{"id":"https://openalex.org/W7225429217","doi":"https://doi.org/10.1097/med.0000000000000988","title":"Lean metabolic dysfunction-associated steatotic liver disease","display_name":"Lean metabolic dysfunction-associated steatotic liver disease","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225429217","doi":"https://doi.org/10.1097/med.0000000000000988","pmid":"https://pubmed.ncbi.nlm.nih.gov/42989688"},"language":"en","primary_location":{"id":"doi:10.1097/med.0000000000000988","doi":"https://doi.org/10.1097/med.0000000000000988","is_oa":false,"landing_page_url":"https://doi.org/10.1097/med.0000000000000988","pdf_url":null,"source":{"id":"https://openalex.org/S177297213","display_name":"Current Opinion in Endocrinology Diabetes and Obesity","issn_l":"1752-296X","issn":["1752-296X","1752-2978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Endocrinology, Diabetes & Obesity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161013644","display_name":"Sambit Das","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sambit Das","raw_affiliation_strings":["Department of Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101479969","display_name":"Vishal Agarwal","orcid":"https://orcid.org/0009-0005-1428-0124","observed_orcids":["https://orcid.org/0009-0005-1428-0124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vishal Agarwal","raw_affiliation_strings":["Department of Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009170217","display_name":"Devadarshini Sahoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devadarshini Sahoo","raw_affiliation_strings":["Department of Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117123276","display_name":"Amogh S. Chappalagavi","orcid":"https://orcid.org/0009-0004-3999-5161","observed_orcids":["https://orcid.org/0009-0004-3999-5161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amogh S. Chappalagavi","raw_affiliation_strings":["Department of Endocrinology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014459309","display_name":"Shubhransu Patro","orcid":"https://orcid.org/0000-0002-3597-4302","observed_orcids":["https://orcid.org/0000-0002-3597-4302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shubhransu Patro","raw_affiliation_strings":["Department of Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lean-masld","display_name":"lean MASLD","score":0.871999979019165},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.6840000152587891},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9850000143051147},{"id":"https://openalex.org/keywords/muscle-loss","display_name":"muscle mass loss","score":0.800000011920929},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.7229999899864197},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.4020000100135803},{"id":"https://openalex.org/keywords/genetic-risk-markers","display_name":"genetic risk markers","score":0.6000000238418579},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.33399999141693115},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7831000089645386},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6585000157356262},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.6389999985694885},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5771999955177307},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5299999713897705},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5015000104904175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4478999972343445},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40950000286102295},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.40139999985694885},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.39629998803138733},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3776000142097473},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.3716000020503998},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.35280001163482666},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.33169999718666077},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.30570000410079956},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2840999960899353},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2689000070095062},{"id":"https://openalex.org/C3018605307","wikidata":"https://www.wikidata.org/wiki/Q200779","display_name":"Complex disease","level":3,"score":0.26600000262260437},{"id":"https://openalex.org/C2991848491","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disease","level":2,"score":0.26190000772476196}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/med.0000000000000988","doi":"https://doi.org/10.1097/med.0000000000000988","is_oa":false,"landing_page_url":"https://doi.org/10.1097/med.0000000000000988","pdf_url":null,"source":{"id":"https://openalex.org/S177297213","display_name":"Current Opinion in Endocrinology Diabetes and Obesity","issn_l":"1752-296X","issn":["1752-296X","1752-2978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Endocrinology, Diabetes & Obesity","raw_type":"journal-article"},{"id":"pmid:42989688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42989688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in endocrinology, diabetes, and obesity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2588130051","https://openalex.org/W3083002817","https://openalex.org/W3190754463","https://openalex.org/W3215115132","https://openalex.org/W4381893710","https://openalex.org/W4392245564","https://openalex.org/W4392515692","https://openalex.org/W4401712318","https://openalex.org/W4406185654","https://openalex.org/W4406560013","https://openalex.org/W4408019056","https://openalex.org/W4408050705","https://openalex.org/W4408540835","https://openalex.org/W4410767800","https://openalex.org/W4411090486","https://openalex.org/W4411533970","https://openalex.org/W4412750571","https://openalex.org/W4413005790","https://openalex.org/W4413745403","https://openalex.org/W4414748813","https://openalex.org/W4416184360","https://openalex.org/W4416894410","https://openalex.org/W4417221225","https://openalex.org/W7160244600","https://openalex.org/W7161231908"],"related_works":["https://openalex.org/W7161231908","https://openalex.org/W4413928872","https://openalex.org/W7160244600","https://openalex.org/W4413005790","https://openalex.org/W4408180090","https://openalex.org/W4415902401","https://openalex.org/W4415925413","https://openalex.org/W4390547132","https://openalex.org/W4403392962","https://openalex.org/W7147730774"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Lean":[3,42,93],"metabolic":[4,33,81],"dysfunction-associated":[5],"steatotic":[6],"liver":[7,31,75,105,132],"disease":[8],"(MASLD)":[9],"is":[10,140],"increasingly":[11],"recognized":[12],"as":[13,99,107],"an":[14],"important":[15],"but":[16],"often":[17],"overlooked":[18],"condition.":[19],"A":[20],"normal":[21],"BMI":[22],"does":[23],"not":[24,96],"necessarily":[25],"mean":[26],"a":[27,47,100],"low":[28],"risk":[29,73,90],"of":[30,49,55,74,103],"or":[32],"disease,":[34,106],"making":[35],"early":[36,87],"recognition":[37],"particularly":[38],"important.":[39],"RECENT":[40],"FINDINGS:":[41],"MASLD":[43,94],"can":[44,69,109],"develop":[45,143],"through":[46],"combination":[48],"visceral":[50],"fat,":[51],"insulin":[52],"resistance,":[53],"loss":[54],"muscle":[56,129],"mass,":[57,130],"genetic":[58,83],"factors,":[59],"and":[60,77,82,89,114,125,134,149],"changes":[61],"in":[62],"the":[63],"gut-liver":[64],"axis.":[65],"Conventional":[66],"BMI-based":[67],"assessment":[68],"miss":[70],"those":[71],"at":[72],"fibrosis":[76],"cardiovascular":[78,136],"complications.":[79],"Emerging":[80],"markers":[84],"may":[85],"improve":[86],"detection":[88],"assessment.":[91],"SUMMARY:":[92],"should":[95,118],"be":[97],"regarded":[98],"benign":[101],"form":[102],"fatty":[104],"it":[108],"still":[110],"carry":[111],"significant":[112],"hepatic":[113],"cardiometabolic":[115],"risks.":[116],"Management":[117],"focus":[119],"on":[120],"healthy":[121],"diet,":[122],"regular":[123],"aerobic":[124],"resistance":[126],"exercise,":[127],"maintaining":[128],"assessing":[131],"fibrosis,":[133],"reducing":[135],"risk.":[137],"Further":[138],"research":[139],"needed":[141],"to":[142],"practical":[144],"tools":[145],"for":[146],"earlier":[147],"diagnosis":[148],"personalized":[150],"treatment.":[151]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}