{"id":"https://openalex.org/W7225422317","doi":"https://doi.org/10.1186/s12885-026-17120-w","title":"Predicting response to anti-PD-(L)1 therapies using plasma-derived extracellular vesicles in NSCLC and advanced melanoma: protocol for a prospective multicenter cohort study","display_name":"Predicting response to anti-PD-(L)1 therapies using plasma-derived extracellular vesicles in NSCLC and advanced melanoma: protocol for a prospective multicenter cohort study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225422317","doi":"https://doi.org/10.1186/s12885-026-17120-w"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-026-17120-w","doi":"https://doi.org/10.1186/s12885-026-17120-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-17120-w","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12885-026-17120-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050400516","display_name":"Cour\u00e8che Kaderbha\u00ef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cour\u00e8che Kaderbhai","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053571734","display_name":"Alice Hervieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alice Hervieu","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078065507","display_name":"Aur\u00e9lie Bertaut","orcid":"https://orcid.org/0000-0002-7934-9509","observed_orcids":["https://orcid.org/0000-0002-7934-9509"]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lie Bertaut","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer,  CTRDS, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer,  CTRDS, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118603498","display_name":"C\u00e9lia De Girval","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9lia de Girval","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108949004","display_name":"Isen Naiken","orcid":"https://orcid.org/0009-0004-5950-5799","observed_orcids":["https://orcid.org/0009-0004-5950-5799"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4387152817","display_name":"ImViA - Imagerie et Vision Artificielle","ror":"https://ror.org/020n3gx08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387152817","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isen Naiken","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, EA 7535, ImViA, 21000, Dijon, France","Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, EA 7535, ImViA, 21000, Dijon, France","institution_ids":["https://openalex.org/I177064439","https://openalex.org/I4387152817","https://openalex.org/I4405253280"]},{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542346","display_name":"Laure Favier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laure Favier","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079143485","display_name":"Cl\u00e9a Fraisse","orcid":"https://orcid.org/0000-0001-5330-0742","observed_orcids":["https://orcid.org/0000-0001-5330-0742","https://orcid.org/0000-0002-6554-5859"]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cl\u00e9a Fraisse","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Oncologie M\u00e9dicale, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161025367","display_name":"Valentin Bosch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4387152817","display_name":"ImViA - Imagerie et Vision Artificielle","ror":"https://ror.org/020n3gx08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387152817","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentin Bosch","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, EA 7535, ImViA, 21000, Dijon, France","Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, EA 7535, ImViA, 21000, Dijon, France","institution_ids":["https://openalex.org/I177064439","https://openalex.org/I4387152817","https://openalex.org/I4405253280"]},{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161107682","display_name":"Eloi G\u00e9linier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eloi G\u00e9linier","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, UMR Inserm 1231, CTM, HSP-pathies, 21000, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439","https://openalex.org/I4210139033","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019788838","display_name":"Anne-Laure R\u00e9role","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Laure R\u00e9role","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Centre de Recherche Clinique, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Centre de Recherche Clinique, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038871191","display_name":"Emilie Rederstorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Rederstorff","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Centre de Recherche Clinique, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, Centre de Recherche Clinique, 21000, Dijon, France","institution_ids":["https://openalex.org/I4210094685","https://openalex.org/I4405253280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014381584","display_name":"Gr\u00e9goire