{"id":"https://openalex.org/W7225423944","doi":"https://doi.org/10.1038/s41598-026-79158-x","title":"NCOA1 and PRPS1 as novel metabolism-related biomarkers in myocardial ischemia\u2013reperfusion injury","display_name":"NCOA1 and PRPS1 as novel metabolism-related biomarkers in myocardial ischemia\u2013reperfusion injury","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225423944","doi":"https://doi.org/10.1038/s41598-026-79158-x"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-79158-x","doi":"https://doi.org/10.1038/s41598-026-79158-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79158-x","pdf_url":"https://www.nature.com/articles/s41598-026-79158-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-79158-x_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161087418","display_name":"Tong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]},{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Liu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","Department of Cardiovascular Surgery, Hebei Medical University Third Hospital, Shijiazhuang, 050010, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Hebei Medical University Third Hospital, Shijiazhuang, 050010, Hebei, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148845463","display_name":"Jiajie Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajie Kong","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148933951","display_name":"Zhouliang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhouliang Huang","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074779366","display_name":"Ying Zhong","orcid":"https://orcid.org/0000-0003-1915-8433","observed_orcids":["https://orcid.org/0000-0003-1915-8433","https://orcid.org/0009-0003-7907-9187"]},"institutions":[{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhong","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148833512","display_name":"Jiaxuan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxuan Lu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148901748","display_name":"Yongke Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongke Cao","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161060125","display_name":"Lei Liu","orcid":"https://orcid.org/0009-0007-6657-7362","observed_orcids":["https://orcid.org/0009-0007-6657-7362"]},"institutions":[{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China"],"raw_orcid":"https://orcid.org/0009-0007-6657-7362","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China","institution_ids":["https://openalex.org/I4210158865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5161060125"],"corresponding_institution_ids":["https://openalex.org/I4210158865"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.953000009059906},{"id":"https://openalex.org/keywords/src-1","display_name":"SRC-1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/prps1","display_name":"PRPS1","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.8740000128746033},{"id":"https://openalex.org/keywords/m0-macrophages","display_name":"M0 macrophages","score":0.7860000133514404},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ribosomal-function","display_name":"ribosomal function","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nucleotide-metabolism","display_name":"nucleotide metabolism","score":1.0},{"id":"https://openalex.org/keywords/6-thioguanine","display_name":"6-thioguanine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/whole-blood-biomarkers","display_name":"whole blood biomarkers","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.772599995136261},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6898999810218811},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5543000102043152},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5511000156402588},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5023000240325928},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4952000081539154},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4602000117301941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4578000009059906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39469999074935913},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.3628000020980835},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.30379998683929443},{"id":"https://openalex.org/C3019646584","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular biomarkers","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.2847999930381775},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28189998865127563},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.27549999952316284},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25949999690055847},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-79158-x","doi":"https://doi.org/10.1038/s41598-026-79158-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79158-x","pdf_url":"https://www.nature.com/articles/s41598-026-79158-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-79158-x","doi":"https://doi.org/10.1038/s41598-026-79158-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-79158-x","pdf_url":"https://www.nature.com/articles/s41598-026-79158-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225423944.pdf","grobid_xml":"https://content.openalex.org/works/W7225423944.