{"id":"https://openalex.org/W7225419922","doi":"https://doi.org/10.21203/rs.3.rs-11560858/v1","title":"A Single Cell Transcriptomic Atlas of CD8+ Cytokine-Induced Killer Cells Generated from Metastatic Colorectal Cancer Patients","display_name":"A Single Cell Transcriptomic Atlas of CD8+ Cytokine-Induced Killer Cells Generated from Metastatic Colorectal Cancer Patients","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225419922","doi":"https://doi.org/10.21203/rs.3.rs-11560858/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11560858/v1","doi":"https://doi.org/10.21203/rs.3.rs-11560858/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11560858/v1","pdf_url":"https://www.researchsquare.com/article/rs-11560858/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11560858/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068199304","display_name":"Kevin Aaron Fenix","orcid":"https://orcid.org/0000-0003-1619-1406","observed_orcids":["https://orcid.org/0000-0003-1619-1406"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kevin Fenix","raw_affiliation_strings":["Adelaide University"],"raw_orcid":"https://orcid.org/0000-0003-1619-1406","affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065710953","display_name":"Elham Shokati","orcid":"https://orcid.org/0000-0001-8704-5495","observed_orcids":["https://orcid.org/0000-0001-8704-5495"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elham Shokati","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026739793","display_name":"Celine Man Ying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Celine Man Ying Li","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069415568","display_name":"Runhao Li","orcid":"https://orcid.org/0000-0001-5577-049X","observed_orcids":["https://orcid.org/0000-0001-5577-049X"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Runhao Li","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102559436","display_name":"C. L. King","orcid":"https://orcid.org/0009-0009-0339-7932","observed_orcids":["https://orcid.org/0009-0009-0339-7932"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cathal King","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161004376","display_name":"Paul Drew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul Drew","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008504224","display_name":"Belinda Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Belinda Evans","raw_affiliation_strings":["Expert by Lived Experience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Expert by Lived Experience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161012993","display_name":"Christine Schutz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Schutz","raw_affiliation_strings":["Expert by Lived Experience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Expert by Lived Experience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134669990","display_name":"Guy Maddern","orcid":"https://orcid.org/0000-0003-2064-181X","observed_orcids":["https://orcid.org/0000-0003-2064-181X"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Guy Maddern","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026598479","display_name":"Michael J. Roach","orcid":"https://orcid.org/0000-0003-1488-5148","observed_orcids":["https://orcid.org/0000-0003-1488-5148"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Roach","raw_affiliation_strings":["Flinders University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flinders University","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014504939","display_name":"Timothy Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Timothy Price","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037217212","display_name":"Yoko Tomita","orcid":"https://orcid.org/0000-0001-7934-2203","observed_orcids":["https://orcid.org/0000-0001-7934-2203"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yoko Tomita","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078950820","display_name":"Eric Smith","orcid":"https://orcid.org/0000-0003-2958-3492","observed_orcids":["https://orcid.org/0000-0003-2958-3492"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Eric Smith","raw_affiliation_strings":["Adelaide University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adelaide University","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-induced-killer-cells","display_name":"cytokine-induced killer cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8949999809265137},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/t-cell-clonotypes","display_name":"T cell clonotypes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7139999866485596},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/memory-like-t-cells","display_name":"memory-like T cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/klf2","display_name":"KLF2","score":0.6179999709129333},{"id":"https://openalex.org/keywords/gfi1","display_name":"GFI1","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/t-cell-differentiation-trajectory","display_name":"T cell differentiation