{"id":"https://openalex.org/W7225412959","doi":"https://doi.org/10.64898/2026.11.05.764467","title":"Development of a Pan-Proteome Multi-Epitope Vaccine Candidate Against Nipah Virus Using Reverse Vaccinology and Immunoinformatics Approaches","display_name":"Development of a Pan-Proteome Multi-Epitope Vaccine Candidate Against Nipah Virus Using Reverse Vaccinology and Immunoinformatics Approaches","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225412959","doi":"https://doi.org/10.64898/2026.11.05.764467"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.764467","doi":"https://doi.org/10.64898/2026.11.05.764467","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764467","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764467.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764467.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109257692","display_name":"M. A. Khan","orcid":"https://orcid.org/0009-0006-7427-2246","observed_orcids":["https://orcid.org/0009-0006-7427-2246"]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Rasel Khan Nishan","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":"https://orcid.org/0009-0006-7427-2246","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093472630","display_name":"Md. Nahian","orcid":"https://orcid.org/0000-0001-6835-986X","observed_orcids":["https://orcid.org/0000-0001-6835-986X"]},"institutions":[{"id":"https://openalex.org/I32883739","display_name":"Stamford University Bangladesh","ror":"https://ror.org/0441jdk54","country_code":"BD","type":"education","lineage":["https://openalex.org/I32883739"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Nahian","raw_affiliation_strings":["Department of Microbiology, Stamford University Bangladesh;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Stamford University Bangladesh;","institution_ids":["https://openalex.org/I32883739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067746530","display_name":"Bithi Akter","orcid":"https://orcid.org/0000-0001-9117-7802","observed_orcids":["https://orcid.org/0000-0001-9117-7802"]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Bithi Akter","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116190183","display_name":"Tabassum Basher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tabassum Basher","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116190182","display_name":"Tanjum Ahmed Nodee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tanjum Ahmed Nodee","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161125069","display_name":"Irin Aminur Asha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Irin Aminur Asha","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116190184","display_name":"Mostafizur Rahaman Sany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mostafizur Rahaman Sany","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161054916","display_name":"Sanjida Akter Sathy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Sanjida Akter Sathy","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161114465","display_name":"Farzana Sharmin Shila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farzana Sharmin Shila","raw_affiliation_strings":["Women & Children Hospital, NHN, Uttara, Dhaka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women & Children Hospital, NHN, Uttara, Dhaka","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161139851","display_name":"Mohammad Ariful Islam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mohammad Ariful Islam","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108072342","display_name":"Abul Kalam Azad","orcid":"https://orcid.org/0000-0002-7516-6430","observed_orcids":["https://orcid.org/0000-0002-7516-6430"]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Abul Kalam Azad","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059489487","display_name":"Md. Shariful Islam","orcid":"https://orcid.org/0000-0002-0329-7650","observed_orcids":["https://orcid.org/0000-0002-0329-7650"]},"institutions":[{"id":"https://openalex.org/I4210125938","display_name":"Jagannath University","ror":"https://ror.org/02c4z7527","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210125938"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Md. Shariful Islam","raw_affiliation_strings":["Department of Microbiology, Jagannath University, Dhaka;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Jagannath University, Dhaka;","institution_ids":["https://openalex.org/I4210125938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059489487"],"corresponding_institution_ids":["https://openalex.org/I4210125938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nipah-virus","display_name":"Nipah virus","score":1.0},{"id":"https://openalex.org/keywords/multiepitope-vaccine","display_name":"multi-epitope vaccine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/reverse-vaccinology","display_name":"reverse vaccinology","score":0.9240000247955322},{"id":"https://openalex.org/keywords/consensus-sequence-generation","display_name":"consensus sequence generation","score":0.382999986410141},{"id":"https://openalex.org/keywords/b-cell-epitopes","display_name":"B-cell epitopes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/codon-optimization","display_name":"codon optimization","score":0.7889999747276306},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mm-gbsa-binding-free-energy","display_name":"MM-GBSA binding free energy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/zoonotic-viruses","display_name":"zoonotic viruses","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.6650999784469604},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5879999995231628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5440999865531921},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5374000072479248},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.527899980545044},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4207000136375427},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4113999903202057},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.39809998869895935},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3610000014305115},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.34310001134872437},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C2779315201","wikidata":"https://www.wikidata.org/wiki/Q414601","display_name":"Sequence homology","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C2781092335","wikidata":"https://www.wikidata.org/wiki/Q867132","display_name":"Diva","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.764467","doi":"https://doi.org/10.64898/2026.11.05.764467","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764467","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764467.