{"id":"https://openalex.org/W7225428518","doi":"https://doi.org/10.1302/1358-992x.2026.11.014","title":"DOXYCYCLINE MONOTHERAPY FOR BONE AND JOINT INFECTIONS: A RETROSPECTIVE COHORT STUDY OF 163 PATIENTS IN A SPECIALIST ORTHOPAEDIC HOSPITAL","display_name":"DOXYCYCLINE MONOTHERAPY FOR BONE AND JOINT INFECTIONS: A RETROSPECTIVE COHORT STUDY OF 163 PATIENTS IN A SPECIALIST ORTHOPAEDIC HOSPITAL","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225428518","doi":"https://doi.org/10.1302/1358-992x.2026.11.014"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.014","doi":"https://doi.org/10.1302/1358-992x.2026.11.014","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160992755","display_name":"Felix-Antoine Garneau-Picard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felix-Antoine Garneau-Picard","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","CHU de Quebec - Universite Laval, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"raw_affiliation_string":"CHU de Quebec - Universite Laval, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082275564","display_name":"Tariq Azamgarhi","orcid":"https://orcid.org/0000-0002-0576-9797","observed_orcids":["https://orcid.org/0000-0002-0576-9797","https://orcid.org/0000-0001-7024-9379"]},"institutions":[{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tariq Azamgarhi","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049436136","display_name":"Simon Warren","orcid":"https://orcid.org/0000-0003-4802-2770","observed_orcids":["https://orcid.org/0000-0003-4802-2770"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Warren","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","Department of Infection, Royal Free London NHS Foundation Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"raw_affiliation_string":"Department of Infection, Royal Free London NHS Foundation Trust, United Kingdom","institution_ids":["https://openalex.org/I169248724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009827427","display_name":"Natasha Karunaharan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natasha Karunaharan","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","Department of Infection, Royal Free London NHS Foundation Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"raw_affiliation_string":"Department of Infection, Royal Free London NHS Foundation Trust, United Kingdom","institution_ids":["https://openalex.org/I169248724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161137380","display_name":"Caty Krick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caty Krick","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161077999","display_name":"Chin Swee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chin Swee","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014950476","display_name":"Antonia Scobie","orcid":"https://orcid.org/0000-0002-0941-9866","observed_orcids":["https://orcid.org/0000-0002-0941-9866"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I2802751111","display_name":"Royal National Orthopaedic Hospital","ror":"https://ror.org/043j9bc42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I4210118734","display_name":"Royal National Orthopaedic Hospital NHS Trust","ror":"https://ror.org/03dx46b94","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210118734"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonia Scobie","raw_affiliation_strings":["Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","Department of Infection, Royal Free London NHS Foundation Trust, United Kingdom","Division of Infection and Immunity, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Infection Unit, Royal National Orthopaedic Hospital NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I2802751111","https://openalex.org/I4210118734"]},{"raw_affiliation_string":"Department of Infection, Royal Free London NHS Foundation Trust, United Kingdom","institution_ids":["https://openalex.org/I169248724"]},{"raw_affiliation_string":"Division of Infection and Immunity, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-and-joint-infections","display_name":"bone and joint infections","score":0.8389999866485596},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.796999990940094},{"id":"https://openalex.org/keywords/staphylococcus-epidermidis","display_name":"Staphylococcus epidermidis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cutibacterium-acnes","display_name":"Propionibacterium acnes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.593999981880188},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5099999904632568},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.31700000166893005},{"id":"https://openalex.org/keywords/reoperation","display_name":"reoperation","score":0.33399999141693115},{"id":"https://openalex.org/keywords/oral-antibiotic-therapy","display_name":"oral antibiotic therapy","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9567000269889832},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7281000018119812},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6868000030517578},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.6809999942779541},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5706999897956848},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.48170000314712524},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4510999917984009},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4480000138282776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39629998803138733},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.39480000734329224},{"id":"https://openalex.org/C2777949923","wikidata":"https://www.wikidata.org/wiki/Q131915","display_name":"Staphylococcus