trajectory","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7505999803543091},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6646999716758728},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5422000288963318},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5411999821662903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5214999914169312},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.43549999594688416},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42340001463890076},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.41929998993873596},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.376800000667572},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3747999966144562},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3596999943256378},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35760000348091125},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3440999984741211},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3346000015735626},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3239000141620636},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.3172000050544739},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27459999918937683},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2703000009059906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.2554999887943268},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11560858/v1","doi":"https://doi.org/10.21203/rs.3.rs-11560858/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11560858/v1","pdf_url":"https://www.researchsquare.com/article/rs-11560858/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11560858/v1","doi":"https://doi.org/10.21203/rs.3.rs-11560858/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11560858/v1","pdf_url":"https://www.researchsquare.com/article/rs-11560858/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334706","display_name":"Cancer Council South Australia","ror":"https://ror.org/03m5qkb69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225419922.pdf","grobid_xml":"https://content.openalex.org/works/W7225419922.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409909511","https://openalex.org/W4415898789","https://openalex.org/W2135150353","https://openalex.org/W2897357454","https://openalex.org/W7218062769","https://openalex.org/W2607258745","https://openalex.org/W3017068514","https://openalex.org/W4390946808","https://openalex.org/W4220797855","https://openalex.org/W1625235397"],"abstract_inverted_index":{"Abstract":[0],"Cytokine-induced":[1],"killer":[2],"(CIK)":[3],"cell":[4,9,70],"therapy":[5],"is":[6],"an":[7,214],"adoptive":[8],"immunotherapy":[10],"under":[11],"investigation":[12],"for":[13],"malignancies":[14],"including":[15,193],"metastatic":[16],"colorectal":[17],"cancer":[18],"(mCRC).":[19],"Clinical":[20],"activity":[21],"has":[22],"been":[23],"attributed":[24],"primarily":[25],"to":[26,63,244],"CD3\u207aCD56\u207a":[27],"NK-like":[28,93,100,118,134,219],"T":[29],"cells,":[30,82],"with":[31,76,147,169,179],"CD8\u207a":[32,46,80,114,220],"cells":[33,66,222],"considered":[34],"a":[35,160,180],"key":[36],"effector":[37],"subset.":[38],"However,":[39],"the":[40],"transcriptional":[41,84],"and":[42,49,58,91,98,198,205,227,242],"clonal":[43,138],"states":[44,85,94,119,125,135,152],"underlying":[45],"CIK-cell":[47,240],"expansion":[48,106],"function":[50],"remain":[51],"poorly":[52],"undefined.":[53],"We":[54],"combined":[55],"single-cell":[56],"RNA":[57],"paired":[59],"T-cell":[60,101],"receptor":[61],"sequencing":[62],"profile":[64],"43,047":[65],"from":[67,73,183],"day-14":[68],"CIK":[69,81,105,221],"products":[71],"generated":[72],"five":[74],"patients":[75],"mCRC.":[77,250],"Among":[78],"14,973":[79],"ten":[83,111],"were":[86,153],"identified,":[87],"comprising":[88],"six":[89],"conventional":[90],"four":[92,121],"(C3,":[95],"C5,":[96,196],"C7":[97,204],"C9).":[99],"frequency":[102],"increased":[103],"during":[104],"in":[107,120,127,163,195,200,203,207,249],"all":[108],"patients.":[109],"The":[110],"most":[112],"expanded":[113],"clonotypes":[115],"preferentially":[116],"occupied":[117],"patients,":[122],"while":[123],"memory-like":[124,151],"predominated":[126],"one,":[128],"revealing":[129],"inter-patient":[130],"heterogeneity.":[131],"Despite":[132],"this,":[133],"showed":[136],"significant":[137],"overlap":[139],"(permutation":[140],"test,":[141],"Benjamini\u2013Hochberg-adjusted":[142],"P":[143],"<":[144],"0.05),":[145],"consistent":[146],"phenotypic":[148],"plasticity,":[149],"whereas":[150],"largely":[154],"clonally":[155],"distinct.":[156],"Trajectory":[157],"analysis":[158,189],"supported":[159],"branching":[161],"model":[162],"which":[164],"intermediate":[165],"C5":[166],"was":[167],"associated":[168],"trajectories":[170],"toward":[171,185],"highly":[172],"cytotoxic":[173,177,226],"Temra-like":[174],"C9":[175],"or":[176],"C3,":[178],"further":[181],"trajectory":[182],"C3":[184],"dysfunctional-like":[186],"C7.":[187],"Regulon":[188],"identified":[190],"state-specific":[191],"programs,":[192],"KLF2":[194],"GFI1":[197],"IKZF2":[199],"C9,":[201],"IKZF1":[202],"FOXM1":[206],"proliferative":[208],"C8.":[209],"Together,":[210],"these":[211],"findings":[212],"identify":[213],"apparent":[215],"branch":[216],"point":[217],"within":[218],"that":[223,232],"may":[224,238],"shape":[225],"dysfunctional":[228],"phenotypes.":[229],"This":[230],"suggests":[231],"targeting":[233],"pathways":[234],"governing":[235],"this":[236],"transition":[237],"improve":[239],"manufacturing":[241],"lead":[243],"more":[245],"effective":[246],"therapeutic":[247],"outcomes":[248]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
