{"id":"https://openalex.org/W7225424124","doi":"https://doi.org/10.1016/j.bbii.2026.100205","title":"A vagal\u2013immune convergence framework for the autonomic, peripheral immune and central neuroimmune effects of meditation","display_name":"A vagal\u2013immune convergence framework for the autonomic, peripheral immune and central neuroimmune effects of meditation","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225424124","doi":"https://doi.org/10.1016/j.bbii.2026.100205"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbii.2026.100205","doi":"https://doi.org/10.1016/j.bbii.2026.100205","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbii.2026.100205","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2949834126000577/pdf","source":{"id":"https://openalex.org/S4387285536","display_name":"Brain Behavior and Immunity Integrative","issn_l":"2949-8341","issn":["2949-8341"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Behavior and Immunity Integrative","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2949834126000577/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136854652","display_name":"Siddhant Nikam","orcid":"https://orcid.org/0009-0007-5330-7881","observed_orcids":["https://orcid.org/0009-0007-5330-7881"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Siddhant Nikam","raw_affiliation_strings":["Sere\u00f1y\u0101 Osteopathy & Holistic Wellness, A-171, South City, Raibareli Road, Lucknow 226025, Uttar Pradesh, India"],"raw_orcid":"https://orcid.org/0009-0007-5330-7881","affiliations":[{"raw_affiliation_string":"Sere\u00f1y\u0101 Osteopathy & Holistic Wellness, A-171, South City, Raibareli Road, Lucknow 226025, Uttar Pradesh, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136818895","display_name":"Nimisha Shankar Narayan","orcid":"https://orcid.org/0009-0002-1875-951X","observed_orcids":["https://orcid.org/0009-0002-1875-951X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nimisha S. Narayan","raw_affiliation_strings":["Sere\u00f1y\u0101 Osteopathy & Holistic Wellness, A-171, South City, Raibareli Road, Lucknow 226025, Uttar Pradesh, India"],"raw_orcid":"https://orcid.org/0009-0002-1875-951X","affiliations":[{"raw_affiliation_string":"Sere\u00f1y\u0101 Osteopathy & Holistic Wellness, A-171, South City, Raibareli Road, Lucknow 226025, Uttar Pradesh, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5136854652"],"corresponding_institution_ids":[],"apc_list":{"value":2570,"currency":"USD","value_usd":2570},"apc_paid":{"value":2570,"currency":"USD","value_usd":2570},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"100205","last_page":"100205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10708","display_name":"Mindfulness and Compassion Interventions","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10708","display_name":"Mindfulness and Compassion Interventions","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.4350999891757965,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meditation","display_name":"meditation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroimmune-mechanisms","display_name":"neuroimmune mechanisms","score":0.609000027179718},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"vagus nerve","score":0.8980000019073486},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.6449999809265137},{"id":"https://openalex.org/keywords/neurovisceral-integration","display_name":"neurovisceral integration","score":0.7540000081062317},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4860000014305115},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8320000171661377},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8159999847412109},{"id":"https://openalex.org/keywords/alpha7-nicotinic-acetylcholine-receptor","display_name":"alpha7 nicotinic acetylcholine receptor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.6880000233650208},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.8579999804496765},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.41600000858306885},{"id":"https://openalex.org/keywords/focused-attention","display_name":"focused attention","score":0.5649999976158142},{"id":"https://openalex.org/keywords/loving-kindness-meditation","display_name":"loving-kindness meditation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/slow-breathing","display_name":"slow-paced