{"id":"https://openalex.org/W7225420164","doi":"https://doi.org/10.1161/circ.154.suppl_1.11014","title":"Abstract 11014: Glucagon-Like Peptide-1 Receptor Agonists and Clinical Outcomes in Antipsychotic-Treated Patients with Schizophrenia and Obesity: A Target Trial Emulation","display_name":"Abstract 11014: Glucagon-Like Peptide-1 Receptor Agonists and Clinical Outcomes in Antipsychotic-Treated Patients with Schizophrenia and Obesity: A Target Trial Emulation","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225420164","doi":"https://doi.org/10.1161/circ.154.suppl_1.11014"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.11014","doi":"https://doi.org/10.1161/circ.154.suppl_1.11014","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.11014","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071138301","display_name":"Raiza Rossi","orcid":"https://orcid.org/0000-0001-6898-2192","observed_orcids":["https://orcid.org/0000-0001-6898-2192"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raiza Rossi","raw_affiliation_strings":["Section of Cardiovascular Medicine, Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiovascular Medicine, Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021474115","display_name":"Sammudeen Ibrahim","orcid":"https://orcid.org/0009-0000-5039-8174","observed_orcids":["https://orcid.org/0009-0000-5039-8174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sammudeen Ibrahim","raw_affiliation_strings":["Mayo Clinic, Athens, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Athens, GA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161063050","display_name":"Mark Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Costa","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032552563","display_name":"Sridhar Mangalesh","orcid":"https://orcid.org/0000-0002-2645-3994","observed_orcids":["https://orcid.org/0000-0002-2645-3994"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Mangalesh","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106702347","display_name":"Kuan Yu Chi","orcid":"https://orcid.org/0000-0003-0763-8157","observed_orcids":["https://orcid.org/0000-0003-0763-8157"]},"institutions":[{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuan Yu Chi","raw_affiliation_strings":["Jacobi Med Cntr, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobi Med Cntr, Bronx, NY","institution_ids":["https://openalex.org/I2800364127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130811749","display_name":"Armin Nouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armin Nouri","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139864277","display_name":"Parvaneh Rastgou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvaneh Rastgou","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113239173","display_name":"Ishmum Z. Chowdhury","orcid":"https://orcid.org/0000-0001-7029-2369","observed_orcids":["https://orcid.org/0000-0001-7029-2369"]},"institutions":[{"id":"https://openalex.org/I2800364127","display_name":"Jacobi Medical Center","ror":"https://ror.org/05hcfns23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800364127"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ishmum Chowdhury","raw_affiliation_strings":["Jacobi Med Cntr, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobi Med Cntr, Bronx, NY","institution_ids":["https://openalex.org/I2800364127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095092157","display_name":"Chidubem G. Ezenna","orcid":"https://orcid.org/0009-0001-3988-6211","observed_orcids":["https://orcid.org/0009-0001-3988-6211"]},"institutions":[{"id":"https://openalex.org/I1338449461","display_name":"Baystate Medical Center","ror":"https://ror.org/01q2nz307","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1338449461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chidubem Ezenna","raw_affiliation_strings":["Univ of Massachusetts \u2013 Baystate Med Cntr, Springfield, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Massachusetts \u2013 Baystate Med Cntr, Springfield, CT","institution_ids":["https://openalex.org/I1338449461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113189074","display_name":"Christopher