{"id":"https://openalex.org/W7225414643","doi":"https://doi.org/10.3389/fmed.2026.1976864","title":"HSPA5-associated transcriptional programs and cellular phenotypes in follicular thyroid carcinoma","display_name":"HSPA5-associated transcriptional programs and cellular phenotypes in follicular thyroid carcinoma","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225414643","doi":"https://doi.org/10.3389/fmed.2026.1976864"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1976864","doi":"https://doi.org/10.3389/fmed.2026.1976864","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1976864","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1976864/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1976864/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161088367","display_name":"Yinghan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghan Liu","raw_affiliation_strings":["Department of Thyroid Surgery, The Second Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, The Second Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161094062","display_name":"Jingchao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingchao Xu","raw_affiliation_strings":["Department of Thyroid Surgery, The Second Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, The Second Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161063980","display_name":"Siqi Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Yu","raw_affiliation_strings":["Department of Breast Surgery, The Second Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Second Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126252085","display_name":"Guangzhi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangzhi Wang","raw_affiliation_strings":["Department of Thyroid Surgery, The Second Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, The Second Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161028086","display_name":"Yongfu Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongfu Zhao","raw_affiliation_strings":["Department of Thyroid Surgery, The Second Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, The Second Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5126252085","https://openalex.org/A5161028086"],"corresponding_institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":1.0},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-chaperone","display_name":"endoplasmic reticulum chaperone","score":0.972000002861023},{"id":"https://openalex.org/keywords/transcriptional-programs","display_name":"transcriptional programs","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/follicular-thyroid-adenoma","display_name":"follicular adenoma","score":0.6370000243186951},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.5270000100135803},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.6342999935150146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6168000102043152},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6161999702453613},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6136999726295471},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5550000071525574},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5388000011444092},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5102999806404114},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.482699990272522},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.4074000120162964},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.36239999532699585},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3422999978065491},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3391999900341034},{"id":"https://openalex.org/C2779341817","wikidata":"https://www.wikidata.org/wiki/Q5464665","display_name":"Follicular thyroid cancer","level":5,"score":0.3285999894142151},{"id":"https://openalex.org/C2778057883","wikidata":"https://www.wikidata.org/wiki/Q92793969","display_name":"Follicular cell","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3165999948978424},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3151000142097473},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3089999854564667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3075999915599823},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2955000102519989},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2777802297","wikidata":"https://www.wikidata.org/wiki/Q2465347","display_name":"Thyroid adenoma","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.28139999508857727},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2711000144481659},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmed.2026.1976864","doi":"https://doi.org/10.3389/fmed.2026.1976864","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1976864","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1976864/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:1c10c045441444409f50255d3c4db1f5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1c10c045441444409f50255d3c4db1f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1976864","doi":"https://doi.org/10.3389/fmed.2026.1976864","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1976864","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1976864/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225414643.pdf","grobid_xml":"https://content.openalex.org/works/W7225414643.