{"id":"https://openalex.org/W7225422376","doi":"https://doi.org/10.64898/2026.11.04.764450","title":"RhoGEF Solo regulates cell density-dependent keratin remodeling and desmosome maturation","display_name":"RhoGEF Solo regulates cell density-dependent keratin remodeling and desmosome maturation","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225422376","doi":"https://doi.org/10.64898/2026.11.04.764450"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764450","doi":"https://doi.org/10.64898/2026.11.04.764450","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764450","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764450.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764450.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093480616","display_name":"Ukyo Kawasaki","orcid":"https://orcid.org/0009-0005-2132-3946","observed_orcids":["https://orcid.org/0009-0005-2132-3946"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ukyo Kawasaki","raw_affiliation_strings":["Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161086527","display_name":"Riku Maruta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Riku Maruta","raw_affiliation_strings":["Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024363113","display_name":"Kensaku Mizuno","orcid":"https://orcid.org/0000-0001-9386-4294","observed_orcids":["https://orcid.org/0000-0001-9386-4294"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensaku Mizuno","raw_affiliation_strings":["Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062018735","display_name":"Shuhei Chiba","orcid":"https://orcid.org/0000-0002-5144-1661","observed_orcids":["https://orcid.org/0000-0002-5144-1661"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuhei Chiba","raw_affiliation_strings":["Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088038458","display_name":"Kazumasa Ohashi","orcid":"https://orcid.org/0000-0001-7617-403X","observed_orcids":["https://orcid.org/0000-0001-7617-403X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazumasa Ohashi","raw_affiliation_strings":["Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088038458"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solo","display_name":"Solo","score":0.7789999842643738},{"id":"https://openalex.org/keywords/rhogef","display_name":"RhoGEF","score":0.9829999804496765},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/keratin-intermediate-filaments","display_name":"keratin intermediate filaments","score":0.925000011920929},{"id":"https://openalex.org/keywords/cell-density","display_name":"cell density","score":0.7879999876022339},{"id":"https://openalex.org/keywords/plakoglobin","display_name":"plakoglobin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/rho-rock-signaling-pathway","display_name":"Rho/ROCK signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.8572999835014343},{"id":"https://openalex.org/C2778757060","wikidata":"https://www.wikidata.org/wiki/Q846957","display_name":"Desmosome","level":3,"score":0.7324000000953674},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7299000024795532},{"id":"https://openalex.org/C48220470","wikidata":"https://www.wikidata.org/wiki/Q21139990","display_name":"Plakoglobin","level":5,"score":0.6539000272750854},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.6309000253677368},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.560699999332428},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5443999767303467},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5325999855995178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5303000211715698},{"id":"https://openalex.org/C50548948","wikidata":"https://www.wikidata.org/wiki/Q14907896","display_name":"Keratin 8","level":3,"score":0.5195000171661377},{"id":"https://openalex.org/C170178370","wikidata":"https://www.wikidata.org/wiki/Q14907905","display_name":"Keratin 5","level":3,"score":0.5152000188827515},{"id":"https://openalex.org/C2777189754","wikidata":"https://www.wikidata.org/wiki/Q5264821","display_name":"Desmoplakin","level":3,"score":0.4480000138282776},{"id":"https://openalex.org/C67326383","wikidata":"https://www.wikidata.org/wiki/Q24768941","display_name":"Desmoglein","level":4,"score":0.41659998893737793},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3853999972343445},{"id":"https://openalex.org/C2778266373","wikidata":"https://www.wikidata.org/wiki/Q14864175","display_name":"Keratin 14","level":5,"score":0.3783999979496002},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.3779999911785126},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27140000462532043},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.2540999948978424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764450","doi":"https://doi.org/10.64898/2026.11.04.764450","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764450","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764450.