{"id":"https://openalex.org/W7225433112","doi":"https://doi.org/10.3390/ijms27219931","title":"Blood Cell Intracellular pH Dynamics and Metabolic Biomarkers Under Simulated Postmortem Interval Conditions: An Exploratory Pilot In Vitro Study","display_name":"Blood Cell Intracellular pH Dynamics and Metabolic Biomarkers Under Simulated Postmortem Interval Conditions: An Exploratory Pilot In Vitro Study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225433112","doi":"https://doi.org/10.3390/ijms27219931"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27219931","doi":"https://doi.org/10.3390/ijms27219931","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219931","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27219931","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161127396","display_name":"Paulino D. Ndunduma","orcid":"https://orcid.org/0009-0004-0795-156X","observed_orcids":["https://orcid.org/0009-0004-0795-156X"]},"institutions":[{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4403386637","display_name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02nxphm19","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paulino D. Ndunduma","raw_affiliation_strings":["Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","Instituto Superior Polit\u00e9cnico de Benguela, Benguela, Angola","UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal"],"raw_orcid":"https://orcid.org/0009-0004-0795-156X","affiliations":[{"raw_affiliation_string":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930"]},{"raw_affiliation_string":"Instituto Superior Polit\u00e9cnico de Benguela, Benguela, Angola","institution_ids":[]},{"raw_affiliation_string":"UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135387186","display_name":"Carolina Cordeiro","orcid":"https://orcid.org/0009-0001-6902-0160","observed_orcids":["https://orcid.org/0009-0001-6902-0160"]},"institutions":[{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4403386637","display_name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02nxphm19","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carolina Cordeiro","raw_affiliation_strings":["Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal"],"raw_orcid":"https://orcid.org/0009-0001-6902-0160","affiliations":[{"raw_affiliation_string":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930"]},{"raw_affiliation_string":"UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022352008","display_name":"Susana Faria","orcid":"https://orcid.org/0000-0001-8014-9902","observed_orcids":["https://orcid.org/0000-0001-8014-9902"]},"institutions":[{"id":"https://openalex.org/I4405257431","display_name":"Centro de Matem\u00e1tica","ror":"https://ror.org/058kv9q68","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405257431","https://openalex.org/I99682543"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Faria","raw_affiliation_strings":["Centre of Mathematics (CMAT), Department of Mathematics, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-8014-9902","affiliations":[{"raw_affiliation_string":"Centre of Mathematics (CMAT), Department of Mathematics, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I4405257431","https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077696361","display_name":"Maria Bego\u00f1a Criado","orcid":"https://orcid.org/0000-0003-1750-5614","observed_orcids":["https://orcid.org/0000-0003-1750-5614"]},"institutions":[{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4403386637","display_name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02nxphm19","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"M. Bego\u00f1a Criado","raw_affiliation_strings":["Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-1750-5614","affiliations":[{"raw_affiliation_string":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930"]},{"raw_affiliation_string":"UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048161447","display_name":"Susana Coimbra","orcid":"https://orcid.org/0000-0001-8411-8038","observed_orcids":["https://orcid.org/0000-0001-8411-8038"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4403386637","display_name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02nxphm19","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Susana Coimbra","raw_affiliation_strings":["UCIBIO i4HB, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal","UCIBIO, Translational Toxicology Research Laboratory, CESPU University, Avenida Central de Gandra 1317, 4585-116 Gandra, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-8411-8038","affiliations":[{"raw_affiliation_string":"UCIBIO i4HB, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"UCIBIO, Translational Toxicology Research Laboratory, CESPU University, Avenida Central de Gandra 1317, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007919248","display_name":"Maria do C\u00e9u Monteiro","orcid":"https://orcid.org/0000-0001-9719-9746","observed_orcids":["https://orcid.org/0000-0001-9719-9746"]},"institutions":[{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4403386637","display_name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02nxphm19","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M. C\u00e9u Monteiro","raw_affiliation_strings":["Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-9719-9746","affiliations":[{"raw_affiliation_string":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930"]},{"raw_affiliation_string":"UCIBIO, Toxicologic Pathology Research Laboratory, CESPU University, 4585-116 Gandra, Portugal","institution_ids":["https://openalex.org/I4210096930","https://openalex.org/I4403386637"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5048161447","https://openalex.org/A5077696361"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210096930","https://openalex.org/I4403386637"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"21","first_page":"9931","last_page":"9931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11706","display_name":"Forensic