{"id":"https://openalex.org/W7225423930","doi":"https://doi.org/10.1302/1358-992x.2026.11.024","title":"ANTICOAGULATION STRATEGIES IN SEPTIC SINGLE-STAGE HIP REVISION: IS ASPIRIN COMPARABLE TO OTHER ANTICOAGULANTS?","display_name":"ANTICOAGULATION STRATEGIES IN SEPTIC SINGLE-STAGE HIP REVISION: IS ASPIRIN COMPARABLE TO OTHER ANTICOAGULANTS?","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225423930","doi":"https://doi.org/10.1302/1358-992x.2026.11.024"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.024","doi":"https://doi.org/10.1302/1358-992x.2026.11.024","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.024","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092710148","display_name":"Tarek Haj Shehadeh","orcid":"https://orcid.org/0000-0002-7446-0064","observed_orcids":["https://orcid.org/0000-0002-7446-0064"]},"institutions":[{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarek Haj Shehadeh","raw_affiliation_strings":["Cleveland Clinic Florida, Weston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Florida, Weston, United States","institution_ids":["https://openalex.org/I4210108700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160994501","display_name":"Jesus Villa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Villa","raw_affiliation_strings":["Cleveland Clinic Florida, Weston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Florida, Weston, United States","institution_ids":["https://openalex.org/I4210108700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068312067","display_name":"Elie S Ghanem","orcid":"https://orcid.org/0000-0002-1945-8885","observed_orcids":["https://orcid.org/0000-0002-1945-8885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elie Ghanem","raw_affiliation_strings":["Missouri Orthopedic Institute, Columbia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Missouri Orthopedic Institute, Columbia, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090148136","display_name":"Carlos A. Higuera Rueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Higuera Rueda","raw_affiliation_strings":["Cleveland Clinic Florida, Weston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Florida, Weston, United States","institution_ids":["https://openalex.org/I4210108700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"24","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.4948999881744385,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.4948999881744385,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.4462999999523163,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.847000002861023},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/apixaban","display_name":"apixaban","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":1.0},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/re-revision","display_name":"re-revision","score":0.7730000019073486},{"id":"https://openalex.org/keywords/postoperative-blood-transfusion","display_name":"postoperative blood transfusion","score":0.5960000157356262},{"id":"https://openalex.org/keywords/wound-disruption","display_name":"wound disruption","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.97079998254776},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.8306000232696533},{"id":"https://openalex.org/C2776265017","wikidata":"https://www.wikidata.org/wiki/Q220570","display_name":"Pulmonary embolism","level":2,"score":0.5546000003814697},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5485000014305115},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5407999753952026},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.5210999846458435},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5169000029563904},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.44679999351501465},{"id":"https://openalex.org/C2775956843","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Septic arthritis","level":3,"score":0.4413999915122986},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.41940000653266907},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.4115000069141388},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.35659998655319214},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.35199999809265137},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3319000005722046},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C2780638905","wikidata":"https://www.wikidata.org/wiki/Q414462","display_name":"Apixaban","level":5,"score":0.3260999917984009},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C2778602436","wikidata":"https://www.wikidata.org/wiki/Q4774943","display_name":"Antibiotic