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764450","doi":"https://doi.org/10.64898/2026.11.04.764450","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764450","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764450.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5799268134","display_name":"\u7e4a\u6bdb\u3092\u4ecb\u3057\u305f\u7d30\u80de\u9593\u60c5\u5831\u4f1d\u9054\u3068\u305d\u306e\u7834\u7dbb\u306b\u57fa\u3065\u304f\u75be\u60a3\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e","funder_award_id":"26K09236","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225422376.pdf","grobid_xml":"https://content.openalex.org/works/W7225422376.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2299193192","https://openalex.org/W2800939740","https://openalex.org/W3006196515","https://openalex.org/W2925801134","https://openalex.org/W4395113221","https://openalex.org/W2752304619","https://openalex.org/W7160254749","https://openalex.org/W2953701326","https://openalex.org/W2029869325","https://openalex.org/W7139294451"],"abstract_inverted_index":{"Desmosomes":[0],"(DSMs)":[1],"are":[2],"specialized":[3],"cell-cell":[4,92],"adhesion":[5,93],"structures":[6],"that":[7,143,174,215],"anchor":[8],"keratin":[9,42,66,89,119,136,210,228],"intermediate":[10],"filaments":[11,26],"and":[12,44,65,170,181,230,243],"play":[13],"a":[14,52,127,198,224],"crucial":[15],"role":[16,73],"in":[17,30,59,76,80,134,138,163,176,226],"maintaining":[18],"the":[19,40,72,115,132,161,193,206],"mechanical":[20,63],"integrity":[21],"of":[22,74,87,117,122,153,195,208],"epithelial":[23],"tissues.":[24],"Keratin":[25],"associate":[27],"with":[28,103],"DSMs":[29,38,175,242],"two":[31],"characteristic":[32],"patterns:":[33],"radial":[34,88,118,135,164,209,227],"spokes":[35,90,137],"extending":[36],"from":[37],"into":[39],"cytoplasmic":[41],"network":[43,67],"circumferential":[45],"rims":[46],"connecting":[47],"neighboring":[48],"DSMs.":[49],"Solo":[50,75,105,111,129,144,187,231],"is":[51,147],"Rho-guanine":[53],"nucleotide":[54],"exchange":[55],"factor":[56],"(RhoGEF)":[57],"involved":[58],"cellular":[60],"responses":[61],"to":[62,82,233],"stress":[64],"reorganization.":[68],"Here,":[69],"we":[70],"investigated":[71],"regulating":[77,244],"keratin-DSM":[78],"interactions":[79],"response":[81],"cell":[83,100,217],"density.":[84,166],"The":[85],"number":[86,116,207],"at":[91,98,107,241],"sites":[94],"was":[95,188],"markedly":[96,204],"reduced":[97],"high":[99],"density,":[101],"concomitant":[102],"increased":[104,114,205,216],"localization":[106,194,240],"these":[108],"sites.":[109],"Conversely,":[110],"knockout":[112],"(KO)":[113],"spokes.":[120,211],"Expression":[121],"wild-type":[123],"Solo,":[124],"but":[125],"not":[126],"GEF-inactive":[128],"mutant,":[130],"rescued":[131],"increase":[133],"confluent":[139,185],"Solo-KO":[140,177],"cells,":[141],"indicating":[142],"RhoGEF":[145],"activity":[146,158],"required":[148,191],"for":[149,192],"this":[150],"regulation.":[151],"Inhibition":[152],"actin":[154,246],"polymerization":[155],"or":[156],"ROCK":[157],"also":[159,189],"suppressed":[160],"reduction":[162,225],"spoke":[165],"Furthermore,":[167],"expansion":[168],"microscopy":[169,172],"electron":[171],"revealed":[173],"cells":[178],"remained":[179],"small":[180],"immature":[182],"even":[183],"under":[184],"conditions.":[186],"partially":[190],"plakoglobin":[196],"(PG),":[197],"core":[199],"DSM":[200,220],"protein,":[201],"whereas":[202],"PG-KO":[203],"These":[212],"findings":[213],"suggest":[214],"density":[218],"promotes":[219],"maturation":[221],"accompanied":[222],"by":[223],"spokes,":[229],"contributes":[232],"both":[234],"processes,":[235],"potentially":[236],"through":[237],"facilitating":[238],"PG":[239],"Rho-ROCK-dependent":[245],"cytoskeletal":[247],"remodeling.":[248]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}
