{"id":"https://openalex.org/W7225429048","doi":"https://doi.org/10.1021/acsomega.6c04873","title":"Microbubble-Assisted Bioresorbable Biphasic Scaffolds Reinforced with TiO2 Nanosheets for Oral and Maxillofacial Bone Repair: In Vitro Evaluation","display_name":"Microbubble-Assisted Bioresorbable Biphasic Scaffolds Reinforced with TiO2 Nanosheets for Oral and Maxillofacial Bone Repair: In Vitro Evaluation","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225429048","doi":"https://doi.org/10.1021/acsomega.6c04873"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c04873","doi":"https://doi.org/10.1021/acsomega.6c04873","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c04873","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04873/69110350/acsomega.6c04873.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04873/69110350/acsomega.6c04873.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032364949","display_name":"Tanchanok Parivatphun","orcid":"https://orcid.org/0000-0003-2310-9466","observed_orcids":["https://orcid.org/0000-0003-2310-9466"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Tanchanok Parivatphun","raw_affiliation_strings":["Prince of Songkla University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince of Songkla University , , , ,","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089008042","display_name":"Matthana Khangkhamano","orcid":"https://orcid.org/0000-0002-0869-9843","observed_orcids":["https://orcid.org/0000-0002-0869-9843"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Matthana Khangkhamano","raw_affiliation_strings":["Prince of Songkla University , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-0869-9843","affiliations":[{"raw_affiliation_string":"Prince of Songkla University , , , ,","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083241849","display_name":"Jirut Meesane","orcid":"https://orcid.org/0000-0002-6242-818X","observed_orcids":["https://orcid.org/0000-0002-6242-818X"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jirut Meesane","raw_affiliation_strings":["Prince of Songkla University , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-6242-818X","affiliations":[{"raw_affiliation_string":"Prince of Songkla University , , , ,","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044665478","display_name":"Rungrote Kokoo","orcid":"https://orcid.org/0000-0003-0141-3643","observed_orcids":["https://orcid.org/0000-0003-0141-3643"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rungrote Kokoo","raw_affiliation_strings":["Faculty of Engineering, King Mongkut\u2019s University of Technology , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, King Mongkut\u2019s University of Technology , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092000782","display_name":"Sittichat Chukaew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sittichat Chukaew","raw_affiliation_strings":["Prince of Songkla University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince of Songkla University , , , ,","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122187009","display_name":"Lerrat Chuaibamrung","orcid":"https://orcid.org/0009-0003-2931-0088","observed_orcids":["https://orcid.org/0009-0003-2931-0088"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Lerrat Chuaibamrung","raw_affiliation_strings":["Prince of Songkla University , , , ,"],"raw_orcid":"https://orcid.org/0009-0003-2931-0088","affiliations":[{"raw_affiliation_string":"Prince of Songkla University , , , ,","institution_ids":["https://openalex.org/I131868736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044665478","https://openalex.org/A5089008042"],"corresponding_institution_ids":["https://openalex.org/I131868736"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biphasic-scaffold","display_name":"biphasic scaffold","score":0.8330000042915344},{"id":"https://openalex.org/keywords/titanium-dioxide-nanosheets","display_name":"titanium dioxide nanosheets","score":0.878000020980835},{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":0.9309999942779541},{"id":"https://openalex.org/keywords/polyvinyl-alcohol","display_name":"polyvinyl alcohol","score":0.9070000052452087},{"id":"https://openalex.org/keywords/silk-fibroin","display_name":"silk fibroin","score":1.0},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.6660000085830688},{"id":"https://openalex.org/keywords/anatase-tio2","display_name":"anatase