prophylaxis","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.024","doi":"https://doi.org/10.1302/1358-992x.2026.11.024","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.024","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161178826","https://openalex.org/W7147184149","https://openalex.org/W3120804397","https://openalex.org/W7161147968","https://openalex.org/W7147125603","https://openalex.org/W4400486613","https://openalex.org/W7045558983","https://openalex.org/W3014841908","https://openalex.org/W2331674580","https://openalex.org/W4285742142"],"abstract_inverted_index":{"Aims":[0],"Septic":[1],"hip":[2],"revision":[3],"(rTHA)":[4],"for":[5,74,88,136],"prosthetic":[6],"joint":[7],"infection":[8,186],"is":[9,334,374],"associated":[10,352],"with":[11,56,283,353],"increased":[12,208],"venous":[13],"thromboembolic":[14],"(VTE)":[15],"complications":[16],"compared":[17,99,222,358,365,378],"to":[18,26,48,100,111,134,223,338,359,366,379,392],"aseptic":[19],"rTHA.":[20,62,81,349,386],"Furthermore,":[21],"previous":[22],"studies":[23,389],"reported":[24],"Aspirin":[25,55,86,117,130,225,350,373],"be":[27],"safe":[28,375],"and":[29,52,110,118,160,183,216,261,326,356,362,376],"effective":[30],"in":[31,286,343],"rTHA,":[32],"however,":[33],"VTE":[34,217,295,340,357],"prophylaxis":[35,89,341],"after":[36,96],"septic":[37,60,79,347,384],"single-stage":[38,61,80,348,385],"rTHA":[39],"hasn't":[40],"been":[41],"described.":[42],"In":[43,272],"this":[44],"study,":[45],"we":[46],"aim":[47],"compare":[49,339],"the":[50,66,129,166,224,274,287,335,344],"safety":[51],"effectiveness":[53],"of":[54,104,116,143,147,163,169,210,229,289,346],"other":[57,380],"anticoagulants":[58],"following":[59,383],"Methods":[63],"We":[64],"queried":[65],"TriNetX":[67],"database":[68],"(cases":[69],"from":[70],"2006":[71],"till":[72],"2025)":[73],"patients":[75,101,112,200,282],"undergoing":[76],"their":[77],"first":[78,336],"Patients":[82],"who":[83],"were":[84,98,165,267],"prescribed":[85,102,113],"monotherapy":[87,103,361],"(defined":[90],"as":[91,132],"prescription":[92],"within":[93],"2":[94],"weeks":[95],"surgery)":[97],"Enoxaparin,":[105],"Apixaban":[106],"or":[107],"Rivaroxaban":[108],"(non-Aspirin)":[109],"a":[114,206],"combination":[115],"non-Aspirin":[119,203,360],"(dual":[120],"therapy).":[121],"1:1":[122],"propensity":[123],"score":[124],"matching":[125],"was":[126,189,351],"performed":[127],"using":[128],"cohort":[131,204],"reference":[133],"control":[135,159],"relevant":[137],"variables,":[138],"including":[139],"age":[140],"at":[141,191],"time":[142],"surgery,":[144],"sex,":[145],"history":[146],"VTE,":[148,177],"stroke,":[149],"cancer,":[150],"coagulopathy,":[151],"tranexamic":[152],"acid":[153],"use,":[154],"body":[155],"mass":[156],"index,":[157],"glycemic":[158],"smoking.":[161],"Outcomes":[162],"interest":[164],"90-day":[167],"incidence":[168,209],"deep":[170],"vein":[171],"thrombosis":[172],"(DVT),":[173],"pulmonary":[174],"embolism":[175],"(PE),":[176],"re-revision,":[178],"death,":[179],"transfusion,":[180],"wound":[181,255,320],"disruption":[182,256,321],"surgical":[184],"site":[185],"(SSI).":[187],"Significance":[188],"set":[190],"p<0.05.":[192],"Results":[193],"The":[194,202,227],"matched":[195,275],"Aspirin-non-Aspirin":[196],"cohorts":[197,278],"included":[198],"978":[199],"each.":[201],"had":[205],"significantly":[207],"DVT":[211,290,355],"(3.68%":[212],"vs":[213,219,232,237,242,247,252,258,264,292,297,302,307,312,317,323,329],"2.15%,":[214],"p=0.044)":[215],"(5.11%":[218],"3.07%,":[220,298],"p=0.022)":[221],"cohort.":[226],"rates":[228,288],"PE":[230],"(1.84%":[231],"1.13%,":[233],"p=0.190),":[234],"re-revision":[235,300],"(11.25%":[236],"12.37%,":[238],"p=0.441),":[239],"death":[240,305],"(2.66%":[241],"2.35%,":[243],"p=0.664),":[244],"transfusion":[245,310],"(9.61%":[246],"8.79%,":[248],"p=0.532),":[249],"bleeding":[250,315],"(4.19%":[251],"4.50%,":[253],"p=0.739),":[254],"(6.34%":[257],"5.52%,":[259],"p=0.444),":[260],"SSI":[262,327],"(2.05%":[263],"2.66%,":[265],"p=0.371)":[266],"similar":[268,363],"between":[269],"both":[270],"cohorts.":[271],"contrast,":[273],"dual":[276,367],"therapy-Aspirin":[277],"each":[279],"comprised":[280],"749":[281],"no":[284],"difference":[285],"(2.94%":[291],"1.87%,":[293],"p=0.177),":[294],"(4.27%":[296],"p=0.216),":[299],"(13.62%":[301],"12.28%,":[303],"p=0.442),":[304],"(1.60%":[306],"2.00%,":[308],"p=0.560),":[309],"(9.75%":[311],"8.41%,":[313],"p=0.369),":[314],"(4.14%":[316],"4.27%,":[318],"p=0.898),":[319],"(6.01%":[322],"6.14%,":[324],"p=0.914)":[325],"(3.20%":[328],"2.67%,":[330],"p=0.541).":[331],"Conclusion":[332],"This":[333],"study":[337],"agents":[342],"setting":[345],"lower":[354],"outcomes":[364],"therapy.":[368],"Our":[369],"data":[370],"suggests":[371],"that":[372],"non-inferior":[377],"anticoagulant":[381],"regimens":[382],"Further":[387],"prospective":[388],"are":[390],"needed":[391],"confirm":[393],"these":[394],"findings.":[395]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}