{"id":"https://openalex.org/W7225429014","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","title":"1190 Spatial and phenotypic characterization of tertiary lymphoid structures and immune organization in cutaneous squamous cell carcinoma using multiplex immunofluorescence","display_name":"1190 Spatial and phenotypic characterization of tertiary lymphoid structures and immune organization in cutaneous squamous cell carcinoma using multiplex immunofluorescence","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225429014","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1190"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.1190","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","pdf_url":"https://jitc.bmj.com/content/14/Suppl_3/A1406.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Late-Breaking Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_3/A1406.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083765234","display_name":"Rachel Mattson","orcid":"https://orcid.org/0000-0003-1503-509X","observed_orcids":["https://orcid.org/0000-0003-1503-509X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Mattson","raw_affiliation_strings":["PredxBio, Inc., Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PredxBio, Inc., Pittsburgh, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103008841","display_name":"Rodrigo Xavier das Neves","orcid":"https://orcid.org/0000-0001-6669-6002","observed_orcids":["https://orcid.org/0000-0001-6669-6002"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo Xavier Das Neves","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161115237","display_name":"Samy Kotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samy Kotti","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161000678","display_name":"Paul Sharoubeem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Sharoubeem","raw_affiliation_strings":["PredxBio, Inc., Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PredxBio, Inc., Pittsburgh, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161102719","display_name":"Mark Melanson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Melanson","raw_affiliation_strings":["PredxBio, Inc., Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PredxBio, Inc., Pittsburgh, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070023198","display_name":"Amanda W. Lund","orcid":"https://orcid.org/0000-0001-7389-9983","observed_orcids":["https://orcid.org/0000-0001-7389-9983"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda W Lund","raw_affiliation_strings":["NYU Langone Health, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Health, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044063968","display_name":"Markus Sch\u00f6ber","orcid":"https://orcid.org/0000-0002-9122-2121","observed_orcids":["https://orcid.org/0000-0002-9122-2121","https://orcid.org/0009-0001-1654-5908"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Schober","raw_affiliation_strings":["NYU Langone Health, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Health, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024948606","display_name":"S. Chakra Chennubhotla","orcid":"https://orcid.org/0000-0002-0024-1627","observed_orcids":["https://orcid.org/0000-0002-0024-1627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Chakra Chennubhotla","raw_affiliation_strings":["PredxBio, Inc., Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PredxBio, Inc., Pittsburgh, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011496452","display_name":"Filippo Pullara","orcid":"https://orcid.org/0000-0002-2283-4968","observed_orcids":["https://orcid.org/0000-0002-2283-4968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Filippo Pullara","raw_affiliation_strings":["PredxBio, Inc., Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PredxBio, Inc., Pittsburgh, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030169825","display_name":"Diwakar Davar","orcid":"https://orcid.org/0000-0002-7846-8055","observed_orcids":["https://orcid.org/0000-0002-7846-8055"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diwakar Davar","raw_affiliation_strings":["UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025286759","display_name":"Hassane M. Zarour","orcid":"https://orcid.org/0000-0003-2525-2688","observed_orcids":["https://orcid.org/0000-0003-2525-2688"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassane M Zarour","raw_affiliation_strings":["UPMC Hillman Cancer Center, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Hillman Cancer Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1406","last_page":"A1406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.996999979019165},{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9440000057220459},{"id":"https://openalex.org/keywords/b-cell-aggregates","display_name":"B cell aggregates","score":0.7649999856948853},{"id":"https://openalex.org/keywords/follicular-dendritic-cells","display_name":"follicular dendritic cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/spatial-program","display_name":"spatial program","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tumor-response-prediction","display_name":"tumor response prediction","score":0.49300000071525574},{"id":"https://openalex.org/keywords/immune-heterogeneity","display_name":"immune heterogeneity","score":0.5690000057220459},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5649999976158142},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.8131999969482422},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.7972999811172485},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6848999857902527},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6836000084877014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4934999942779541},{"id":"https://openalex.org/C2984894117","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Indirect immunofluorescence","level":3,"score":0.4787999987602234},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46790000796318054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4359000027179718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42500001192092896},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37700000405311584},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.32919999957084656},{"id":"https://openalex.org/C3019359096","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune surveillance","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C98246554","wikidata":"https://www.wikidata.org/wiki/Q5280334","display_name":"Direct fluorescent antibody","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.1190","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","pdf_url":"https://jitc.bmj.com/content/14/Suppl_3/A1406.