TiO2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/osteoblast-proliferation","display_name":"osteoblast proliferation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/scaffold-degradation","display_name":"scaffold degradation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/alveolar-cleft-reconstruction","display_name":"alveolar cleft reconstruction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hydrothermal-synthesis","display_name":"hydrothermal synthesis","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7437000274658203},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5694000124931335},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5462999939918518},{"id":"https://openalex.org/C122302759","wikidata":"https://www.wikidata.org/wiki/Q2345087","display_name":"Fibroin","level":3,"score":0.5440999865531921},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4113999903202057},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3982999920845032},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.3846000134944916},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C92880739","wikidata":"https://www.wikidata.org/wiki/Q2639556","display_name":"Nanocomposite","level":2,"score":0.31459999084472656},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C202271784","wikidata":"https://www.wikidata.org/wiki/Q189218","display_name":"Molar","level":2,"score":0.2535000145435333},{"id":"https://openalex.org/C2993697008","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Bone matrix","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsomega.6c04873","doi":"https://doi.org/10.1021/acsomega.6c04873","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c04873","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04873/69110350/acsomega.6c04873.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c04873","doi":"https://doi.org/10.1021/acsomega.6c04873","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c04873","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04873/69110350/acsomega.6c04873.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322692","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84"},{"id":"https://openalex.org/F4320326657","display_name":"Faculty of Medicine, Prince of Songkla University","ror":null},{"id":"https://openalex.org/F4320329659","display_name":"Thailand Science Research and Innovation","ror":"https://ror.org/000025p04"},{"id":"https://openalex.org/F4320337243","display_name":"Graduate School, Prince of Songkla University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225429048.pdf","grobid_xml":"https://content.openalex.org/works/W7225429048.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W16501288","https://openalex.org/W1742598426","https://openalex.org/W1964033905","https://openalex.org/W1969040530","https://openalex.org/W1981068073","https://openalex.org/W1985639021","https://openalex.org/W1995921720","https://openalex.org/W1997356708","https://openalex.org/W2000709661","https://openalex.org/W2001380203","https://openalex.org/W2007310752","https://openalex.org/W2007886041","https://openalex.org/W2009298899","https://openalex.org/W2016814255","https://openalex.org/W2026513267","https://openalex.org/W2028713594","https://openalex.org/W2029284022","https://openalex.org/W2038606570","https://openalex.org/W2041309288","https://openalex.org/W2049287584","https://openalex.org/W2061761744","https://openalex.org/W2063695925","https://openalex.org/W2066393865","https://openalex.org/W2093131724","https://openalex.org/W2106570763","https://openalex.org/W2111074923","https://openalex.org/W2112705999","https://openalex.org/W2127214109","https://openalex.org/W2146232677","https://openalex.org/W2149757979","https://openalex.org/W2163748007","https://openalex.org/W2514893673","https://openalex.org/W2556433362","https://openalex.org/W2769855594","https://openalex.org/W2808190121","https://openalex.org/W2899630416","https://openalex.org/W2919631899","https://openalex.org/W2946737581","https://openalex.org/W2951814602","https://openalex.org/W2952835325","https://openalex.org/W2963549319","https://openalex.org/W2967720432","https://openalex.org/W2976877796","https://openalex.org/W2981886733","https://openalex.org/W2985173323","https://openalex.org/W2990861612","