{"id":"https://openalex.org/W7225413762","doi":"https://doi.org/10.18609/vac.2026.055","title":"Scaling cell-based vaccine manufacturing: process redesign achieves an approximately 20-fold increase in relative viral titer","display_name":"Scaling cell-based vaccine manufacturing: process redesign achieves an approximately 20-fold increase in relative viral titer","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225413762","doi":"https://doi.org/10.18609/vac.2026.055"},"language":"en","primary_location":{"id":"doi:10.18609/vac.2026.055","doi":"https://doi.org/10.18609/vac.2026.055","is_oa":true,"landing_page_url":"https://doi.org/10.18609/vac.2026.055","pdf_url":null,"source":{"id":"https://openalex.org/S4387281712","display_name":"Vaccine Insights","issn_l":"2752-5422","issn":["2752-5422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine Insights","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.18609/vac.2026.055","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153638134","display_name":"Giovanna Alves de Sousa Dutra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119216","display_name":"Vaxxinova (Norway)","ror":"https://ror.org/02k4een92","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210119216"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Giovanna Alves de Sousa Dutra","raw_affiliation_strings":["Vaxxinova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaxxinova","institution_ids":["https://openalex.org/I4210119216"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161125474","display_name":"Irana Coletti Malaspina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irana Coletti Malaspina","raw_affiliation_strings":["Corning Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corning Life Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"9","first_page":"451\u2013458","last_page":"451\u2013458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process-scaling","display_name":"process scaling","score":0.5600000023841858},{"id":"https://openalex.org/keywords/adherent-cell-culture","display_name":"adherent cell culture","score":0.7689999938011169},{"id":"https://openalex.org/keywords/roller-bottles","display_name":"roller bottles","score":0.8579999804496765},{"id":"https://openalex.org/keywords/virus-titer","display_name":"viral titer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/process-redesign","display_name":"process redesign","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cell-lines","display_name":"cell lines","score":0.4729999899864197},{"id":"https://openalex.org/keywords/operator-reduction","display_name":"operator reduction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/computational-time-reduction","display_name":"computation time reduction","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5342000126838684},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.5091999769210815},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.45320001244544983},{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44780001044273376},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.40299999713897705},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.382999986410141},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3813000023365021},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.37229999899864197},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.35120001435279846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33640000224113464},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3303000032901764},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C99862985","wikidata":"https://www.wikidata.org/wiki/Q10858068","display_name":"Production line","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28360000252723694},{"id":"https://openalex.org/C2988729646","wikidata":"https://www.wikidata.org/wiki/Q838129","display_name":"Process development","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2734000086784363},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.25949999690055847},{"id":"https://openalex.org/C3019666875","wikidata":"https://www.wikidata.org/wiki/Q455037","display_name":"Assembly line","level":2,"score":0.25769999623298645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18609/vac.2026.055","doi":"https://doi.org/10.18609/vac.2026.055","is_oa":true,"landing_page_url":"https://doi.org/10.18609/vac.2026.055","pdf_url":null,"source":{"id":"https://openalex.org/S4387281712","display_name":"Vaccine Insights","issn_l":"2752-5422","issn":["2752-5422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine Insights","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18609/vac.2026.055","doi":"https://doi.org/10.18609/vac.2026.055","is_oa":true,"landing_page_url":"https://doi.org/10.18609/vac.2026.055","pdf_url":null,"source":{"id":"https://openalex.org/S4387281712","display_name":"Vaccine Insights","issn_l":"2752-5422","issn":["2752-5422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine Insights","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3014425511","https://openalex.org/W2235891297","https://openalex.org/W2340683291","https://openalex.org/W7223130775","https://openalex.org/W2911828437","https://openalex.org/W4285393540","https://openalex.org/W2968097295","https://openalex.org/W2783864131","https://openalex.org/W3016136190","https://openalex.org/W4377983603"],"abstract_inverted_index":{"Scaling":[0],"adherent":[1],"viral":[2,56],"vaccine":[3],"processes":[4],"in":[5,12,49,54,61,70,77],"roller":[6],"bottles":[7],"often":[8],"increases":[9],"operational":[10],"burden":[11],"proportion":[13],"to":[14,65],"production":[15],"capacity,":[16],"with":[17,42,87],"vessel":[18],"count,":[19],"manual":[20],"handling,":[21],"and":[22,83,89,101],"staffing":[23],"becoming":[24],"limiting":[25],"before":[26],"cell":[27,40],"biology":[28],"does.":[29],"This":[30],"article":[31],"describes":[32],"a":[33,38,43,58,75],"process":[34],"redesign":[35],"that":[36,93],"combined":[37],"new":[39],"line":[41],"consolidated":[44],"static":[45],"culture":[46],"platform,":[47],"resulting":[48],"an":[50,67,84],"approximately":[51],"20-fold":[52],"increase":[53],"relative":[55],"titer,":[57],"60%":[59],"reduction":[60,69,76],"operators":[62],"(from":[63,73],"five":[64],"two),":[66],"86%":[68],"units":[71],"handled":[72],"400\u201357),":[74],"processing":[78],"time":[79],"from":[80],"4.5\u20131.5":[81],"h,":[82],"antibiotic-free":[85],"process,":[86],"animal":[88],"serological":[90],"studies":[91],"confirming":[92],"the":[94],"final":[95],"product":[96],"maintained":[97],"its":[98],"expected":[99],"characteristics":[100],"immunological":[102],"response.":[103]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
