{"id":"https://openalex.org/W7225420626","doi":"https://doi.org/10.1186/s12964-026-03331-y","title":"A multi-omics profile reveals porcine developmental nonlinearity organizes intestinal maturation and long-term metabolic phenotypes","display_name":"A multi-omics profile reveals porcine developmental nonlinearity organizes intestinal maturation and long-term metabolic phenotypes","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225420626","doi":"https://doi.org/10.1186/s12964-026-03331-y"},"language":"en","primary_location":{"id":"doi:10.1186/s12964-026-03331-y","doi":"https://doi.org/10.1186/s12964-026-03331-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-03331-y","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12964-026-03331-y","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035817373","display_name":"Qinqin Xie","orcid":"https://orcid.org/0009-0001-6678-8078","observed_orcids":["https://orcid.org/0009-0001-6678-8078"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinqin Xie","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143780610","display_name":"Pengfei Yu","orcid":"https://orcid.org/0009-0009-8511-1693","observed_orcids":["https://orcid.org/0009-0009-8511-1693"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Yu","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160989479","display_name":"Shuang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Liu","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161081411","display_name":"Qingyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyu Wang","raw_affiliation_strings":["Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012448103","display_name":"Jiamin Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiamin Gu","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161020708","display_name":"Jiao Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Dong","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161016768","display_name":"Cheng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Liu","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161133131","display_name":"Yiting Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Wang","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085704829","display_name":"Lingyao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyao Xu","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160994846","display_name":"Haixia Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixia Li","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123399611","display_name":"Fen Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fen Wu","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159608498","display_name":"Xiaowei Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Ye","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064186451","display_name":"Caiyun Cao","orcid":"https://orcid.org/0009-0009-2797-6453","observed_orcids":["https://orcid.org/0009-0009-2797-6453"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiyun Cao","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126776898","display_name":"Zhenyang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyang Zhang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161128634","display_name":"Wei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhao","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101440916","display_name":"Jian Miao","orcid":"https://orcid.org/0000-0001-9670-0121","observed_orcids":["https://orcid.org/0000-0001-9670-0121"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Miao","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152439799","display_name":"Zitao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zitao Chen","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090195340","display_name":"Daxi Ren","orcid":"https://orcid.org/0000-0002-8016-0033","observed_orcids":["https://orcid.org/0000-0002-8016-0033"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daxi Ren","raw_affiliation_strings":["Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159603683","display_name":"Yuchun Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuchun Pan","raw_affiliation_strings":["Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443040","display_name":"Zhe Zhang","orcid":"https://orcid.org/0000-0003-4208-8461","observed_orcids":["https://orcid.org/0000-0003-4208-8461"]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhe Zhang","raw_affiliation_strings":["Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161046146","display_name":"Qishan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qishan Wang","raw_affiliation_strings":["Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161107166","display_name":"Zhen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen Wang","raw_affiliation_strings":["Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Institute, Zhejiang University, Yongyou Industrial Park, Yazhou Bay Sci-Tech City, Sanya, 572025, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Key Laboratory of Livestock and Poultry Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100443040","https://openalex.org/A5159603683","https://openalex.org/A5161046146","https://openalex.org/A5161107166"],"corresponding_institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I76130692"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.14110000431537628,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-development","display_name":"intestinal