{"id":"https://openalex.org/W7225432606","doi":"https://doi.org/10.1126/sciadv.aef2882","title":"The (amide-)N-methylnicotinamide is a microbe-derived NAD + precursor that drives gut stem cell renewal","display_name":"The (amide-)N-methylnicotinamide is a microbe-derived NAD + precursor that drives gut stem cell renewal","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225432606","doi":"https://doi.org/10.1126/sciadv.aef2882","pmid":"https://pubmed.ncbi.nlm.nih.gov/42993840","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13742186"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aef2882","doi":"https://doi.org/10.1126/sciadv.aef2882","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aef2882","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aef2882?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aef2882?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080693490","display_name":"Jiangmeng Han","orcid":"https://orcid.org/0000-0002-8671-8501","observed_orcids":["https://orcid.org/0000-0002-8671-8501"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangmeng Han","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0002-8671-8501","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023177933","display_name":"Jayson M. Antonio","orcid":"https://orcid.org/0000-0001-6855-5617","observed_orcids":["https://orcid.org/0000-0001-6855-5617"]},"institutions":[{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayson M. Antonio","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0001-6855-5617","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I4390039302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010732557","display_name":"Jagannatham Naidu Bhupana","orcid":"https://orcid.org/0009-0009-3304-5831","observed_orcids":["https://orcid.org/0009-0009-3304-5831"]},"institutions":[{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jagannatham Naidu Bhupana","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0009-0009-3304-5831","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I4390039302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074686762","display_name":"Garam Choi","orcid":"https://orcid.org/0000-0003-1375-105X","observed_orcids":["https://orcid.org/0000-0003-1375-105X"]},"institutions":[{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garam Choi","raw_affiliation_strings":["Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","Department of Medicine, Rutgers Biomedical and Health Sciences, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","institution_ids":["https://openalex.org/I4390039302"]},{"raw_affiliation_string":"Department of Medicine, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","institution_ids":["https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101605462","display_name":"Jiaxing Yang","orcid":"https://orcid.org/0009-0005-8439-1428","observed_orcids":["https://orcid.org/0009-0005-8439-1428"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxing Yang","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0009-0005-8439-1428","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047478706","display_name":"Eric N. Chiles","orcid":"https://orcid.org/0000-0003-3354-607X","observed_orcids":["https://orcid.org/0000-0003-3354-607X"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Chiles","raw_affiliation_strings":["Metabolomics Shared Resource, Rutgers Cancer Institute, New Brunswick, NJ 08901, USA"],"raw_orcid":"https://orcid.org/0000-0003-3354-607X","affiliations":[{"raw_affiliation_string":"Metabolomics Shared Resource, Rutgers Cancer Institute, New Brunswick, NJ 08901, USA","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003368789","display_name":"Yan Tong","orcid":"https://orcid.org/0009-0004-0633-8130","observed_orcids":["https://orcid.org/0009-0004-0633-8130"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Tong","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0009-0004-0633-8130","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078338854","display_name":"Rajmohamed Mohamed Asik","orcid":"https://orcid.org/0000-0002-6327-0134","observed_orcids":["https://orcid.org/0000-0002-6327-0134"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Asik Rajmohamed","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0002-6327-0134","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069733399","display_name":"Hung-Ting Wu","orcid":"https://orcid.org/0000-0003-4700-479X","observed_orcids":["https://orcid.org/0000-0003-4700-479X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung-Ting Wu","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0003-4700-479X","affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103238395","display_name":"Dahui Wang","orcid":"https://orcid.org/0009-0002-4345-104X","observed_orcids":["https://orcid.org/0009-0002-4345-104X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dahui Wang","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0009-0002-4345-104X","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071399872","display_name":"Vik Meadows","orcid":"https://orcid.org/0000-0002-8983-4305","observed_orcids":["https://orcid.org/0000-0002-8983-4305"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vik Meadows","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0002-8983-4305","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080479977","display_name":"Nicolas Lapaque","orcid":"https://orcid.org/0000-0003-0824-0108","observed_orcids":["https://orcid.org/0000-0003-0824-0108"]},"institutions":[{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4405263412","display_name":"MetaGenoPolis","ror":"https://ror.org/00j4knb04","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4405263412"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Lapaque","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France","Universit\u00e9 