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Late-Breaking Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.1190","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.1190","pdf_url":"https://jitc.bmj.com/content/14/Suppl_3/A1406.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Late-Breaking Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225429014.pdf","grobid_xml":"https://content.openalex.org/works/W7225429014.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309478932","https://openalex.org/W7225159254","https://openalex.org/W4386890375","https://openalex.org/W7214109247","https://openalex.org/W4416586284","https://openalex.org/W3133768216","https://openalex.org/W7225193617","https://openalex.org/W4308375765","https://openalex.org/W4366088024","https://openalex.org/W4288036375"],"abstract_inverted_index":{"Background":[0],"Tertiary":[1],"lymphoid":[2],"structures":[3],"(TLS)":[4],"are":[5],"increasingly":[6],"recognized":[7],"as":[8,296],"important":[9],"components":[10],"of":[11,42,63,120,159,203,257,305,358,374,383,394],"the":[12,64,198,212,370,384,392],"tumor":[13,53],"immune":[14,43,181,205,322],"microenvironment,":[15],"but":[16],"their":[17,23,131],"biological":[18],"relevance":[19],"may":[20,329],"depend":[21],"on":[22,150],"organization,":[24],"cellular":[25,132,274],"composition,":[26],"and":[27,38,82,100,110,123,134,154,161,170,177,183,193,200,214,232,264,276,321,328,343,377],"maturation":[28,320],"state.":[29],"We":[30],"used":[31,142],"multiplex":[32],"immunofluorescence":[33],"(mIF)":[34],"to":[35,130,143,273,293,349],"characterize":[36],"TLS":[37,113,160,207,292,319],"broader":[39,306],"spatial":[40,118,162,184,251,289,307,353],"patterns":[41],"organization":[44,185,259,323],"in":[45,59,68,180,197,244],"post-treatment":[46,313,344],"cutaneous":[47],"squamous":[48],"cell":[49,97],"carcinoma":[50],"(cSCC).Methods":[51],"Post-treatment":[52],"specimens":[54,220,246,263,345],"from":[55,283,369],"10":[56],"patients":[57],"enrolled":[58],"a":[60,76,88,297],"neoadjuvant":[61,187],"study":[62],"PD-1":[65],"inhibitor":[66],"pembrolizumab":[67],"PD-1\u2013na\u00efve":[69],"cSCC":[70],"(ClinicalTrials.gov":[71],"NCT04808999)":[72],"were":[73,85,105,115,164,195,209],"profiled":[74],"using":[75],"40-marker":[77],"mIF":[78,173],"panel.":[79],"Marker":[80],"performance":[81],"technical":[83],"outliers":[84],"evaluated":[86,106],"through":[87,117],"standardized":[89],"quality-control":[90],"process.":[91],"Image-processing":[92],"workflows":[93],"incorporated":[94],"artifact":[95],"detection,":[96],"segmentation,":[98],"phenotyping,":[99],"tissue-region":[101],"annotation.":[102],"Immune":[103],"phenotypes":[104],"across":[107,167,211,262,325],"tumor,":[108],"tumor-adjacent,":[109],"stromal":[111],"compartments.":[112,266],"candidates":[114,208],"identified":[116,210,254],"clustering":[119],"B":[121],"cells":[122],"classified":[124],"into":[125],"three":[126],"maturity":[127],"categories":[128],"according":[129,272],"composition":[133,153,182],"organization.":[135],"Separately,":[136],"an":[137],"outcome-agnostic":[138],"spatial-program":[139],"analysis":[140,252],"was":[141,367],"identify":[144],"recurring":[145,255],"multicellular":[146,258,299],"tissue":[147,168,265,270,308],"states":[148],"based":[149],"local":[151],"phenotype":[152,300],"cell\u2013cell":[155],"relationships.":[156],"The":[157],"distributions":[158],"programs":[163,256,268],"then":[165],"explored":[166],"compartments":[169],"response":[171,326],"groups.Results":[172],"revealed":[174],"substantial":[175],"interpatient":[176],"intratumoral":[178],"heterogeneity":[179,280],"following":[186],"pembrolizumab.":[188],"Exploratory":[189],"differences":[190],"between":[191],"responders":[192],"nonresponders":[194],"observed":[196],"abundance":[199,285,336],"regional":[201],"distribution":[202],"selected":[204],"phenotypes.":[206],"cohort":[213],"stratified":[215],"by":[216,391],"maturity.":[217],"Representative":[218],"responder":[219],"contained":[221],"organized":[222],"CD20":[223],"+":[224],"B-cell":[225],"aggregates":[226,243],"with":[227,237,340],"CD21+":[228],"follicular":[229],"dendritic-cell":[230],"networks":[231],"PNAd-associated":[233],"vascular":[234],"features":[235,354],"consistent":[236],"more":[238],"mature":[239],"TLS,":[240],"whereas":[241],"candidate":[242],"nonresponder":[245],"appeared":[247],"less":[248],"organized.":[249],"Outcome-agnostic":[250],"additionally":[253],"that":[260,318],"varied":[261],"These":[267],"distinguished":[269],"regions":[271],"context":[275],"interactions,":[277],"revealing":[278],"organizational":[279],"not":[281],"evident":[282],"immune-cell":[284,335],"summaries":[286],"alone.Conclusions":[287],"High-plex":[288],"profiling":[290],"enables":[291],"be":[294,347],"characterized":[295],"structured":[298],"while":[301],"supporting":[302],"data-driven":[303],"identification":[304],"states.":[309],"In":[310],"this":[311,375,395],"small":[312],"cohort,":[314],"exploratory":[315],"findings":[316],"suggest":[317],"differ":[324],"groups":[327],"provide":[330],"complementary":[331],"information":[332],"beyond":[333],"conventional":[334],"measurements.":[337],"Larger":[338],"cohorts":[339],"paired":[341],"pre-":[342],"will":[346],"required":[348],"determine":[350],"whether":[351],"these":[352],"represent":[355],"baseline":[356],"correlates":[357],"response,":[359],"treatment-induced":[360],"remodeling,":[361],"or":[362],"both.Consent":[363],"Written":[364],"informed":[365],"consent":[366,386],"obtained":[368],"patient":[371],"for":[372,389],"publication":[373],"abstract":[376],"any":[378],"accompanying":[379],"images.":[380],"A":[381],"copy":[382],"written":[385],"is":[387],"available":[388],"review":[390],"Editor":[393],"journal.":[396]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
