{"id":"https://openalex.org/W7225414698","doi":"https://doi.org/10.1302/1358-992x.2026.11.086","title":"CLONALITY OF STAPHYLOCOCCUS AUREUS IN FRACTURE-RELATED AND PROSTHETIC JOINT INFECTIONS AND IMPLICATIONS FOR THERAPEUTIC PHAGE DEVELOPMENT","display_name":"CLONALITY OF STAPHYLOCOCCUS AUREUS IN FRACTURE-RELATED AND PROSTHETIC JOINT INFECTIONS AND IMPLICATIONS FOR THERAPEUTIC PHAGE DEVELOPMENT","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225414698","doi":"https://doi.org/10.1302/1358-992x.2026.11.086"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.086","doi":"https://doi.org/10.1302/1358-992x.2026.11.086","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.086","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089105555","display_name":"Nazary Nebeluk","orcid":"https://orcid.org/0000-0003-3426-7005","observed_orcids":["https://orcid.org/0000-0003-3426-7005"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazary Nebeluk","raw_affiliation_strings":["Institute of Human Virology, Baltimore, United States","University of Maryland School of Medicine, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, Baltimore, United States","institution_ids":[]},{"raw_affiliation_string":"University of Maryland School of Medicine, Baltimore, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015368781","display_name":"James B. Doub","orcid":"https://orcid.org/0000-0002-4977-0968","observed_orcids":["https://orcid.org/0000-0002-4977-0968"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Doub","raw_affiliation_strings":["Institute of Human Virology, Baltimore, United States","University of Maryland School of Medicine, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, Baltimore, United States","institution_ids":[]},{"raw_affiliation_string":"University of Maryland School of Medicine, Baltimore, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032805931","display_name":"Luke J. Tallon","orcid":"https://orcid.org/0000-0002-4656-4480","observed_orcids":["https://orcid.org/0000-0002-4656-4480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Tallon","raw_affiliation_strings":["Institute for Genome Sciences, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Sciences, Baltimore, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046271125","display_name":"Rob Hand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Hand","raw_affiliation_strings":["Institute for Genome Sciences, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Sciences, Baltimore, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003335270","display_name":"Kranthi Vavikolanu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kranthi Vavikolanu","raw_affiliation_strings":["Institute for Genome Sciences, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Sciences, Baltimore, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063015989","display_name":"Ivette Santana-Cruz","orcid":"https://orcid.org/0000-0002-8111-0361","observed_orcids":["https://orcid.org/0000-0002-8111-0361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivette Santana-Cruz","raw_affiliation_strings":["Institute for Genome Sciences, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genome Sciences, Baltimore, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089558580","display_name":"Ashley E. Levack","orcid":"https://orcid.org/0000-0002-9506-6322","observed_orcids":["https://orcid.org/0000-0002-9506-6322"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Levack","raw_affiliation_strings":["Loyola University Stritch School of Medicine, Maywood, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Stritch School of Medicine, Maywood, United States","institution_ids":["https://openalex.org/I1304196042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fracture-related-infection","display_name":"fracture-related infection","score":0.8500000238418579},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":1.0},{"id":"https://openalex.org/keywords/bacterial-clonality","display_name":"bacterial clonality","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tar","display_name":"tar","score":0.847000002861023},{"id":"https://openalex.org/keywords/tarp","display_name":"TARP","score":0.9890000224113464},{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C2778253522","wikidata":"https://www.wikidata.org/wiki/Q899834","display_name":"Teichoic acid","level":4,"score":0.7694000005722046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7587000131607056},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.680899977684021},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.6086999773979187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5595999956130981},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5285000205039978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5130000114440918},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.45669999718666077},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.42730000615119934},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.41359999775886536},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.40959998965263367},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.4043999910354614},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.383899986743927},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.3668000102043152},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.34610000252723694},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.33340001106262207},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.3199999928474426},{"id":"https://openalex.org/C57326107","wikidata":"https://www.wikidata.org/wiki/Q4244196","display_name":"Phage