Paris-Saclay, INRAE, MetaGenoPolis, MGP, 78350 Jouy-en-Josas, France"],"raw_orcid":"https://orcid.org/0000-0003-0824-0108","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France","institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, INRAE, MetaGenoPolis, MGP, 78350 Jouy-en-Josas, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4405263412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073303183","display_name":"Jean\u2010Pierre Etchegaray","orcid":"https://orcid.org/0000-0002-6663-8870","observed_orcids":["https://orcid.org/0000-0002-6663-8870"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Etchegaray","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0002-6663-8870","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034807007","display_name":"Rafa\u0142 Filip","orcid":"https://orcid.org/0000-0002-5954-151X","observed_orcids":["https://orcid.org/0000-0002-5954-151X","https://orcid.org/0000-0002-5644-6381"]},"institutions":[{"id":"https://openalex.org/I98559091","display_name":"University of Rzesz\u00f3w","ror":"https://ror.org/03pfsnq21","country_code":"PL","type":"education","lineage":["https://openalex.org/I98559091"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rafal Filip","raw_affiliation_strings":["Institute of Medicine, Medical College of Rzeszow University, Department of Gastroenterology with IBD Unit, Clinical Hospital, Rzeszow, Poland"],"raw_orcid":"https://orcid.org/0000-0002-5954-151X","affiliations":[{"raw_affiliation_string":"Institute of Medicine, Medical College of Rzeszow University, Department of Gastroenterology with IBD Unit, Clinical Hospital, Rzeszow, Poland","institution_ids":["https://openalex.org/I98559091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047477696","display_name":"Ta\u2010Chiang Liu","orcid":"https://orcid.org/0000-0002-2800-9360","observed_orcids":["https://orcid.org/0000-0002-2800-9360"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ta-Chiang Liu","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0002-2800-9360","affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064588944","display_name":"Pawel R. Kiela","orcid":"https://orcid.org/0000-0002-0014-3517","observed_orcids":["https://orcid.org/0000-0002-0014-3517"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pawel R. Kiela","raw_affiliation_strings":["Department of Pediatrics, Steele Children\u2019s Research Center, University of Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ 85724, USA"],"raw_orcid":"https://orcid.org/0000-0002-0014-3517","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Steele Children\u2019s Research Center, University of Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013622731","display_name":"Nicholas J. Bessman","orcid":"https://orcid.org/0000-0002-6645-0990","observed_orcids":["https://orcid.org/0000-0002-6645-0990"]},"institutions":[{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Bessman","raw_affiliation_strings":["Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","Department of Medicine, Rutgers Biomedical and Health Sciences, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","institution_ids":["https://openalex.org/I4390039302"]},{"raw_affiliation_string":"Department of Medicine, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","institution_ids":["https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016002022","display_name":"Ronaldo P. Ferraris","orcid":"https://orcid.org/0000-0001-6887-5020","observed_orcids":["https://orcid.org/0000-0001-6887-5020"]},"institutions":[{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronaldo P. Ferraris","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0001-6887-5020","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I4390039302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042421898","display_name":"Ching\u2010On Wong","orcid":"https://orcid.org/0000-0002-8602-2125","observed_orcids":["https://orcid.org/0000-0002-8602-2125"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ching-On Wong","raw_affiliation_strings":["Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0002-8602-2125","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077598643","display_name":"Xiaoyang Su","orcid":"https://orcid.org/0000-0001-8081-1396","observed_orcids":["https://orcid.org/0000-0001-8081-1396","https://orcid.org/0009-0009-9539-9141"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaoyang Su","raw_affiliation_strings":["Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA","Metabolomics Shared Resource, Rutgers Cancer Institute, New Brunswick, NJ 08901, USA"],"raw_orcid":"https://orcid.org/0000-0001-8081-1396","affiliations":[{"raw_affiliation_string":"Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Metabolomics Shared Resource, Rutgers Cancer Institute, New Brunswick, NJ 08901, USA","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038078180","display_name":"Nan Gao","orcid":"https://orcid.org/0000-0003-4264-7438","observed_orcids":["https://orcid.org/0000-0003-4264-7438"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nan Gao","raw_affiliation_strings":["Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0003-4264-7438","affiliations":[{"raw_affiliation_string":"Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA","institution_ids":["https://openalex.org/I4390039302"]},{"raw_affiliation_string":"Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I4390039302"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5038078180","https://openalex.org/A5042421898","https://openalex.org/A5077598643"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"45","first_page":"eaef2882","last_page":"eaef2882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-methylnicotinamide","display_name":"N1-methylnicotinamide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nad-precursors","display_name":"NAD+ precursors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.8420000076293945},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/preiss-handler-pathway","display_name":"Preiss-Handler pathway","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nad-salvage-pathway","display_name":"NAD+ salvage pathway","score":0.7319999933242798},{"id":"https://openalex.org/keywords/intestinal-epithelial-repair","display_name":"intestinal epithelial repair","score":0.6949999928474426},{"id":"https://openalex.org/keywords/microbial-metabolites","display_name":"microbial metabolites","score":0.6190000176429749},{"id":"https://openalex.org/keywords/nad-supplementation","display_name":"NAD+ supplementation","score":0.3919999897480011},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.9391000270843506},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.671500027179718},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6611999869346619},{"id":"https://openalex.org/C2780391879","wikidata":"https://www.wikidata.org/wiki/Q18035058","display_name":"Nicotinamide phosphoribosyltransferase","level":4,"score":0.5936999917030334},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.5564000010490417},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5368000268936157},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5120999813079834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5019999742507935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47530001401901245},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.4505999982357025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4453999996185303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4049000144004822},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.38199999928474426},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3671000003814697},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3416999876499176},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2777088662","wikidata":"https://www.wikidata.org/wiki/Q21547155","display_name":"Nicotinamide mononucleotide","level":5,"score":0.3093999922275543},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C124964019","wikidata":"https://www.wikidata.org/wiki/Q11616062","display_name":"Precursor cell","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2630999982357025},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.25529998540878296}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.aef2882","doi":"https://doi.org/10.1126/sciadv.aef2882","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aef2882","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aef2882?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmid:42993840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42993840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13742186","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13742186/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aef2882","doi":"https://doi.org/10.1126/sciadv.aef2882","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aef2882","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aef2882?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1063459721","display_name":"Cell differentiation regulates intestinal tight junctions","funder_award_id":"1754783","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3389133027","display_name":"Mucosal modulation by LGG and R. gnavus specific tryptophan metabolites","funder_award_id":"R01AT010243","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G445924120","display_name":"Intestinal lysozyme controls mucosal immune response to microbiota","funder_award_id":"R01DK119198","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G54753500","display_name":"EAGER: Integration and analysis of high-dimensional dataset","funder_award_id":"2128307","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000862921","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA072720","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876543","display_name":"Paneth cell heterogeneity in infection and inflammation","funder_award_id":"R01DK132885","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000892905","display_name":"Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation","funder_award_id":"R01DK139790","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000897816","display_name":"Role of TTYH1 in mobilizing lipids and ApoE in glia: Implications for brain aging and neurodegeneration","funder_award_id":"R01AG081379","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000898848","display_name":"Investigating the Role of SLC45A4 in GABA Metabolism","funder_award_id":"R01GM149664","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000910661","display_name":"The role of local iron homeostasis in inflammatory bowel disease","funder_award_id":"K01DK128308","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000920704","display_name":"PARP1 and PARylation as novel effectors of gut inflammation","funder_award_id":"R01DK136240","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G951317382","display_name":"TET-mediated DNA oxidations in mucosal innate defense","funder_award_id":"R21AI167079","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225432606.pdf","grobid_xml":"https://content.openalex.org/works/W7225432606.