{"id":"https://openalex.org/W7225429577","doi":"https://doi.org/10.14202/vetworld.2026.4951-4969","title":"Metabolite profiling and antimalarial activity of Azadirachta indica leaf extract: An integrated in vivo and in silico investigation","display_name":"Metabolite profiling and antimalarial activity of Azadirachta indica leaf extract: An integrated in vivo and in silico investigation","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225429577","doi":"https://doi.org/10.14202/vetworld.2026.4951-4969"},"language":"en","primary_location":{"id":"doi:10.14202/vetworld.2026.4951-4969","doi":"https://doi.org/10.14202/vetworld.2026.4951-4969","is_oa":true,"landing_page_url":"https://doi.org/10.14202/vetworld.2026.4951-4969","pdf_url":"https://veterinaryworld.org/Vol.19/November-2026/3.pdf","source":{"id":"https://openalex.org/S2738474774","display_name":"Veterinary World","issn_l":"0972-8988","issn":["0972-8988","2231-0916"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318729","host_organization_name":"Veterinary World","host_organization_lineage":["https://openalex.org/P4310318729"],"host_organization_lineage_names":["Veterinary World"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary World","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7225429577"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://veterinaryworld.org/Vol.19/November-2026/3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071428520","display_name":"Dewa Ayu Agus Sri Laksemi","orcid":"https://orcid.org/0000-0001-5579-5531","observed_orcids":["https://orcid.org/0000-0001-5579-5531"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Dewa Ayu Agus Sri Laksemi","raw_affiliation_strings":["Udayana University"],"raw_orcid":"https://orcid.org/0000-0001-5579-5531","affiliations":[{"raw_affiliation_string":"Udayana University","institution_ids":["https://openalex.org/I126826664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082015167","display_name":"Putu Indah Budi Apsari","orcid":"https://orcid.org/0000-0003-0572-9581","observed_orcids":["https://orcid.org/0000-0003-0572-9581"]},"institutions":[{"id":"https://openalex.org/I3132096736","display_name":"Warmadewa University","ror":"https://ror.org/02eehp307","country_code":"ID","type":"education","lineage":["https://openalex.org/I3132096736"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Putu Indah Budi Apsari","raw_affiliation_strings":["Warmadewa University"],"raw_orcid":"https://orcid.org/0000-0003-0572-9581","affiliations":[{"raw_affiliation_string":"Warmadewa University","institution_ids":["https://openalex.org/I3132096736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040815146","display_name":"Made Bayu Permasutha","orcid":"https://orcid.org/0000-0003-4788-3114","observed_orcids":["https://orcid.org/0000-0003-4788-3114"]},"institutions":[{"id":"https://openalex.org/I4210090826","display_name":"Universitas Pendidikan Ganesha","ror":"https://ror.org/00bmjd793","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210090826"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Made Bayu Permasutha","raw_affiliation_strings":["Universitas Pendidikan Ganesha"],"raw_orcid":"https://orcid.org/0000-0003-4788-3114","affiliations":[{"raw_affiliation_string":"Universitas Pendidikan Ganesha","institution_ids":["https://openalex.org/I4210090826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088170768","display_name":"I Gusti Kamasan Nyoman Arijana","orcid":"https://orcid.org/0000-0001-5374-3340","observed_orcids":["https://orcid.org/0000-0001-5374-3340"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I Gusti Kamasan Nyoman Arijana","raw_affiliation_strings":["Udayana University"],"raw_orcid":"https://orcid.org/0000-0001-5374-3340","affiliations":[{"raw_affiliation_string":"Udayana University","institution_ids":["https://openalex.org/I126826664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087331606","display_name":"I Ketut Tunas","orcid":"https://orcid.org/0000-0002-6932-1377","observed_orcids":["https://orcid.org/0000-0002-6932-1377"]},"institutions":[{"id":"https://openalex.org/I4405275029","display_name":"Universitas Bali Internasional","ror":"https://ror.org/02tede246","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405275029"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I Ketut Tunas","raw_affiliation_strings":["Health Information Management Study Program, Bali International University, Denpasar, Bali 80239, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Information Management Study Program, Bali International University, Denpasar, Bali 80239, Indonesia","institution_ids":["https://openalex.org/I4405275029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023962631","display_name":"I Made Agus Gelgel Wirasuta","orcid":"https://orcid.org/0000-0002-0946-6208","observed_orcids":["https://orcid.org/0000-0002-0946-6208"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I Made Agus Gelgel Wirasuta","raw_affiliation_strings":["Udayana University"],"raw_orcid":"https://orcid.org/0000-0002-0946-6208","affiliations":[{"raw_affiliation_string":"Udayana University","institution_ids":["https://openalex.org/I126826664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071428520"],"corresponding_institution_ids":["https://openalex.org/I126826664"],"apc_list":{"value":600,"currency":"USD","value_usd":600},"apc_paid":{"value":600,"currency":"USD","value_usd":600},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4951","last_page":"4951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neem","display_name":"Azadirachta