{"id":"https://openalex.org/W7225418003","doi":"https://doi.org/10.21203/rs.3.rs-11622408/v1","title":"Immune Inflammation in Brown Adipose Tissue and Altered Lipid Metabolism in the Liver Under Geomagnetic Field Shielding","display_name":"Immune Inflammation in Brown Adipose Tissue and Altered Lipid Metabolism in the Liver Under Geomagnetic Field Shielding","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225418003","doi":"https://doi.org/10.21203/rs.3.rs-11622408/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11622408/v1","doi":"https://doi.org/10.21203/rs.3.rs-11622408/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11622408/v1","pdf_url":"https://www.researchsquare.com/article/rs-11622408/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11622408/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151753131","display_name":"Xuejing Ma","orcid":"https://orcid.org/0000-0002-8554-6074","observed_orcids":["https://orcid.org/0000-0002-8554-6074"]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejing Ma","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072750321","display_name":"Dunqin Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dunqin Gao","raw_affiliation_strings":["Chinese Academy of Medical Science & Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Science & Peking Union Medical College","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018207765","display_name":"Guanqun Kou","orcid":"https://orcid.org/0000-0002-4106-6095","observed_orcids":["https://orcid.org/0000-0002-4106-6095"]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanqun Kou","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102219098","display_name":"Wenya Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenya Xu","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011571848","display_name":"Jiaxuan Zhao","orcid":"https://orcid.org/0009-0009-9348-0472","observed_orcids":["https://orcid.org/0009-0009-9348-0472"]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxuan Zhao","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161075133","display_name":"Huili Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huili Wang","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121217497","display_name":"Songyuan Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songyuan Duan","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161072894","display_name":"Jingyi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Zhang","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161134001","display_name":"Ruoxi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoxi Zhang","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161127165","display_name":"Xinyi Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112851","display_name":"Cangzhou Normal University","ror":"https://ror.org/01de7qg49","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210112851"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Jiang","raw_affiliation_strings":["Cangzhou Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cangzhou Normal University","institution_ids":["https://openalex.org/I4210112851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypomagnetic-field","display_name":"hypomagnetic field","score":0.9810000061988831},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9089999794960022},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.871999979019165},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9200000166893005},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.828000009059906},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/triglyceride-accumulation","display_name":"triglyceride accumulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glycerophospholipid-metabolism","display_name":"glycerophospholipid metabolism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.7210999727249146},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5774000287055969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5641999840736389},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5631999969482422},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5490999817848206},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.5285000205039978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5038999915122986},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5011000037193298},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.48350000381469727},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.45100000500679016},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.41040000319480896},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.37610000371932983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36169999837875366},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3578999936580658},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.35440000891685486},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.3237999975681305},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.3181999921798706},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26019999384880066},{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.25999999046325684}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11622408/v1","doi":"https://doi.org/10.21203/rs.3.rs-11622408/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11622408/v1","pdf_url":"https://www.researchsquare.com/article/rs-11622408/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11622408/v1","doi":"https://doi.org/10.21203/rs.3.rs-11622408/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11622408/v1","pdf_url":"https://www.researchsquare.com/article/rs-11622408/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320326853","display_name":"Peking Union Medical College","ror":"https://ror.org/02drdmm93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225418003.pdf","grobid_xml":"https://content.openalex.org/works/W7225418003.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7128484451","https://openalex.org/W2903171865","https://openalex.org/W4294904199","https://openalex.org/W2807581187","https://openalex.org/W2617082402","https://openalex.org/W2529277147","https://openalex.org/W4417417193","https://openalex.org/W4296935039","https://openalex.org/W2417229180","https://openalex.org/W2394499266"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"Hypomagnetic":[2],"field":[3,48],"is":[4,35],"an":[5],"environmental":[6],"factor":[7],"in":[8,15,66,103,154,171],"deep":[9],"space":[10],"that":[11,163],"affect":[12],"multiple":[13],"systems":[14],"human":[16],"body,":[17],"but":[18],"how":[19],"they":[20],"impact":[21],"the":[22,72],"immunometabolism":[23],"of":[24],"metabolic":[25,117],"tissues":[26],"such":[27,119],"as":[28,88,90,120],"brown":[29],"adipose":[30],"tissue":[31],"(BAT)":[32],"and":[33,49,56,68,81,85,106,124,127,146,173],"liver":[34,57],"still":[36],"unclear.":[37],"This":[38],"study":[39],"used":[40],"geomagnetic":[41],"shielding":[42],"(GS)":[43],"environment":[44,61,74,112,165],"to":[45,93,115,132,167],"simulate":[46],"hypomagnetic":[47],"preliminarily":[50],"explored":[51],"its":[52],"effects":[53],"on":[54,101],"BAT":[55,67,172],"immunometabolism.":[58],"Results":[59],"GS":[60,73,105,111,158,164],"caused":[62],"different":[63],"immunometabolic":[64,169],"changes":[65,170],"liver.":[69],"In":[70,109],"BAT,":[71],"was":[75,113,141],"associated":[76],"with":[77],"immune":[78,129],"inflammatory":[79],"pathways":[80,118],"also":[82,136],"affected":[83],"glucose":[84],"lipid":[86,94,116],"metabolism":[87],"well":[89],"autophagy":[91],"related":[92,131],"droplets":[95],"(LDs).":[96],"Transferrin":[97],"receptors":[98],"were":[99,135],"enriched":[100],"LDs":[102,156],"both":[104,144],"non-GS":[107],"conditions.":[108,159],"liver,":[110,174],"linked":[114],"cholesterol,":[121],"fatty":[122],"acid,":[123],"glycerophospholipid":[125],"metabolism,":[126],"innate":[128],"responses":[130],"antiviral":[133],"defense":[134],"activated.":[137],"Fatty":[138],"acid":[139],"synthase":[140],"upregulated":[142],"at":[143],"transcriptomic":[145],"LD":[147],"proteomic":[148],"levels.":[149],"Furthermore,":[150],"TAG":[151],"accumulated":[152],"significantly":[153],"hepatic":[155],"under":[157],"These":[160],"results":[161],"suggest":[162],"leads":[166],"tissue-specific":[168],"providing":[175],"a":[176],"theoretical":[177],"basis":[178],"for":[179,184],"developing":[180],"health":[181],"protection":[182],"strategies":[183],"astronauts.":[185]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
