{"id":"https://openalex.org/W7225413689","doi":"https://doi.org/10.1038/s41598-026-78951-y","title":"Development of a clinical prediction model and risk score for extended-spectrum beta-lactamase-producing urinary tract infection in a tertiary-care outpatient setting","display_name":"Development of a clinical prediction model and risk score for extended-spectrum beta-lactamase-producing urinary tract infection in a tertiary-care outpatient setting","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225413689","doi":"https://doi.org/10.1038/s41598-026-78951-y"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-78951-y","doi":"https://doi.org/10.1038/s41598-026-78951-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78951-y","pdf_url":"https://www.nature.com/articles/s41598-026-78951-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-78951-y_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161125410","display_name":"Natchaphon Kliangchuai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Natchaphon Kliangchuai","raw_affiliation_strings":["Department of Family Medicine and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059601250","display_name":"Phoomjai Sornsenee","orcid":"https://orcid.org/0000-0001-6992-033X","observed_orcids":["https://orcid.org/0000-0001-6992-033X"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Phoomjai Sornsenee","raw_affiliation_strings":["Department of Family Medicine and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059601250"],"corresponding_institution_ids":["https://openalex.org/I131868736"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extended-spectrum-beta-lactamase","display_name":"extended-spectrum beta-lactamase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.953000009059906},{"id":"https://openalex.org/keywords/clinical-prediction-model","display_name":"clinical prediction model","score":0.859000027179718},{"id":"https://openalex.org/keywords/risk-score","display_name":"risk score","score":0.9449999928474426},{"id":"https://openalex.org/keywords/outpatient-care","display_name":"outpatient care","score":0.7900000214576721},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9229999780654907},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5799999833106995},{"id":"https://openalex.org/keywords/bedridden-status","display_name":"bedridden status","score":0.7480000257492065},{"id":"https://openalex.org/keywords/urinary-catheter","display_name":"urinary catheter","score":0.8379999995231628},{"id":"https://openalex.org/keywords/systemic-corticosteroid-therapy","display_name":"systemic corticosteroid therapy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/empirical-antibiotic-selection","display_name":"empirical antibiotic selection","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antimicrobial-stewardship","display_name":"antimicrobial stewardship","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8834999799728394},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6863999962806702},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6159999966621399},{"id":"https://openalex.org/C43346845","wikidata":"https://www.wikidata.org/wiki/Q8057732","display_name":"Youden's J statistic","level":3,"score":0.5561000108718872},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5529999732971191},{"id":"https://openalex.org/C2776040555","wikidata":"https://www.wikidata.org/wiki/Q19903321","display_name":"Antimicrobial stewardship","level":4,"score":0.5300999879837036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.515500009059906},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5011000037193298},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.49639999866485596},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4596000015735626},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.43939998745918274},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40400001406669617},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3864000141620636},{"id":"https://openalex.org/C124306116","wikidata":"https://www.wikidata.org/wiki/Q2512965","display_name":"Ambulatory care","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C2776216170","wikidata":"https://www.wikidata.org/wiki/Q632522","display_name":"Bacteriuria","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C2779457091","wikidata":"https://www.wikidata.org/wiki/Q105186","display_name":"Pharmacist","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25209999084472656},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-78951-y","doi":"https://doi.org/10.1038/s41598-026-78951-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78951-y","pdf_url":"https://www.nature.com/articles/s41598-026-78951-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-78951-y","doi":"https://doi.org/10.1038/s41598-026-78951-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78951-y","pdf_url":"https://www.nature.com/articles/s41598-026-78951-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320326657","display_name":"Faculty of Medicine, Prince of Songkla University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225413689.pdf","grobid_xml":"https://content.openalex.org/works/W7225413689.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1559439200","https://openalex.org/W3123538866","https://openalex.org/W4380264405"],"related_works":["https://openalex.org/W3121071264","https://openalex.org/W2903511090","https://openalex.org/W4414283663","https://openalex.org/W4406275870","https://openalex.org/W7116708387","https://openalex.org/W4225078405","https://openalex.org/W4409776312","https://openalex.org/W3123538866","https://openalex.org/W2269714961","https://openalex.org/W4282038603"],"abstract_inverted_index":{"Extended-spectrum":[0],"beta-lactamase":[1],"(ESBL)-producing":[2],"organisms":[3],"are":[4,20],"common":[5],"in":[6,43,156,190],"outpatient":[7,18,37,193],"urinary":[8,100],"tract":[9,101],"infections":[10],"(UTIs).":[11],"However,":[12],"practical":[13],"risk":[14,66],"stratification":[15],"tools":[16],"for":[17,92],"care":[19],"limited.":[21],"In":[22,175],"this":[23,157],"retrospective":[24],"cohort":[25],"study,":[26],"we":[27],"included":[28],"993":[29],"culture-confirmed":[30],"UTI":[31,52,90],"episodes":[32],"from":[33],"710":[34],"adults":[35],"attending":[36],"clinics":[38],"at":[39],"a":[40,63],"tertiary-care":[41,192],"hospital":[42],"Thailand":[44],"between":[45],"2020":[46],"and":[47,60,118,137,170,187],"2024.":[48],"Predictors":[49],"of":[50,94,147],"ESBL-producing":[51,89],"were":[53,121],"identified":[54],"using":[55,72,86],"Firth\u2019s":[56],"penalized":[57],"logistic":[58],"regression":[59],"incorporated":[61],"into":[62],"point-based":[64],"clinical":[65],"score.":[67],"Model":[68],"discrimination":[69,129],"was":[70,84,162],"assessed":[71],"the":[73,76,144,152,160,180],"area":[74],"under":[75],"receiver":[77],"operating":[78],"characteristic":[79],"curve":[80],"(AUROC).":[81],"Internal":[82],"validation":[83],"performed":[85],"bootstrap":[87,134,140],"resampling.":[88],"accounted":[91],"34.4%":[93],"all":[95],"UTIs.":[96],"Bedridden":[97],"status,":[98],"underlying":[99],"disease,":[102],"recent":[103,110,119],"catheter":[104],"exposure,":[105,113],"prior":[106],"ESBL-positive":[107],"urine":[108],"culture,":[109],"systemic":[111,115],"antibiotic":[112,185],"current":[114],"corticosteroid":[116],"therapy,":[117],"chemotherapy":[120],"independent":[122],"predictors.":[123],"The":[124],"score":[125,146,181],"demonstrated":[126],"favorable":[127],"apparent":[128],"(AUROC":[130],"0.832,":[131],"95%":[132],"patient-level":[133,139],"CI":[135],"0.801\u20130.862)":[136],"underwent":[138],"internal":[141],"validation.":[142],"At":[143],"cutoff":[145],"\u2265":[148],"5,":[149],"which":[150],"provided":[151],"maximum":[153],"Youden":[154],"index":[155],"study":[158],"population,":[159],"sensitivity":[161],"79.8%;":[163],"specificity,":[164],"76.5%;":[165],"positive":[166],"predictive":[167,172],"value,":[168,173],"64.1%;":[169],"negative":[171],"87.8%.":[174],"summary,":[176],"following":[177],"external":[178],"validation,":[179],"may":[182],"support":[183],"empirical":[184],"selection":[186],"antimicrobial":[188],"stewardship":[189],"similar":[191],"populations.":[194]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}