalex.org/W2769329384","https://openalex.org/W2770020522","https://openalex.org/W2892113269","https://openalex.org/W2997347248","https://openalex.org/W3019322471","https://openalex.org/W3093673763","https://openalex.org/W3094272820","https://openalex.org/W3118781803","https://openalex.org/W3194413091","https://openalex.org/W3210339211","https://openalex.org/W4225161572","https://openalex.org/W4225883300","https://openalex.org/W4303198934","https://openalex.org/W4320038730","https://openalex.org/W4367316704","https://openalex.org/W4391178154","https://openalex.org/W4399808054","https://openalex.org/W4400672401","https://openalex.org/W4404184348","https://openalex.org/W4405133550","https://openalex.org/W4405721111"],"related_works":["https://openalex.org/W82609195","https://openalex.org/W4384492962","https://openalex.org/W2122162592","https://openalex.org/W1966546311","https://openalex.org/W2033413582","https://openalex.org/W2347286987","https://openalex.org/W2032500744","https://openalex.org/W2049992435","https://openalex.org/W2999710696","https://openalex.org/W1655717730"],"abstract_inverted_index":{"Neurodegeneration":[0],"is":[1,7,228],"a":[2,24,76,231],"progressive":[3],"biological":[4],"phenomenon":[5],"that":[6,73,83,158,181,226],"significantly":[8,160,183],"driven":[9],"by":[10,27,33,168,196,237],"neuronal":[11,30,239],"apoptosis.":[12],"The":[13,36,176,222],"current":[14],"study":[15,224],"aimed":[16],"to":[17,93],"investigate":[18],"the":[19,63,89,104,108,112,132,148,162,185,203,206],"neuroprotective":[20],"potential":[21,90,102],"of":[22,39,84,91,107,119,164,194,205],"Magnoflorine,":[23],"natural":[25],"alkaloid,":[26],"inhibiting":[28],"Caspase-3-mediated":[29],"apoptosis":[31,142,177,188],"induced":[32],"Kainic":[34,60,85,170,186,207],"acid.":[35],"caspase-3-inhibiting":[37],"property":[38],"Magnoflorine":[40,74,92,159,182,197,227],"was":[41,122],"initially":[42],"predicted":[43],"using":[44],"in":[45,127,189,210,213,246],"silico":[46],"methods":[47],"such":[48,130],"as":[49,62,131,217,230],"molecular":[50,55],"docking,":[51],"MMGBSA":[52,70],"analysis,":[53],"and":[54,69,144,154,174],"dynamics":[56],"(MD)":[57],"simulations,":[58],"taking":[59],"acid":[61,114],"reference":[64],"neurotoxic":[65],"ligand.":[66],"Molecular":[67],"docking":[68],"analysis":[71],"showed":[72,180],"has":[75],"higher":[77],"binding":[78],"affinity":[79],"for":[80,235],"caspase-3":[81,95],"than":[82,111],"acid,":[86],"which":[87,241],"predicts":[88],"inhibit":[94],"expression.":[96],"MD":[97],"simulations":[98],"further":[99,243],"highlighted":[100],"this":[101],"through":[103,125,202,245],"greater":[105],"stability":[106],"Caspase-3-Magnoflorine":[109],"complex":[110,115],"Caspase-3-Kainic":[113],"over":[116],"200":[117],"ns":[118],"simulations.":[120],"It":[121],"finally":[123],"evaluated":[124],"multiple":[126],"vitro":[128],"techniques":[129],"MTT":[133,153],"cell":[134,172],"viability":[135,163],"assay,":[136,139,143],"LDH":[137,155],"cytotoxicity":[138],"Annexin":[140],"V-PI":[141],"immunocytochemistry":[145,201],"performed":[146],"on":[147],"retinoic":[149],"acid-differentiated":[150],"SH-SY5Y":[151,166,191,215],"cells.":[152,192],"assays":[156],"revealed":[157],"improved":[161],"differentiated":[165,190,214],"cells":[167],"reducing":[169],"acid-induced":[171,187,208],"death":[173],"cytotoxicity.":[175],"assay":[178],"also":[179],"reduced":[184],"Inhibition":[193],"Caspase-3":[195,211],"became":[198],"evident":[199],"during":[200],"reversal":[204],"increase":[209],"expression":[212],"cells,":[216],"observed":[218],"from":[219],"immunofluorescence":[220],"intensity.":[221],"present":[223],"suggests":[225],"emerging":[229],"valuable":[232],"therapeutic":[233],"agent":[234],"neurodegeneration":[236],"alleviating":[238],"apoptosis,":[240],"requires":[242],"validation":[244],"vivo":[247],"studies.":[248]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-08T00:00:00"}