S. Chinnatambi","orcid":"https://orcid.org/0009-0009-1735-3156","observed_orcids":["https://orcid.org/0009-0009-1735-3156"]},"institutions":[{"id":"https://openalex.org/I1292197403","display_name":"Piedmont Athens Regional","ror":"https://ror.org/05azzyk65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1292197403","https://openalex.org/I4210153954"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S Chinnatambi","raw_affiliation_strings":["Piedmont Athens Regional, Athens, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Piedmont Athens Regional, Athens, GA","institution_ids":["https://openalex.org/I1292197403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161061703","display_name":"Abdul Daaim Mohammed-Murtala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdul Daaim Mohammed-Murtala","raw_affiliation_strings":["37 Military Hosp, Tamale, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"37 Military Hosp, Tamale, Ghana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161077495","display_name":"Abdulla Damluji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdulla Damluji","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161056030","display_name":"Michael Nanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Nanna","raw_affiliation_strings":["Yale Sch of Medicine, East Lyme, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, East Lyme, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.996999979019165},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antipsychotic-induced-weight-gain","display_name":"antipsychotic-induced weight gain","score":0.7929999828338623},{"id":"https://openalex.org/keywords/major-adverse-cardiac-and-cerebrovascular-events","display_name":"major adverse cardiac and cerebrovascular events","score":0.8650000095367432},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8730000257492065},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.984000027179718},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.984000027179718},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.3610000014305115},{"id":"https://openalex.org/keywords/target-trial-emulation","display_name":"target trial emulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.5239999890327454},{"id":"https://openalex.org/keywords/trinetx","display_name":"TriNetX","score":0.6060000061988831},{"id":"https://openalex.org/keywords/psychiatric-hospitalization","display_name":"psychiatric hospitalization","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9610000252723694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6669999957084656},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5996999740600586},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5946000218391418},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5934000015258789},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.5307999849319458},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5196999907493591},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.47189998626708984},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4537999927997589},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3644999861717224},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.35429999232292175},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2953999936580658},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C2910202354","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic Agent","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.11014","doi":"https://doi.org/10.1161/circ.154.suppl_1.11014","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.11014","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7163718255","https://openalex.org/W7170965333","https://openalex.org/W4377565083","https://openalex.org/W7213369223","https://openalex.org/W2890415448","https://openalex.org/W7171355542","https://openalex.org/W7225403371","https://openalex.org/W4399432737","https://openalex.org/W7223475622","https://openalex.org/W4249844731"],"abstract_inverted_index":{"Introduction:":[0],"Cardiovascular":[1],"morbidity":[2],"is":[3],"disproportionately":[4],"high":[5],"in":[6,62,80,349],"individuals":[7,81,374],"with":[8,27,59,82,85,102,222,227,244,327,338,358,376],"schizophrenia.":[9],"Although":[10],"antipsychotics":[11],"are":[12,24],"essential":[13],"for":[14,232