epidermidis","level":4,"score":0.3750999867916107},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2777438270","wikidata":"https://www.wikidata.org/wiki/Q5248564","display_name":"Debridement (dental)","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2781343496","wikidata":"https://www.wikidata.org/wiki/Q1178507","display_name":"Osteitis","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.2854999899864197},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C2775956843","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Septic arthritis","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C2777556957","wikidata":"https://www.wikidata.org/wiki/Q2377991","display_name":"Osteonecrosis of the jaw","level":4,"score":0.2587999999523163},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.2558000087738037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.014","doi":"https://doi.org/10.1302/1358-992x.2026.11.014","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406954953","https://openalex.org/W4409262743","https://openalex.org/W7165389819","https://openalex.org/W7171932738","https://openalex.org/W4389029713","https://openalex.org/W7140863988","https://openalex.org/W4406942808","https://openalex.org/W4414438392","https://openalex.org/W7131649100","https://openalex.org/W2732887588"],"abstract_inverted_index":{"Introduction":[0],"Doxycycline":[1,228,319],"is":[2],"not":[3,161],"internationally":[4],"used":[5],"as":[6,343],"an":[7],"oral":[8,66,306,346],"option":[9,348],"for":[10,36,160,231,286,290,349],"bone":[11,25],"and":[12,21,27,46,87,92,119,136,148,182,207,223],"joint":[13,43],"infection":[14,44,194],"(BJI)":[15],"compared":[16],"with":[17,49,105,179,336],"clindamycin,":[18],"co-trimoxazole,":[19],"fluoroquinolones,":[20],"rifampicin,":[22],"despite":[23],"favourable":[24],"penetration":[26],"tolerability.":[28,338],"This":[29,54],"study":[30,57],"aimed":[31],"to":[32,256,326],"evaluate":[33],"doxycycline":[34,106,342],"monotherapy":[35,107,320],"curative":[37],"treatment":[38,234,242],"of":[39,199,233,240],"BJI,":[40],"including":[41,175],"prosthetic":[42],"(PJI),":[45],"osteomyelitis":[47],"(OM)":[48],"or":[50,99,111,117,165],"without":[51],"metalwork.":[52],"Methods":[53],"retrospective":[55],"cohort":[56,252,261,266],"included":[58,141,157,172],"patients":[59,191,298],"aged":[60],"\u226514":[61],"years":[62],"from":[63],"a":[64,71,344],"prospective":[65],"antibiotic":[67,347],"therapy":[68],"database":[69],"at":[70,133,273],"specialist":[72],"orthopaedic":[73],"hospital":[74],"(May":[75],"2017-February":[76],"2025).":[77],"Inclusion":[78],"criteria":[79,164],"were:":[80,250],"diagnosed":[81],"BJI":[82,351],"(PJI":[83],"per":[84,101,124],"European":[85],"Bone":[86],"Joint":[88],"Infection":[89],"Society":[90],"[EBJIS]":[91],"International":[93],"Consensus":[94],"Meeting":[95],"[ICM]":[96],"2018":[97],"criteria,":[98],"OM":[100,178,184],"standard":[102],"criteria)":[103],"treated":[104],"(6":[108],"weeks":[109,113],"total,":[110],"12":[112],"following":[114],"single-stage":[115],"revision":[116],"debridement":[118],"implant":[120],"retention":[121],"(DAIR)).":[122],"As":[123],"the":[125],"OVIVA":[126,333],"study,":[127],"primary":[128],"outcome":[129],"was":[130,187,229],"definite":[131,247,323],"failure":[132,248,257,271,324],"42,":[134],"180,":[135],"365":[137,245,274],"days.":[138],"Secondary":[139],"outcomes":[140],"probable/possible":[142],"failure,":[143,288],"adverse":[144,291,301],"effects,":[145],"early":[146,287],"discontinuation":[147,280],"mortality.":[149],"Results":[150],"Of":[151],"214":[152],"screened":[153],"patients,":[154],"163":[155],"were":[156,202,214,276],"(51":[158],"excluded":[159],"meeting":[162],"diagnostic":[163],"being":[166],"on":[167],"combination":[168],"therapy/suppressive":[169],"regimen).":[170],"Diagnoses":[171],"PJI":[173,260],"(n=101,":[174],"25":[176],"megaprostheses),":[177],"metalwork":[180],"(n=39)":[181],"native":[183],"(n=23).":[185],"Surgery":[186],"performed":[188],"in":[189,204,209,236,282,330],"161/163":[190],"(98.8%).":[192],"Prior":[193],"episodes":[195],"affected":[196],"39.9%":[197],"(65/163)":[198],"patients.":[200],"Infections":[201],"polymicrobial":[203],"15.2%":[205],"(25/163)":[206],"culture-negative":[208],"5.5%":[210],"(9/163).":[211],"Main":[212],"pathogens":[213],"Staphylococcus":[215,219],"aureus":[216],"(68/163,":[217],"41.7%),":[218],"epidermidis":[220],"(46/163,":[221],"28.2%)":[222],"Cutibacterium":[224],"acnes":[225],"(34/163,":[226],"20.9%).":[227],"administered":[230],"\u226550%":[232],"duration":[235],"94.6%":[237],"(mean":[238,254],"82%":[239],"total":[241],"duration).":[243],"At":[244],"days,":[246],"rates":[249,272,325],"whole":[251],"21.9%":[253],"time":[255],"152":[258],"days);":[259,264],"27%":[262],"(215":[263],"non-PJI":[265],"14%":[267],"(163":[268],"days).":[269],"Probable/possible":[270],"days":[275],"4.8%":[277],"overall.":[278],"Early":[279],"occurred":[281],"6.1%":[283],"(n=10):":[284],"3":[285],"7":[289],"effects":[292,302],"(pruritus,":[293],"headache,":[294],"oesophagitis).":[295],"Twenty":[296],"further":[297],"had":[299],"mild":[300],"(13":[303],"gastrointestinal,":[304],"5":[305],"thrush,":[307],"4":[308],"liver":[309],"enzyme":[310],"elevations,":[311],"1":[312],"photosensitivity).":[313],"No":[314],"treatment-related":[315],"mortality":[316],"occurred.":[317],"Conclusions":[318],"demonstrated":[321],"comparable":[322],"historical":[327],"cohorts":[328],"(18.6%":[329],"previous":[331],"institutional":[332],"implementation":[334],"study),":[335],"good":[337],"These":[339],"findings":[340],"support":[341],"safe":[345],"Gram-positive":[350],"treatment.":[352]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
