{"id":"https://openalex.org/W7225425014","doi":"https://doi.org/10.1021/acsomega.6c08821","title":"Pharmaceutical Salt Formation as a Strategy to Enhance In Situ Drug Loading into Apatite-Based Materials","display_name":"Pharmaceutical Salt Formation as a Strategy to Enhance In Situ Drug Loading into Apatite-Based Materials","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225425014","doi":"https://doi.org/10.1021/acsomega.6c08821"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c08821","doi":"https://doi.org/10.1021/acsomega.6c08821","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c08821","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c08821/69110275/acsomega.6c08821.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c08821/69110275/acsomega.6c08821.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049199328","display_name":"Francisco Javier Acebedo-Mart\u00ednez","orcid":"https://orcid.org/0000-0001-9486-2645","observed_orcids":["https://orcid.org/0000-0001-9486-2645"]},"institutions":[{"id":"https://openalex.org/I4210097224","display_name":"Institute of Nanostructured Materials","ror":"https://ror.org/00w6r1881","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097224","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francisco Javier Acebedo-Marti\u0301nez","raw_affiliation_strings":["Istituto per lo Studio dei Materiali Nanostrutturati (ISMN)-Consiglio Nazionale Delle Ricerche (CNR) , Via P. Gobetti 101 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto per lo Studio dei Materiali Nanostrutturati (ISMN)-Consiglio Nazionale Delle Ricerche (CNR) , Via P. Gobetti 101 , ,","institution_ids":["https://openalex.org/I4210097224","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065086080","display_name":"Carolina Alarc\u00f3n-Payer","orcid":"https://orcid.org/0000-0001-5836-1050","observed_orcids":["https://orcid.org/0000-0001-5836-1050"]},"institutions":[{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carolina Alarco\u0301n-Payer","raw_affiliation_strings":["Hospital Universitario Virgen de las Nieves , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Virgen de las Nieves , , ,","institution_ids":["https://openalex.org/I4210116170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091353739","display_name":"Alicia Dom\u00ednguez\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0001-8669-6712","observed_orcids":["https://orcid.org/0000-0001-8669-6712"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alicia Domi\u0301nguez-Marti\u0301n","raw_affiliation_strings":["University of Granada , , ,"],"raw_orcid":"https://orcid.org/0000-0001-8669-6712","affiliations":[{"raw_affiliation_string":"University of Granada , , ,","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032730516","display_name":"Antonio Frontera","orcid":"https://orcid.org/0000-0001-7840-2139","observed_orcids":["https://orcid.org/0000-0001-7840-2139"]},"institutions":[{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Frontera","raw_affiliation_strings":["Universitat de les Illes Balears , , Crta. de Valldemossa km 7.5 , ,"],"raw_orcid":"https://orcid.org/0000-0001-7840-2139","affiliations":[{"raw_affiliation_string":"Universitat de les Illes Balears , , Crta. de Valldemossa km 7.5 , ,","institution_ids":["https://openalex.org/I50441567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078270809","display_name":"Jaime G\u00f3mez\u2010Morales","orcid":"https://orcid.org/0000-0002-9395-7797","observed_orcids":["https://orcid.org/0000-0002-9395-7797"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210095677","display_name":"Instituto Andaluz de Ciencias de la Tierra","ror":"https://ror.org/00v0g9w49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095677"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jaime Go\u0301mez-Morales","raw_affiliation_strings":["IACT-CSIC , , Avda. de las Palmeras 4 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IACT-CSIC , , Avda. de las Palmeras 4 , ,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210095677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146616283","display_name":"Marisa M. Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marisa M. Morales","raw_affiliation_strings":["University of Granada , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Granada , , ,","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022310387","display_name":"Sara Rojas","orcid":"https://orcid.org/0000-0002-7874-2122","observed_orcids":["https://orcid.org/0000-0002-7874-2122"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sara Rojas","raw_affiliation_strings":["University of Granada , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7874-2122","affiliations":[{"raw_affiliation_string":"University of Granada , , ,","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091147103","display_name":"Duane Choquesillo\u2010Lazarte","orcid":"https://orcid.org/0000-0002-7077-8972","observed_orcids":["https://orcid.org/0000-0002-7077-8972"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210095677","display_name":"Instituto Andaluz de Ciencias de la Tierra","ror":"https://ror.org/00v0g9w49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095677"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Duane Choquesillo-Lazarte","raw_affiliation_strings":["IACT-CSIC , , Avda. de las Palmeras 4 , ,"],"raw_orcid":"https://orcid.org/0000-0002-7077-8972","affiliations":[{"raw_affiliation_string":"IACT-CSIC , , Avda. de las Palmeras 4 , ,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210095677"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5049199328","https://openalex.org/A5078270809","https://openalex.org/A5091147103"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210095677","https://openalex.org/I4210097224","https://openalex.org/I4210155236"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dexketoprofen","display_name":"dexketoprofen","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-solubility-enhancement","display_name":"drug solubility enhancement","score":0.7570000290870667},{"id":"https://openalex.org/keywords/ph-dependent-drug-release","display_name":"pH-dependent drug release","score":0.7059999704360962},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C2777746296","wikidata":"https://www.wikidata.org/wiki/Q178397","display_name":"Apatite","level":2,"score":0.7900000214576721},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.722000002861023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6805999875068665},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6184999942779541},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5307999849319458},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.5098999738693237},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.45750001072883606},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.3767000138759613},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.36340001225471497},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3416000008583069},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3301999866962433},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsomega.6c08821","doi":"https://doi.org/10.1021/acsomega.6c08821","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c08821","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c08821/69110275/acsomega.6c08821.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c08821","doi":"https://doi.org/10.1021/acsomega.6c08821","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c08821","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c08821/69110275/acsomega.6c08821.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1272900390","display_name":null,"funder_award_id":"PID2023","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G3172037162","display_name":null,"funder_award_id":"PID2020-115637GB-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3821589238","display_name":null,"funder_award_id":"PID2023-151538NB-I00","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4337418631","display_name":null,"funder_award_id":"FQM-283","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G5635532810","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G5660714196","display_name":null,"funder_award_id":"PID2023-151538NB-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G6010635150","display_name":null,"funder_award_id":"PID2023-151538NB-I00","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G6422428231","display_name":null,"funder_award_id":"PF-01","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G6731524417","display_name":null,"funder_award_id":"PID2020","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G7805626310","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8744161295","display_name":null,"funder_award_id":"HORIZON-MSCA-2024-PF-01","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G8806739147","display_name":null,"funder_award_id":"HORIZON-MSCA-2024-PF-01-01","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G94776570","display_name":null,"funder_award_id":"PID2020\u2013115637GB-I00","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G997863397","display_name":null,"funder_award_id":"PID2020-115637GB-I00","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225425014.pdf","grobid_xml":"https://content.openalex.org/works/W7225425014.