development","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.46000000834465027},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8069999814033508},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.8159999847412109},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/developmental-trajectories","display_name":"developmental trajectories","score":0.6800000071525574},{"id":"https://openalex.org/keywords/obesity-susceptibility","display_name":"obesity susceptibility","score":0.6010000109672546},{"id":"https://openalex.org/keywords/pck1","display_name":"PCK1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.6439999938011169},{"id":"https://openalex.org/keywords/developmental-programming","display_name":"developmental programming","score":0.6899999976158142},{"id":"https://openalex.org/keywords/metabolic-phenotypes","display_name":"metabolic phenotypes","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cellular-niches","display_name":"cellular niches","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8001000285148621},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6366000175476074},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4968999922275543},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40860000252723694},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.367900013923645},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.3677999973297119},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3603000044822693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33869999647140503},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.32409998774528503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3003999888896942},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.29170000553131104},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2782000005245209},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27489998936653137},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25380000472068787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12964-026-03331-y","doi":"https://doi.org/10.1186/s12964-026-03331-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-03331-y","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12964-026-03331-y","doi":"https://doi.org/10.1186/s12964-026-03331-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-03331-y","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2746424298","https://openalex.org/W7140120732","https://openalex.org/W7161492273","https://openalex.org/W7135387469","https://openalex.org/W7134260074","https://openalex.org/W6939904704","https://openalex.org/W2806362852","https://openalex.org/W4414842535","https://openalex.org/W4411880178","https://openalex.org/W2093229186"],"abstract_inverted_index":{"Intestinal":[0],"development":[1],"is":[2],"a":[3,153,225],"highly":[4],"orchestrated":[5],"dynamic":[6,194],"process":[7],"for":[8,228,243],"metabolic":[9,34,170,233,244],"homeostasis":[10],"and":[11,31,51,64,70,80,117,134,147,171,208,217,235,240],"long-term":[12],"physiological":[13,220],"health.":[14],"Developmental":[15],"nonlinearity":[16],"offers":[17,201],"new":[18,202],"insights":[19,203],"on":[20,67],"developmental":[21,26,55,96,155,197,206,230],"dynamics.":[22],"However,":[23],"how":[24,210],"nonlinear":[25,77,93,108,114,167,177],"dynamics":[27,130,168,213],"coordinate":[28],"intestinal":[29,41,121,149,205],"maturation":[30],"contribute":[32],"to":[33,75,103,169],"phenotypes":[35],"remains":[36],"unclear.":[37],"We":[38,60,151,174],"construct":[39],"an":[40],"multi-omics":[42],"framework":[43,227],"of":[44,107,191,232],"1,153,328":[45],"biological":[46,118],"molecules,":[47],"integrating":[48,89],"transcriptomics,":[49],"metabolomics,":[50],"single-cell":[52],"dataset":[53],"across":[54,214],"stages":[56],"from":[57],"136":[58],"pigs.":[59],"performed":[61,74],"trajectory":[62],"clustering":[63],"functional":[65],"identification":[66],"molecules.":[68,109],"Multi-tissue":[69],"cross-species":[71,138],"analyses":[72,139],"were":[73,101],"characterize":[76],"regulatory":[78],"factors":[79],"conserved":[81,141],"molecular":[82,115,142,212,241],"trajectories":[83,116,143],"at":[84,158],"the":[85,105,188],"cellular":[86,124,164],"level.":[87],"By":[88],"phenotypes,":[90],"we":[91],"identified":[92,152,176],"molecules":[94,127,178],"within":[95,131],"transient":[97],"windows.":[98],"Functional":[99],"experiments":[100],"conducted":[102],"validate":[104],"role":[106,190],"Our":[110,199],"analysis":[111],"revealed":[112,140],"widespread":[113],"pathways":[119],"during":[120],"development.":[122],"At":[123],"resolution,":[125],"age-related":[126],"exhibited":[128],"collaborative":[129,193],"cell":[132],"populations":[133],"tissue":[135],"ecosystems,":[136],"while":[137],"in":[144,196],"both":[145],"porcine":[146],"human":[148],"systems.":[150],"critical":[154],"transition":[156],"window":[157],"60\u201390":[159],"days,":[160],"characterized":[161],"by":[162],"unique":[163],"niches,":[165],"linking":[166],"fat-related":[172],"phenotypes.":[173,221],"further":[175],"associated":[179],"with":[180],"obesity":[181],"susceptibility,":[182],"such":[183],"as":[184],"PCK1":[185],",":[186],"highlighting":[187],"pivotal":[189],"multi-level":[192],"systems":[195],"programming.":[198],"study":[200],"into":[204],"patterns":[207],"demonstrates":[209],"coordinated":[211],"cells,":[215],"tissues,":[216],"species":[218],"shape":[219],"The":[222],"findings":[223],"establish":[224],"valuable":[226],"understanding":[229],"origins":[231],"traits,":[234],"identify":[236],"potential":[237],"temporal":[238],"windows":[239],"targets":[242],"intervention.":[245]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
