{"id":"https://openalex.org/W7225423648","doi":"https://doi.org/10.5281/zenodo.23999436","title":"A Review on Oxygen-Generating Hydrogel Patches and Other Related Oxygen-Based Technologies for Accelerated Diabetic Wound Closure","display_name":"A Review on Oxygen-Generating Hydrogel Patches and Other Related Oxygen-Based Technologies for Accelerated Diabetic Wound Closure","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225423648","doi":"https://doi.org/10.5281/zenodo.23999436"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23999436","doi":"https://doi.org/10.5281/zenodo.23999436","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23999436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23999436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137953073","display_name":"Manasi Thakare","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manasi Thakare","raw_affiliation_strings":["Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161062401","display_name":"Natasha Crasto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natasha Crasto","raw_affiliation_strings":["Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129556944","display_name":"VINAY PAL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinay Pal","raw_affiliation_strings":["Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135144537","display_name":"Ajinkya Sonawane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajinkya Sonawane","raw_affiliation_strings":["Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080142776","display_name":"Mohit Gautam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohit Gautam","raw_affiliation_strings":["Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137348360","display_name":"shrutika patil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shrutika Patil","raw_affiliation_strings":["Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.9259999990463257},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.6510000228881836},{"id":"https://openalex.org/keywords/calcium-peroxide","display_name":"calcium peroxide","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hydrogel-design","display_name":"hydrogel design","score":0.578000009059906},{"id":"https://openalex.org/keywords/microneedles","display_name":"microneedles","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nanofibers","display_name":"nanofibers","score":0.9760000109672546},{"id":"https://openalex.org/keywords/photosynthesis","display_name":"photosynthesis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8209999799728394},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.7789999842643738},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.7279999852180481},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6315000057220459},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5299999713897705},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4903999865055084},{"id":"https://openalex.org/C2994142871","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen delivery","level":3,"score":0.3874000012874603},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35850000381469727},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3427000045776367},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3230000138282776},{"id":"https://openalex.org/C2993873987","wikidata":"https://www.wikidata.org/wiki/Q184753","display_name":"Wound closure","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29660001397132874},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.2667999863624573}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23999436","doi":"https://doi.org/10.5281/zenodo.23999436","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23999436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23999438","doi":"https://doi.org/10.5281/zenodo.23999438","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23999438","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23999436","doi":"https://doi.org/10.5281/zenodo.23999436","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23999436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385633390","https://openalex.org/W4393373052","https://openalex.org/W7164644287","https://openalex.org/W4385472675","https://openalex.org/W3195672774","https://openalex.org/W4411282230","https://openalex.org/W7219728161","https://openalex.org/W7128296922","https://openalex.org/W4388014103","https://openalex.org/W7212811638"],"abstract_inverted_index":{"Wound":[0],"healing":[1,175],"can":[2,85,130],"be":[3,86,184],"compromised":[4],"in":[5,26,176],"a":[6,23,177],"diabetic":[7,178],"environment":[8,179],"due":[9],"to":[10,103,106,172,186],"chronic":[11],"hypoxia,":[12],"lack":[13],"of":[14],"neo":[15,36,134],"angiogenesis,":[16],"inflammation":[17],"and":[18,35,60,94,114,136,152,163,191],"oxidative":[19],"stress.":[20],"Oxygen":[21,38],"is":[22],"key":[24],"component":[25],"many":[27,81],"biological":[28],"processes,":[29],"such":[30,75,88,145],"as":[31,76,89,146],"collagen":[32],"synthesis,":[33],"anti-infective":[34,110],"angiogenesis.":[37],"releasing":[39,55,68,167],"hydrogels":[40,168],"have":[41,99,169],"shown":[42,100],"great":[43,101,170],"potential":[44,102,171],"at":[45],"increasing":[46],"the":[47,66,107,148,159],"local":[48],"oxygen":[49,54,67,105,117,149,160,166],"levels.":[50],"This":[51,62],"review":[52,63,144],"discusses":[53],"mechanisms,":[56],"hydrogel":[57],"design,":[58],"materials":[59,74,83],"potential.":[61],"focuses":[64],"on":[65,157],"mechanism":[69],"by":[70],"using":[71],"peroxide":[72],"based":[73],"calcium":[77],"peroxide.":[78],"There":[79],"are":[80,189],"other":[82],"that":[84,126],"used":[87],"microneedles,":[90],"nanofibers,":[91],"catalytic":[92],"biomaterials":[93],"photosynthesis.":[95],"Many":[96],"multifunctional":[97,128],"platforms":[98,129],"deliver":[104],"site,":[108],"provide":[109],"properties,":[111],"prevent":[112],"biofilms":[113],"control":[115],"reactive":[116],"species.":[118],"From":[119],"pre-clinical":[120],"studies":[121],"it":[122],"has":[123],"been":[124],"found":[125],"these":[127],"stimulate":[131],"cellular":[132],"activity,":[133],"angiogenesis":[135],"extracellular":[137],"matrix.":[138],"Challenges":[139],"were":[140],"highlighted":[141],"throughout":[142],"this":[143],"controlling":[147],"release,":[150,161],"cytotoxicity":[151],"stability.":[153],"Research":[154],"should":[155],"focus":[156],"optimizing":[158],"dosing":[162],"biocompatibility.":[164],"Overall":[165],"improve":[173],"wound":[174],"but":[180],"further":[181],"validation":[182],"would":[183],"required":[185],"ensure":[187],"they":[188],"safe":[190],"effective.":[192]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}