{"id":"https://openalex.org/W7225425754","doi":"https://doi.org/10.64898/2026.11.05.764532","title":"Decoding the molecular cues regulating the transition of Influenza virus polymerase from transcriptase to replicase.","display_name":"Decoding the molecular cues regulating the transition of Influenza virus polymerase from transcriptase to replicase.","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225425754","doi":"https://doi.org/10.64898/2026.11.05.764532"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.764532","doi":"https://doi.org/10.64898/2026.11.05.764532","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764532","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764532.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764532.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018392464","display_name":"Aratrika De","orcid":"https://orcid.org/0000-0002-0398-5445","observed_orcids":["https://orcid.org/0000-0002-0398-5445"]},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aratrika De","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Indian Institute of Technology (IIT) Kharagpur, India, West Bengal, India;"],"raw_orcid":"https://orcid.org/0000-0002-0398-5445","affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Indian Institute of Technology (IIT) Kharagpur, India, West Bengal, India;","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073711229","display_name":"Arunava Roy","orcid":"https://orcid.org/0000-0002-8486-0539","observed_orcids":["https://orcid.org/0000-0002-8486-0539"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arunava Roy","raw_affiliation_strings":["Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, Louisiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8486-0539","affiliations":[{"raw_affiliation_string":"Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, Louisiana, United States of America","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087648504","display_name":"Arindam Mondal","orcid":"https://orcid.org/0000-0001-7991-5809","observed_orcids":["https://orcid.org/0000-0001-7991-5809"]},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Arindam Mondal","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Indian Institute of Technology (IIT) Kharagpur, India, West Bengal, India;"],"raw_orcid":"https://orcid.org/0000-0001-7991-5809","affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Indian Institute of Technology (IIT) Kharagpur, India, West Bengal, India;","institution_ids":["https://openalex.org/I145894827"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087648504"],"corresponding_institution_ids":["https://openalex.org/I145894827"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pb2-protein","display_name":"PB2 protein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/salt-bridges","display_name":"salt bridges","score":0.8029999732971191},{"id":"https://openalex.org/keywords/interdomain-interactions","display_name":"domain-domain interactions","score":0.6980000138282776},{"id":"https://openalex.org/keywords/serine-substitution","display_name":"serine substitution","score":0.6200000047683716},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.8371000289916992},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.599399983882904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5490999817848206},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5467000007629395},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.45840001106262207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44620001316070557},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.4205000102519989},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4196999967098236},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.4101000130176544},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4002000093460083},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.3950999975204468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C68434959","wikidata":"https://www.wikidata.org/wiki/Q1908996","display_name":"Viral matrix protein","level":3,"score":0.33660000562667847},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2928999960422516},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.2904999852180481},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.28529998660087585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28529998660087585},{"id":"https://openalex.org/C10852380","wikidata":"https://www.wikidata.org/wiki/Q7933613","display_name":"Viral structural protein","level":5,"score":0.2587999999523163},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.25380000472068787},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2522999942302704},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.764532","doi":"https://doi.org/10.64898/2026.11.05.764532","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764532","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764532.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.764532","doi":"https://doi.org/10.64898/2026.11.05.764532","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764532","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764532.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7056019243","display_name":null,"funder_award_id":"CRG/2022/003628","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320306227","display_name":"Arthritis National Research Foundation","ror":"https://ror.org/03abbex33"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320325376","display_name":"Department of Science and Technology, Government of West Bengal","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320333109","display_name":"Morsani College of Medicine","ror":null},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225425754.pdf","grobid_xml":"https://content.openalex.org/works/W7225425754.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2888931739","https://openalex.org/W7161624220"],"related_works":["https://openalex.org/W3081724017","https://openalex.org/W4385197457","https://openalex.org/W4391531332","https://openalex.org/W2238439239","https://openalex.org/W2151568253","https://openalex.org/W3083493094","https://openalex.org/W3152713887","https://openalex.org/W2940065515","https://openalex.org/W3044925703","https://openalex.org/W4206234411"],"abstract_inverted_index":{"Influenza":[0],"virus":[1,213],"polymerase":[2,29,101,122,138,172],"(FluPol)":[3],"dynamically":[4],"transitions":[5,190],"between":[6,77],"distinct":[7,41],"conformational":[8,173,189],"states":[9,43],"to":[10,44],"coordinate":[11],"viral":[12],"gene":[13],"transcription":[14],"and":[15,26,33,55,80,103,112,126,175,191],"genome":[16,32],"replication.":[17,36,128],"While":[18],"vRNP-associated":[19],"monomeric":[20],"FluPol":[21,38],"supports":[22],"transcription,":[23],"ANP32-dependent":[24],"asymmetric":[25],"ANP32-independent":[27],"symmetric":[28],"dimers":[30],"mediate":[31],"antigenome":[34],"(vRNA/cRNA)":[35],"How":[37],"coordinates":[39],"these":[40,131,163],"functional":[42],"maintain":[45],"the":[46,63,66,83,87,157,205],"transcription-replication":[47,192],"balance":[48,193],"remains":[49],"poorly":[50],"understood.":[51],"Here,":[52],"we":[53],"identify":[54],"characterize":[56],"interdomain":[57,184],"interactions":[58],"within":[59,186],"PB2":[60,78,187],"that":[61,151,170],"govern":[62],"stability":[64],"of":[65,69,90,159,194,207,211],"replication-competent":[67],"conformation":[68],"FluPol.":[70],"Specifically,":[71],"a":[72,166,182,208],"highly":[73],"conserved":[74,183],"salt":[75],"bridge":[76],"Mid-E282":[79],"NLS-K752":[81],"stabilizes":[82],"replicase":[84],"conformation,":[85],"while":[86],"charge":[88,161],"state":[89],"residue":[91],"627":[92],"(E":[93],"or":[94],"K)":[95],"dictates":[96],"ANP32":[97,124],"engagement,":[98],"together":[99],"coordinating":[100],"dimerization":[102],"replication":[104],"activity.":[105],"Strikingly,":[106],"bat":[107],"influenza":[108,212],"A":[109],"viruses":[110],"H17N10":[111],"H18N11":[113],"harbor":[114],"unconventional":[115],"serine":[116],"substitutions":[117,133],"at":[118,142,162],"both":[119,143],"positions,":[120],"compromising":[121],"dimerization,":[123],"interaction,":[125],"vRNA/cRNA":[127],"Remarkably,":[129],"introducing":[130],"bat-signature":[132],"(E282S/K627S)":[134],"into":[135],"human":[136,146],"H1N1":[137],"results":[139],"in":[140,145],"phosphorylation":[141,152],"positions":[144],"cells.":[147],"These":[148],"findings":[149],"suggest":[150],"can":[153],"partially":[154],"compensate":[155],"for":[156],"loss":[158],"negative":[160],"residues,":[164],"revealing":[165],"phosphomimetic":[167,202],"adaptation":[168],"mechanism":[169],"modulates":[171],"dynamics":[174],"function.":[176],"Collectively,":[177],"our":[178],"study":[179],"reveals":[180],"how":[181],"interaction":[185],"regulates":[188],"FluPol,":[195],"which":[196],"might":[197],"have":[198],"been":[199],"driven":[200],"by":[201],"adaptations":[203],"during":[204],"course":[206],"diverse":[209],"range":[210],"evolution.":[214]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