breathing","score":0.6899999976158142},{"id":"https://openalex.org/keywords/mantra-meditation","display_name":"mantra meditation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8270000219345093},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.6759999990463257},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.6150000095367432},{"id":"https://openalex.org/keywords/sympathoadrenal-system","display_name":"sympathoadrenal system","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.6139000058174133},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5465999841690063},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4839000105857849},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4228000044822693},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3889000117778778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32989999651908875},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3253999948501587},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27410000562667847},{"id":"https://openalex.org/C521822307","wikidata":"https://www.wikidata.org/wiki/Q108458","display_name":"Meditation","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.2614000141620636}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbii.2026.100205","doi":"https://doi.org/10.1016/j.bbii.2026.100205","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbii.2026.100205","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2949834126000577/pdf","source":{"id":"https://openalex.org/S4387285536","display_name":"Brain Behavior and Immunity Integrative","issn_l":"2949-8341","issn":["2949-8341"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Behavior and Immunity Integrative","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbii.2026.100205","doi":"https://doi.org/10.1016/j.bbii.2026.100205","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbii.2026.100205","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2949834126000577/pdf","source":{"id":"https://openalex.org/S4387285536","display_name":"Brain Behavior and Immunity Integrative","issn_l":"2949-8341","issn":["2949-8341"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Behavior and Immunity Integrative","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225424124.pdf","grobid_xml":"https://content.openalex.org/works/W7225424124.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W758061270","https://openalex.org/W1555591710","https://openalex.org/W1971901983","https://openalex.org/W1978441796","https://openalex.org/W1980555794","https://openalex.org/W1985329135","https://openalex.org/W1989652160","https://openalex.org/W1990151307","https://openalex.org/W1995525413","https://openalex.org/W2002797282","https://openalex.org/W2007143131","https://openalex.org/W2016148530","https://openalex.org/W2016521818","https://openalex.org/W2023941297","https://openalex.org/W2026267776","https://openalex.org/W2044269412","https://openalex.org/W2046214258","https://openalex.org/W2047570180","https://openalex.org/W2055487408","https://openalex.org/W2057688664","https://openalex.org/W2069368135","https://openalex.org/W2073295417","https://openalex.org/W2084473597","https://openalex.org/W2086697336","https://openalex.org/W2096215189","https://openalex.org/W2098489144","https://openalex.org/W2101070580","https://openalex.org/W2101119621","https://openalex.org/W2110289523","https://openalex.org/W2110654247","https://openalex.org/W2122626461","https://openalex.org/W2125978064","https://openalex.org/W2126795224","https://openalex.org/W2127377767","https://openalex.org/W2128107556","https://openalex.org/W2139463883","https://openalex.org/W2140888963","https://openalex.org/W2144241704","https://openalex.org/W2145080987","https://openalex.org/W2145625835","https://openalex.org/W2149612743","https://openalex.org/W2154549730","https://openalex.org/W2155805591","https://openalex.org/W2171148059","https://openalex.org/W2264102940","https://openalex.org/W2285097695","https://openalex.org/W2293546053","https://openalex.org/W2307885823","https://openalex.org/W2465360896","https://openalex.org/W2469268362","https://openalex.org/W2474892006","https://openalex.org/W2492193723","https://openalex.org/W2576421220","https://openalex.org/W2587469802","https://openalex.org/W2626809438","https://openalex.org/W2750106872","https://openalex.org/W2762577230","https://openalex.org/W2763043462","https://openalex.org/W2776183201","https://openalex.org/W2792824670","https://openalex.org/W2796983933","https://openalex.org/W2897365776","https://openalex.org/W2922251948","https://openalex.org/W2968947492","https://openalex.org/W2978455156","https://openalex.org/W2983360131","https://openalex.org/W3068647859","https://openalex.org/W3087252530","https://openalex.org/W3098150983","https://openalex.org/W3118522706","https://openalex.org/W3179157836","https://openalex.org/W3186768888","https://openalex.org/W3212948629","https://openalex.org/W4205966599","https://openalex.org/W4221007122","https://openalex.org/W4238596965","https://openalex.org/W4281980701","https://openalex.org/W4283312963","https://openalex.org/W4377695563","https://openalex.org/W4396540795","https://openalex.org/W7204045019"],"related_works":["https://openalex.org/W4395099502","https://openalex.org/W7211893904","https://openalex.org/W2884256037","https://openalex.org/W1986471349","https://openalex.org/W3009192738","https://openalex.org/W438972512","https://openalex.org/W2168229022","https://openalex.org/W2059617767","https://openalex.org/W2417130992","https://openalex.org/W3008551030"],"abstract_inverted_index":{"Meditation":[0],"is":[1,156,177],"widely":[2],"reported":[3],"to":[4,22,159,194,232],"reduce":[5,209],"physiological":[6],"markers":[7],"of":[8,34,46,79,119,127,133,182],"stress,":[9],"yet":[10],"the":[11,38,43,47,52,131,180,192],"field":[12],"lacks":[13],"a":[14,160,169],"mechanistic":[15],"account":[16],"that":[17,125,150,205,217],"connects":[18],"specific":[19,23],"meditative":[20],"practices":[21,142],"immune":[24,154],"outcomes.":[25],"This":[26],"review":[27],"integrates":[28],"four":[29],"literatures:":[30],"(1)":[31],"autonomic":[32],"effects":[33,102],"meditation,":[35],"framed":[36],"by":[37,179],"neurovisceral":[39],"integration":[40],"model;":[41],"(2)":[42],"molecular":[44],"architecture":[45],"efferent":[48],"pathways":[49],"through":[50],"which":[51,174],"brain":[53],"restrains":[54],"inflammation":[55,80],"\u2014":[56],"vagal\u2013splenic":[57],"cholinergic":[58],"(\u03b17":[59],"nicotinic":[60],"receptor,":[61],"JAK2\u2013STAT3,":[62],"NF-\u03baB),":[63],"sympathetic\u2013adrenergic":[64],"and":[65,70,81,84,86,90,95,100,109,113,140,163,190,216,229],"glucocorticoid-receptor":[66],"signalling;":[67],"(3)":[68],"afferent":[69],"central":[71,195],"mechanisms,":[72],"including":[73],"vagal":[74],"cytokine":[75],"sensing,":[76],"insular":[77],"representation":[78],"microglial":[82],"priming":[83],"reprogramming;":[85],"(4)":[87],"trial,":[88],"transcriptomic":[89,164],"epigenetic":[91],"evidence":[92,149],"on":[93,103],"meditation":[94],"immunity.":[96],"Meta-analyses":[97],"show":[98],"small":[99],"heterogeneous":[101],"vagally":[104],"mediated":[105],"heart":[106,219],"rate":[107,220],"variability":[108,221],"circulating":[110],"C-reactive":[111],"protein":[112],"interleukin-6,":[114],"with":[115],"more":[116,212],"consistent":[117],"down-regulation":[118],"NF-\u03baB-related":[120],"gene":[121],"expression.":[122],"We":[123,166],"argue":[124],"part":[126],"this":[128],"heterogeneity":[129],"reflects":[130],"conflation":[132],"mechanistically":[134],"distinct":[135],"practices.":[136],"Focused-attention,":[137],"open-monitoring,":[138],"loving-kindness/compassion":[139],"slow-breath/mantra":[141],"have":[143],"dissociable":[144],"neural":[145],"signatures,":[146],"but":[147,225],"direct":[148],"they":[151],"produce":[152],"different":[153],"signatures":[155],"currently":[157],"limited":[158],"few":[161],"endocrine":[162],"findings.":[165],"therefore":[167],"present":[168],"Vagal\u2013Immune":[170],"Convergence":[171],"framework":[172,193,199],"in":[173],"each":[175],"link":[176],"graded":[178],"strength":[181],"its":[183],"evidence,":[184],"distinguish":[185],"established":[186],"mechanisms":[187],"from":[188],"hypotheses,":[189],"extend":[191],"neuroimmune":[196],"targets.":[197],"The":[198],"yields":[200],"falsifiable":[201],"predictions,":[202],"for":[203],"example,":[204],"socio-affective":[206],"training":[207],"will":[208,222],"stress-evoked":[210],"interleukin-6":[211],"than":[213],"attention-based":[214,224],"training,":[215],"baseline":[218],"moderate":[223],"not":[226],"breath-based":[227],"effects,":[228],"specifies":[230],"designs":[231],"test":[233],"them.":[234]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}