{"id":"https://openalex.org/W7225420944","doi":"https://doi.org/10.1016/j.jrras.2026.102802","title":"Yaobi-Sutong formula modulates endothelial responses and MAPK1/NF-\u03baB signaling in experimental inflammatory intervertebral disc injury","display_name":"Yaobi-Sutong formula modulates endothelial responses and MAPK1/NF-\u03baB signaling in experimental inflammatory intervertebral disc injury","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225420944","doi":"https://doi.org/10.1016/j.jrras.2026.102802"},"language":"en","primary_location":{"id":"doi:10.1016/j.jrras.2026.102802","doi":"https://doi.org/10.1016/j.jrras.2026.102802","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102802","pdf_url":null,"source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jrras.2026.102802","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161104526","display_name":"Qiu Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu Ding","raw_affiliation_strings":["Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160997952","display_name":"Yi Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhou","raw_affiliation_strings":["Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101606946","display_name":"Gang Ma","orcid":"https://orcid.org/0009-0005-4045-5266","observed_orcids":["https://orcid.org/0009-0005-4045-5266"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Ma","raw_affiliation_strings":["Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039165043","display_name":"Qiaosong Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaosong Deng","raw_affiliation_strings":["Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100722507","display_name":"Jiang Jiang","orcid":"https://orcid.org/0000-0003-2483-2947","observed_orcids":["https://orcid.org/0000-0003-2483-2947"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiang Jiang","raw_affiliation_strings":["Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantong Hospital of Traditional Chinese Medicine/Orthopedics, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, No. 6 North Hai'erxiang Road, Chongchuan District, Nantong City, 226001, Jiangsu Province, China","institution_ids":["https://openalex.org/I131434179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100722507"],"corresponding_institution_ids":["https://openalex.org/I131434179"],"apc_list":{"value":1400,"currency":"USD","value_usd":1400},"apc_paid":{"value":1400,"currency":"USD","value_usd":1400},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"4","first_page":"102802","last_page":"102802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lumbar-disc-herniation","display_name":"lumbar disc herniation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intervertebral-disc-injury","display_name":"intervertebral disc injury","score":0.9769999980926514},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.5590000152587891},{"id":"https://openalex.org/keywords/buyang-huanwu-decoction","display_name":"Buyang Huanwu Decoction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.628000020980835},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.718999981880188},{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.638700008392334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6380000114440918},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5619000196456909},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5498999953269958},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5364999771118164},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5105999708175659},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.505299985408783},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4350999891757965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4068000018596649},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3837999999523163},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.35370001196861267},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3449000120162964},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3431999981403351},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3230000138282776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C2781212864","wikidata":"https://www.wikidata.org/wiki/Q15551438","display_name":"Panax notoginseng","level":3,"score":0.3082999885082245},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2515000104904175},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jrras.2026.102802","doi":"https://doi.org/10.1016/j.jrras.2026.102802","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102802","pdf_url":null,"source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a8124a4a2ab74bb2bfb0c17e7677eb00","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a8124a4a2ab74bb2bfb0c17e7677eb00","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Radiation