{"id":"https://openalex.org/W7225416631","doi":"https://doi.org/10.1302/1358-992x.2026.11.099","title":"IN VIVO EVALUATION OF THE EFFICACY OF LOCALLY DELIVERED ANTIBIOTICS ENCAPSULATED IN MICROPARTICLES FOR EARLY PJI: IMPROVING THE RESULTS OF DAIR","display_name":"IN VIVO EVALUATION OF THE EFFICACY OF LOCALLY DELIVERED ANTIBIOTICS ENCAPSULATED IN MICROPARTICLES FOR EARLY PJI: IMPROVING THE RESULTS OF DAIR","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225416631","doi":"https://doi.org/10.1302/1358-992x.2026.11.099"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.099","doi":"https://doi.org/10.1302/1358-992x.2026.11.099","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.099","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113011996","display_name":"Jos\u00e9 Mar\u00eda Martinez Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Mar\u00eda Mart\u00ednez Rodr\u00edguez","raw_affiliation_strings":["Fundacion Jimenez Diaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Jimenez Diaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159432733","display_name":"Ana Isabel Fraguas Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Isabel Fraguas S\u00e1nchez","raw_affiliation_strings":["Universidad Complutense de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Complutense de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083952650","display_name":"Juan Aparicio Blanco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Aparicio Blanco","raw_affiliation_strings":["Universidad Complutense de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Complutense de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161086138","display_name":"Cristina Mart\u00edn Sabroso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Mart\u00edn Sabroso","raw_affiliation_strings":["Universidad Complutense de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Complutense de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042111950","display_name":"Federico Navarro Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Federico Navarro Garc\u00eda","raw_affiliation_strings":["Universidad Complutense de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Complutense de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161130191","display_name":"Victor Estuardo Le\u00f3n Rom\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Victor Estuardo Le\u00f3n Rom\u00e1n","raw_affiliation_strings":["Fundacion Jimenez Diaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Jimenez Diaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112592538","display_name":"Emilio Calvo Crespo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Emilio Calvo Crespo","raw_affiliation_strings":["Fundacion Jimenez Diaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Jimenez Diaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5141277187","display_name":"Irene Isabel L\u00f3pez Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Irene Isabel L\u00f3pez Torres","raw_affiliation_strings":["Fundacion Jimenez Diaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Jimenez Diaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"99","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9909999966621399},{"id":"https://openalex.org/keywords/local-antibiotic-delivery","display_name":"local antibiotic delivery","score":0.7310000061988831},{"id":"https://openalex.org/keywords/microparticles","display_name":"microparticles","score":0.7749999761581421},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":1.0},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8730000257492065},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.6700000166893005},{"id":"https://openalex.org/keywords/antibiotic-loaded-implants","display_name":"antibiotic-loaded implants","score":0.47699999809265137},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5230000019073486},{"id":"https://openalex.org/keywords/synovial-fluid-culture","display_name":"synovial fluid culture","score":0.5680000185966492},{"id":"https://openalex.org/keywords/3d-printed-implants","display_name":"3D-printed implants","score":0.5590000152587891},{"id":"https://openalex.org/keywords/antimicrobial-efficacy","display_name":"antimicrobial efficacy","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8431000113487244},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6557999849319458},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5922999978065491},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.5533999800682068},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5214999914169312},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.4837000072002411},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.4343999922275543},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.3626999855041504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C2777417762","wikidata":"https://www.wikidata.org/wiki/Q1863402","display_name":"Joint replacement","level":3,"score":0.31520000100135803},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C192285135","wikidata":"https://www.wikidata.org/wiki/Q954757","display_name":"Colony-forming unit","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C2777581609","wikidata":"https://www.wikidata.org/wiki/Q293148","display_name":"Rhodococcus