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1796086621","https://openalex.org/W1966327575","https://openalex.org/W1966369019","https://openalex.org/W1997183854","https://openalex.org/W2002490399","https://openalex.org/W2055531243","https://openalex.org/W2084276537","https://openalex.org/W2106625264","https://openalex.org/W2107277218","https://openalex.org/W2110065044","https://openalex.org/W2130410032","https://openalex.org/W2145150141","https://openalex.org/W2146512944","https://openalex.org/W2168420558","https://openalex.org/W2337882641","https://openalex.org/W2341141208","https://openalex.org/W2478132860","https://openalex.org/W2582111083","https://openalex.org/W2586097538","https://openalex.org/W2621007532","https://openalex.org/W2762087180","https://openalex.org/W2766712571","https://openalex.org/W2803862531","https://openalex.org/W2945161487","https://openalex.org/W2980472864","https://openalex.org/W2980520209","https://openalex.org/W3011868091","https://openalex.org/W3013967177","https://openalex.org/W3015020891","https://openalex.org/W3016093449","https://openalex.org/W3030834164","https://openalex.org/W3036810408","https://openalex.org/W3108493784","https://openalex.org/W3123922203","https://openalex.org/W3133823534","https://openalex.org/W3154085979","https://openalex.org/W3162306949","https://openalex.org/W4375951588","https://openalex.org/W4391878282","https://openalex.org/W4394753932","https://openalex.org/W4414716846","https://openalex.org/W4415026081","https://openalex.org/W7108207777"],"related_works":["https://openalex.org/W4376106139","https://openalex.org/W4392294891","https://openalex.org/W3204695050","https://openalex.org/W2582111083","https://openalex.org/W4385769304","https://openalex.org/W4292054919","https://openalex.org/W3184827529","https://openalex.org/W7203503814","https://openalex.org/W4280574718","https://openalex.org/W3152903142"],"abstract_inverted_index":{"Background":[0],"Follicular":[1],"thyroid":[2,122],"carcinoma":[3],"(FTC)":[4],"is":[5,175],"difficult":[6],"to":[7],"distinguish":[8],"from":[9],"benign":[10],"follicular":[11,132],"lesions":[12],"before":[13],"surgery.":[14],"This":[15],"study":[16],"examined":[17],"heat":[18],"shock":[19],"protein":[20],"family":[21],"A":[22],"member":[23],"5":[24],"(HSPA5),":[25],"an":[26],"endoplasmic":[27],"reticulum":[28],"chaperone,":[29],"and":[30,37,54,67,78,84,95,102,108,131,146,159,164,181,188],"its":[31,182],"association":[32],"with":[33,60,93,177],"ferroptosis-related":[34,178],"transcriptional":[35,179],"programs":[36],"cellular":[38],"phenotypes":[39],"in":[40,65,113,120,192,199],"FTC.":[41],"Methods":[42],"Five":[43],"public":[44],"transcriptomic":[45],"cohorts":[46],"were":[47,80],"integrated":[48],"for":[49],"candidate":[50],"discovery,":[51],"external":[52],"characterization,":[53],"paired-tissue":[55],"evaluation.":[56],"HSPA5":[57,91,149,174,198],"was":[58,111,134],"silenced":[59],"two":[61],"short-hairpin":[62],"RNA":[63],"constructs":[64],"FTC-238":[66,145],"FTC-133":[68,147],"cells.":[69],"Knockdown,":[70],"metabolic":[71],"activity,":[72],"DNA":[73],"synthesis,":[74],"wound":[75],"closure,":[76],"migration,":[77],"invasion":[79],"evaluated":[81],"using":[82],"molecular":[83],"cell-based":[85],"assays.":[86],"Results":[87],"In":[88,143],"exploratory":[89],"analyses,":[90],"correlated":[92],"ferroptosis-driver":[94],"lipid-peroxidation":[96],"scores":[97],"(Spearman":[98],"rho":[99],"=":[100,106,125,141],"0.709":[101],"0.791;":[103],"false-discovery":[104],"rates":[105],"0.023":[107],"0.013).":[109],"Expression":[110],"higher":[112],"eight":[114],"patient-matched":[115],"primary":[116],"FTC":[117,130,193],"samples":[118],"than":[119],"adjacent":[121],"(":[123],"P":[124],"0.0078).":[126],"External":[127],"discrimination":[128],"between":[129],"adenoma":[133],"limited":[135],"(area":[136],"under":[137],"the":[138,152,160,169],"receiver-operating-characteristic":[139],"curve":[140],"0.51).":[142],"both":[144],"cells,":[148,166],"silencing":[150],"reduced":[151],"24-h":[153,185],"Cell":[154],"Counting":[155],"Kit-8":[156],"(CCK-8)":[157],"signal":[158],"numbers":[161],"of":[162,197],"migrating":[163],"invading":[165],"but":[167],"increased":[168],"5-ethynyl-2'-deoxyuridine":[170],"(EdU)-positive":[171],"fraction.":[172],"Conclusion":[173],"associated":[176],"programs,":[180],"depletion":[183],"reduces":[184],"CCK-8":[186],"signals":[187],"Transwell":[189],"cell":[190,201],"counts":[191],"models.":[194],"The":[195],"role":[196],"ferroptotic":[200],"death":[202],"requires":[203],"functional":[204],"validation.":[205]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}