{"id":"https://openalex.org/W7225429464","doi":"https://doi.org/10.3389/fcimb.2026.2003998","title":"Host\u2013pathogen interactions in severe odontogenic infection: linking abscess findings to anatomical spread","display_name":"Host\u2013pathogen interactions in severe odontogenic infection: linking abscess findings to anatomical spread","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225429464","doi":"https://doi.org/10.3389/fcimb.2026.2003998"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.2003998","doi":"https://doi.org/10.3389/fcimb.2026.2003998","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.2003998","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2003998/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2003998/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161093665","display_name":"Zhaogao Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaogao Zhang","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Shanghai Jiading District Dental Disease Prevention and Control Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Shanghai Jiading District Dental Disease Prevention and Control Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121262406","display_name":"Ziqi Yang","orcid":"https://orcid.org/0009-0003-6629-0709","observed_orcids":["https://orcid.org/0009-0003-6629-0709"]},"institutions":[{"id":"https://openalex.org/I4405281751","display_name":"Medical College of Jinzhou Medical University","ror":"https://ror.org/04v04rx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281751"]},{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqi Yang","raw_affiliation_strings":["School of Stomatology, Medical College of Jinzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Stomatology, Medical College of Jinzhou Medical University","institution_ids":["https://openalex.org/I4405281751","https://openalex.org/I85430964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121287490","display_name":"Yihao Pei","orcid":"https://orcid.org/0009-0004-8949-519X","observed_orcids":["https://orcid.org/0009-0004-8949-519X"]},"institutions":[{"id":"https://openalex.org/I4405281751","display_name":"Medical College of Jinzhou Medical University","ror":"https://ror.org/04v04rx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281751"]},{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yihao Pei","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Shanghai Jiading District Dental Disease Prevention and Control Institute","School of Stomatology, Medical College of Jinzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Shanghai Jiading District Dental Disease Prevention and Control Institute","institution_ids":[]},{"raw_affiliation_string":"School of Stomatology, Medical College of Jinzhou Medical University","institution_ids":["https://openalex.org/I4405281751","https://openalex.org/I85430964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5121287490"],"corresponding_institution_ids":["https://openalex.org/I4405281751","https://openalex.org/I85430964"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-infection","display_name":"odontogenic infection","score":0.9950000047683716},{"id":"https://openalex.org/keywords/maxillofacial-abscess","display_name":"maxillofacial abscess","score":0.949999988079071},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/deep-neck-infection","display_name":"deep neck infection","score":0.765999972820282},{"id":"https://openalex.org/keywords/oral-bacterial-communities","display_name":"oral bacterial communities","score":0.7620000243186951},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/surgical-drainage","display_name":"surgical drainage","score":0.7900000214576721},{"id":"https://openalex.org/keywords/host-susceptibility","display_name":"host susceptibility","score":0.5929999947547913},{"id":"https://openalex.org/keywords/microbial-adaptation","display_name":"microbial adaptation","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2777035434","wikidata":"https://www.wikidata.org/wiki/Q164655","display_name":"Abscess","level":2,"score":0.6832000017166138},{"id":"https://openalex.org/C2778125672","wikidata":"https://www.wikidata.org/wiki/Q769266","display_name":"Odontogenic","level":2,"score":0.5960999727249146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5454999804496765},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C3020564189","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factors","level":3,"score":0.391400009393692},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.390500009059906},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3637000024318695},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3075000047683716},{"id":"https://openalex.org/C2781102351","wikidata":"https://www.wikidata.org/wiki/Q14323716","display_name":"Odontogenic infection","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28760001063346863},{"id":"https://openalex.org/C2776916960","wikidata":"https://www.wikidata.org/wiki/Q637156","display_name":"Warrant","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C2993328841","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotic