{"id":"https://openalex.org/W7225422909","doi":"https://doi.org/10.1002/art.70395","title":"Synovial Tissue\u2010Guided Interleukin\u201017A Inhibition for Refractory Arthritis in a Patient With Systemic Juvenile Idiopathic Arthritis","display_name":"Synovial Tissue\u2010Guided Interleukin\u201017A Inhibition for Refractory Arthritis in a Patient With Systemic Juvenile Idiopathic Arthritis","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225422909","doi":"https://doi.org/10.1002/art.70395","pmid":"https://pubmed.ncbi.nlm.nih.gov/42994095"},"language":"en","primary_location":{"id":"doi:10.1002/art.70395","doi":"https://doi.org/10.1002/art.70395","is_oa":true,"landing_page_url":"https://doi.org/10.1002/art.70395","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.70395","source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.70395","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032632012","display_name":"Indira Sriram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indira Sriram","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048591298","display_name":"Tomohiro Kawabe","orcid":"https://orcid.org/0000-0002-1567-1881","observed_orcids":["https://orcid.org/0000-0002-1567-1881"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomohiro Kawabe","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":"https://orcid.org/0000-0002-1567-1881","affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014111309","display_name":"Hitoshi Irabu","orcid":"https://orcid.org/0000-0003-4370-4975","observed_orcids":["https://orcid.org/0000-0003-4370-4975"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hitoshi Irabu","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101688332","display_name":"Mariana Correia Marques","orcid":"https://orcid.org/0000-0002-1195-1595","observed_orcids":["https://orcid.org/0000-0002-1195-1595"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariana Correia Marques","raw_affiliation_strings":["Translational Genetics and Genomics Section National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health  Bethesda USA"],"raw_orcid":"https://orcid.org/0000-0002-1195-1595","affiliations":[{"raw_affiliation_string":"Translational Genetics and Genomics Section National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health  Bethesda USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075882884","display_name":"Clara Lin","orcid":"https://orcid.org/0000-0002-5840-875X","observed_orcids":["https://orcid.org/0000-0002-5840-875X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Lin","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022264899","display_name":"Alisa Gaskell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alisa Gaskell","raw_affiliation_strings":["Center for Innovative Genomics Precision Medicine Institute Children's Hospital Colorado  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovative Genomics Precision Medicine Institute Children's Hospital Colorado  Aurora CO USA","institution_ids":["https://openalex.org/I4210096275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058765037","display_name":"Jun Inamo","orcid":"https://orcid.org/0000-0002-9927-7936","observed_orcids":["https://orcid.org/0000-0002-9927-7936"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Inamo","raw_affiliation_strings":["Division of Rheumatology University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":"https://orcid.org/0000-0002-9927-7936","affiliations":[{"raw_affiliation_string":"Division of Rheumatology University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001478843","display_name":"Michael R. Clay","orcid":"https://orcid.org/0000-0003-1659-8927","observed_orcids":["https://orcid.org/0000-0003-1659-8927"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Clay","raw_affiliation_strings":["Department of Pathology University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119308553","display_name":"Roselyn Fierkens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roselyn Fierkens","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073464643","display_name":"Robert C. Fuhlbrigge","orcid":"https://orcid.org/0000-0002-0911-9310","observed_orcids":["https://orcid.org/0000-0002-0911-9310"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Fuhlbrigge","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067287714","display_name":"Jeremy D. Prager","orcid":"https://orcid.org/0000-0002-8123-2529","observed_orcids":["https://orcid.org/0000-0002-8123-2529"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy D. Prager","raw_affiliation_strings":["Department of Otolaryngology\u2010Head and Neck Surgery University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2010Head and Neck Surgery University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066493498","display_name":"Norman R. Friedman","orcid":"https://orcid.org/0000-0002-3982-0650","observed_orcids":["https://orcid.org/0000-0002-3982-0650"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman R. Friedman","raw_affiliation_strings":["Department of Otolaryngology\u2010Head and Neck Surgery University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2010Head and Neck Surgery University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084724799","display_name":"Sarah A. Gitomer","orcid":"https://orcid.org/0000-0001-6951-7225","observed_orcids":["https://orcid.org/0000-0001-6951-7225"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A. Gitomer","raw_affiliation_strings":["Department of Otolaryngology\u2010Head and Neck Surgery University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2010Head and Neck Surgery University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089958351","display_name":"Michael J. Ombrello","orcid":"https://orcid.org/0000-0003-3322-4089","observed_orcids":["https://orcid.org/0000-0003-3322-4089"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Ombrello","raw_affiliation_strings":["Translational Genetics and Genomics Section National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health  Bethesda USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Genetics and Genomics Section National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health  Bethesda USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070380272","display_name":"Kentaro Yomogida","orcid":"https://orcid.org/0000-0002-2250-677X","observed_orcids":["https://orcid.org/0000-0002-2250-677X","https://orcid.org/0000-0003-4171-6606"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kentaro Yomogida","raw_affiliation_strings":["Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA"],"raw_orcid":"https://orcid.org/0000-0003-4171-6606","affiliations":[{"raw_affiliation_string":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora CO