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1963488568","https://openalex.org/W1966949133","https://openalex.org/W1981111904","https://openalex.org/W1981368803","https://openalex.org/W1982475454","https://openalex.org/W1988091937","https://openalex.org/W1992964622","https://openalex.org/W2001454290","https://openalex.org/W2005895791","https://openalex.org/W2007543270","https://openalex.org/W2051469879","https://openalex.org/W2080481030","https://openalex.org/W2092157292","https://openalex.org/W2092414695","https://openalex.org/W2104919283","https://openalex.org/W2121444977","https://openalex.org/W2126437802","https://openalex.org/W2148941593","https://openalex.org/W2322282453","https://openalex.org/W2335434301","https://openalex.org/W2338444201","https://openalex.org/W2566345673","https://openalex.org/W2626916274","https://openalex.org/W2768732998","https://openalex.org/W2783752292","https://openalex.org/W2886483335","https://openalex.org/W3001909770","https://openalex.org/W3102323169","https://openalex.org/W3118330034","https://openalex.org/W3130309548","https://openalex.org/W3187334817","https://openalex.org/W3197859688","https://openalex.org/W3207254605","https://openalex.org/W3213042299","https://openalex.org/W4205567487","https://openalex.org/W4211216582","https://openalex.org/W4224240443","https://openalex.org/W4282940769","https://openalex.org/W4301393451","https://openalex.org/W4306725817","https://openalex.org/W4313423897","https://openalex.org/W4319027029","https://openalex.org/W4319600005","https://openalex.org/W4323568352","https://openalex.org/W4366371727","https://openalex.org/W4381847987","https://openalex.org/W4386154688","https://openalex.org/W4389857626","https://openalex.org/W4389893422","https://openalex.org/W4391310903","https://openalex.org/W4396560181","https://openalex.org/W4401863072","https://openalex.org/W4402740563","https://openalex.org/W4403875034","https://openalex.org/W4407038104","https://openalex.org/W4408404616","https://openalex.org/W4409780888"],"related_works":["https://openalex.org/W4409780888","https://openalex.org/W3038986235","https://openalex.org/W2036367168","https://openalex.org/W3085885928","https://openalex.org/W4405702084","https://openalex.org/W4313466271","https://openalex.org/W7172204213","https://openalex.org/W4414813308","https://openalex.org/W2895703405","https://openalex.org/W4286252267"],"abstract_inverted_index":{"Abstract":[0],"Water-based":[1],"loading":[2,57,83],"is":[3,177],"attractive":[4],"for":[5,91],"pharmaceutical":[6,48,174],"and":[7,10,54,67,73,81,115,126,134,150,157],"industrial":[8],"applications":[9],"helps":[11],"prevent":[12],"damage":[13],"to":[14,50,104,142,181],"drug":[15,82],"carriers;":[16],"however,":[17],"the":[18,42,77,92,109,121,130,135,138,143,183],"poor":[19],"aqueous":[20,79],"solubility":[21,53,80],"of":[22,44,124,137,146,185],"many":[23],"APIs,":[24],"such":[25],"as":[26],"ciprofloxacin":[27],"(CIP),":[28],"limits":[29],"their":[30],"incorporation":[31,123,184],"into":[32,58,189],"these":[33,37,170],"systems.":[34],"To":[35],"overcome":[36],"limitations,":[38],"this":[39],"work":[40],"explores":[41],"use":[43],"a":[45],"ciprofloxacin\u2013dexketoprofen":[46],"(CIP\u2013DKT)":[47],"salt":[49,175],"improve":[51],"API":[52,155],"in":[55],"situ":[56],"sensitive":[59,190],"apatite":[60,64,95,113,132],"platforms,":[61],"including":[62],"biomimetic":[63,131],"nanoparticles":[65],"(Ap)":[66],"apatite-mineralized":[68],"eggshell":[69],"membranes":[70],"(ApESM).":[71],"Computational":[72],"solid-state":[74],"characterization":[75],"rationalized":[76],"improved":[78,165],"observed":[84],"with":[85,164],"CIP\u2013DKT.":[86],"CIP":[87,125],"showed":[88],"higher":[89],"affinity":[90,101],"negatively":[93],"charged":[94],"surface,":[96],"whereas":[97],"DKT":[98,127],"displayed":[99],"lower":[100],"and,":[102],"due":[103,141],"its":[105],"acidic":[106],"nature,":[107],"altered":[108],"synthesis":[110],"pH,":[111],"affecting":[112],"morphology":[114,133],"ESM":[116],"mineralization.":[117],"Interestingly,":[118],"CIP\u2013DKT":[119],"enabled":[120],"simultaneous":[122],"while":[128],"preserving":[129],"mineralization":[136],"ESMs,":[139],"likely":[140],"buffering":[144],"effect":[145],"CIP.":[147],"Final":[148],"HPLC":[149],"antibacterial":[151,159],"assays":[152],"confirmed":[153],"pH-dependent":[154],"release":[156],"sustained":[158],"activity":[160],"against":[161],"Escherichia":[162],"coli,":[163],"diffusion":[166],"from":[167],"ApESM\u2013CIP\u2013DKT.":[168],"Overall,":[169],"results":[171],"demonstrate":[172],"that":[173],"formation":[176],"an":[178],"efficient":[179],"strategy":[180],"enhance":[182],"poorly":[186],"soluble":[187],"APIs":[188],"materials":[191],"under":[192],"water-based":[193],"processing":[194],"conditions.":[195]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}