indica","score":0.996999979019165},{"id":"https://openalex.org/keywords/neem-leaf-extract","display_name":"neem leaf extract","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antimalarial-activity","display_name":"antimalarial activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasmodium-berghei-anka","display_name":"Plasmodium berghei ANKA","score":0.9259999990463257},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dihydrofolate-reductase-thymidylate-synthase","display_name":"dihydrofolate reductase-thymidylate synthase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chloroquine-resistance-transporter","display_name":"chloroquine resistance transporter","score":0.9229999780654907},{"id":"https://openalex.org/keywords/plasmepsin-ii","display_name":"plasmepsin II","score":0.9900000095367432},{"id":"https://openalex.org/keywords/flavonols","display_name":"flavonols","score":0.7009999752044678},{"id":"https://openalex.org/keywords/scopoletin","display_name":"scopoletin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.7452999949455261},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.6590999960899353},{"id":"https://openalex.org/C2781035296","wikidata":"https://www.wikidata.org/wiki/Q21698","display_name":"Azadirachta","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6025999784469604},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5648999810218811},{"id":"https://openalex.org/C2778059366","wikidata":"https://www.wikidata.org/wiki/Q707939","display_name":"Artesunate","level":4,"score":0.5522000193595886},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5235999822616577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5077000260353088},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.47620001435279846},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4731000065803528},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4584999978542328},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.45260000228881836},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4343000054359436},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.4311000108718872},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C2781160685","wikidata":"https://www.wikidata.org/wiki/Q5276420","display_name":"Dihydroartemisinin","level":5,"score":0.4032999873161316},{"id":"https://openalex.org/C2779691961","wikidata":"https://www.wikidata.org/wiki/Q1308044","display_name":"Artemisia annua","level":5,"score":0.382999986410141},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33090001344680786},{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.30320000648498535},{"id":"https://openalex.org/C2779106036","wikidata":"https://www.wikidata.org/wiki/Q2629666","display_name":"Flavonols","level":4,"score":0.29739999771118164},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.26579999923706055},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.26159998774528503}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14202/vetworld.2026.4951-4969","doi":"https://doi.org/10.14202/vetworld.2026.4951-4969","is_oa":true,"landing_page_url":"https://doi.org/10.14202/vetworld.2026.4951-4969","pdf_url":"https://veterinaryworld.org/Vol.19/November-2026/3.pdf","source":{"id":"https://openalex.org/S2738474774","display_name":"Veterinary World","issn_l":"0972-8988","issn":["0972-8988","2231-0916"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318729","host_organization_name":"Veterinary World","host_organization_lineage":["https://openalex.org/P4310318729"],"host_organization_lineage_names":["Veterinary World"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary World","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14202/vetworld.2026.4951-4969","doi":"https://doi.org/10.14202/vetworld.2026.4951-4969","is_oa":true,"landing_page_url":"https://doi.org/10.14202/vetworld.2026.4951-4969","pdf_url":"https://veterinaryworld.org/Vol.19/November-2026/3.pdf","source":{"id":"https://openalex.org/S2738474774","display_name":"Veterinary World","issn_l":"0972-8988","issn":["0972-8988","2231-0916"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318729","host_organization_name":"Veterinary World","host_organization_lineage":["https://openalex.org/P4310318729"],"host_organization_lineage_names":["Veterinary World"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary World","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318932","display_name":"Universitas Udayana","ror":"https://ror.org/035qsg823"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225429577.pdf","grobid_xml":"https://content.openalex.org/works/W7225429577.