https://openalex.org/W2996117381","https://openalex.org/W3022241261","https://openalex.org/W3022982296","https://openalex.org/W3033369592","https://openalex.org/W3037791105","https://openalex.org/W3048700879","https://openalex.org/W3081086371","https://openalex.org/W3097392543","https://openalex.org/W3097526304","https://openalex.org/W3114176730","https://openalex.org/W3119898972","https://openalex.org/W3135650325","https://openalex.org/W3174423711","https://openalex.org/W3189708132","https://openalex.org/W3208974836","https://openalex.org/W4200328505","https://openalex.org/W4205183307","https://openalex.org/W4205508725","https://openalex.org/W4206561054","https://openalex.org/W4210634893","https://openalex.org/W4220866081","https://openalex.org/W4282943502","https://openalex.org/W4293769852","https://openalex.org/W4309677796","https://openalex.org/W4317434639","https://openalex.org/W4317933269","https://openalex.org/W4321457645","https://openalex.org/W4377697256","https://openalex.org/W4384407057","https://openalex.org/W4388452672","https://openalex.org/W4389669596","https://openalex.org/W4392864346","https://openalex.org/W4406703959","https://openalex.org/W4409165238","https://openalex.org/W4409252313","https://openalex.org/W4409284238","https://openalex.org/W4416409878","https://openalex.org/W4417466469","https://openalex.org/W7105678509","https://openalex.org/W7117158346","https://openalex.org/W7162866132"],"related_works":["https://openalex.org/W4213240921","https://openalex.org/W2742456780","https://openalex.org/W4205508725","https://openalex.org/W7167635711","https://openalex.org/W7124550304","https://openalex.org/W7120342338","https://openalex.org/W2616651209","https://openalex.org/W4386278523","https://openalex.org/W2752635605","https://openalex.org/W2144744444"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2],"presents":[3],"the":[4,67,84,91,110,121,149],"development":[5],"of":[6,69,87,142],"bioresorbable":[7],"biphasic":[8],"scaffolds":[9,51,125,171],"incorporating":[10],"titanium":[11],"dioxide":[12],"(TiO2)":[13],"nanostructures,":[14],"specifically":[15],"nanoparticles":[16],"(TNPs)":[17],"and":[18,26,41,60,72,78,100,118,133,145,160,180,187],"nanosheets":[19],"(TNSs),":[20],"into":[21],"a":[22,33,46,56,61,103],"poly(vinyl":[23],"alcohol)":[24],"(PVA)":[25],"silk":[27],"fibroin":[28],"(SF)":[29],"polymeric":[30],"matrix":[31],"using":[32],"bubbling":[34],"technique":[35],"followed":[36],"by":[37],"freeze-drying.":[38],"Both":[39],"TNPs":[40,99],"TNSs":[42,101,150],"were":[43],"synthesized":[44],"via":[45],"hydrothermal":[47],"method.":[48],"The":[49,152],"resulting":[50],"featured":[52],"two":[53],"distinct":[54],"layers:":[55],"porous":[57],"sponge-like":[58],"structure":[59],"dense":[62],"film,":[63],"designed":[64],"to":[65,108,156],"mimic":[66],"architecture":[68],"natural":[70],"bone":[71],"soft":[73],"tissue":[74,182],"interfaces":[75],"in":[76,148],"oral":[77,179],"maxillofacial":[79,181],"regions.":[80],"Structural":[81],"characterization":[82],"confirmed":[83],"successful":[85],"integration":[86],"TiO2":[88,154],"nanostructures":[89],"within":[90,120],"scaffold":[92,161],"matrix.":[93,122],"X-ray":[94],"diffraction":[95],"showed":[96],"that":[97,169],"both":[98,143],"exhibited":[102,126],"pure":[104],"anatase":[105],"phase.":[106],"Compared":[107],"TNPs,":[109],"nanosheet":[111],"form":[112],"offered":[113],"significantly":[114],"improved":[115,157],"molecular":[116],"mobility":[117],"dispersion":[119],"Additionally,":[123],"TNSs-incorporated":[124],"favorable":[127],"porosity,":[128],"compressive":[129],"strength,":[130],"swelling":[131],"behavior,":[132],"degradation":[134],"rate.":[135],"In":[136],"vitro":[137],"studies":[138],"demonstrated":[139],"enhanced":[140],"proliferation":[141],"osteoblasts":[144],"fibroblasts,":[146],"particularly":[147],"scaffolds.":[151],"anatase-phase":[153],"contributed":[155],"cell-material":[158],"interactions":[159],"performance":[162],"without":[163],"significant":[164],"cytotoxicity.":[165],"These":[166],"findings":[167],"suggest":[168],"TNSs-based":[170],"hold":[172],"strong":[173],"potential":[174],"as":[175],"functional":[176],"biomaterials":[177],"for":[178],"repair,":[183],"including":[184],"alveolar":[185],"cleft":[186],"mandibular":[188],"ridge":[189],"reconstruction.":[190]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}