Entomology and Diptera Studies","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11706","display_name":"Forensic Entomology and Diptera Studies","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.9039999842643738},{"id":"https://openalex.org/keywords/postmortem-interval-estimation","display_name":"postmortem interval estimation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8970000147819519},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.8259999752044678},{"id":"https://openalex.org/keywords/plasma-glucose","display_name":"plasma glucose","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ammonia","display_name":"ammonia","score":0.7269999980926514},{"id":"https://openalex.org/keywords/bcecf-am","display_name":"BCECF-AM","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7746999859809875},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.6442000269889832},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5949000120162964},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4722000062465668},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46149998903274536},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4253000020980835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42289999127388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40059998631477356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37720000743865967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3472000062465668},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3449999988079071},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25360000133514404},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms27219931","doi":"https://doi.org/10.3390/ijms27219931","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219931","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms27219931","doi":"https://doi.org/10.3390/ijms27219931","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219931","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W64825761","https://openalex.org/W104635689","https://openalex.org/W204998232","https://openalex.org/W1586939748","https://openalex.org/W1905116571","https://openalex.org/W2000316749","https://openalex.org/W2006873905","https://openalex.org/W2010636670","https://openalex.org/W2013208161","https://openalex.org/W2034369442","https://openalex.org/W2052096223","https://openalex.org/W2072734698","https://openalex.org/W2180622752","https://openalex.org/W2509485635","https://openalex.org/W2894957071","https://openalex.org/W3093733788","https://openalex.org/W3110571340","https://openalex.org/W3176033533","https://openalex.org/W3202060898","https://openalex.org/W4312202282","https://openalex.org/W4379094703","https://openalex.org/W4383552222","https://openalex.org/W4386752686","https://openalex.org/W4387105750","https://openalex.org/W4387166903","https://openalex.org/W4391230846","https://openalex.org/W4399476088","https://openalex.org/W4403222228","https://openalex.org/W4409335724","https://openalex.org/W4409635754","https://openalex.org/W4412891532","https://openalex.org/W7127038544","https://openalex.org/W7165780499"],"related_works":["https://openalex.org/W7160308049","https://openalex.org/W2006873905","https://openalex.org/W6939687486","https://openalex.org/W3182904903","https://openalex.org/W2401348694","https://openalex.org/W1822848878","https://openalex.org/W2588435158","https://openalex.org/W2315925167","https://openalex.org/W4312202282","https://openalex.org/W2523427391"],"abstract_inverted_index":{"Intracellular":[0,78,140],"pH":[1,79,141],"(pHi)":[2],"may":[3],"provide":[4],"complementary":[5],"information":[6],"on":[7,186],"postmortem":[8,53],"cellular":[9],"metabolism":[10],"and":[11,31,41,48,69,75,86,92,107,123,147,165,178],"homeostasis,":[12],"but":[13],"its":[14],"temporal":[15,26,145,172],"behavior":[16],"remains":[17],"poorly":[18],"understood.":[19],"This":[20],"pilot":[21],"in":[22,28,33,136],"vitro":[23],"study":[24],"evaluated":[25],"changes":[27],"platelet":[29],"pHi":[30,32,94,135],"a":[34,51,143,168,180],"mixed":[35],"non-platelet":[36],"blood-cell":[37,138],"population":[38],"(predominantly":[39],"erythrocytes":[40],"leukocytes),":[42],"together":[43],"with":[44,134,150],"plasma":[45],"glucose,":[46],"lactate,":[47,164],"ammonia":[49,124],"during":[50,97,153],"simulated":[52,155],"interval":[54],"(PMI).":[55],"Venous":[56],"blood":[57],"from":[58],"eight":[59],"healthy":[60],"volunteers":[61],"was":[62,80,132],"maintained":[63],"at":[64,71,104,112,128],"24":[65,76,113,129],"\u00b1":[66],"3":[67,100],"\u00b0C":[68],"analyzed":[70],"0,":[72],"3,":[73],"6,":[74],"h.":[77,114,130],"assessed":[81],"by":[82],"BCECF-AM":[83],"flow":[84],"cytometry,":[85],"metabolites":[87],"were":[88],"quantified":[89],"enzymatically.":[90],"Platelet":[91],"non-platelet-cell":[93,162],"remained":[95],"stable":[96],"the":[98,154,187],"first":[99],"h,":[101,106],"decreased":[102,117],"significantly":[103,126],"6":[105],"increased":[108,121,125],"toward":[109],"baseline":[110],"values":[111],"Glucose":[115],"concentrations":[116],"over":[118],"time,":[119],"lactate":[120],"progressively,":[122],"only":[127],"Lactate":[131],"associated":[133],"both":[137],"populations.":[139],"exhibited":[142],"biphasic":[144],"pattern":[146],"distinct":[148],"relationships":[149],"metabolic":[151],"biomarkers":[152],"PMI.":[156],"An":[157],"exploratory":[158],"mixed-effects":[159],"model":[160],"incorporating":[161],"pHi,":[163],"glucose":[166],"explained":[167],"substantial":[169],"proportion":[170],"of":[171,184,196],"variability":[173],"(marginal":[174],"R2":[175],"=":[176],"0.907)":[177],"yielded":[179],"leave-one-donor-out":[181],"cross-validation":[182],"RMSE":[183],"0.4998":[185],"log-transformed":[188],"time":[189],"scale.":[190],"These":[191],"findings":[192],"support":[193],"further":[194],"investigation":[195],"multi-marker":[197],"approaches":[198],"for":[199],"PMI":[200],"estimation.":[201]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