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.764467","doi":"https://doi.org/10.64898/2026.11.05.764467","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.764467","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.764467.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225412959.pdf","grobid_xml":"https://content.openalex.org/works/W7225412959.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1503364994","https://openalex.org/W1973980688","https://openalex.org/W2003952795","https://openalex.org/W2014274241","https://openalex.org/W2015176909","https://openalex.org/W2035240910","https://openalex.org/W2057477511","https://openalex.org/W2086561953","https://openalex.org/W2094476373","https://openalex.org/W2102367710","https://openalex.org/W2110298304","https://openalex.org/W2120467372","https://openalex.org/W2127322768","https://openalex.org/W2143397050","https://openalex.org/W2588895177","https://openalex.org/W3197808674","https://openalex.org/W4226068113","https://openalex.org/W4308773001","https://openalex.org/W4308870604","https://openalex.org/W4324309801","https://openalex.org/W4388221118","https://openalex.org/W4388966793","https://openalex.org/W4391648610","https://openalex.org/W4396790348","https://openalex.org/W4402897621","https://openalex.org/W4402924532","https://openalex.org/W4404054932","https://openalex.org/W4410331718"],"related_works":["https://openalex.org/W7203695831","https://openalex.org/W4312816939","https://openalex.org/W4400040977","https://openalex.org/W7124499873","https://openalex.org/W7202189339","https://openalex.org/W4410331718","https://openalex.org/W4396790348","https://openalex.org/W7159040224","https://openalex.org/W4404160893","https://openalex.org/W7225003348"],"abstract_inverted_index":{"Nipah":[0],"virus":[1],"(NiV)":[2],"is":[3,14],"a":[4,20,29,167,173,197,216,231],"high-consequence":[5],"zoonotic":[6],"pathogen":[7],"for":[8,71,118,238],"which":[9,51],"no":[10],"licensed":[11],"human":[12,162],"vaccine":[13,31,111,236],"currently":[15],"available.":[16],"This":[17],"study":[18],"applied":[19],"consensus-guided":[21],"pan-proteome":[22,233],"immunoinformatics":[23],"framework":[24],"to":[25,108],"design":[26],"and":[27,56,63,76,92,104,135,146,155,189,209,245],"prioritize":[28,228],"multi-epitope":[30,235],"candidate":[32,145,237],"using":[33],"sequence":[34,219],"information":[35],"from":[36],"all":[37],"nine":[38],"NiV":[39,45,234],"proteins.":[40],"A":[41],"total":[42],"of":[43,50,152,170,201,241],"901":[44],"protein":[46],"sequences":[47],"were":[48,57,69,98,115],"retrieved,":[49],"842":[52],"passed":[53],"quality":[54],"filtering":[55,82],"processed":[58],"through":[59],"clustering,":[60],"multiple-sequence":[61],"alignment,":[62],"protein-specific":[64],"consensus":[65],"generation.":[66],"Consensus-derived":[67],"fragments":[68],"screened":[70],"cytotoxic":[72],"T-lymphocyte,":[73,75],"helper":[74],"B-cell":[77,127],"epitopes,":[78,128],"followed":[79,183],"by":[80,184],"multi-criterion":[81],"based":[83],"on":[84],"antigenicity,":[85],"allergenicity,":[86],"toxicity,":[87],"conservancy,":[88],"class-specific":[89],"immune-response":[90,133],"properties,":[91,120],"human-proteome":[93],"similarity.":[94],"Ten":[95],"epitope-selection":[96],"strategies":[97],"combined":[99,148],"with":[100,221],"two":[101],"adjuvant":[102],"candidates":[103,114],"three":[105],"construct":[106,139],"architectures":[107],"generate":[109],"60":[110],"constructs.":[112],"Shortlisted":[113],"subsequently":[116],"evaluated":[117],"physicochemical":[119],"HLA":[121],"population":[122,150],"coverage,":[123],"structural":[124,187],"characteristics,":[125],"conformational":[126,181],"TLR3":[129,163],"docking,":[130],"molecular":[131],"dynamics,":[132],"simulation,":[134,176],"expression-oriented":[136],"optimization.":[137],"VC033_V6_BD_L03":[138,229],"was":[140],"prioritized":[141],"as":[142,230],"the":[143,177],"lead":[144],"showed":[147],"predicted":[149,206],"coverage":[151],"99.78%":[153],"worldwide":[154],"99.96%":[156],"in":[157],"South":[158],"Asia.":[159],"Docking":[160],"against":[161],"structure":[164],"1ZIW":[165],"yielded":[166,196],"ClusPro":[168],"score":[169],"-1624.8.":[171],"During":[172],"100-ns":[174],"molecular-dynamics":[175],"complex":[178],"underwent":[179],"early":[180],"reorganization":[182],"lower":[185],"late-phase":[186],"variation":[188],"persistent":[190],"interchain":[191],"hydrogen":[192],"bonding.":[193],"MM/GBSA":[194],"analysis":[195],"mean":[198],"interaction-energy":[199],"estimate":[200],"-20.52,":[202],"15.42":[203],"kcal/mol.":[204],"C-ImmSim":[205],"coordinated":[207],"humoral":[208],"cellular":[210],"responses,":[211],"while":[212],"codon":[213],"optimization":[214],"generated":[215],"1,539-bp":[217],"expression":[218],"compatible":[220],"virtual":[222],"cloning":[223],"into":[224],"pET-28a(+).":[225],"These":[226],"analyses":[227],"consensus-derived,":[232],"experimental":[239],"evaluation":[240],"expression,":[242],"immunogenicity,":[243],"safety,":[244],"protective":[246],"efficacy.":[247]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-07T00:00:00"}