therapy","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2558000087738037}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fcimb.2026.2003998","doi":"https://doi.org/10.3389/fcimb.2026.2003998","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.2003998","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2003998/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4335d3bcfab940d39b0abf62937d63b8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4335d3bcfab940d39b0abf62937d63b8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.2003998","doi":"https://doi.org/10.3389/fcimb.2026.2003998","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.2003998","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.2003998/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225429464.pdf","grobid_xml":"https://content.openalex.org/works/W7225429464.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W2014953319","https://openalex.org/W2015394063","https://openalex.org/W2051942261","https://openalex.org/W2087920724","https://openalex.org/W2115726166","https://openalex.org/W2135451045","https://openalex.org/W2289643138","https://openalex.org/W2769542288","https://openalex.org/W3170273965","https://openalex.org/W3200531480","https://openalex.org/W4220663457","https://openalex.org/W4304893027","https://openalex.org/W4308507719","https://openalex.org/W4380793302","https://openalex.org/W4380997448","https://openalex.org/W4383501290","https://openalex.org/W4386266557","https://openalex.org/W4388377720","https://openalex.org/W4392699848","https://openalex.org/W4399572545","https://openalex.org/W4402995543","https://openalex.org/W4405221404","https://openalex.org/W4406362656","https://openalex.org/W4406612845","https://openalex.org/W4410735809","https://openalex.org/W4411497601","https://openalex.org/W4412043245","https://openalex.org/W4412507748","https://openalex.org/W4413900263","https://openalex.org/W4414283974","https://openalex.org/W4415356464","https://openalex.org/W4417261909","https://openalex.org/W4417494288","https://openalex.org/W7118864519","https://openalex.org/W7120105567","https://openalex.org/W7125426806","https://openalex.org/W7129068527","https://openalex.org/W7151310561","https://openalex.org/W7155049310","https://openalex.org/W7155547897","https://openalex.org/W7161182005"],"related_works":["https://openalex.org/W1546279269","https://openalex.org/W4390285072","https://openalex.org/W2096604736","https://openalex.org/W7118864519","https://openalex.org/W3125680451","https://openalex.org/W601750879","https://openalex.org/W3153285072","https://openalex.org/W4416382838","https://openalex.org/W2026728181","https://openalex.org/W1967771647"],"abstract_inverted_index":{"Why":[0],"do":[1],"some":[2],"odontogenic":[3,168],"infections":[4],"remain":[5],"confined":[6],"to":[7,46,80,122,156],"one":[8],"anatomical":[9,84],"space":[10],"while":[11,66],"others":[12],"extend":[13],"into":[14],"the":[15,37,108,164],"deep":[16],"neck?":[17],"Recent":[18],"studies":[19,50,68],"have":[20,69],"identified":[21,70],"severity-associated":[22],"microbial":[23,95,140,154],"communities":[24],"in":[25],"maxillofacial":[26],"abscesses,":[27],"but":[28],"organisms":[29],"detected":[30],"after":[31],"infection":[32,169],"has":[33],"spread":[34,85],"may":[35,162],"reflect":[36],"established":[38,158],"abscess":[39,59],"environment":[40],"as":[41,43],"well":[42],"processes":[44],"contributing":[45],"its":[47],"development.":[48],"Experimental":[49],"demonstrate":[51],"that":[52,90,173],"selected":[53],"oral":[54],"bacterial":[55],"combinations":[56],"can":[57],"enhance":[58],"formation":[60],"and":[61,97,113,127,141,170],"impair":[62],"neutrophil":[63],"antimicrobial":[64],"activity,":[65],"human":[67],"inflammatory":[71],"responses":[72,100],"at":[73],"infected":[74],"sites.":[75],"Whether":[76],"these":[77],"interactions":[78,152],"contribute":[79],"specific":[81],"patterns":[82],"of":[83,166],"remains":[86],"unresolved.":[87],"We":[88],"propose":[89],"mechanistic":[91],"investigation":[92],"should":[93],"connect":[94],"activity":[96],"local":[98,139],"host":[99,111,142],"with":[101,144],"anatomically":[102,124],"defined":[103],"clinical":[104,178],"manifestations,":[105],"accounting":[106],"for":[107,177],"dental":[109],"source,":[110],"susceptibility,":[112],"treatment":[114,134],"before":[115],"sampling.":[116],"Surgical":[117],"drainage":[118],"offers":[119],"an":[120,157],"opportunity":[121],"obtain":[123],"characterized":[125],"specimens":[126],"follow":[128],"subsequent":[129],"biological":[130],"changes,":[131],"although":[132],"concurrent":[133],"limits":[135],"causal":[136],"attribution.":[137],"Pairing":[138],"measurements":[143],"targeted":[145],"functional":[146],"experiments":[147],"could":[148],"help":[149],"distinguish":[150],"pathogenic":[151],"from":[153],"adaptation":[155],"abscess.":[159],"This":[160],"approach":[161],"clarify":[163],"biology":[165],"severe":[167],"identify":[171],"findings":[172],"warrant":[174],"independent":[175],"evaluation":[176],"relevance.":[179]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