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W111805191","https://openalex.org/W1604649731","https://openalex.org/W1855226200","https://openalex.org/W1965006127","https://openalex.org/W1976558061","https://openalex.org/W1979410391","https://openalex.org/W1997114875","https://openalex.org/W1999282770","https://openalex.org/W2001709760","https://openalex.org/W2011386434","https://openalex.org/W2012178564","https://openalex.org/W2019394625","https://openalex.org/W2025786976","https://openalex.org/W2032230795","https://openalex.org/W2033382767","https://openalex.org/W2038011036","https://openalex.org/W2043348459","https://openalex.org/W2051909115","https://openalex.org/W2054636918","https://openalex.org/W2070386387","https://openalex.org/W2082393205","https://openalex.org/W2083516240","https://openalex.org/W2097290206","https://openalex.org/W2097948853","https://openalex.org/W2101942841","https://openalex.org/W2107606668","https://openalex.org/W2108128080","https://openalex.org/W2130410032","https://openalex.org/W2134939903","https://openalex.org/W2153400713","https://openalex.org/W2159100311","https://openalex.org/W2160251091","https://openalex.org/W2168729166","https://openalex.org/W2312701756","https://openalex.org/W2312895542","https://openalex.org/W2473313158","https://openalex.org/W2522309832","https://openalex.org/W2531686927","https://openalex.org/W2589117823","https://openalex.org/W2594820540","https://openalex.org/W2600704889","https://openalex.org/W2618676341","https://openalex.org/W2753842728","https://openalex.org/W2755548020","https://openalex.org/W2786518893","https://openalex.org/W2791767508","https://openalex.org/W2806668299","https://openalex.org/W2810653208","https://openalex.org/W2897899009","https://openalex.org/W2944723276","https://openalex.org/W2945027985","https://openalex.org/W2945524439","https://openalex.org/W2951518977","https://openalex.org/W2963439295","https://openalex.org/W2965140029","https://openalex.org/W2972160552","https://openalex.org/W2988597656","https://openalex.org/W2991261602","https://openalex.org/W3009944800","https://openalex.org/W3041064193","https://openalex.org/W3051806837","https://openalex.org/W3115773653","https://openalex.org/W3115974950","https://openalex.org/W3122720862","https://openalex.org/W3131032229","https://openalex.org/W3162798025","https://openalex.org/W3163646903","https://openalex.org/W3164106843","https://openalex.org/W3201884458","https://openalex.org/W3203797435","https://openalex.org/W4206615841","https://openalex.org/W4210535212","https://openalex.org/W4220662719","https://openalex.org/W4285004753","https://openalex.org/W4291415391","https://openalex.org/W4292117699","https://openalex.org/W4294647595","https://openalex.org/W4306406986","https://openalex.org/W4312045006","https://openalex.org/W4312095698","https://openalex.org/W4317691729","https://openalex.org/W4319159135","https://openalex.org/W4321004238","https://openalex.org/W4322491972","https://openalex.org/W4382982290","https://openalex.org/W4386152965","https://openalex.org/W4386526210","https://openalex.org/W4386818182","https://openalex.org/W4390534091","https://openalex.org/W4391469807","https://openalex.org/W4393192118","https://openalex.org/W4393231653","https://openalex.org/W4394934999","https://openalex.org/W4396762965","https://openalex.org/W4396778272","https://openalex.org/W4399242596","https://openalex.org/W4399572324","https://openalex.org/W4401200169","https://openalex.org/W4403745200","https://openalex.org/W4404741945","https://openalex.org/W4405137486","https://openalex.org/W4406986798","https://openalex.org/W4407942972","https://openalex.org/W4409947830","https://openalex.org/W4410915812"],"related_works":["https://openalex.org/W4382982290","https://openalex.org/W7124315630","https://openalex.org/W7166041182","https://openalex.org/W4311572757","https://openalex.org/W3136425725","https://openalex.org/W2063540145","https://openalex.org/W4390065260","https://openalex.org/W4379375358","https://openalex.org/W7171238508","https://openalex.org/W4400772772"],"abstract_inverted_index":{"Nicotinamide":[0],"Adenine":[1],"Dinucleotide":[2],"(NAD)":[3],"is":[4,44,101],"a":[5,45,50,156,163],"critical":[6],"cellular":[7],"coenzyme":[8],"whose":[9],"decline":[10],"associates":[11],"with":[12,55,128],"various":[13],"chronic":[14],"and":[15,25,58,75,86,92,95,145],"inflammatory":[16],"diseases.":[17],"Improved":[18],"NAD":[19,78,104,152,167],"restoration":[20],"may":[21],"reduce":[22],"disease":[23],"risks":[24],"extend":[26],"healthy":[27],"lifespan.":[28],"We":[29],"report":[30],"here":[31],"that":[32,68,99,138,169],"certain":[33],"commensal":[34],"bacteria":[35],"including":[36],"specific":[37],"probiotic":[38],"species":[39],"produce":[40],"(amide-)N-methylnicotinamide":[41],"(N-MNA),":[42],"which":[43],"structural":[46],"isomer":[47],"of":[48,88,111,119,165],"methylnicotinamide,":[49],"nicotinamide":[51],"degradative":[52],"metabolite.":[53],"Patients":[54],"gut":[56,146],"dysbiosis":[57],"inflammation":[59],"show":[60],"reduced":[61],"stool":[62],"N-MNA.":[63],"Stable":[64],"isotope":[65],"tracing":[66,134],"revealed":[67,137],"N-MNA":[69,100,140,154],"can":[70],"be":[71],"rapidly":[72],"taken":[73],"up":[74],"incorporated":[76],"into":[77,159],"redox":[79],"reactions":[80],"by":[81],"intestinal":[82,129],"epithelial":[83,147],"cells":[84],"(IECs)":[85],"non-IECs":[87],"fruit":[89],"fly,":[90],"mouse,":[91],"human.":[93],"Genetic":[94],"pharmacological":[96],"analyses":[97],"suggest":[98],"converted":[102],"to":[103,150],"+":[105],"via":[106],"the":[107,112,171],"Preiss-Handler":[108],"pathway,":[109],"independent":[110],"salvage":[113],"pathway.":[114],"Cell-type-specific":[115],"ablation":[116],"or":[117],"overexpression":[118],"SIRT1,":[120],"an":[121],"NAD-consuming":[122],"enzyme,":[123],"in":[124,135],"Drosophila":[125],",":[126],"along":[127],"stem":[130],"cell":[131],"(ISC)":[132],"lineage":[133],"mice":[136],"systemic":[139],"supplementation":[141],"promotes":[142],"ISC":[143],"regeneration":[144],"repair.":[148],"Compared":[149],"known":[151],"precursors,":[153],"brings":[155],"methyl":[157],"group":[158],"host":[160],"cells,":[161],"representing":[162],"class":[164],"microbe-derived":[166],"precursor":[168],"stimulates":[170],"tissue":[172],"regenerative":[173],"power.":[174]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}