{"id":"https://openalex.org/W7225420862","doi":"https://doi.org/10.22336/rjo.2026.65","title":"Severe Atypical Conjunctivitis: A Novel OphthalmicPresentation of Erdheim-Chester Disease","display_name":"Severe Atypical Conjunctivitis: A Novel OphthalmicPresentation of Erdheim-Chester Disease","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7225420862","doi":"https://doi.org/10.22336/rjo.2026.65","pmid":"https://pubmed.ncbi.nlm.nih.gov/43001132","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13744678"},"language":"en","primary_location":{"id":"doi:10.22336/rjo.2026.65","doi":"https://doi.org/10.22336/rjo.2026.65","is_oa":true,"landing_page_url":"https://doi.org/10.22336/rjo.2026.65","pdf_url":"https://rjo.ro/wp-content/uploads/2026/10/18.Andrea-Cordoba_RJO_2026.pdf","source":{"id":"https://openalex.org/S4210175898","display_name":"Romanian Journal of Ophthalmology","issn_l":"2457-4325","issn":["2457-4325","2501-2533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40"],"host_organization":"https://openalex.org/P4310314538","host_organization_name":"Romanian Society of Ophthalmology","host_organization_lineage":["https://openalex.org/P4310314538"],"host_organization_lineage_names":["Romanian Society of Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rjo.ro/wp-content/uploads/2026/10/18.Andrea-Cordoba_RJO_2026.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrea C\u00f3rdoba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128920","display_name":"Universidad CES","ror":"https://ror.org/037p13h95","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210128920"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Andrea C\u00f3rdoba","raw_affiliation_strings":["Cornea Service, Ophthalmology Department, School of Medicine, CES University - CLOFAN Clinic - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornea Service, Ophthalmology Department, School of Medicine, CES University - CLOFAN Clinic - Medellin, Colombia","institution_ids":["https://openalex.org/I4210128920"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Javier Andres D\u00edaz-Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128920","display_name":"Universidad CES","ror":"https://ror.org/037p13h95","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210128920"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Javier Andres D\u00edaz-Vargas","raw_affiliation_strings":["Ophthalmology Department, School of Medicine, CES University - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, School of Medicine, CES University - Medellin, Colombia","institution_ids":["https://openalex.org/I4210128920"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Juan Manuel Correa Alvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128920","display_name":"Universidad CES","ror":"https://ror.org/037p13h95","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210128920"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Juan Manuel Correa Alvarez","raw_affiliation_strings":["Ophthalmology Department, School of Medicine, CES University - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, School of Medicine, CES University - Medellin, Colombia","institution_ids":["https://openalex.org/I4210128920"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pedro Jose Ramirez Wiesner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128920","display_name":"Universidad CES","ror":"https://ror.org/037p13h95","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210128920"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Pedro Jose Ramirez Wiesner","raw_affiliation_strings":["Ophthalmology Department, School of Medicine, CES University - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, School of Medicine, CES University - Medellin, Colombia","institution_ids":["https://openalex.org/I4210128920"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Camilo Restrepo-Perdomo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Camilo Restrepo-Perdomo","raw_affiliation_strings":["Ophthalmic Pathology Service, Pathology Department, School of Medicine, University of Antioquia - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmic Pathology Service, Pathology Department, School of Medicine, University of Antioquia - Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mauricio Jaramillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128920","display_name":"Universidad CES","ror":"https://ror.org/037p13h95","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210128920"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Mauricio Jaramillo","raw_affiliation_strings":["Oncology Service, Ophthalmology Department, School of Medicine, CES University - CLOFAN Clinic - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Ophthalmology Department, School of Medicine, CES University - CLOFAN Clinic - Medellin, Colombia","institution_ids":["https://openalex.org/I4210128920"]}]},{"author_position":"last","author":{"id":null,"display_name":"Miguel Cuevas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128920","display_name":"Universidad CES","ror":"https://ror.org/037p13h95","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210128920"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Miguel Cuevas","raw_affiliation_strings":["Cornea Service, Ophthalmology Department, School of Medicine, CES University - CLOFAN Clinic - Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornea Service, Ophthalmology Department, School of Medicine, CES University - CLOFAN Clinic - Medellin, Colombia","institution_ids":["https://openalex.org/I4210128920"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"3","first_page":"468","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erdheim-chester-disease","display_name":"Erdheim-Chester disease","score":1.0},{"id":"https://openalex.org/keywords/conjunctivitis","display_name":"conjunctivitis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/conjunctival-involvement","display_name":"conjunctival involvement","score":0.8429999947547913},{"id":"https://openalex.org/keywords/histiocytosis","display_name":"histiocytosis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cd163","display_name":"CD163","score":0.9890000224113464},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8399999737739563},{"id":"https://openalex.org/keywords/surgical-debridement","display_name":"surgical debridement","score":0.7319999933242798},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/corneal-epithelial-defects","display_name":"corneal epithelial