typing","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.29580000042915344},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C157887575","wikidata":"https://www.wikidata.org/wiki/Q417216","display_name":"Insertion sequence","level":5,"score":0.27639999985694885},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.26899999380111694},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.26269999146461487}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.086","doi":"https://doi.org/10.1302/1358-992x.2026.11.086","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.086","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7208810124","https://openalex.org/W4391918247","https://openalex.org/W3014390618","https://openalex.org/W3205552671","https://openalex.org/W4212766905","https://openalex.org/W3135723846","https://openalex.org/W4220788449","https://openalex.org/W4392370547","https://openalex.org/W4412040426","https://openalex.org/W7167511884"],"abstract_inverted_index":{"Introduction":[0],"&":[1],"Aim":[2],"Biofilm-associated":[3],"musculoskeletal":[4,316],"infections,":[5,241],"such":[6],"as":[7],"fracture-related":[8],"infection":[9,14,141,254,293],"(FRI)":[10],"and":[11,22,62,64,96,142,148,154,179,205,211,224,253,261,271,288,306],"prosthetic":[12],"joint":[13],"(PJI),":[15],"are":[16,23,39,263],"commonly":[17],"caused":[18],"by":[19,41,120,133],"Staphylococcus":[20],"aureus":[21,59,86,259],"difficult":[24],"to":[25,53,65,80,122,126,166,235],"eradicate":[26],"with":[27,93,193,267],"conventional":[28],"antibiotics.":[29],"Precision":[30],"approaches,":[31],"including":[32,303],"bacteriophage":[33,78,304],"therapy,":[34,305],"depend":[35],"on":[36],"whether":[37],"infections":[38,266],"driven":[40],"a":[42,101,123,186,281,296],"single":[43,282],"bacterial":[44,247],"clone":[45],"or":[46,107],"comprise":[47],"multiple":[48],"coexisting":[49],"strains.":[50],"We":[51],"aimed":[52],"determine":[54],"the":[55,278,308],"clonality":[56,294],"of":[57,103,157,189,217,280,311],"S.":[58,81,85,258],"in":[60,69,171],"FRIs":[61,95,178,260],"PJIs":[63,262],"assess":[66,127,167],"intra-infection":[67,128,169,269],"variation":[68,156,238],"wall":[70],"teichoic":[71],"acid":[72],"(WTA)":[73],"glycosylation":[74,173,244,273],"genes":[75,160,232],"critical":[76,297],"for":[77,113,286,299,315],"attachment":[79],"aureus.":[82],"Methods":[83],"Clinical":[84],"isolates":[87,181,197,218],"were":[88,111,118,164],"obtained":[89],"intraoperatively":[90],"from":[91,182],"patients":[92],"confirmed":[94],"PJIs.":[97],"For":[98],"each":[99,140,183],"infection,":[100],"minimum":[102],"eight":[104],"morphologically":[105],"distinct":[106],"randomly":[108],"selected":[109],"colonies":[110,138,204],"submitted":[112],"whole-genome":[114,201],"sequencing.":[115],"Genomic":[116],"variants":[117,136,202],"identified":[119],"alignment":[121],"reference":[124],"genome":[125],"relatedness.":[129],"Clonality":[130],"was":[131,226],"evaluated":[132],"comparing":[134],"shared":[135,200],"across":[137,246],"within":[139,239],"assessing":[143],"overlap":[144,207],"between":[145,208],"individual":[146,209,240],"colony":[147,210],"merged":[149,212],"variant":[150,213],"profiles.":[151,214],"The":[152,215],"presence":[153],"sequence":[155,237],"WTA":[158,172,230,272],"glycosyltransferase":[159,231],"(tarS,":[161],"tarM,":[162,223],"tarP)":[163],"analyzed":[165],"potential":[168,245],"heterogeneity":[170],"capacity.":[174],"Results":[175],"Across":[176],"all":[177],"PJIs,":[180],"patient":[184],"demonstrated":[185,198],"high":[187],"degree":[188],"genetic":[190],"relatedness":[191],"consistent":[192],"clonal":[194,265],"infections.":[195,317],"FRI":[196],">92%":[199],"among":[203],">98%":[206],"majority":[216],"contained":[219],"tarS,":[220],"fewer":[221],"harbored":[222],"tarP":[225],"absent.":[227],"When":[228],"present,":[229],"showed":[233],"minimal":[234],"no":[236],"indicating":[242],"uniform":[243],"populations":[248],"despite":[249],"differing":[250],"clinical":[251,284],"contexts":[252],"chronicity.":[255],"Conclusions":[256],"Both":[257],"predominantly":[264],"limited":[268],"genomic":[270],"variability.":[274],"These":[275],"findings":[276],"support":[277],"use":[279],"representative":[283],"isolate":[285],"microbiological":[287],"phage":[289],"therapeutic":[290],"testing.":[291],"Understanding":[292],"provides":[295],"foundation":[298],"precision":[300],"anti-biofilm":[301],"strategies,":[302],"informs":[307],"rational":[309],"development":[310],"targeted":[312],"adjunctive":[313],"treatments":[314]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