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1528525585","https://openalex.org/W1601835947","https://openalex.org/W1966327575","https://openalex.org/W2009909952","https://openalex.org/W2040366777","https://openalex.org/W2110256992","https://openalex.org/W2159675211","https://openalex.org/W2159707944","https://openalex.org/W2160310346","https://openalex.org/W2334701308","https://openalex.org/W2746333362","https://openalex.org/W2788142646","https://openalex.org/W3037755212","https://openalex.org/W3038341522","https://openalex.org/W3038740562","https://openalex.org/W3213673096","https://openalex.org/W4200158124","https://openalex.org/W4206839115","https://openalex.org/W4206970610","https://openalex.org/W4220801316","https://openalex.org/W4221076557","https://openalex.org/W4281628173","https://openalex.org/W4282973032","https://openalex.org/W4283511977","https://openalex.org/W4292260212","https://openalex.org/W4294216483","https://openalex.org/W4295924166","https://openalex.org/W4296417007","https://openalex.org/W4304098546","https://openalex.org/W4304182704","https://openalex.org/W4310602721","https://openalex.org/W4318815931","https://openalex.org/W4321377311","https://openalex.org/W4321782655","https://openalex.org/W4378072538","https://openalex.org/W4378782318","https://openalex.org/W4379052745","https://openalex.org/W4388630445","https://openalex.org/W4393247056","https://openalex.org/W4395052837","https://openalex.org/W4399811617","https://openalex.org/W4400078967","https://openalex.org/W4402036182","https://openalex.org/W4402322162","https://openalex.org/W4402460192","https://openalex.org/W4404355851","https://openalex.org/W4405948531","https://openalex.org/W4407262150","https://openalex.org/W4408464590","https://openalex.org/W4410838310","https://openalex.org/W4411721895","https://openalex.org/W4412089746"],"related_works":["https://openalex.org/W4410872900","https://openalex.org/W7202280125","https://openalex.org/W4410838310","https://openalex.org/W7150829931","https://openalex.org/W7165904333","https://openalex.org/W4417030170","https://openalex.org/W4410222690","https://openalex.org/W4391320640","https://openalex.org/W4401136211","https://openalex.org/W4415651563"],"abstract_inverted_index":{"Mitochondrial":[0],"metabolism":[1],"(MM)":[2],"plays":[3],"a":[4],"critical":[5],"role":[6],"in":[7,38,66,93,183],"myocardial":[8],"ischemia\u2013reperfusion":[9],"injury":[10],"(MIRI),":[11],"yet":[12],"reliable":[13],"metabolism-related":[14,171],"biomarkers":[15,37,172],"for":[16,138,149],"this":[17],"condition":[18],"remain":[19],"largely":[20],"unexplored.":[21],"Here,":[22],"we":[23,58],"integrated":[24],"transcriptomic":[25],"datasets":[26],"from":[27],"public":[28],"repositories":[29],"with":[30,129],"MM-related":[31],"gene":[32,42],"sets":[33],"to":[34],"identify":[35,165],"candidate":[36,60,78,112,170],"MIRI.":[39],"Through":[40],"weighted":[41],"co-expression":[43],"network":[44],"analysis":[45,99],"(WGCNA),":[46],"differential":[47],"expression":[48,65,91],"profiling,":[49],"and":[50,56,62,71,81,87,110,120,132,156,167,187],"two":[51],"machine":[52],"learning":[53],"algorithms":[54],"(SVM-RFE":[55],"Boruta),":[57],"screened":[59],"genes":[61],"validated":[63],"their":[64],"both":[67,111],"independent":[68,185],"GEO":[69],"cohorts":[70,186],"clinical":[72],"whole-blood":[73],"samples":[74],"via":[75],"RT-qPCR.":[76],"Two":[77],"biomarkers,":[79,113],"NCOA1":[80,166],"PRPS1":[82,168],",":[83],"were":[84],"consistently":[85],"identified":[86,127],"validated,":[88],"showing":[89],"opposing":[90],"patterns":[92],"MIRI":[94],"versus":[95],"controls.":[96],"Immune":[97],"infiltration":[98],"revealed":[100],"significant":[101],"correlations":[102],"between":[103,117],"the":[104,150],"estimated":[105],"abundance":[106],"of":[107],"M0":[108],"macrophages":[109],"indicating":[114],"an":[115,175],"association":[116],"these":[118],"molecular":[119,143],"immune-related":[121],"features.":[122],"Pathway":[123],"enrichment":[124],"analyses":[125],"further":[126,139,159,181],"associations":[128],"ribosomal":[130],"function":[131],"nucleotide":[133],"metabolism,":[134],"providing":[135],"potential":[136],"directions":[137],"mechanistic":[140,188],"investigation.":[141],"Notably,":[142],"docking":[144,147],"yielded":[145],"moderate":[146],"scores":[148],"predicted":[151],"biomarker\u2013drug":[152],"pairs,":[153],"including":[154],"NCOA1\u2013methylthioninium":[155],"PRPS1\u2013thioguanine,":[157],"warranting":[158],"experimental":[160],"evaluation.":[161],"Collectively,":[162],"our":[163],"findings":[164],"as":[169],"selected":[173],"through":[174],"MRG-based":[176],"screening":[177],"framework,":[178],"which":[179],"warrant":[180],"validation":[182],"larger":[184],"studies.":[189]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}