{"id":"https://openalex.org/W7225432185","doi":"https://doi.org/10.64898/2026.11.04.26367313","title":"Optimizing Lumipulse plasma pTau217/A\u03b242 ratio cutpoints in an Asian cohort with high cerebrovascular disease burden","display_name":"Optimizing Lumipulse plasma pTau217/A\u03b242 ratio cutpoints in an Asian cohort with high cerebrovascular disease burden","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225432185","doi":"https://doi.org/10.64898/2026.11.04.26367313"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.26367313","doi":"https://doi.org/10.64898/2026.11.04.26367313","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.26367313","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.04.26367313.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.04.26367313.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128213798","display_name":"Joyce R. Chong","orcid":"https://orcid.org/0000-0002-2869-0096","observed_orcids":["https://orcid.org/0000-0002-2869-0096"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce R. Chong","raw_affiliation_strings":["School of Medicine and Public Health, University of Wisconsin-Madison;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Public Health, University of Wisconsin-Madison;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041189642","display_name":"Ting Yu Amelia Yam","orcid":"https://orcid.org/0009-0003-2117-3859","observed_orcids":["https://orcid.org/0009-0003-2117-3859"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Amelia T. Y. Yam","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113203597","display_name":"An Qi Toh","orcid":"https://orcid.org/0009-0008-9519-3867","observed_orcids":["https://orcid.org/0009-0008-9519-3867"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anqi Toh","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013653258","display_name":"Gandan Jiang","orcid":"https://orcid.org/0009-0001-6608-2841","observed_orcids":["https://orcid.org/0009-0001-6608-2841"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Gandan Jiang","raw_affiliation_strings":["Eisai Co. Ltd., Tokyo 112-8088, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Co. Ltd., Tokyo 112-8088, Japan;","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113208015","display_name":"Temmei Ito","orcid":"https://orcid.org/0000-0001-5834-594X","observed_orcids":["https://orcid.org/0000-0001-5834-594X"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Temmei Ito","raw_affiliation_strings":["Eisai Co. Ltd., Tokyo 112-8088, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Co. Ltd., Tokyo 112-8088, Japan;","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034158814","display_name":"Chizuru Kobayashi","orcid":"https://orcid.org/0009-0009-5655-8111","observed_orcids":["https://orcid.org/0009-0009-5655-8111"]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chizuru Kobayashi","raw_affiliation_strings":["Eisai Co. Ltd., Tokyo 112-8088, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Co. Ltd., Tokyo 112-8088, Japan;","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032272237","display_name":"Amitabh Dash","orcid":"https://orcid.org/0000-0002-9351-4021","observed_orcids":["https://orcid.org/0000-0002-9351-4021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amitabh Dash","raw_affiliation_strings":["Eisai (Singapore) Pte. Ltd., Singapore 189721, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai (Singapore) Pte. Ltd., Singapore 189721, Singapore;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121114999","display_name":"Pallavi Sachdev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pallavi Sachdev","raw_affiliation_strings":["Eisai Inc., Nutley, NJ 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Inc., Nutley, NJ 07110, USA","institution_ids":["https://openalex.org/I4210151718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161133561","display_name":"Christopher P. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Christopher P. Chen","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082858635","display_name":"Mitchell K.P. Lai","orcid":"https://orcid.org/0000-0001-7685-1424","observed_orcids":["https://orcid.org/0000-0001-7685-1424"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Mitchell KP Lai","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore;"],"raw_orcid":"https://orcid.org/0000-0001-7685-1424","affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore;","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082858635"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.12809999287128448,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.8659999966621399},{"id":"https://openalex.org/keywords/alzheimer-s-disease-biomarkers","display_name":"Alzheimer's disease biomarkers","score":0.7170000076293945},{"id":"https://openalex.org/keywords/asian-populations","display_name":"Asian populations","score":0.4959999918937683},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5109999775886536},{"id":"https://openalex.org/keywords/negative-predictive-value","display_name":"negative predictive value","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6809999942779541},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.6611999869346619},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6496000289916992},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6243000030517578},{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.5307999849319458},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43939998745918274},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.4327000081539154},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.3912999927997589},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3725000023841858},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35679998993873596},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C53789813","wikidata":"https://www.wikidata.org/wiki/Q3553769","display_name":"Positive predicative value","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C144494922","wikidata":"https://www.wikidata.org/wiki/Q6547272","display_name":"Likelihood ratios in diagnostic testing","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.28279998898506165},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.26367313","doi":"https://doi.org/10.64898/2026.11.04.26367313","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.26367313","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.04.26367313.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.26367313","doi":"https://doi.org/10.64898/2026.11.04.26367313","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.26367313","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.04.26367313.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1615912019","display_name":null,"funder_award_id":"MOH-001972","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G4914752715","display_name":null,"funder_award_id":"NUHSRO/2024/028/T1/Seed-Sep23/06","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225432185.pdf","grobid_xml":"https://content.openalex.org/works/W7225432185.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7202080485","https://openalex.org/W7162990292","https://openalex.org/W7167683510","https://openalex.org/W7204761931","https://openalex.org/W4414422801","https://openalex.org/W7119531447","https://openalex.org/W3141652702","https://openalex.org/W4408994149","https://openalex.org/W2999349682","https://openalex.org/W7158514717"],"abstract_inverted_index":{"The":[0],"generalizability":[1],"of":[2,22,132,138],"FDA-cleared":[3,95,135],"Lumipulse":[4],"plasma":[5],"pTau217":[6,59],"/":[7],"A\u03b242":[8,30],"ratio":[9,33,57,76],"cutpoints":[10,43,77,96,133],"to":[11],"Asian":[12],"populations":[13],"remains":[14],"uncertain,":[15],"especially":[16],"in":[17,34],"those":[18],"with":[19,38,69,119],"high":[20],"burden":[21],"concomitant":[23],"cerebrovascular":[24],"disease":[25],"(CeVD).":[26],"We":[27],"evaluated":[28],"pTau217,":[29],"and":[31,53,87,103,116],"their":[32],"205":[35],"Singapore-based":[36],"participants":[37],"corresponding":[39],"amyloid":[40,140],"neuroimaging.":[41],"In-house":[42],"were":[44],"derived":[45],"using":[46],"a":[47],"three-range":[48],"strategy":[49],"targeting":[50],"95%":[51,88],"sensitivity":[52,102],"specificity.":[54],"Plasma":[55,75],"pTau217/A\u03b242":[56],"outperformed":[58],"alone":[60],"(area":[61],"under":[62],"the":[63,127],"curve,":[64],"0.951":[65],"versus":[66],"0.925;":[67],"p=0.004),":[68],"comparable":[70],"performance":[71],"across":[72],"CeVD":[73],"severities.":[74],"achieved":[78],"98%":[79],"negative":[80,104],"predictive":[81,85,105,113],"value,":[82,86],"88%":[83],"positive":[84,112],"accuracy,":[89],"classifying":[90],"10%":[91],"as":[92,122],"intermediate-risk.":[93,123],"Using":[94],"for":[97,129],"our":[98],"cohort":[99],"retained":[100],"97%":[101],"value":[106,114],"but":[107],"yielded":[108],"lower":[109],"specificity":[110],"(86%),":[111],"(77%)":[115],"accuracy":[117],"(85%),":[118],"29%":[120],"classified":[121],"Our":[124],"findings":[125],"support":[126],"need":[128],"population-specific":[130],"validation":[131],"from":[134],"blood":[136],"biomarkers":[137],"brain":[139],"pathology.":[141]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}