{"id":"https://openalex.org/W7225433167","doi":"https://doi.org/10.3389/fimmu.2026.1938186","title":"Oxeiptosis-associated transcriptional states, immune heterogeneity, and oxidative-stress susceptibility in triple-negative breast cancer","display_name":"Oxeiptosis-associated transcriptional states, immune heterogeneity, and oxidative-stress susceptibility in triple-negative breast cancer","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225433167","doi":"https://doi.org/10.3389/fimmu.2026.1938186"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1938186","doi":"https://doi.org/10.3389/fimmu.2026.1938186","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1938186","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938186/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938186/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001258631","display_name":"Ziyun Zhuang","orcid":"https://orcid.org/0000-0001-7969-6888","observed_orcids":["https://orcid.org/0000-0001-7969-6888"]},"institutions":[{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]},{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyun Zhuang","raw_affiliation_strings":["Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","School of Medicine, Shantou University Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Medicine, Shantou University Medical College","institution_ids":["https://openalex.org/I4210120522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124946693","display_name":"Haiyu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyu Zhang","raw_affiliation_strings":["Department of Urology, Peking University First Hospital, Peking University","School of Medicine, Shantou University Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Peking University First Hospital, Peking University","institution_ids":["https://openalex.org/I4210130930"]},{"raw_affiliation_string":"School of Medicine, Shantou University Medical College","institution_ids":["https://openalex.org/I4210120522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103292393","display_name":"Jiawei Lei","orcid":"https://orcid.org/0009-0004-9811-5638","observed_orcids":["https://orcid.org/0009-0004-9811-5638"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Lei","raw_affiliation_strings":["Department of Family Medicine, Shengjing Hospital, China Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Shengjing Hospital, China Medical University","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123521459","display_name":"Changgui Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changgui Zou","raw_affiliation_strings":["Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161059460","display_name":"Yingcong Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingcong Lin","raw_affiliation_strings":["Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159669773","display_name":"Ciqiu Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ciqiu Yang","raw_affiliation_strings":["Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130343592","display_name":"Yitian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yitian Chen","raw_affiliation_strings":["Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Cancer, Cancer Center, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5130343592","https://openalex.org/A5159669773"],"corresponding_institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oxeiptosis","display_name":"oxeiptosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6620000004768372},{"id":"https://openalex.org/keywords/alg3","display_name":"ALG3","score":0.906000018119812},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.6589999794960022},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tumor-immune-heterogeneity","display_name":"tumor immune heterogeneity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.9110000133514404},{"id":"https://openalex.org/keywords/docetaxel-combination-therapy","display_name":"docetaxel combination therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7357000112533569},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6625000238418579},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5824000239372253},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.5698000192642212},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5212000012397766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46239998936653137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4390999972820282},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35679998993873596},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3165999948978424},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.31209999322891235},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3075999915599823},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.27160000801086426},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2687000036239624},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2531999945640564}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1938186","doi":"https://doi.org/10.3389/fimmu.2026.1938186","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1938186","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938186/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:23687594699f43818e848f3403c4ec21","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/23687594699f43818e848f3403c4ec21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1938186","doi":"https://doi.org/10.3389/fimmu.2026.1938186","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1938186","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1938186/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4398336666","display_name":null,"funder_award_id":"82203724","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320335480","display_name":"Guangzhou Municipal Science and Technology Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225433167.pdf","grobid_xml":"https://content.openalex.org/works/W7225433167.