equi","level":4,"score":0.2775999903678894},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C189539697","wikidata":"https://www.wikidata.org/wiki/Q1125312","display_name":"Microbiological culture","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C2778353156","wikidata":"https://www.wikidata.org/wiki/Q415739","display_name":"Cefazolin","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.26179999113082886},{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2540999948978424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.099","doi":"https://doi.org/10.1302/1358-992x.2026.11.099","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.099","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205909766","https://openalex.org/W2915917503","https://openalex.org/W7049138436","https://openalex.org/W2588785346","https://openalex.org/W3030293924","https://openalex.org/W4403429666","https://openalex.org/W4304842857","https://openalex.org/W4386084430","https://openalex.org/W3082332680","https://openalex.org/W2135233366"],"abstract_inverted_index":{"Objectives":[0],"The":[1],"purpose":[2],"of":[3,12,22,31,39,84,89,96,136,206,220,229,275,284,307,372,382],"the":[4,9,32,37,67,105,130,137,141,153,176,188,197,215,221,258,269,276,370,373,380],"study":[5,43],"was":[6,44,73,191],"to":[7,116,140,182,194,214,268,287,368],"evaluate":[8],"antimicrobial":[10],"efficacy":[11],"rifampicin":[13,345],"and":[14,35,62,112,125,147,159,161,212,264,299,311,334,375],"ciprofloxacin":[15],"loaded":[16,360],"microparticles":[17],"using":[18,46],"a":[19,76,85,365],"rabbit":[20],"model":[21,51],"early":[23,383],"prosthetic":[24,142],"joint":[25,70],"infection":[26,97],"(PJI).":[27],"Methods":[28],"Previous":[29],"approval":[30],"local":[33,134,357],"EC":[34],"following":[36],"declaration":[38],"Helsinki,":[40],"an":[41,47],"experimental":[42],"conducted":[45],"in":[48,52,175,204,223,236,245,250,278,290,304,314,326,338],"vivo":[49],"PJI":[50],"New":[53,169],"Zealand":[54,170],"White":[55,171],"rabbits.":[56],"Preoperative":[57],"data,":[58],"including":[59],"body":[60],"temperature":[61],"weight":[63],"were":[64,102,110,114,150,157,164,173,202,302],"recorded.":[65,151],"In":[66,104,152],"first":[68],"phase,":[69,107,155],"replacement":[71],"surgery":[72],"performed":[74],"with":[75,178,240,343,361],"3D":[77],"printed":[78],"specie-specific":[79],"implant,":[80],"followed":[81],"by":[82],"inoculation":[83],"biofilm":[86],"forming":[87],"strain":[88],"S.":[90],"Aureus.":[91],"During":[92,210],"follow-up,":[93],"clinical":[94,208,227,282,349],"signs":[95,228,283],"(effusion,":[98],"dehiscence,":[99],"or":[100,254],"fistula)":[101],"assessed.":[103],"second":[106,216],"microbiological":[108,148],"samples":[109,163,256,301],"collected":[111],"animals":[113,156,180],"assigned":[115],"two":[117,259],"treatment":[118,381],"groups:":[119],"group":[120,127,190],"A":[121,280,309],"received":[122,129],"surgical":[123,217,271],"irrigation":[124],"debridement;":[126],"B":[128,316],"same":[131],"procedure":[132],"plus":[133],"application":[135],"antibiotic":[138],"formulation":[139],"surface.":[143],"Post-operative":[144],"clinical,":[145],"analytical":[146],"variables":[149],"final":[154],"euthanized":[158],"blood":[160],"tissue":[162,255,300],"collected.":[165],"Results":[166],"Sixteen":[167],"male":[168],"rabbits":[172],"included":[174],"study,":[177],"8":[179],"allocated":[181],"each":[183],"group.":[184],"One":[185],"subject":[186],"from":[187,295],"control":[189],"excluded":[192],"due":[193],"death":[195],"during":[196],"follow-up":[198,211],"period.":[199],"Both":[200],"groups":[201,225,260],"comparable":[203],"terms":[205],"preoperative":[207],"parameters.":[209],"prior":[213],"procedure,":[218],"100%":[219],"subjects":[222,277,310],"both":[224,296],"exhibited":[226],"infection.":[230],"Microbiological":[231,293],"cultures":[232,294],"yielded":[233],"pathogen":[234],"isolation":[235],"all":[237],"cases":[238],"(100%),":[239],"no":[241],"statistically":[242,323],"significant":[243,324],"differences":[244,325],"colony-forming":[246],"unit":[247],"(CFU)":[248],"counts":[249],"either":[251],"synovial":[252,297],"fluid":[253,298],"between":[257],"(p":[261,317],"=":[262,318],".39":[263],".42,":[265],"respectively).":[266],"Prior":[267],"third":[270],"intervention,":[272],"85.7%":[273,305],"(6/7)":[274,306],"Group":[279,291,308,315,339],"showed":[281],"infection,":[285],"compared":[286],"14.2%":[288,312],"(1/8)":[289,313],"B.":[292],"positive":[303],".04).":[319],"Biochemical":[320],"analyses":[321],"revealed":[322],"liver":[327],"enzyme":[328],"levels":[329],"(ALT":[330],"[p=.02],":[331],"AST":[332],"[p=.03],":[333],"bilirubin":[335],"[p.04]),":[336],"higher":[337],"B,":[340],"presumably":[341],"associated":[342],"systemic":[344],"absorption,":[346],"although":[347],"without":[348],"relevance.":[350],"Conclusions":[351],"Although":[352],"more":[353],"studies":[354],"are":[355],"required,":[356],"delivery":[358],"systems":[359],"antibiotics":[362],"may":[363],"be":[364],"useful":[366],"strategy":[367],"enhance":[369],"results":[371],"debridement":[374],"implant":[376],"retention":[377],"strategies":[378],"for":[379],"PJI.":[384]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}