{"id":"https://openalex.org/W7225427643","doi":"https://doi.org/10.1007/s10735-026-11039-z","title":"Mechanism of Tongqiao Huashuan decoction regulating neuroinflammation and its effect on intestinal flora in vascular dementia rats","display_name":"Mechanism of Tongqiao Huashuan decoction regulating neuroinflammation and its effect on intestinal flora in vascular dementia rats","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225427643","doi":"https://doi.org/10.1007/s10735-026-11039-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42993338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743600"},"language":"en","primary_location":{"id":"doi:10.1007/s10735-026-11039-z","doi":"https://doi.org/10.1007/s10735-026-11039-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10735-026-11039-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10735-026-11039-z.pdf","source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10735-026-11039-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161043359","display_name":"Jing Cai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Cai","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075783520","display_name":"\u848b\u6653\u6e20","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282170","display_name":"Shizhen College of Guizhou University of Traditional Chinese Medicine","ror":"https://ror.org/05e2reg39","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405282170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqu Jiang","raw_affiliation_strings":["Shizhen College of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550200, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shizhen College of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550200, Guizhou Province, China","institution_ids":["https://openalex.org/I4405282170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147964454","display_name":"Shuyao Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110640572","display_name":"Guiyang College of Traditional Chinese Medicine","ror":"https://ror.org/02bb8n686","country_code":"CN","type":"education","lineage":["https://openalex.org/I110640572"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyao Yu","raw_affiliation_strings":["The First Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China","institution_ids":["https://openalex.org/I110640572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161085000","display_name":"Zhongsheng Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110640572","display_name":"Guiyang College of Traditional Chinese Medicine","ror":"https://ror.org/02bb8n686","country_code":"CN","type":"education","lineage":["https://openalex.org/I110640572"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongsheng Tang","raw_affiliation_strings":["Department of Anatomy, Guizhou University of Traditional Chinese Medicine, Guiyang City, 550000, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Guizhou University of Traditional Chinese Medicine, Guiyang City, 550000, Guizhou Province, China","institution_ids":["https://openalex.org/I110640572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161018413","display_name":"Shijie Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110640572","display_name":"Guiyang College of Traditional Chinese Medicine","ror":"https://ror.org/02bb8n686","country_code":"CN","type":"education","lineage":["https://openalex.org/I110640572"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Zhu","raw_affiliation_strings":["Department of Anatomy, Guizhou University of Traditional Chinese Medicine, Guiyang City, 550000, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Guizhou University of Traditional Chinese Medicine, Guiyang City, 550000, Guizhou Province, China","institution_ids":["https://openalex.org/I110640572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100597927","display_name":"Wenjing Huang","orcid":"https://orcid.org/0009-0007-1783-2531","observed_orcids":["https://orcid.org/0009-0007-1783-2531","https://orcid.org/0009-0006-3376-2812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjing Huang","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161108702","display_name":"Yuan Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Huang","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148479432","display_name":"Jing Cai","orcid":"https://orcid.org/0000-0002-0038-4310","observed_orcids":["https://orcid.org/0000-0002-0038-4310"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yuanhua Wu","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China. cjing0851@163.com"],"raw_orcid":"https://orcid.org/0000-0002-0038-4310","affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, 550001, Guizhou Province, China. cjing0851@163.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5148479432"],"corresponding_institution_ids":[],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9350000023841858},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hippocampal-neuroprotection","display_name":"hippocampal neuroprotection","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6990000009536743},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.6740000247955322},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6240000128746033},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.4300000071525574},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6039999723434448},{"id":"https://openalex.org/keywords/16s-rrna","display_name":"16S rRNA","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.5453000068664551},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49950000643730164},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4320000112056732},{"id":"https://openalex.org/C190409667","wikidata":"https://www.wikidata.org/wiki/Q1136912","display_name":"Decoction","level":2,"score":0.39820000529289246},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3935999870300293},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.38690000772476196},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.38580000400543213},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.37290000915527344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3646000027656555},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.34880000352859497},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3402000069618225},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3276999890804291},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3084000051021576},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28949999809265137},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.25380000472068787},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25220000743865967},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10735-026-11039-z","doi":"https://doi.org/10.1007/s10735-026-11039-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10735-026-11039-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10735-026-11039-z.pdf","source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},{"id":"pmid:42993338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42993338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular histology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13743600","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13743600/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Mol Histol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10735-026-11039-z","doi":"https://doi.org/10.1007/s10735-026-11039-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10735-026-11039-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10735-026-11039-z.pdf","source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225427643.pdf","grobid_xml":"https://content.openalex.org/works/W7225427643.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1991398699","https://openalex.org/W2300735552","https://openalex.org/W2531529425","https://openalex.org/W2796344372","https://openalex.org/W2802537586","https://openalex.org/W2966749056","https://openalex.org/W2979506777","https://openalex.org/W2982303713","https://openalex.org/W2990784894","https://openalex.org/W3018901764","https://openalex.org/W3111897458","https://openalex.org/W3159655893","https://openalex.org/W3193421084","https://openalex.org/W3194029913","https://openalex.org/W3213529963","https://openalex.org/W4200423719","https://openalex.org/W4210386120","https://openalex.org/W4220897376","https://openalex.org/W4281862380","https://openalex.org/W4296622584","https://openalex.org/W4297236086","https://openalex.org/W4300981633","https://openalex.org/W4389057299","https://openalex.org/W4402554705","https://openalex.org/W4405492630","https://openalex.org/W4408012301","https://openalex.org/W4414481278","https://openalex.org/W4415606337"],"related_works":["https://openalex.org/W3031413429","https://openalex.org/W4403561513","https://openalex.org/W2560224696","https://openalex.org/W4412392664","https://openalex.org/W4283010722","https://openalex.org/W4413117191","https://openalex.org/W2008991320","https://openalex.org/W2393293458","https://openalex.org/W4408720612","https://openalex.org/W2175486164"],"abstract_inverted_index":{"To":[0],"investigate":[1],"molecular":[2],"changes":[3],"associated":[4,270],"with":[5,46,172,196,271],"the":[6,20,93,102,126,137,197,264],"protective":[7,273],"effect":[8],"of":[9,34,104,139,245],"Tongqiao":[10],"Huashuan":[11],"Decoction":[12],"(THD)":[13],"in":[14,49,125,164,232,259,263],"vascular":[15],"dementia":[16],"(VD),":[17],"focusing":[18],"on":[19,29,183],"NF\u2011\u03baB\u2011related":[21],"inflammatory":[22,120],"response,":[23],"and":[24,59,82,88,123,128,132,145,185,192,214,248],"to":[25],"observe":[26],"its":[27],"influence":[28],"intestinal":[30,228],"flora.":[31],"The":[32],"components":[33],"THD":[35,165,217,226,236,253],"were":[36,71,90,179],"identified":[37],"using":[38,92],"Liquid":[39],"chromatography\u2011quadrupole":[40],"time\u2011of\u2011flight":[41],"tandem":[42],"mass":[43],"spectrometry":[44],"(LC\u2011Q\u2011TOF\u2011MS/MS)":[45],"electrospray":[47],"ionization":[48],"positive/negative":[50],"modes,":[51],"a":[52,60],"methanol\u20110.1%":[53],"formic":[54],"acid":[55],"gradient":[56],"mobile":[57],"phase,":[58],"C18":[61],"column":[62],"(1.7":[63],"\u03bcm,":[64],"2.1":[65],"\u00d7":[66],"100":[67,177],"mm).":[68],"Sprague\u2011Dawley":[69],"rats":[70,201],"divided":[72],"into":[73],"four":[74],"groups:":[75],"Sham,":[76],"VD,":[77],"VD":[78,200,233,260],"+":[79],"TCM":[80],"(THD),":[81],"VD+Donepezil":[83],"(donepezil":[84],"hydrochloride).":[85],"Spatial":[86],"learning":[87],"memory":[89],"assessed":[91],"Morris":[94],"Water":[95],"Maze.":[96],"Transmission":[97],"electron":[98],"microscopy":[99],"(TEM)":[100],"analyzed":[101,154],"ultrastructure":[103],"hippocampal":[105,206],"CA1":[106],"neurons.":[107],"Enzyme\u2011linked":[108],"immunosorbent":[109],"assay":[110],"(ELISA)":[111],"detected":[112,160],"interleukin\u20111\u03b2":[113],"(IL\u20111\u03b2),":[114],"tumor":[115],"necrosis":[116],"factor\u2011\u03b1":[117],"(TNF\u2011\u03b1),":[118],"macrophage":[119],"protein\u20112":[121],"(MIP\u20112),":[122],"IL\u20116":[124],"hippocampus":[127],"serum.":[129],"Immunohistochemistry":[130],"(IHC)":[131],"Western":[133],"blotting":[134],"(WB)":[135],"measured":[136],"expression":[138,244],"sirtuin":[140],"1":[141],"(SIRT1),":[142],"NF\u2011\u03baB,":[143],"caspase\u20111,":[144],"NOD\u2011like":[146],"receptor":[147],"protein":[148],"3":[149],"(NLRP3).":[150],"Fecal":[151],"flora":[152,229],"was":[153],"via":[155],"16S":[156],"rRNA":[157],"sequencing.":[158],"LC\u2011Q\u2011TOF\u2011MS/MS":[159],"998":[161],"chemical":[162],"constituents":[163,171],"extract.":[166],"Among":[167],"them,":[168],"24":[169],"high\u2011signal\u2011intensity":[170],"mass\u2011spectrometry":[173],"response":[174],"values":[175],">":[176],"000":[178],"tentatively":[180],"annotated":[181],"based":[182],"exact\u2011mass":[184],"MS/MS":[186],"fragmentation":[187],"matching":[188],"against":[189],"public":[190],"databases":[191],"published":[193],"literature.":[194],"Compared":[195],"Sham":[198],"group,":[199],"exhibited":[202],"longer":[203],"escape":[204],"latency,":[205],"neuronal":[207],"damage,":[208],"elevated":[209],"proinflammatory":[210],"factors,":[211],"upregulated":[212],"caspase\u20111/NLRP3/NF\u2011\u03baB,":[213],"downregulated":[215],"SIRT1/I\u03baB\u03b1.":[216],"treatment":[218],"reversed":[219],"these":[220],"VD\u2011induced":[221],"pathological":[222],"abnormalities.":[223],"In":[224],"addition,":[225],"restored":[227],"dysbiosis":[230],"observed":[231],"model":[234],"rats.":[235,261],"ameliorates":[237],"VD\u2011related":[238],"cognitive":[239],"dysfunction,":[240],"accompanied":[241],"by":[242],"altered":[243],"SIRT1/I\u03baB\u03b1/NF\u2011\u03baB\u2011related":[246],"proteins":[247],"reduced":[249],"pro\u2011inflammatory":[250],"cytokines.":[251],"Meanwhile,":[252],"can":[254],"restore":[255],"disturbed":[256],"gut":[257],"microbiota":[258],"Changes":[262],"SIRT1/I\u03baB\u03b1/NF\u2011\u03baB":[265],"signaling":[266],"cascade":[267],"are":[268],"therefore":[269],"THD\u2011mediated":[272],"outcomes.":[274]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}