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W2035618305","https://openalex.org/W2146058212","https://openalex.org/W2156871941","https://openalex.org/W2775328130","https://openalex.org/W2807671526","https://openalex.org/W2898120081","https://openalex.org/W2949829455","https://openalex.org/W3006930853","https://openalex.org/W3108823610","https://openalex.org/W3187504732","https://openalex.org/W3198511950","https://openalex.org/W3205385275","https://openalex.org/W4200468913","https://openalex.org/W4210957314","https://openalex.org/W4221004322","https://openalex.org/W4282943635","https://openalex.org/W4311869224","https://openalex.org/W4386034505","https://openalex.org/W4389366631","https://openalex.org/W4392682815","https://openalex.org/W4393935425","https://openalex.org/W4399042313","https://openalex.org/W4400390474","https://openalex.org/W4402551965","https://openalex.org/W4402604581","https://openalex.org/W4403201947","https://openalex.org/W4407194428","https://openalex.org/W4407203128","https://openalex.org/W4408642518","https://openalex.org/W4409627357","https://openalex.org/W4412522195","https://openalex.org/W4413739838","https://openalex.org/W4416093595","https://openalex.org/W7124685262","https://openalex.org/W7125137026","https://openalex.org/W7167819614","https://openalex.org/W7202173654"],"related_works":["https://openalex.org/W7221173550","https://openalex.org/W7223362702","https://openalex.org/W2992216278","https://openalex.org/W4384201182","https://openalex.org/W4400624338","https://openalex.org/W4416870105","https://openalex.org/W2066549335","https://openalex.org/W4405808417","https://openalex.org/W4308202701","https://openalex.org/W7203832275"],"abstract_inverted_index":{"Background":[0],"Triple-negative":[1],"breast":[2,90,187],"cancer":[3,91,188],"(TNBC)":[4],"exhibits":[5],"substantial":[6],"variation":[7],"in":[8,70,89,121,152,247,275,295],"treatment":[9],"response.":[10],"In":[11,93,277],"the":[12,30,44,108,115,161,165,211,244,283],"phase":[13],"2":[14],"NeoSAC":[15],"trial,":[16],"higher":[17,131],"baseline":[18],"oxeiptosis-associated":[19,64,82,132],"transcriptional":[20,37,133,265],"activity":[21],"was":[22,73,85],"associated":[23,268],"with":[24,123,130,190,253,269],"pathological":[25],"complete":[26],"response":[27,285],"(pCR).":[28],"However,":[29],"malignant-cell":[31,271],"and":[32,58,67,87,98,120,142,145,156,170,181,201,210,235,272,298],"immune":[33,68,168,273],"features":[34,69,274],"underlying":[35],"this":[36],"state":[38],"remain":[39],"poorly":[40],"defined,":[41],"as":[42],"do":[43],"molecular":[45],"factors":[46],"that":[47,193],"influence":[48],"cellular":[49,105,284],"susceptibility":[50],"to":[51,62,75,103,107,238,286],"oxidative":[52,288],"stress.":[53,289],"Methods":[54],"We":[55,112],"integrated":[56],"single-cell":[57],"bulk":[59],"transcriptomic":[60],"analyses":[61],"characterize":[63],"tumor":[65],"states":[66,266],"TNBC.":[71,276],"CellChat":[72,149],"used":[74,102],"infer":[76],"candidate":[77,153],"intercellular":[78],"communication":[79,158],"patterns.":[80],"An":[81],"prognostic":[83,184],"model":[84,175],"developed":[86],"evaluated":[88],"cohorts.":[92,196],"MDA-MB-231":[94,278],"cells,":[95,279],"ALG3":[96,225,241,280],"loss-":[97],"gain-of-function":[99],"experiments":[100],"were":[101,267],"assess":[104],"responses":[106,209],"KEAP1":[109],"activator":[110],"VVD-130037.":[111],"also":[113],"examined":[114],"effects":[116],"of":[117,138,167],"VVD-130037":[118,197,251],"alone":[119],"combination":[122],"docetaxel":[124,254],"on":[125],"tumor-cell":[126],"growth.":[127],"Results":[128],"TNBCs":[129],"scores":[134],"showed":[135,183],"greater":[136,256],"representation":[137],"memory":[139],"T":[140],"cells":[141],"selected":[143],"dendritic":[144],"inflammatory":[146],"myeloid":[147],"populations.":[148],"inferred":[150],"differences":[151],"MIF-related,":[154],"SPP1-CD44,":[155],"MHC-associated":[157],"patterns":[159],"between":[160,195],"score-defined":[162],"groups,":[163],"suggesting":[164],"coexistence":[166],"engagement":[169],"regulatory":[171],"features.":[172],"A":[173],"five-gene":[174],"comprising":[176],"MAL2,":[177],"TYMP,":[178],"LIMCH1,":[179],"ALG3,":[180],"PDLIM4":[182],"value":[185],"across":[186],"cohorts,":[189],"moderate":[191],"performance":[192],"varied":[194],"increased":[198],"intracellular":[199],"ROS":[200,229],"reduced":[202,227],"AIFM1":[203,232,248],"Ser116":[204,233,249],"phosphorylation.":[205,250],"N-acetyl-L-cysteine":[206],"attenuated":[207,231],"these":[208],"accompanying":[212],"growth":[213,223,257],"inhibition,":[214],"whereas":[215],"z-VAD-fmk":[216],"did":[217],"not":[218],"provide":[219],"comparable":[220],"protection":[221],"against":[222],"inhibition.":[224],"depletion":[226],"VVD-130037-induced":[228,287],"accumulation,":[230],"dephosphorylation,":[234],"decreased":[236],"sensitivity":[237],"VVD-containing":[239],"treatment.":[240],"overexpression":[242],"promoted":[243],"VVD-associated":[245],"decrease":[246],"combined":[252],"produced":[255],"inhibition":[258],"than":[259],"either":[260],"agent":[261],"alone.":[262],"Conclusion":[263],"Oxeiptosis-associated":[264],"distinct":[270],"expression":[281],"modified":[282],"These":[290],"findings":[291],"warrant":[292],"further":[293],"investigation":[294],"independent":[296],"clinical":[297],"experimental":[299],"models.":[300]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}