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1642606694","https://openalex.org/W2054790479","https://openalex.org/W2081243368","https://openalex.org/W2119711891","https://openalex.org/W2156133038","https://openalex.org/W2345918943","https://openalex.org/W2597145668","https://openalex.org/W2769588514","https://openalex.org/W2791358329","https://openalex.org/W2911073353","https://openalex.org/W3016370224","https://openalex.org/W3022591587","https://openalex.org/W3084158514","https://openalex.org/W3194985501","https://openalex.org/W3215363711","https://openalex.org/W4211254494","https://openalex.org/W4281389925","https://openalex.org/W4321850260","https://openalex.org/W4380681521","https://openalex.org/W4393049009","https://openalex.org/W4400494639","https://openalex.org/W4401220039","https://openalex.org/W4407757992","https://openalex.org/W4409988389","https://openalex.org/W4415350875","https://openalex.org/W4417080372","https://openalex.org/W7154996703"],"related_works":["https://openalex.org/W2260386176","https://openalex.org/W1533687240","https://openalex.org/W2089685624","https://openalex.org/W7098926170","https://openalex.org/W4389090001","https://openalex.org/W1561871257","https://openalex.org/W2400231708","https://openalex.org/W4388662277","https://openalex.org/W3047181945","https://openalex.org/W7057403520"],"abstract_inverted_index":{"Background":[0],"and":[1,49,56,60,113,119,148,156,163,179,195,202,207,227,252,278,292,302],"Aim:":[2],"Antimalarial":[3],"drug":[4],"resistance":[5,146,260],"highlights":[6],"the":[7,35,184,258],"need":[8],"to":[9,33,86,299],"identify":[10],"alternative":[11],"bioactive":[12],"compounds.":[13],"Azadirachta":[14,306],"indica":[15,39,264],"(neem)":[16],"contains":[17],"phytochemicals":[18],"with":[19,78,212,257],"potential":[20],"antiplasmodial":[21],"properties,":[22],"although":[23,237],"their":[24],"molecular":[25,137,314,316],"interactions":[26,52,248],"remain":[27],"incompletely":[28],"characterized.":[29],"This":[30],"study":[31],"aimed":[32],"characterize":[34],"metabolites":[36,55,135],"of":[37,98],"A.":[38,263],"leaf":[40,63,265,319],"extract,":[41,320],"evaluate":[42],"its":[43],"antimalarial":[44,269,308],"activity":[45,270],"against":[46,139,271,294],"Plasmodium":[47,140,321],"berghei,":[48,322],"investigate":[50],"predicted":[51,168,247],"between":[53],"selected":[54],"parasite-associated":[57],"proteins.":[58],"Materials":[59],"Methods:":[61],"Ethanolic":[62],"extract":[64,96,266],"was":[65,125,240],"characterized":[66],"using":[67,127],"liquid":[68,310],"chromatography\u2013high-resolution":[69,311],"mass":[70,312],"spectrometry":[71],"(LC-HRMS).":[72],"Twenty-five":[73],"male":[74],"BALB/c":[75],"mice":[76],"infected":[77],"chloroquine-sensitive":[79,272],"P.":[80,273],"berghei":[81],"ANKA":[82],"were":[83,230],"randomly":[84],"assigned":[85],"five":[87],"groups":[88,93,229],"(n":[89],"=":[90],"5).":[91],"Three":[92],"received":[94],"oral":[95],"doses":[97],"250,":[99,205],"500,":[100,206],"or":[101],"750":[102,208],"mg/kg":[103],"body":[104],"weight":[105],"for":[106,214],"four":[107],"consecutive":[108],"days.":[109],"Artesunate":[110],"(2.4":[111],"mg/kg)":[112],"distilled":[114],"water":[115],"served":[116],"as":[117],"positive":[118],"negative":[120],"controls,":[121],"respectively.":[122],"Parasitemia":[123,197],"suppression":[124,198,219],"evaluated":[126],"a":[128],"modified":[129],"Peters'":[130],"4-day":[131],"suppressive":[132],"test.":[133],"Selected":[134],"underwent":[136],"docking":[138],"falciparum":[141],"dihydrofolate":[142],"reductase\u2013thymidylate":[143],"synthase,":[144],"chloroquine":[145,259],"transporter,":[147],"plasmepsin":[149],"II,":[150],"alongside":[151],"exploratory":[152],"host-response":[153],"targets":[154],"caspase-3":[155],"Bcl-2.":[157],"Molecular":[158],"dynamics":[159],"simulations":[160],"(100":[161],"ns)":[162],"binding":[164],"free-energy":[165],"calculations":[166],"assessed":[167],"interaction":[169],"stability.":[170],"Results:":[171],"LC-HRMS":[172],"tentatively":[173],"identified":[174,245,281],"33":[175],"metabolites,":[176],"predominantly":[177],"flavonols":[178],"flavonol":[180],"glycosides.":[181],"Scopoletin":[182],"exhibited":[183],"greatest":[185],"relative":[186],"abundance,":[187],"followed":[188],"by":[189],"rutin,":[190],"trifolin,":[191],"isoquercetin,":[192],"quercetin":[193],"3-\u03b2-D-glucoside,":[194],"morin.":[196],"reached":[199],"78.11%,":[200],"82.08%,":[201],"76.83%":[203],"at":[204,221],"mg/kg,":[209],"respectively,":[210],"compared":[211],"95.75%":[213],"artesunate.":[215],"The":[216],"highest":[217],"numerical":[218],"occurred":[220],"500":[222],"mg/kg.":[223],"Differences":[224],"among":[225],"extract-treated":[226],"artesunate":[228],"not":[231,241],"statistically":[232],"significant":[233],"(p":[234],">":[235],"0.05),":[236],"therapeutic":[238,303],"equivalence":[239],"established.":[242],"Computational":[243],"analyses":[244,280],"favorable":[246],"involving":[249],"catechin,":[250],"luteolin,":[251],"2-coumaroylquinic":[253],"acid,":[254],"particularly":[255],"luteolin":[256],"transporter.":[261],"Conclusion:":[262],"demonstrated":[267],"preliminary":[268],"berghei.":[274],"Integrated":[275],"metabolite":[276],"profiling":[277],"computational":[279],"candidate":[282],"compounds":[283],"warranting":[284],"further":[285],"investigation.":[286],"Experimental":[287],"target":[288],"validation,":[289],"individual-compound":[290],"testing,":[291],"evaluation":[293],"drug-resistant":[295],"parasites":[296],"are":[297],"necessary":[298],"establish":[300],"mechanisms":[301],"relevance.":[304],"Keywords:":[305],"indica,":[307],"activity,":[309],"spectrometry,":[313],"docking,":[315],"dynamics,":[317],"neem":[318],"phytochemical":[323],"profiling.":[324]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-11-07T00:00:00"}
