{"id":"https://openalex.org/W7225428115","doi":"https://doi.org/10.1161/circ.154.suppl_1.14621","title":"Abstract 14621: Outcomes of Combined Catheter Ablation and Left Atrial Appendage Occlusion versus Left Atrial Appendage Occlusion Alone in Atrial Fibrillation: A Systematic Review and Meta-Analysis","display_name":"Abstract 14621: Outcomes of Combined Catheter Ablation and Left Atrial Appendage Occlusion versus Left Atrial Appendage Occlusion Alone in Atrial Fibrillation: A Systematic Review and Meta-Analysis","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225428115","doi":"https://doi.org/10.1161/circ.154.suppl_1.14621"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.14621","doi":"https://doi.org/10.1161/circ.154.suppl_1.14621","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.14621","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012815436","display_name":"Chaudhry Saad Sohail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaudhry Saad Sohail","raw_affiliation_strings":["Univ of Mississippi Med Cntr, Jackson, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Mississippi Med Cntr, Jackson, MS","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161037260","display_name":"Humna Raheem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Humna Raheem","raw_affiliation_strings":["Dow Univ of Health Sciences, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Univ of Health Sciences, Karachi, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107199524","display_name":"Kumail Mustafa Ali","orcid":"https://orcid.org/0009-0000-6896-2052","observed_orcids":["https://orcid.org/0009-0000-6896-2052"]},"institutions":[{"id":"https://openalex.org/I2801518632","display_name":"Jinnah Sindh Medical University","ror":"https://ror.org/010pmyd80","country_code":"PK","type":"education","lineage":["https://openalex.org/I2801518632"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Kumail Mustafa Ali","raw_affiliation_strings":["Jinnah Sindh Med Univ, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinnah Sindh Med Univ, Karachi, Pakistan","institution_ids":["https://openalex.org/I2801518632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153988899","display_name":"Ahmed Muneeb Rashid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ahmed Muneeb Rashid","raw_affiliation_strings":["Dow Univ of Health Sciencees, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Univ of Health Sciencees, Karachi, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027489725","display_name":"Mobin Kheirkhahan","orcid":"https://orcid.org/0000-0002-5094-6975","observed_orcids":["https://orcid.org/0000-0002-5094-6975"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mobin Kheirkhahan","raw_affiliation_strings":["Univ of Mississippi Med Cntr, Jackson, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Mississippi Med Cntr, Jackson, MS","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055608656","display_name":"Syed Sarmad Javaid","orcid":"https://orcid.org/0000-0001-9304-7200","observed_orcids":["https://orcid.org/0000-0001-9304-7200"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Sarmad Javaid","raw_affiliation_strings":["UMMC, Jackson, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMMC, Jackson, MS","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124229471","display_name":"Muzamil Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muzamil Hussain","raw_affiliation_strings":["Univ of Mississippi Med Cntr, Jackson, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Mississippi Med Cntr, Jackson, MS","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113026600","display_name":"Hafsa Azam","orcid":"https://orcid.org/0009-0007-6357-9389","observed_orcids":["https://orcid.org/0009-0007-6357-9389","https://orcid.org/0000-0002-4571-5005"]},"institutions":[{"id":"https://openalex.org/I2801518632","display_name":"Jinnah Sindh Medical University","ror":"https://ror.org/010pmyd80","country_code":"PK","type":"education","lineage":["https://openalex.org/I2801518632"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Hafsa Azam","raw_affiliation_strings":["Jinnah Sindh Med Univ, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinnah Sindh Med Univ, Karachi, Pakistan","institution_ids":["https://openalex.org/I2801518632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122826425","display_name":"Michael E. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E Hall","raw_affiliation_strings":["Univ of Mississippi Med Cntr, Madison, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Mississippi Med Cntr, Madison, MS","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006797434","display_name":"Mubbasher Ameer Syed","orcid":"https://orcid.org/0000-0002-8512-8104","observed_orcids":["https://orcid.org/0000-0002-8512-8104"]},"institutions":[{"id":"https://openalex.org/I4405262556","display_name":"HCA Florida Orange Park Hospital","ror":"https://ror.org/040eafj92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801024494","https://openalex.org/I4405262556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mubbasher Syed","raw_affiliation_strings":["HCA Orange Park Florida Hosp, Orange Park, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HCA Orange Park Florida Hosp, Orange Park, FL","institution_ids":["https://openalex.org/I4405262556"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/left-atrial-appendage-occlusion","display_name":"left atrial appendage closure","score":0.9589999914169312},{"id":"https://openalex.org/keywords/catheter-ablation","display_name":"catheter ablation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peri-device-leak","display_name":"peri-device leak","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pericardial-effusion","display_name":"pericardial effusion","score":0.9200000166893005},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.7689999938011169},{"id":"https://openalex.org/keywords/device-related-thrombus","display_name":"device-related thrombus","score":0.7990000247955322},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.7239999771118164},{"id":"https://openalex.org/keywords/non-valvular-atrial-fibrillation","display_name":"non-valvular atrial fibrillation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7229999899864197},{"id":"https://openalex.org/keywords/procedural-safety","display_name":"procedural safety","score":0.3840000033378601},{"id":"https://openalex.org/keywords/thromboembolic-risk","display_name":"thromboembolic risk","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9603999853134155},{"id":"https://openalex.org/C2780434050","wikidata":"https://www.wikidata.org/wiki/Q6516934","display_name":"Left atrial appendage occlusion","level":4,"score":0.7936000227928162},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7087000012397766},{"id":"https://openalex.org/C2781175549","wikidata":"https://www.wikidata.org/wiki/Q1306218","display_name":"Pericardial effusion","level":2,"score":0.6815000176429749},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.6406999826431274},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.6171000003814697},{"id":"https://openalex.org/C2776131983","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Catheter ablation","level":3,"score":0.6166999936103821},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6152999997138977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5889999866485596},{"id":"https://openalex.org/C2910272107","wikidata":"https://www.wikidata.org/wiki/Q1615482","display_name":"Atrial Appendage","level":4,"score":0.5159000158309937},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.4668000042438507},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.4607999920845032},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.42989999055862427},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4171999990940094},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.40230000019073486},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.4009999930858612},{"id":"https://openalex.org/C41451933","wikidata":"https://www.wikidata.org/wiki/Q13415392","display_name":"Appendage","level":2,"score":0.3125},{"id":"https://openalex.org/C2778607678","wikidata":"https://www.wikidata.org/wiki/Q929313","display_name":"Cardiac