Research and Applied Sciences, Vol 19, Iss 4, Pp 102802- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jrras.2026.102802","doi":"https://doi.org/10.1016/j.jrras.2026.102802","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102802","pdf_url":null,"source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W2032955209","https://openalex.org/W2035936653","https://openalex.org/W2066963386","https://openalex.org/W2074196937","https://openalex.org/W2116168426","https://openalex.org/W2150271931","https://openalex.org/W2171783221","https://openalex.org/W2275204317","https://openalex.org/W2290466312","https://openalex.org/W2550854745","https://openalex.org/W2741524999","https://openalex.org/W2748471981","https://openalex.org/W2900349643","https://openalex.org/W2903826050","https://openalex.org/W2990009339","https://openalex.org/W3016856442","https://openalex.org/W3092678179","https://openalex.org/W3122153935","https://openalex.org/W3125740254","https://openalex.org/W3130707799","https://openalex.org/W3176344170","https://openalex.org/W3185060928","https://openalex.org/W4220676933","https://openalex.org/W4290839758","https://openalex.org/W4312174617","https://openalex.org/W4384944142","https://openalex.org/W4386407428","https://openalex.org/W4389793298","https://openalex.org/W4392938672","https://openalex.org/W4393092959","https://openalex.org/W4396863005","https://openalex.org/W4402014731"],"related_works":["https://openalex.org/W4388525147","https://openalex.org/W4280499723","https://openalex.org/W4416062021","https://openalex.org/W2607871350","https://openalex.org/W2375441091","https://openalex.org/W4303961684","https://openalex.org/W7154501461","https://openalex.org/W2386872265","https://openalex.org/W4391014909","https://openalex.org/W2379299008"],"abstract_inverted_index":{"Background":[0],"and":[1,15,24,44,71,99,116,129,141,155,166,169,207,216,236],"objective":[2],"Lumbar":[3],"disc":[4,74,239],"herniation":[5],"(LDH)":[6],"is":[7],"a":[8,34],"common":[9],"cause":[10],"of":[11,65,85,195,230],"acute":[12],"low":[13],"back":[14],"radicular":[16],"pain.":[17,29],"Increasing":[18],"evidence":[19,226],"suggests":[20],"that":[21],"microvascular":[22],"impairment":[23],"inflammation":[25],"contribute":[26],"to":[27,79,112],"LDH-associated":[28],"Yaobi":[30],"Sutong":[31],"Formula":[32],"(YSF),":[33],"traditional":[35],"herbal":[36],"prescription":[37],"derived":[38],"from":[39],"Buyang":[40],"Huanwu":[41],"Decoction":[42,46],"(BYHWD)":[43],"Wutou":[45],"(WTD),":[47],"may":[48],"modulate":[49],"inflammation-related":[50],"responses,":[51,191],"but":[52],"its":[53],"effects":[54,64,84],"on":[55,67,87],"endothelial":[56,69,91,189,204,234],"dysfunction":[57,70,235],"remain":[58],"unclear.":[59],"This":[60],"study":[61],"investigated":[62],"the":[63,173,185],"YSF":[66,86,121,124,147,158,199,231],"inflammation-associated":[68,233],"experimental":[72,237],"intervertebral":[73,238],"injury,":[75],"with":[76,162,182,202],"particular":[77],"attention":[78],"MAPK1-related":[80,196],"signaling.":[81,197],"Methods":[82],"The":[83],"Human":[88],"umbilical":[89],"vein":[90],"cells":[92],"(HUVECs)":[93],"viability,":[94,127],"migration,":[95,128],"tube-like":[96,130],"network":[97,131],"formation,":[98],"MAPK1/NF-\u03baB-related":[100],"protein":[101],"phosphorylation":[102,140,215],"were":[103],"evaluated":[104],"in":[105,153,156,172,188,232],"vitro.":[106],"A":[107],"rat":[108],"model":[109],"was":[110,160,200],"established":[111],"assess":[113],"histopathological":[114,209],"alterations":[115],"vascular-associated":[117],"marker":[118],"expression":[119],"following":[120],"treatment.":[122],"Results":[123],"improved":[125,163,203],"HUVEC":[126],"formation":[132],"under":[133],"inflammatory":[134],"conditions.":[135],"Inflammatory":[136],"stimulation":[137],"reduced":[138,217],"MAPK1":[139,177,214],"increased":[142,167,213],"NF-\u03baB":[143,218],"p65":[144,219],"phosphorylation,":[145],"whereas":[146],"treatment":[148,159],"partially":[149],"reversed":[150],"these":[151],"changes":[152],"vitro":[154],"vivo.":[157],"associated":[161,201],"histological":[164],"appearance":[165],"CD31":[168],"VEGFR2":[170],"immunoreactivity":[171],"sampled":[174],"endplate-adjacent":[175],"tissues.":[176],"knockdown":[178],"or":[179],"MEK":[180],"inhibition":[181],"PD98059":[183],"attenuated":[184,208],"YSF-associated":[186],"improvements":[187],"functional":[190,205],"suggesting":[192],"possible":[193],"involvement":[194],"Conclusion":[198],"responses":[206],"alterations,":[210],"accompanied":[211],"by":[212],"phosphorylation.":[220],"These":[221],"findings":[222],"provide":[223],"preliminary":[224],"preclinical":[225],"supporting":[227],"further":[228],"investigation":[229],"injury.":[240]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-07T00:00:00"}