{"id":"https://openalex.org/W7225424281","doi":"https://doi.org/10.1302/1358-992x.2026.11.047","title":"DYNAMIC ASSESSMENT OF CEFEPIME/ENMETAZOBACTAM CONCENTRATIONS IN MEDULLA SPINALIS, THE SUBARACHNOID AND EPIDURAL SPACE: AN EXPERIMENTAL PORCINE STUDY","display_name":"DYNAMIC ASSESSMENT OF CEFEPIME/ENMETAZOBACTAM CONCENTRATIONS IN MEDULLA SPINALIS, THE SUBARACHNOID AND EPIDURAL SPACE: AN EXPERIMENTAL PORCINE STUDY","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225424281","doi":"https://doi.org/10.1302/1358-992x.2026.11.047"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.047","doi":"https://doi.org/10.1302/1358-992x.2026.11.047","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.047","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110274656","display_name":"Maria Bech Damsgaard Nielsen","orcid":"https://orcid.org/0000-0002-4183-5958","observed_orcids":["https://orcid.org/0000-0002-4183-5958"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maria Bech Damsgaard Nielsen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104388953","display_name":"Mads Kristian Duborg Mikkelsen","orcid":"https://orcid.org/0009-0005-1688-954X","observed_orcids":["https://orcid.org/0009-0005-1688-954X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mads Kristian Duborg Mikkelsen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032653608","display_name":"Hans Christian Rasmussen","orcid":"https://orcid.org/0000-0001-9101-9302","observed_orcids":["https://orcid.org/0000-0001-9101-9302"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hans Christian Rasmussen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053955789","display_name":"Magnus Andreas Hvistendahl","orcid":"https://orcid.org/0000-0002-4086-0238","observed_orcids":["https://orcid.org/0000-0002-4086-0238"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Magnus Andreas Hvistendahl","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053386127","display_name":"Josefine Slater","orcid":"https://orcid.org/0000-0002-3589-2278","observed_orcids":["https://orcid.org/0000-0002-3589-2278"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Josefine Slater","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060451952","display_name":"Kresten Wendell Rickers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kresten Wendell Rickers","raw_affiliation_strings":["Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161091981","display_name":"Haisheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Haisheng Li","raw_affiliation_strings":["Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036124188","display_name":"Christoph Crocoll","orcid":"https://orcid.org/0000-0003-2754-3518","observed_orcids":["https://orcid.org/0000-0003-2754-3518"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christoph Crocoll","raw_affiliation_strings":["Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084624554","display_name":"Michal Poborsky","orcid":"https://orcid.org/0000-0002-7105-3316","observed_orcids":["https://orcid.org/0000-0002-7105-3316"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michal Poborsky","raw_affiliation_strings":["Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059783402","display_name":"Nis Pedersen J\u00f8rgensen","orcid":"https://orcid.org/0000-0002-6153-2604","observed_orcids":["https://orcid.org/0000-0002-6153-2604"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nis Pedersen J\u00f8rgensen","raw_affiliation_strings":["Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Danmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135213504","display_name":"Alex Soriano","orcid":"https://orcid.org/0000-0002-9374-0811","observed_orcids":["https://orcid.org/0000-0002-9374-0811"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alex Soriano","raw_affiliation_strings":["Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Hospital Cl\u00ednic of Barcelona, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067993090","display_name":"Maiken Stilling","orcid":"https://orcid.org/0000-0002-4530-2075","observed_orcids":["https://orcid.org/0000-0002-4530-2075"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maiken Stilling","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004660859","display_name":"Mats Bue","orcid":"https://orcid.org/0000-0001-7215-8323","observed_orcids":["https://orcid.org/0000-0001-7215-8323"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mats Bue","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Danmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subarachnoid-space","display_name":"subarachnoid space","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epidural-space","display_name":"epidural space","score":0.9990000128746033},{"id":"https://openalex.org/keywords/unbound-drug-concentration","display_name":"unbound drug concentration","score":0.6520000100135803},{"id":"https://openalex.org/keywords/esbl-producing-enterobacterales","display_name":"ESBL-producing Enterobacteriaceae","score":0.8149999976158142},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.6449999809265137},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.6620000004768372},{"id":"https://openalex.org/keywords/short-term-infusion","display_name":"short-term