tamponade","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C2780378346","wikidata":"https://www.wikidata.org/wiki/Q1349983","display_name":"Leak","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C2776494729","wikidata":"https://www.wikidata.org/wiki/Q1848900","display_name":"Contraindication","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.14621","doi":"https://doi.org/10.1161/circ.154.suppl_1.14621","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.14621","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7164393076","https://openalex.org/W4392563708","https://openalex.org/W4404363441","https://openalex.org/W7134957029","https://openalex.org/W7203576314","https://openalex.org/W7155363023","https://openalex.org/W1858712491","https://openalex.org/W7127575148","https://openalex.org/W2982872472","https://openalex.org/W4409510727"],"abstract_inverted_index":{"Background:":[0],"Atrial":[1],"fibrillation":[2],"(AF)":[3],"is":[4,16],"a":[5,157,199,321],"major":[6,140,222,296],"cause":[7],"of":[8,107,164,172,202,288],"thromboembolism,":[9],"and":[10,32,49,60,68,77,86,111,143,179,185,221,277,295,311,326,342],"left":[11,87,129,180,239,278,304],"atrial":[12,88,101,130,181,240,279,305],"appendage":[13,89,131,182,241,280,306],"occlusion":[14,90,183,281],"(LAAO)":[15],"an":[17],"established":[18],"strategy":[19],"for":[20,65,80],"stroke":[21,257],"prevention":[22],"in":[23,95,237],"selected":[24],"patients.":[25],"Catheter":[26],"ablation":[27,85,178,276],"(CA)":[28],"provides":[29],"rhythm":[30],"control,":[31],"performing":[33],"CA":[34,59],"concomitantly":[35],"with":[36,62,99,149,191,198,285,299,329,362],"LAAO":[37,61,64,94],"may":[38,333,365],"reduce":[39,334],"procedural":[40,324,327,335,343,356],"burden;":[41],"however,":[42],"its":[43],"impact":[44],"on":[45],"peri-device":[46,122,203,289,340],"seal,":[47],"efficacy,":[48],"safety":[50],"outcomes":[51,126],"remains":[52],"uncertain.":[53],"We":[54,72],"aimed":[55],"to":[56,373],"compare":[57,352],"concomitant":[58,83,176,194,330,353],"isolated":[63,93,188,192,300],"device-related,":[66],"safety,":[67],"clinical":[69],"outcomes.":[70],"Methods:":[71],"searched":[73],"PubMed,":[74],"Embase,":[75],"Scopus,":[76],"Cochrane":[78],"CENTRAL":[79],"studies":[81,104,169,348,370],"comparing":[82],"catheter":[84,177,275],"(CA+LAAO)":[91,184,282],"versus":[92,354],"adults":[96],"(\u226518":[97],"years)":[98],"non-valvular":[100],"fibrillation.":[102],"Included":[103],"consisted":[105],"predominantly":[106],"retrospective":[108],"observational":[109],"cohorts,":[110],"no":[112],"randomized":[113,369],"controlled":[114],"trials":[115],"were":[116,154,170,233,314],"identified.":[117],"The":[118],"primary":[119],"outcome":[120],"was":[121,196,283],"leak":[123,204],"(PDL).":[124],"Secondary":[125],"included":[127,347],"complete":[128,238,303],"closure,":[132,307],"device-related":[133,249,308],"thrombus":[134,250],"(DRT),":[135],"pericardial":[136,211,291],"effusion":[137,212,292],"requiring":[138,213,293],"intervention,":[139,294],"bleeding,":[141],"stroke,":[142,310],"all-cause":[144,265],"mortality.":[145],"Risk":[146],"ratios":[147],"(RRs)":[148],"95%":[150,207,217,226,245,253,260,269],"confidence":[151],"intervals":[152],"(CIs)":[153],"calculated":[155],"using":[156],"random-effects":[158],"meta-analysis":[159],"model.":[160],"Results:":[161],"A":[162],"total":[163],"110,244":[165],"participants":[166],"from":[167],"7":[168],"included,":[171],"whom":[173],"2,784":[174],"underwent":[175,187],"107,460":[186],"LAAO.":[189],"Compared":[190],"LAAO,":[193,301],"CA+LAAO":[195],"associated":[197,284,361],"higher":[200,286],"rate":[201],"(RR":[205,215,224,243,251,258,267],"1.26,":[206],"CI":[208,218,227,246,254,261,270],"1.03-1.55;":[209],"p=0.02),":[210,220],"intervention":[214],"1.74,":[216],"1.11-2.73;":[219],"bleeding":[223,297],"1.63,":[225],"1.14-2.33;":[228],"p=0.008).":[229],"No":[230],"significant":[231],"differences":[232],"observed":[234],"between":[235,316,323],"groups":[236],"closure":[242],"0.96,":[244],"0.90-1.01;":[247],"p=0.13),":[248],"0.71,":[252],"0.37-1.36;":[255],"p=0.30),":[256],"0.63,":[259],"0.21-1.88;":[262],"p=0.41),":[263],"or":[264],"mortality":[266,312],"1.24,":[268],"0.50-3.08;":[271],"p=0.64).":[272],"Conclusion:":[273],"Concomitant":[274],"rates":[287,313],"leak,":[290],"compared":[298],"while":[302,337],"thrombus,":[309],"similar":[315],"groups.":[317],"These":[318],"findings":[319],"suggest":[320],"trade-off":[322],"efficiency":[325],"risk":[328],"CA+LAAO,":[331],"which":[332],"burden":[336],"modestly":[338],"compromising":[339],"seal":[341],"safety.":[344],"However,":[345],"the":[346,375],"did":[349],"not":[350],"directly":[351],"staged":[355],"strategies,":[357],"where":[358],"cumulative":[359],"risks":[360],"multiple":[363],"procedures":[364],"differ.":[366],"Further":[367],"prospective":[368],"are":[371],"needed":[372],"define":[374],"optimal":[376],"treatment":[377],"approach.":[378]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
