{"id":"https://openalex.org/W7225335002","doi":"https://doi.org/10.1080/14737140.2026.2760188","title":"Trastuzumab deruxtecan in HER2-expressing urothelial carcinoma: current evidence, biomarker challenges, and future therapeutic strategies","display_name":"Trastuzumab deruxtecan in HER2-expressing urothelial carcinoma: current evidence, biomarker challenges, and future therapeutic strategies","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225335002","doi":"https://doi.org/10.1080/14737140.2026.2760188","pmid":"https://pubmed.ncbi.nlm.nih.gov/42988609"},"language":"en","primary_location":{"id":"doi:10.1080/14737140.2026.2760188","doi":"https://doi.org/10.1080/14737140.2026.2760188","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14737140.2026.2760188","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1080/14737140.2026.2760188","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037756908","display_name":"Giandomenico Roviello","orcid":"https://orcid.org/0000-0001-5504-8237","observed_orcids":["https://orcid.org/0000-0001-5504-8237","https://orcid.org/0000-0002-5185-6701"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giandomenico Roviello","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117723305","display_name":"Kristian Shtembari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Kristian Shtembari","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092083647","display_name":"Ismaela Anna Vascotto","orcid":"https://orcid.org/0009-0003-9594-1451","observed_orcids":["https://orcid.org/0009-0003-9594-1451"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ismaela Anna Vascotto","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111305445","display_name":"Martina Izzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Izzi","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040172365","display_name":"Chiara Calandrelli","orcid":"https://orcid.org/0009-0001-2335-2100","observed_orcids":["https://orcid.org/0009-0001-2335-2100"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Calandrelli","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044581032","display_name":"Silvia Mancini","orcid":"https://orcid.org/0000-0003-0673-3347","observed_orcids":["https://orcid.org/0000-0003-0673-3347"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Mancini","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025495477","display_name":"Marinella Micol Mela","orcid":"https://orcid.org/0000-0002-8027-2852","observed_orcids":["https://orcid.org/0000-0002-8027-2852"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marinella Micol Mela","raw_affiliation_strings":["Careggi University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Careggi University Hospital","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024837477","display_name":"Virginia Rossi","orcid":"https://orcid.org/0000-0002-8524-4033","observed_orcids":["https://orcid.org/0000-0002-8524-4033"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Virginia Rossi","raw_affiliation_strings":["Careggi University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Careggi University Hospital","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031114600","display_name":"Roberta Giorgione","orcid":"https://orcid.org/0000-0002-1674-6312","observed_orcids":["https://orcid.org/0000-0002-1674-6312"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Giorgione","raw_affiliation_strings":["Careggi University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Careggi University Hospital","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090870392","display_name":"Serena Pillozzi","orcid":"https://orcid.org/0000-0001-8861-8718","observed_orcids":["https://orcid.org/0000-0001-8861-8718"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Pillozzi","raw_affiliation_strings":["University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002745641","display_name":"Lorenzo Antonuzzo","orcid":"https://orcid.org/0000-0003-3349-5604","observed_orcids":["https://orcid.org/0000-0003-3349-5604"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Antonuzzo","raw_affiliation_strings":["Careggi University Hospital","University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Careggi University Hospital","institution_ids":["https://openalex.org/I4210115393"]},{"raw_affiliation_string":"University of Florence","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":1.0},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.7559999823570251},{"id":"https://openalex.org/keywords/erbb2-amplification","display_name":"ERBB2 amplification","score":0.8539999723434448},{"id":"https://openalex.org/keywords/her2-mutation","display_name":"HER2 mutation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9380000233650208},{"id":"https://openalex.org/keywords/enfortumab-vedotin","display_name":"enfortumab vedotin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.7670000195503235},{"id":"https://openalex.org/keywords/her2-testing","display_name":"HER2 testing","score":0.7730000019073486},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7630000114440918},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.824999988079071},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9297999739646912},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.6327000260353088},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5788999795913696},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5295000076293945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4749000072479248},{"id":"https://openalex.org/C3020745361","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial cancer","level":4,"score":0.34220001101493835},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34040001034736633},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.3370000123977661},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.305400013923645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.25189998745918274}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1080/14737140.2026.2760188","doi":"https://doi.org/10.1080/14737140.2026.2760188","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14737140.2026.2760188","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},{"id":"pmid:42988609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42988609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anticancer therapy","raw_type":"Journal Article"},{"id":"doi:10.6084/m9.figshare.34933165","doi":"https://doi.org/10.6084/m9.figshare.34933165","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34933165","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34933165.v1","doi":"https://doi.org/10.6084/m9.figshare.34933165.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34933165.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1080/14737140.2026.2760188","doi":"https://doi.org/10.1080/14737140.2026.2760188","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14737140.2026.2760188","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W2124913341","https://openalex.org/W2314772071","https://openalex.org/W2794611921","https://openalex.org/W3081686441","https://openalex.org/W3120256215","https://openalex.org/W4214527799","https://openalex.org/W4221034335","https://openalex.org/W4302009796","https://openalex.org/W4306973340","https://openalex.org/W4385659305","https://openalex.org/W4387579755","https://openalex.org/W4387847725","https://openalex.org/W4387865238","https://openalex.org/W4388852914","https://openalex.org/W4392498919","https://openalex.org/W4396626913","https://openalex.org/W4400272766","https://openalex.org/W4402437965","https://openalex.org/W4403418835","https://openalex.org/W4407498477","https://openalex.org/W4409487606","https://openalex.org/W4410929528","https://openalex.org/W4412002616","https://openalex.org/W4412379249","https://openalex.org/W4412438954","https://openalex.org/W4413006465","https://openalex.org/W4415340539","https://openalex.org/W4416441639","https://openalex.org/W7116397930","https://openalex.org/W7118827995","https://openalex.org/W7154751607","https://openalex.org/W7159656880","https://openalex.org/W7160527896","https://openalex.org/W7165202675"],"related_works":["https://openalex.org/W4411529663","https://openalex.org/W7154886911","https://openalex.org/W3198382745","https://openalex.org/W4200636040","https://openalex.org/W4407665965","https://openalex.org/W4299811995","https://openalex.org/W3207628921","https://openalex.org/W3092320691","https://openalex.org/W7222979437","https://openalex.org/W4398213516"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Urothelial":[1],"carcinoma":[2],"(UC)":[3],"has":[4],"become":[5],"a":[6,91],"prototype":[7],"for":[8,73,95],"antibody-drug":[9],"conjugate":[10],"(ADC)-based":[11],"therapy,":[12],"but":[13,33],"relapse":[14],"after":[15,130],"first-line":[16],"enfortumab":[17,131],"vedotin":[18,132],"plus":[19],"pembrolizumab":[20],"remains":[21],"common.":[22],"HER2":[23,51,123],"protein":[24],"expression,":[25],"ERBB2":[26],"amplification":[27,108],"and":[28,42,60,82,126],"activating":[29],"mutations":[30],"identify":[31],"overlapping":[32],"distinct":[34],"populations;":[35],"this":[36],"review":[37],"focuses":[38],"on":[39],"HER2-expressing":[40],"disease":[41,85],"separately":[43],"examines":[44],"genomic":[45],"alterations.":[46],"AREAS":[47],"COVERED:":[48],"We":[49],"examine":[50],"testing,":[52,120],"trastuzumab":[53],"deruxtecan":[54],"(T-DXd)":[55],"pharmacology,":[56],"clinical":[57],"evidence,":[58],"safety,":[59],"treatment":[61,116],"sequencing.":[62],"PubMed/MEDLINE":[63],"was":[64],"searched":[65],"from":[66],"database":[67],"inception":[68],"through":[69],"20":[70],"August":[71],"2026":[72],"urothelial/bladder":[74],"cancer,":[75],"HER2/ERBB2,":[76],"T-DXd,":[77],"other":[78],"ADCs,":[79],"biomarkers,":[80],"heterogeneity,":[81],"interstitial":[83],"lung":[84],"(ILD).":[86],"EXPERT":[87],"OPINION:":[88],"T-DXd":[89],"is":[90],"promising":[92],"later-line":[93],"option":[94],"selected":[96],"patients,":[97],"with":[98],"the":[99],"strongest":[100],"evidence":[101],"in":[102],"HER2-positive":[103],"(immunohistochemistry":[104],"[IHC]":[105],"3+)":[106],"UC;":[107],"or":[109],"mutation":[110],"alone":[111],"does":[112],"not":[113],"establish":[114],"equivalent":[115],"eligibility.":[117],"Standardized":[118],"UC-specific":[119],"reassessment":[121],"of":[122],"at":[124],"progression,":[125],"prospective":[127],"biomarker-rich":[128],"studies":[129],"are":[133],"needed":[134],"to":[135],"define":[136],"its":[137],"optimal":[138],"use.":[139]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-06T00:00:00"}