{"id":"https://openalex.org/W7225423265","doi":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","title":"Assessing High-Dose Versus Standard-Dose Influenza Vaccine Protection Against Severe Outcomes in Older Adults with Chronic Conditions","display_name":"Assessing High-Dose Versus Standard-Dose Influenza Vaccine Protection Against Severe Outcomes in Older Adults with Chronic Conditions","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225423265","doi":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i"},"language":"en","primary_location":{"id":"doi:10.33590/microbiolinfectdisamj/a4orio6i","doi":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","is_oa":true,"landing_page_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","pdf_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","source":{"id":"https://openalex.org/S4404677245","display_name":"Microbiology & infectious diseases :","issn_l":"2977-4055","issn":["2977-4055"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Infectious Diseases The American Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161065166","display_name":"Sanofi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sanofi","raw_affiliation_strings":["Sanofi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi","institution_ids":["https://openalex.org/I3018075036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161065166"],"corresponding_institution_ids":["https://openalex.org/I3018075036"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-dose-influenza-vaccine","display_name":"high-dose influenza vaccine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/standard-dose-influenza-vaccine","display_name":"standard-dose influenza vaccine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/influenza-hospitalization","display_name":"influenza hospitalization","score":0.6449999809265137},{"id":"https://openalex.org/keywords/pneumonia-hospitalization","display_name":"pneumonia hospitalization","score":0.6340000033378601},{"id":"https://openalex.org/keywords/vaccine-effectiveness","display_name":"vaccine effectiveness","score":0.6389999985694885},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.5460000038146973},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8511000275611877},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.460099995136261},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.33500000834465027},{"id":"https://openalex.org/C133239900","wikidata":"https://www.wikidata.org/wiki/Q2043512","display_name":"Live attenuated influenza vaccine","level":4,"score":0.328000009059906},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.30869999527931213},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33590/microbiolinfectdisamj/a4orio6i","doi":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","is_oa":true,"landing_page_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","pdf_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","source":{"id":"https://openalex.org/S4404677245","display_name":"Microbiology & infectious diseases :","issn_l":"2977-4055","issn":["2977-4055"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Infectious Diseases The American Medical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33590/microbiolinfectdisamj/a4orio6i","doi":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","is_oa":true,"landing_page_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","pdf_url":"https://doi.org/10.33590/microbiolinfectdisamj/a4orio6i","source":{"id":"https://openalex.org/S4404677245","display_name":"Microbiology & infectious diseases :","issn_l":"2977-4055","issn":["2977-4055"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Infectious Diseases The American Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225423265.pdf","grobid_xml":"https://content.openalex.org/works/W7225423265.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7204654693"],"related_works":["https://openalex.org/W7127906933","https://openalex.org/W4415370169","https://openalex.org/W7214508148","https://openalex.org/W7224425494","https://openalex.org/W2278109367","https://openalex.org/W4417271885","https://openalex.org/W7107856625","https://openalex.org/W7159556196","https://openalex.org/W2277413323","https://openalex.org/W2922184142"],"abstract_inverted_index":{"Among":[0],"older":[1,103],"adults":[2],"(\u226565":[3],"years)":[4],"hospitalized":[5],"with":[6],"influenza":[7,98],"in":[8,11,102],"the":[9],"USA":[10],"2025-26,":[12],"33.9%":[13],"had":[14,19],"renal":[15],"disease":[16],"and":[17,28,41,83],"44.2%":[18],"chronic":[20],"lung":[21],"disease.5":[22],"466,320":[23],"participants":[24,67,78],"enrolled":[25],"across":[26],"Denmark":[27,74],"Spain":[29,92],"9":[30,45,108],"Prespecified":[31],"pooled":[32],"analysis":[33],"of":[34,60],"methodologically":[35],"harmonized,":[36],"individually":[37,96],"randomized":[38,97],"DANFLU-2":[39,68],"7":[40],"GALFLU":[42,85],"8":[43],"trials":[44],"Why":[46],"Chronic":[47],"Conditions":[48],"Matter":[49],"HD-IIV":[50,61,69,86],"FLUNITY-HD":[51,105],"Study":[52],"Design":[53],"Hospitalization":[54],"for":[55],"Pneumonia":[56],"or":[57],"Influenza":[58],"Benefit":[59],"vs":[62,70,87],"SD-IIV":[63,71,88],"Methodologically":[64],"harmonized":[65],"332k":[66],"against":[72,89],"hospitalizations":[73,90],"\u226565":[75],"years":[76],"134k":[77],"NH23/24":[79],"-24/25":[80],"NH22/23,":[81],"23/24,":[82],"24/25":[84],"Galicia,":[91],"65-79":[93],"yearsThe":[94],"largest":[95],"vaccine":[99],"effectiveness":[100],"study":[101],"adults.9":[104],"(Pooled":[106],"Analysis)":[107],"Flu":[109],"seasons":[110]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