,237,346,373],"symptom":[15],"control":[16],"and":[17,35,77,109,124,138,160,167,173,177,212,284,314,332,340,354,360,370],"the":[18,72,143,351],"cornerstone":[19],"of":[20,97,132,146,196,205,247,317],"schizophrenia":[21,83,339,359],"treatment,":[22],"they":[23],"strongly":[25],"associated":[26,58,243,326,357],"weight":[28],"gain,":[29],"insulin":[30],"resistance,":[31],"type":[32],"2":[33,107],"diabetes,":[34],"dyslipidemia.":[36],"While":[37],"glucagon-like":[38],"peptide-1":[39],"receptor":[40],"agonists":[41],"(GLP1-RAs)":[42],"have":[43],"emerged":[44],"as":[45,129],"promising":[46],"agents":[47],"to":[48],"address":[49],"antipsychotic-associated":[50],"metabolic":[51,355],"dysfunction,":[52],"real-world":[53],"data":[54],"on":[55],"cardiovascular":[56,123,353],"outcomes":[57,79,141],"GLP1-RA":[60,75,239,323],"use":[61,76,111,324],"this":[63],"population":[64],"remains":[65],"limited.":[66],"Research":[67],"Question:":[68],"This":[69],"study":[70],"evaluated":[71],"association":[73],"between":[74],"clinical":[78],"compared":[84,226],"non-GLP1-RA":[86],"users.":[87],"Methods:":[88],"We":[89],"conducted":[90],"a":[91,113,130,201,343],"target":[92],"trial":[93],"emulation":[94],"using":[95],"TriNetX":[96],"adults":[98,337],"aged":[99],"\u226518":[100],"years":[101,195],"schizophrenia,":[103],"BMI":[104],"\u226527":[105],"kg/m":[106],",":[108],"antipsychotic":[110,361,377],"across":[112],"3-year":[114],"follow-up":[115],"period.":[116],"The":[117,182],"primary":[118],"outcome":[119],"was":[120,241,325],"major":[121],"adverse":[122,162,295],"cerebrovascular":[125],"events":[126],"(MACCE),":[127],"defined":[128],"composite":[131],"all-cause":[133,215],"mortality,":[134],"myocardial":[135],"infarction":[136],"(MI),":[137],"stroke.":[139],"Secondary":[140],"included":[142,184],"individual":[144],"components":[145],"MACCE,":[147],"heart":[148],"failure":[149],"(HF),":[150],"revascularization,":[151],"acute":[152],"kidney":[153],"injury":[154],"(AKI),":[155],"pancreatitis,":[156],"mental":[157,285],"health":[158,286],"hospitalization,":[159],"gastrointestinal":[161,294],"effects.":[163],"Cox":[164],"proportional":[165],"hazards":[166,246],"Kaplan-Meier":[168],"survival":[169,225,335],"analyses":[170],"were":[171,179,297,312],"performed,":[172],"falsification":[174],"endpoints":[175,311],"(cellulitis":[176],"appendicitis)":[178],"assessed.":[180],"Results:":[181],"analysis":[183],"16,477":[185],"patients":[186],"per":[187],"group":[188],"after":[189],"propensity":[190],"score":[191],"matching.":[192],"Over":[193],"3":[194],"follow-up,":[197],"GLP-1RA":[198,301],"users":[199,302],"had":[200],"37%":[202],"lower":[203,214,245,329],"hazard":[204],"MACCE":[206],"(HR":[207,217,249,255,261,267,273,279,288,303],"0.63,":[208],"95%":[209,219,251,257,263,269,275,281,290,305],"CI":[210,220,252,258,264,270,276,282,291,306],"0.59-0.67)":[211],"substantially":[213],"mortality":[216],"0.42,":[218],"0.38-0.45),":[221],"higher":[223,333],"event-free":[224,334],"non-users":[228],"(83.3%":[229],"vs":[230,235],"76.6%":[231],"MACCE;":[233],"93.4%":[234],"86.5%":[236],"mortality).":[238],"exposure":[240],"also":[242],"MI":[248],"0.75,":[250],"0.68-0.82),":[253],"stroke":[254],"0.85,":[256],"0.78-0.93),":[259],"HF":[260],"0.89,":[262],"0.85-0.93),":[265],"revascularization":[266],"0.86,":[268],"0.77-0.97),":[271],"AKI":[272],"0.71,":[274],"0.67-0.75),":[277],"pancreatitis":[278],"0.73,":[280],"0.62-0.88),":[283],"hospitalization":[287],"0.47,":[289],"0.26-0.86),":[292],"while":[293],"effects":[296],"modestly":[298],"increased":[299],"among":[300,336],"1.10,":[304],"1.06-1.15)":[307],"(Figure":[308],"1).":[309],"Falsification":[310],"null":[313],"not":[315],"suggestive":[316],"residual":[318],"unmeasured":[319],"confounding.":[320],"Conclusions:":[321],"Overall,":[322],"significantly":[328],"cardiometabolic":[330],"risk":[331],"overweight/obesity,":[341],"suggesting":[342],"potential":[344],"role":[345],"these":[347],"therapies":[348],"mitigating":[350],"substantial":[352],"burden":[356],"therapy.":[362],"These":[363],"findings":[364],"may":[365],"help":[366],"inform":[367],"future":[368],"research,":[369],"prescribing":[371],"guidelines":[372],"treated":[375],"therapies.":[378]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