USA","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-juvenile-idiopathic-arthritis","display_name":"systemic juvenile idiopathic arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-17a-inhibition","display_name":"IL-17A inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.8690000176429749},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.8550000190734863},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.7409999966621399},{"id":"https://openalex.org/keywords/refractory-arthritis","display_name":"refractory arthritis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/childhood-arthritis","display_name":"pediatric arthritis","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8295999765396118},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.7699000239372253},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6866000294685364},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.682200014591217},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5695000290870667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45410001277923584},{"id":"https://openalex.org/C2780574019","wikidata":"https://www.wikidata.org/wiki/Q861224","display_name":"Juvenile rheumatoid arthritis","level":3,"score":0.44200000166893005},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4300999939441681},{"id":"https://openalex.org/C2776821229","wikidata":"https://www.wikidata.org/wiki/Q16965166","display_name":"Inflammatory arthritis","level":3,"score":0.4074000120162964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3977999985218048},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3921000063419342},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3853999972343445},{"id":"https://openalex.org/C2780366729","wikidata":"https://www.wikidata.org/wiki/Q3350500","display_name":"Oligoarthritis","level":4,"score":0.36469998955726624},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.36329999566078186},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.36059999465942383},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.3190000057220459},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3156999945640564},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.26089999079704285},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.2574999928474426}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/art.70395","doi":"https://doi.org/10.1002/art.70395","is_oa":true,"landing_page_url":"https://doi.org/10.1002/art.70395","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.70395","source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatology","raw_type":"journal-article"},{"id":"pmid:42994095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42994095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & rheumatology (Hoboken, N.J.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/art.70395","doi":"https://doi.org/10.1002/art.70395","is_oa":true,"landing_page_url":"https://doi.org/10.1002/art.70395","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.70395","source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G1565180698","display_name":null,"funder_award_id":"P30 CA046934","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G185023344","display_name":null,"funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6329885580","display_name":null,"funder_award_id":"K08DK128544","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308537","display_name":"Boettcher Foundation","ror":"https://ror.org/0277pn602"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333552","display_name":"Cancer Center, University of Colorado","ror":"https://ror.org/04cqn7d42"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225422909.pdf","grobid_xml":"https://content.openalex.org/works/W7225422909.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2897866391","https://openalex.org/W1979036381","https://openalex.org/W625508532","https://openalex.org/W2330890205","https://openalex.org/W2112065614","https://openalex.org/W4252105710","https://openalex.org/W2113685732","https://openalex.org/W2332190203","https://openalex.org/W4412054220","https://openalex.org/W2333634585"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,169],"objective":[2],"of":[3,16,202],"this":[4],"study":[5],"was":[6,47,68,93],"to":[7,40,150,160,175,190],"characterize":[8],"the":[9,145],"clinical,":[10],"immunologic,":[11],"and":[12,35,61,122,177,198,210],"synovial":[13,66,71,91,96],"tissue":[14,92,97,212],"features":[15],"a":[17,20,28],"patient":[18],"with":[19,49,70,95,100],"systemic":[21],"juvenile":[22,78],"idiopathic":[23,79],"arthritis":[24,37,80],"(sJIA)":[25],"who":[26],"carries":[27],"novel":[29],"heterozygous":[30],"STAT5B":[31,186],"loss-of-function":[32],"variant":[33],"(p.Gln139Ter)":[34],"whose":[36],"responded":[38],"markedly":[39,114,181],"interleukin-17A":[41],"(IL-17A)":[42],"inhibition.":[43,184],"METHODS:":[44],"Patient":[45,65,90],"blood":[46,50],"compared":[48,69,94],"from":[51,73,98],"healthy":[52],"donors":[53],"(n":[54,83,103],"=":[55,84,104,120,128,167],"5)":[56],"for":[57,86],"immunoblotting,":[58],"phospho-flow":[59],"cytometry":[60],"immune":[62,87],"cell":[63,88],"profiling.":[64,89],"fluid":[67,72],"seronegative":[74],"oligoarticular":[75],"or":[76],"polyarticular":[77],"(oligo/poly":[81],"JIA)":[82],"5-6)":[85],"children":[99],"oligo/poly":[101],"JIA":[102,151],"11)":[105],"using":[106],"Xenium":[107],"spatial":[108,211],"transcriptomics.":[109],"RESULTS:":[110],"T":[111,132,137],"cells":[112,141,156,204],"showed":[113],"increased":[115],"IL-17A":[116,183],"production":[117],"(z":[118,126,165],"score":[119,127,166],"34.5)":[121],"reduced":[123],"FOXP3":[124],"expression":[125],"-2.25)":[129],"in":[130,148,153,219],"regulatory":[131],"cells.":[133],"Spatial":[134],"transcriptomics":[135],"revealed":[136],"helper":[138],"17":[139],"(Th17)":[140],"distributed":[142],"diffusely":[143],"throughout":[144],"patient's":[146,170],"synovium,":[147],"contrast":[149],"controls":[152],"which":[154],"Th17":[155,203],"were":[157],"largely":[158],"restricted":[159],"tertiary":[161],"lymphoid":[162],"structures":[163],"(TLS)":[164],"3.08).":[168],"severe":[171],"arthritis,":[172],"previously":[173],"refractory":[174,220],"IL-1":[176],"IL-6":[178],"blockade,":[179],"improved":[180],"after":[182],"CONCLUSION:":[185],"haploinsufficiency":[187],"may":[188,214],"contribute":[189],"an":[191,199],"sJIA":[192],"phenotype":[193],"characterized":[194],"by":[195],"Th17/IL-17":[196],"dysregulation":[197],"altered":[200],"distribution":[201],"outside":[205],"TLS.":[206],"Integrated":[207],"genetic,":[208],"functional,":[209],"analyses":[213],"help":[215],"identify":[216],"therapeutic":[217],"targets":[218],"pediatric":[221],"arthritis.":[222]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
