{"id":"https://openalex.org/W7225422790","doi":"https://doi.org/10.1002/cyto.b.70090","title":"CD27 and PD \u20101 expression patterns and exploratory ratio\u2010based immunophenotypic indices in people living with HIV","display_name":"CD27 and PD \u20101 expression patterns and exploratory ratio\u2010based immunophenotypic indices in people living with HIV","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225422790","doi":"https://doi.org/10.1002/cyto.b.70090","pmid":"https://pubmed.ncbi.nlm.nih.gov/42992584"},"language":"en","primary_location":{"id":"doi:10.1002/cyto.b.70090","doi":"https://doi.org/10.1002/cyto.b.70090","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.70090","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.70090","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.70090","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017507760","display_name":"Veysel Ak\u00e7a","orcid":"https://orcid.org/0000-0001-8619-4851","observed_orcids":["https://orcid.org/0000-0001-8619-4851"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Veysel Akca","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sand\u0131kl\u0131 State Hospital  Afyon Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8619-4851","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sand\u0131kl\u0131 State Hospital  Afyon Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073769238","display_name":"Burak Ekrem \u00c7itil","orcid":"https://orcid.org/0000-0003-1043-1763","observed_orcids":["https://orcid.org/0000-0003-1043-1763"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Burak Ekrem \u00c7itil","raw_affiliation_strings":["Department of Medical Microbiology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine  Mu\u011fla Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1043-1763","affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine  Mu\u011fla Turkey","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003548311","display_name":"Turhan Togan","orcid":"https://orcid.org/0000-0002-5490-8888","observed_orcids":["https://orcid.org/0000-0002-5490-8888"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Turhan Togan","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine  Mu\u011fla Turkey"],"raw_orcid":"https://orcid.org/0000-0002-5490-8888","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Faculty of Medicine  Mu\u011fla Turkey","institution_ids":["https://openalex.org/I79946792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017507760"],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cd27","display_name":"CD27","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chronic-immune-activation","display_name":"chronic immune activation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":0.7889999747276306},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.8220000267028809},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.40299999713897705},{"id":"https://openalex.org/keywords/hiv-viral-load","display_name":"HIV viral load","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2909287720","wikidata":"https://www.wikidata.org/wiki/Q28456127","display_name":"CD4-CD8 Ratio","level":5,"score":0.7918000221252441},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6883000135421753},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6057000160217285},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5561000108718872},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5049999952316284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4722999930381775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4291999936103821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4083000123500824},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.3986999988555908},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.3418999910354614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34040001034736633},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/cyto.b.70090","doi":"https://doi.org/10.1002/cyto.b.70090","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.70090","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.70090","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},{"id":"pmid:42992584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42992584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry. Part B, Clinical cytometry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cyto.b.70090","doi":"https://doi.org/10.1002/cyto.b.70090","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.70090","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.70090","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225422790.pdf","grobid_xml":"https://content.openalex.org/works/W7225422790.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1975268934","https://openalex.org/W2004962341","https://openalex.org/W2072500831","https://openalex.org/W2086201314","https://openalex.org/W2432649889","https://openalex.org/W2581174947","https://openalex.org/W2588612665","https://openalex.org/W2808038919","https://openalex.org/W2808199943","https://openalex.org/W2912648593","https://openalex.org/W2980979967","https://openalex.org/W3019379912","https://openalex.org/W3196070940","https://openalex.org/W4226178357","https://openalex.org/W4301394762","https://openalex.org/W4307188235","https://openalex.org/W4313546182","https://openalex.org/W4317932852","https://openalex.org/W4380149102","https://openalex.org/W4404493356"],"related_works":["https://openalex.org/W4412890917","https://openalex.org/W4313429249","https://openalex.org/W2028840312","https://openalex.org/W1529713629","https://openalex.org/W2794196642","https://openalex.org/W2336468940","https://openalex.org/W3044037611","https://openalex.org/W2888964270","https://openalex.org/W2169755657","https://openalex.org/W2463625467"],"abstract_inverted_index":{"Abstract":[0],"Chronic":[1],"immune":[2,247,261],"activation":[3],"and":[4,22,25,37,70,78,84,103,115,120,162,186,206,220,245,265],"T\u2010cell":[5,35,130,138],"exhaustion":[6],"persist":[7],"in":[8,127,202,208,263,269],"people":[9],"living":[10],"with":[11,117,216,231,240,260],"HIV":[12,221],"(PLWH)":[13],"despite":[14],"effective":[15],"antiretroviral":[16],"therapy":[17],"(ART).":[18],"We":[19],"investigated":[20],"CD27":[21,77,97,106,155,175,189],"PD\u20101":[23,79,101,110,146,165,179,193],"expression":[24,80],"evaluated":[26],"ratio\u2010based":[27,250],"indices":[28,32,251,258],"as":[29,255],"exploratory":[30,256],"immunophenotypic":[31,257],"related":[33],"to":[34],"differentiation":[36],"exhaustion.":[38],"In":[39],"this":[40],"single\u2010center,":[41],"analytical":[42],"cross\u2010sectional":[43],"study,":[44],"199":[45],"PLWH":[46,264],"were":[47,113,125,200,229,238],"categorized":[48],"into":[49],"BIC/FTC/TAF":[50],"(":[51,56,61,66,72,132,140,149,158,168,182,196],"n":[52,57,62,67,73],"=":[53,58,63,68,74,142,151,160,170,184,198],"57),":[54],"DTG/TDF/FTC":[55],"51),":[59],"DTG/3TC":[60,204],"39),":[64],"viremic":[65],"22),":[69],"treatment\u2010naive":[71,209],"30)":[75],"groups.":[76],"on":[81],"CD4":[82,95,128,144,173],"+":[83,86,96,98,100,102,105,107,109,111,129,137,145,147,154,156,164,166,174,176,178,180,188,190,192,194],"CD8":[85,104,136,153,163,187],"T":[87],"cells":[88],"was":[89],"assessed":[90],"by":[91],"flow":[92],"cytometry.":[93],"The":[94,172],"/CD4":[99,177],"/CD8":[108,191],"ratios":[112,212,237],"calculated":[114],"correlated":[116],"selected":[118],"clinical":[119],"immunological":[121,243],"parameters.":[122],"Significant":[123],"differences":[124],"observed":[126,230],"count":[131,139],"p":[133,141,150,159,169,183,197],"<":[134],"0.001),":[135],"0.041),":[143],"percentage":[148,157,167],"0.022),":[152],"0.004),":[161],"0.001).":[171],"ratio":[181,195],"0.019)":[185],"0.010)":[199],"highest":[201],"the":[203],"group":[205],"lowest":[207],"individuals.":[210],"Both":[211],"showed":[213],"inverse":[214],"correlations":[215,228],"age,":[217],"diagnostic":[218],"delay,":[219],"RNA":[222],"levels":[223],"at":[224],"diagnosis,":[225],"whereas":[226],"positive":[227],"baseline":[232],"CD4/CD8":[233],"ratio.":[234],"Higher":[235],"CD27/PD\u20101":[236],"associated":[239,259],"more":[241],"favorable":[242],"profiles":[244],"preserved":[246],"balance.":[248],"These":[249],"may":[252],"have":[253],"potential":[254],"status":[262],"warrant":[266],"further":[267],"validation":[268],"prospective":[270],"studies.":[271]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