defects","score":0.7680000066757202},{"id":"https://openalex.org/keywords/atypical-presentation","display_name":"atypical presentation","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6951000094413757},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6114000082015991},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.2485000044107437},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24379999935626984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2363000065088272},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2190999984741211},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21860000491142273},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.21529999375343323},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.20739999413490295},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.20730000734329224}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003231","descriptor_name":"Conjunctivitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003231","descriptor_name":"Conjunctivitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031249","descriptor_name":"Erdheim-Chester Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D031249","descriptor_name":"Erdheim-Chester Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.22336/rjo.2026.65","doi":"https://doi.org/10.22336/rjo.2026.65","is_oa":true,"landing_page_url":"https://doi.org/10.22336/rjo.2026.65","pdf_url":"https://rjo.ro/wp-content/uploads/2026/10/18.Andrea-Cordoba_RJO_2026.pdf","source":{"id":"https://openalex.org/S4210175898","display_name":"Romanian Journal of Ophthalmology","issn_l":"2457-4325","issn":["2457-4325","2501-2533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40"],"host_organization":"https://openalex.org/P4310314538","host_organization_name":"Romanian Society of Ophthalmology","host_organization_lineage":["https://openalex.org/P4310314538"],"host_organization_lineage_names":["Romanian Society of Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:43001132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43001132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of ophthalmology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13744678","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13744678/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rom J Ophthalmol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.22336/rjo.2026.65","doi":"https://doi.org/10.22336/rjo.2026.65","is_oa":true,"landing_page_url":"https://doi.org/10.22336/rjo.2026.65","pdf_url":"https://rjo.ro/wp-content/uploads/2026/10/18.Andrea-Cordoba_RJO_2026.pdf","source":{"id":"https://openalex.org/S4210175898","display_name":"Romanian Journal of Ophthalmology","issn_l":"2457-4325","issn":["2457-4325","2501-2533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40"],"host_organization":"https://openalex.org/P4310314538","host_organization_name":"Romanian Society of Ophthalmology","host_organization_lineage":["https://openalex.org/P4310314538"],"host_organization_lineage_names":["Romanian Society of Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225420862.pdf","grobid_xml":"https://content.openalex.org/works/W7225420862.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W599553243","https://openalex.org/W1979760483","https://openalex.org/W2785322927","https://openalex.org/W2898120789","https://openalex.org/W3011169548","https://openalex.org/W3048688883","https://openalex.org/W3096665490","https://openalex.org/W3165637566","https://openalex.org/W3205243900","https://openalex.org/W3208740722","https://openalex.org/W4308952715","https://openalex.org/W4392389017","https://openalex.org/W4400408881","https://openalex.org/W4400944331"],"related_works":["https://openalex.org/W2902505201","https://openalex.org/W4225275324","https://openalex.org/W4400944331","https://openalex.org/W6924913849","https://openalex.org/W4402146684","https://openalex.org/W4280551103","https://openalex.org/W2981995240","https://openalex.org/W1577707725","https://openalex.org/W2038365323","https://openalex.org/W7161546369"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"describe":[2],"an":[3,49,59],"atypical":[4,25,119,170],"ophthalmological":[5],"presentation":[6],"of":[7,43,52,65,125],"Erdheim-Chester":[8,44,78,84,150],"disease":[9,85,151],"characterized":[10],"by":[11],"conjunctival":[12,95,120],"involvement.":[13],"Methods:":[14],"Interventional":[15],"case":[16],"report.":[17],"A":[18],"27-year-old":[19],"woman":[20],"presented":[21,102],"with":[22,28,62,68,104,131,166],"severe":[23,105],"bilateral":[24,106],"conjunctivitis":[26],"associated":[27],"a":[29,40,53,63,109],"rubbery":[30],"subconjunctival":[31,54,111,167],"nodule":[32],"in":[33,83],"the":[34,157,162],"inferior":[35],"fornix,":[36],"which":[37],"led":[38],"to":[39],"histopathological":[41],"diagnosis":[42,124,186],"disease.":[45,79,128],"Results:":[46],"We":[47],"performed":[48],"excisional":[50],"biopsy":[51],"nodule.":[55],"Histological":[56],"analysis":[57],"revealed":[58],"inflammatory":[60],"infiltrate":[61],"predominance":[64],"large":[66,69],"histiocytes":[67],"foamy":[70],"cytoplasm,":[71],"CD68+,":[72],"CD163+,":[73],"CD1a-,":[74],"and":[75,91,113,136,154,187],"S100-;":[76],"confirming":[77],"Discussion:":[80],"Ophthalmological":[81],"involvement":[82,96],"typically":[86],"manifests":[87],"as":[88,179],"eyelid":[89],"xanthelasmas":[90],"intraconal":[92],"orbital":[93],"masses;":[94],"is":[97,152,182],"rarely":[98],"described.":[99],"Our":[100],"patient":[101],"predominantly":[103],"refractory":[107],"conjunctivitis,":[108],"yellowish":[110],"nodule,":[112],"secondary":[114],"corneal":[115],"epithelial":[116],"defects.":[117],"Recognizing":[118],"manifestations":[121],"facilitates":[122],"earlier":[123],"this":[126],"systemic":[127,132],"Multidisciplinary":[129],"management":[130],"polychemotherapy,":[133],"surgical":[134],"debridement,":[135],"topical":[137],"1%":[138],"5-fluorouracil":[139],"achieved":[140],"marked":[141],"clinical":[142],"improvement":[143],"without":[144],"relapse":[145],"after":[146],"4":[147],"months.":[148],"Conclusion:":[149],"rare":[153],"commonly":[155],"involves":[156],"eyes.":[158],"Although":[159],"infrequently":[160],"affected,":[161],"conjunctiva":[163],"may":[164],"present":[165],"nodules":[168],"or":[169],"conjunctivitis.":[171],"Ophthalmologists":[172],"must":[173],"remain":[174],"vigilant":[175],"for":[176,184],"these":[177],"presentations,":[178],"early":[180],"recognition":[181],"crucial":[183],"timely":[185],"appropriate":[188],"management.":[189]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-07T00:00:00"}