infusion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/target-attainment","display_name":"target attainment","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.6909999847412109},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.7360000014305115},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8942000269889832},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.8537999987602234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8007000088691711},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7639999985694885},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.590399980545044},{"id":"https://openalex.org/C2777050379","wikidata":"https://www.wikidata.org/wiki/Q2552927","display_name":"Cefepime","level":5,"score":0.5641000270843506},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.367000013589859},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.36149999499320984},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3206999897956848},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.047","doi":"https://doi.org/10.1302/1358-992x.2026.11.047","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.047","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7205326689","https://openalex.org/W7161776568","https://openalex.org/W4415871685","https://openalex.org/W2046547277","https://openalex.org/W7124720151","https://openalex.org/W3014752593","https://openalex.org/W2102013604","https://openalex.org/W3014294254","https://openalex.org/W3093201596","https://openalex.org/W79484858"],"abstract_inverted_index":{"Background":[0],"Central":[1],"nervous":[2],"system":[3],"(CNS)":[4],"infections":[5,319],"caused":[6,320],"by":[7,112,147,321],"ESBL-producing":[8,322],"Enterobacterales":[9],"are":[10],"associated":[11],"with":[12],"high":[13],"morbidity":[14],"and":[15,57,76,119,129,139,145,176,188,209,214,234,254,279,292],"risk":[16],"of":[17,55,90,103,157,201,297,299,317],"therapeutic":[18],"failure.":[19],"While":[20],"several":[21],"newer":[22],"\u03b2-lactam/\u03b2-lactamase":[23],"inhibitor":[24],"combinations":[25],"have":[26,41],"shown":[27],"encouraging":[28],"activity":[29],"against":[30],"gram-negative":[31],"CNS":[32,40,68,318],"infections,":[33],"pharmacokinetic":[34,167,269],"data":[35,189,270],"for":[36,169,173,179,211,308,312],"cefepime/enmetazobactam":[37,91,272,313],"from":[38,190,207,230,250,255],"the":[39,52,73,77,135,155,158,186,203,212,222,226,242,246,266,275,286,289,293,315],"not":[42],"previously":[43],"been":[44],"described.":[45],"Methods":[46],"Microdialysis":[47,62,128],"was":[48,152],"employed":[49],"to":[50,84],"quantify":[51],"unbound":[53],"concentrations":[54,163],"cefepime":[56],"enmetazobactam":[58,180],"following":[59],"intravenous":[60],"administration.":[61,300],"catheters":[63,192],"were":[64,82,132,193,283],"placed":[65],"in":[66,285,314],"three":[67,123],"compartments:":[69],"The":[70],"medulla":[71,287],"spinalis,":[72,288],"subarachnoid":[74,290],"space,":[75,295],"epidural":[78,294],"space.":[79],"Sixteen":[80],"pigs":[81,184],"randomised":[83],"receive":[85],"either":[86],"a":[87,305],"short-term":[88],"infusion":[89,100],"(2":[92],"g/0.5":[93,105],"g":[94,106,115],"over":[95,108,116],"2":[96,177],"h)":[97,138,142],"or":[98],"continuous":[99],"(initial":[101],"dosage":[102],"1":[104,113],"administered":[107],"15":[109],"min":[110],"followed":[111],"g/0.25":[114],"7":[117],"h":[118,125],"45":[120],"min)":[121],"during":[122,134,161],"8":[124],"dosing":[126,143,159,216,224,244,310],"intervals.":[127],"plasma":[130],"samples":[131],"collected":[133],"first":[136,213,223,267],"(0-8":[137],"third":[140,215,243],"(16-24":[141],"interval":[144,160],"quantified":[146],"LC\u2013MS/MS.":[148],"Pharmacokinetic":[149],"target":[150,281],"attainment":[151],"evaluated":[153],"as":[154],"percentage":[156],"which":[162],"exceeded":[164],"clinically":[165],"relevant":[166],"targets":[168],"Enterobacterales;":[170],"4":[171],"mg/L":[172,178],"Cefepime":[174],"(T>MIC4)":[175],"(T>Cthreshold2).":[181],"Results":[182],"All":[183],"completed":[185],"study,":[187],"44/48":[191],"collected.":[194],"For":[195,219],"cefepime:":[196],"In":[197,221,241],"all":[198,239,260],"compartments,":[199],"regardless":[200],"administration,":[202],"mean":[204,227,247],"T>MIC4":[205],"ranged":[206,229,249],"98-100%":[208],"97-100%":[210],"interval,":[217,225,245],"respectively.":[218],"enmetazobactam:":[220],"T>Cthreshold2":[228,248],"82-99%":[231],"(short-term":[232,252],"infusion)":[233,237,258],"96-100%":[235],"(continuous":[236,257],"across":[238,259],"compartments.":[240,261],"85-100%":[251],"infusion),":[253],"89-100%":[256],"Conclusions":[262],"This":[263],"study":[264],"presents":[265],"dynamic":[268],"on":[271],"penetration":[273],"into":[274],"CNS.":[276],"High":[277],"T>MIC":[278],"T>Cthreshold":[280],"attainments":[282],"achieved":[284],"space":[291],"irrespective":[296],"mode":[298],"These":[301],"novel":[302],"findings":[303],"offer":[304],"quantitative":[306],"foundation":[307],"optimising":[309],"strategies":[311],"management":[316],"Enterobacterales.":[323]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}