Cullot","orcid":"https://orcid.org/0000-0003-3925-705X","observed_orcids":["https://orcid.org/0000-0003-3925-705X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gr\u00e9goire Cullot","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, UMPI, UMR Inserm 1231, CTM, HSP-pathies, CIC1432, Module Plurith\u00e9matique, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, UMPI, UMR Inserm 1231, CTM, HSP-pathies, CIC1432, Module Plurith\u00e9matique, 21000, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210094685","https://openalex.org/I4210139033","https://openalex.org/I4405253280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063702031","display_name":"Jessica Gobbo","orcid":"https://orcid.org/0000-0003-3201-9067","observed_orcids":["https://orcid.org/0000-0003-3201-9067"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I4210139033","display_name":"Centre de recherche Translationnelle en M\u00e9decine mol\u00e9culaire","ror":"https://ror.org/04d70nb60","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210117091","https://openalex.org/I4210135996","https://openalex.org/I4210139033","https://openalex.org/I4399657933","https://openalex.org/I4405253280"]},{"id":"https://openalex.org/I4405253280","display_name":"Universit\u00e9 Bourgogne Europe","ror":"https://ror.org/00g700j37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jessica Gobbo","raw_affiliation_strings":["Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, UMPI, UMR Inserm 1231, CTM, HSP-pathies, CIC1432, Module Plurith\u00e9matique, 21000, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Bourgogne Europe, Centre Georges-Fran\u00e7ois Leclerc, Unicancer, UMPI, UMR Inserm 1231, CTM, HSP-pathies, CIC1432, Module Plurith\u00e9matique, 21000, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210094685","https://openalex.org/I4210139033","https://openalex.org/I4405253280"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5063702031"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210094685","https://openalex.org/I4210139033","https://openalex.org/I4405253280"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.48559999465942383,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9610000252723694},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7179999947547913},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.847000002861023},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8410000205039978},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/immune-resistance","display_name":"immune resistance","score":0.4429999887943268},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8009999990463257},{"id":"https://openalex.org/keywords/nanoparticle-tracking-analysis","display_name":"nanoparticle tracking analysis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/longitudinal-biomarker-monitoring","display_name":"longitudinal biomarker monitoring","score":0.6190000176429749},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.6240000128746033},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7473999857902527},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5906000137329102},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5299999713897705},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5214999914169312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5072000026702881},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.49570000171661377},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.491100013256073},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.43560001254081726},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.43220001459121704},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.42649999260902405},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4000000059604645},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3628000020980835},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3603000044822693},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.36000001430511475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.3490999937057495},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3488999903202057},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.34459999203681946},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.33399999141693115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3107999861240387},{"id":"https://openalex.org/C2779177807","wikidata":"https://www.wikidata.org/wiki/Q3658562","display_name":"non-small cell lung cancer (NSCLC)","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12885-026-17120-w","doi":"https://doi.org/10.1186/s12885-026-17120-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-17120-w","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12885-026-17120-w","doi":"https://doi.org/10.1186/s12885-026-17120-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-17120-w","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7140076395","https://openalex.org/W4415941832","https://openalex.org/W3213202280","https://openalex.org/W3099502788","https://openalex.org/W3126528925","https://openalex.org/W4392626677","https://openalex.org/W4297906517","https://openalex.org/W4388046009","https://openalex.org/W4280647847","https://openalex.org/W6939251615"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Immune":[2],"checkpoint":[3],"inhibitors":[4],"(ICIs),":[5],"including":[6,40],"anti-programmed":[7],"cell":[8,22],"death-1/programmed":[9],"death":[10],"ligand-1":[11],"(anti-PD-(L)1)":[12],"therapies,":[13],"have":[14],"improved":[15],"outcomes":[16],"in":[17,109,123,147,273],"patients":[18,114,148,166],"with":[19,115,149,159,294],"advanced":[20,152],"non-small":[21],"lung":[23],"cancer":[24],"(NSCLC)":[25],"and":[26,37,44,53,72,78,93,144,177,187,198,223,238,285,288,292,322,335],"melanoma.":[27],"However,":[28],"objective":[29,227],"response":[30,64,105,245],"rates":[31],"remain":[32,59],"limited":[33],"(40":[34],"to":[35,61,65,104,106,136,229,248,302],"60%),":[36],"existing":[38],"biomarkers,":[39],"tumor":[41,49,55,77,91,145],"PD-L1":[42],"expression":[43],"emerging":[45],"markers":[46],"such":[47],"as":[48,307],"mutational":[50],"burden":[51],"(TMB)":[52],"circulating":[54],"DNA":[56],"(ctDNA)":[57],"dynamics,":[58],"insufficient":[60],"accurately":[62],"predict":[63],"ICIs.":[66],"Extracellular":[67],"vesicles":[68],"(EVs),":[69],"carrying":[70],"proteins":[71,206],"nucleic":[73],"acids":[74],"originating":[75],"from":[76,185],"immune":[79,95,143],"cells,":[80],"represent":[81],"a":[82,110,130],"promising":[83],"minimally":[84,323],"invasive":[85,324],"source":[86],"of":[87,113,141,164,260,270,279,310],"biomarkers":[88,146,237,275,309],"reflecting":[89],"both":[90],"biology":[92],"systemic":[94],"status.":[96],"We":[97],"previously":[98],"identified":[99],"an":[100,261],"EV-associated":[101,142,205,274,304],"signature":[102],"linked":[103],"anti-PD-(L)1":[107,160,179,311],"therapy":[108],"small":[111,220],"cohort":[112],"NSCLC":[116,155],"or":[117,153,156],"melanoma,":[118],"supporting":[119],"its":[120],"further":[121],"validation":[122],"larger":[124],"prospective":[125,315],"cohorts.":[126],"Methods":[127],"EVpredict":[128],"is":[129,228],"prospective,":[131],"multicenter,":[132],"non-randomized":[133],"study":[134,300],"designed":[135],"evaluate":[137],"the":[138,231,258],"predictive":[139,264,266,281,308],"value":[140,282],"unresectable":[150],"locally":[151],"metastatic":[154],"melanoma":[157],"treated":[158],"therapies.":[161],"A":[162],"total":[163],"378":[165],"will":[167,172,182,207,216],"be":[168,173,183,208,217],"enrolled.":[169],"Blood":[170],"samples":[171],"collected":[174],"longitudinally":[175],"before":[176],"during":[178,276],"treatment.":[180],"EVs":[181],"isolated":[184],"plasma":[186],"characterized":[188],"by":[189,210,219,242],"nanoparticle":[190],"tracking":[191],"analysis":[192],"(NTA),":[193],"transmission":[194],"electron":[195],"microscopy":[196],"(TEM),":[197],"EV":[199,235],"marker":[200],"profiling,":[201],"following":[202],"MISEV2023":[203],"guidelines.":[204],"quantified":[209],"multiplex":[211],"ELISA,":[212],"while":[213],"EV-derived":[214,262,329],"miRNAs":[215],"analyzed":[218],"RNA":[221],"sequencing":[222],"RT-qPCR.":[224],"The":[225],"primary":[226,284],"determine":[230],"association":[232],"between":[233],"baseline":[234],"protein":[236],"treatment":[239],"response,":[240],"assessed":[241],"best":[243],"overall":[244],"(BOR)":[246],"according":[247],"RECIST":[249],"1.1":[250],"criteria":[251],"within":[252],"6":[253],"months.":[254],"Secondary":[255],"objectives":[256],"include":[257,314],"identification":[259],"miRNA":[263],"signature,":[265],"score":[267],"development,":[268],"evaluation":[269],"longitudinal":[271,325],"changes":[272],"follow-up,":[277],"assessment":[278],"their":[280],"for":[283],"secondary":[286],"resistance":[287],"progression-free":[289],"survival":[290],"(PFS),":[291],"comparison":[293],"current":[295],"standard":[296],"biomarkers.":[297],"Discussion":[298],"This":[299],"aims":[301],"validate":[303],"multimolecular":[305],"signatures":[306,330],"response.":[312],"Strengths":[313],"multicenter":[316],"recruitment,":[317],"standardized":[318],"sampling,":[319],"centralized":[320],"processing,":[321],"monitoring.":[326],"If":[327],"validated,":[328],"could":[331],"improve":[332],"patient":[333],"stratification":[334],"support":[336],"more":[337],"personalized":[338],"immunotherapy":[339],"strategies.":[340],"Trial":[341],"registration":[342],"ClinicalTrials.gov":[343],"identifier":[344],"NCT07376512.":[345],"Registered":[346],"29":[347],"January":[348],"2026,":[349],"https://clinicaltrials.gov/study/NCT07376512?term=evpredict&viewType=Card&rank=1":[350]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
